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Citations to this article

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21
Huabiao Chen, … , Xu G. Yu, Mathias Lichterfeld
Huabiao Chen, … , Xu G. Yu, Mathias Lichterfeld
Published March 14, 2011
Citation Information: J Clin Invest. 2011;121(4):1549-1560. https://doi.org/10.1172/JCI44539.
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Research Article AIDS/HIV Article has an altmetric score of 8

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

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Abstract

Elite controllers represent a unique group of HIV-1–infected persons with undetectable HIV-1 replication in the absence of antiretroviral therapy. However, the mechanisms contributing to effective viral immune defense in these patients remain unclear. Here, we show that compared with HIV-1 progressors and HIV-1–negative persons, CD4+ T cells from elite controllers are less susceptible to HIV-1 infection. This partial resistance to HIV-1 infection involved less effective reverse transcription and mRNA transcription from proviral DNA and was associated with strong and selective upregulation of the cyclin-dependent kinase inhibitor p21 (also known as cip-1 and waf-1). Experimental blockade of p21 in CD4+ T cells from elite controllers resulted in a marked increase of viral reverse transcripts and mRNA production and led to higher enzymatic activities of cyclin-dependent kinase 9 (CDK9), which serves as a transcriptional coactivator of HIV-1 gene expression. This suggests that p21 acts as a barrier against HIV-1 infection in CD4+ T cells from elite controllers by inhibiting a cyclin-dependent kinase required for effective HIV-1 replication. These data demonstrate a mechanism of host resistance to HIV-1 in elite controllers and may open novel perspectives for clinical strategies to prevent or treat HIV-1 infection.

Authors

Huabiao Chen, Chun Li, Jinghe Huang, Thai Cung, Katherine Seiss, Jill Beamon, Mary F. Carrington, Lindsay C. Porter, Patrick S. Burke, Yue Yang, Bethany J. Ryan, Ruiwu Liu, Robert H. Weiss, Florencia Pereyra, William D. Cress, Abraham L. Brass, Eric S. Rosenberg, Bruce D. Walker, Xu G. Yu, Mathias Lichterfeld

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
Citations: 2 5 11 1 8 10 8 8 9 12 10 17 9 8 1 119
Citation information
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Citations to this article in year 2018 (8)

Title and authors Publication Year
Inhibition of HIV early replication by the p53 and its downstream gene p21
B Shi, HJ Sharifi, S DiGrigoli, M Kinnetz, K Mellon, W Hu, CM de Noronha
Virology Journal 2018
A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers
E Martin-Gayo, MB Cole, KE Kolb, Z Ouyang, J Cronin, SW Kazer, J Ordovas-Montanes, M Lichterfeld, BD Walker, N Yosef, AK Shalek, XG Yu
Genome biology 2018
Reprint of: Virus-Specific T Cells: Broadening Applicability
AJ Barrett, S Prockop, CM Bollard
Biology of Blood and Marrow Transplantation 2018
Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells
HH Kuo, R Ahmad, GQ Lee, C Gao, HR Chen, Z Ouyang, MJ Szucs, D Kim, A Tsibris, TW Chun, E Battivelli, E Verdin, ES Rosenberg, SA Carr, XG Yu, M Lichterfeld
Immunity 2018
Post-translational Modification-Based Regulation of HIV Replication
L Chen, OT Keppler, C Schölz
Frontiers in microbiology 2018
Are microRNAs Important Players in HIV-1 Infection? An Update
M Balasubramaniam, J Pandhare, C Dash
Viruses 2018
Y-box-binding protein 1 supports the early and late steps of HIV replication
C Weydert, B van Heertum, L Dirix, SD Houwer, FD Wit, J Mast, SJ Husson, K Busschots, R König, R Gijsbers, JD Rijck, Z Debyser, D Harrich
PloS one 2018
Analysis of ex vivo HIV-1 infection in a controller-discordant couple
Madlala P, Van de Velde P, Van Remoortel B, Vets S, Van Wijngaerden E, Van Laethem K, Gijsbers R, Schrijvers R, Debyser Z
Journal of Virus Eradication 2018

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