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Usage Information

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
Seth A. Wander, Bryan T. Hennessy, Joyce M. Slingerland
Seth A. Wander, Bryan T. Hennessy, Joyce M. Slingerland
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Science in Medicine

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

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Abstract

Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2. The mTOR pathway is often aberrantly activated in cancers. While hypoxia, nutrient deprivation, and DNA damage restrain mTORC1 activity, multiple genetic events constitutively activate mTOR in cancers. Here we provide a brief overview of the signaling pathways up- and downstream of mTORC1 and -2, and discuss the insights into therapeutic anticancer targets — both those that have been tried in the clinic with limited success and those currently under clinical development — that knowledge of these pathways gives us.

Authors

Seth A. Wander, Bryan T. Hennessy, Joyce M. Slingerland

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Usage data is cumulative from November 2025 through November 2026.

Usage JCI PMC
Text version 2,277 168
PDF 329 43
Figure 240 1
Table 389 0
Citation downloads 263 0
Totals 3,498 212
Total Views 3,710
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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