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Usage Information

Genomic amplicons target vesicle recycling in breast cancer
Gordon B. Mills, … , Yosef Yarden, Jim C. Norman
Gordon B. Mills, … , Yosef Yarden, Jim C. Norman
Published July 20, 2009
Citation Information: J Clin Invest. 2009;119(8):2123-2127. https://doi.org/10.1172/JCI40256.
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Commentary

Genomic amplicons target vesicle recycling in breast cancer

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Abstract

Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a “driver” of the 8p11–12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.

Authors

Gordon B. Mills, Igor Jurisica, Yosef Yarden, Jim C. Norman

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 327 18
PDF 68 12
Figure 102 0
Table 48 0
Citation downloads 50 0
Totals 595 30
Total Views 625
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