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Citations to this article

Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation
Gesine Hansen, … , Rosemarie H. DeKruyff, Dale T. Umetsu
Gesine Hansen, … , Rosemarie H. DeKruyff, Dale T. Umetsu
Published January 15, 1999
Citation Information: J Clin Invest. 1999;103(2):175-183. https://doi.org/10.1172/JCI5155.
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Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

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Abstract

Allergic asthma, which is present in as many as 10% of individuals in industrialized nations, is characterized by chronic airway inflammation and hyperreactivity induced by allergen-specific Th2 cells secreting interleukin-4 (IL-4) and IL-5. Because Th1 cells antagonize Th2 cell functions, it has been proposed that immune deviation toward Th1 can protect against asthma and allergies. Using an adoptive transfer system, we assessed the roles of Th1, Th2, and Th0 cells in a mouse model of asthma and examined the capacity of Th1 cells to counterbalance the proasthmatic effects of Th2 cells. Th1, Th2, and Th0 lines were generated from ovalbumin (OVA)-specific T-cell receptor (TCR) transgenic mice and transferred into lymphocyte-deficient, OVA-treated severe combined immunodeficiency (SCID) mice. OVA-specific Th2 and Th0 cells induced significant airway hyperreactivity and inflammation. Surprisingly, Th1 cells did not attenuate Th2 cell–induced airway hyperreactivity and inflammation in either SCID mice or in OVA-immunized immunocompetent BALB/c mice, but rather caused severe airway inflammation. These results indicate that antigen-specific Th1 cells may not protect or prevent Th2-mediated allergic disease, but rather may cause acute lung pathology. These findings have significant implications with regard to current therapeutic goals in asthma and allergy and suggest that conversion of Th2-dominated allergic inflammatory responses into Th1-dominated responses may lead to further problems.

Authors

Gesine Hansen, Gerald Berry, Rosemarie H. DeKruyff, Dale T. Umetsu

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1997 1995 Total
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Citations to this article in year 2013 (8)

Title and authors Publication Year
From bedside to bench to clinic trials: identifying new treatments for severe asthma
A Mishra, X Yao, SJ Levine
Disease models & mechanisms 2013
Physiopathologie de la réponse inflammatoire dans l’asthme de l’adulte
S Létuvé, C Taillé
EMC - Pneumologie 2013
Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma
CC Lee, YT Lai, HT Chang, JW Liao, WC Shyu, CY Li, CN Wang
Biochemical Pharmacology 2013
Oesophagostomum dentatum extract modulates T cell-dependent immune responses to bystander antigens and prevents the development of allergy in mice
I Schabussova, O Ul-Haq, E Hoflehner, J Akgün, A Wagner, G Loupal, A Joachim, B Ruttkowski, RM Maizels, U Wiedermann
PloS one 2013
Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice
C Brandenberger, NL Rowley, DN Jackson-Humbles, Q Zhang, LA Bramble, RP Lewandowski, JG Wagner, W Chen, BL Kaplan, NE Kaminski, GL Baker, RM Worden, JR Harkema
Particle and Fibre Toxicology 2013
Differences in respiratory syncytial virus and influenza infection in a house-dust-mite-induced asthma mouse model: consequences for steroid sensitivity
H Mori, NS Parker, D Rodrigues, K Hulland, D Chappell, JS Hincks, H Bright, SM Evans, DJ Lamb
Clinical Science 2013
Delayed Asthmatic Response to Allergen Challenge and Cytokines Released by Nonspecifically Stimulated Blood Cells
Z Pelikan
ISRN Inflammation 2013
Oesophagostomum dentatum Extract Modulates T Cell-Dependent Immune Responses to Bystander Antigens and Prevents the Development of Allergy in Mice
I Schabussova, O Ul-Haq, E Hoflehner, J Akgün, A Wagner, G Loupal, A Joachim, B Ruttkowski, RM Maizels, U Wiedermann, L Chatenoud
PloS one 2013

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