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Citations to this article

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
Mirco Castoldi, … , Matthias W. Hentze, Martina U. Muckenthaler
Mirco Castoldi, … , Matthias W. Hentze, Martina U. Muckenthaler
Published March 1, 2011
Citation Information: J Clin Invest. 2011;121(4):1386-1396. https://doi.org/10.1172/JCI44883.
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Research Article Hepatology Article has an altmetric score of 7

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

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Abstract

Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. Here we show that the liver-specific microRNA miR-122 is important for regulating Hamp mRNA expression and tissue iron levels. Efficient and specific depletion of miR-122 by injection of a locked-nucleic-acid–modified (LNA-modified) anti-miR into WT mice caused systemic iron deficiency, characterized by reduced plasma and liver iron levels, mildly impaired hematopoiesis, and increased extramedullary erythropoiesis in the spleen. Moreover, miR-122 inhibition increased the amount of mRNA transcribed by genes that control systemic iron levels, such as hemochromatosis (Hfe), hemojuvelin (Hjv), bone morphogenetic protein receptor type 1A (Bmpr1a), and Hamp. Importantly, miR-122 directly targeted the 3′ untranslated region of 2 mRNAs that encode activators of hepcidin expression, Hfe and Hjv. These data help to explain the increased Hamp mRNA levels and subsequent iron deficiency in mice with reduced miR-122 levels and establish a direct mechanistic link between miR-122 and the regulation of systemic iron metabolism.

Authors

Mirco Castoldi, Maja Vujic Spasic, Sandro Altamura, Joacim Elmén, Morten Lindow, Judit Kiss, Jens Stolte, Richard Sparla, Lorenza A. D’Alessandro, Ursula Klingmüller, Robert E. Fleming, Thomas Longerich, Hermann J. Gröne, Vladimir Benes, Sakari Kauppinen, Matthias W. Hentze, Martina U. Muckenthaler

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
Citations: 3 3 7 8 7 10 7 6 7 11 11 12 14 18 4 1 129
Citation information
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Citations to this article in year 2018 (6)

Title and authors Publication Year
miR-155 and miR-122 Expression of Spermatozoa in Obese Subjects
P López, A Castro, M Flórez, K Miranda, P Aranda, C Sánchez-González, J Llopis, M Arredondo
Frontiers in Genetics 2018
Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA
K Sekiba, M Otsuka, M Ohno, M Yamagami, T Kishikawa, T Suzuki, R Ishibashi, T Seimiya, E Tanaka, K Koike
World journal of gastroenterology : WJG 2018
The Role of miRNAs in the Pathophysiology of Liver Diseases and Toxicity
F Schueller, S Roy, M Vucur, C Trautwein, T Luedde, C Roderburg
International journal of molecular sciences 2018
A General Overview on Non-coding RNA-Based Diagnostic and Therapeutic Approaches for Liver Diseases
S Roy, C Trautwein, T Luedde, C Roderburg
Frontiers in pharmacology 2018
Glycogen Synthase Kinase 3β Enhances Hepatitis C Virus Replication by Supporting miR-122
M Saleh, S Rüschenbaum, C Welsch, S Zeuzem, D Moradpour, J Gouttenoire, CM Lange
Frontiers in microbiology 2018
Iron Metabolism in Cancer
Y Wang, L Yu, J Ding, Y Chen
International journal of molecular sciences 2018

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