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Citations to this article

CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production
Victor Peperzak, … , Elise A.M. Veraar, Jannie Borst
Victor Peperzak, … , Elise A.M. Veraar, Jannie Borst
Published December 1, 2009
Citation Information: J Clin Invest. 2010;120(1):168-178. https://doi.org/10.1172/JCI40178.
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Research Article Immunology Article has an altmetric score of 1

CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production

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Abstract

Immunity to infections relies on clonal expansion of CD8+ T cells, their maintenance as effector CTLs, and their selection into a memory population. These processes rely on delivery of survival signals to activated CD8+ T cells. We here reveal the mechanism by which costimulatory CD27-CD70 interactions sustain survival of CD8+ effector T cells in infected tissue. By unbiased genome-wide gene expression analysis, we identified the Il2 gene as the most prominent CD27 target gene in murine CD8+ T cells. In vitro, CD27 directed IL-2 expression and promoted clonal expansion of primed CD8+ T cells exclusively by IL-2–dependent survival signaling. In mice intranasally infected with influenza virus, Cd27–/– CD8+ effector T cells displayed reduced IL-2 production, accompanied by impaired accumulation in lymphoid organs and in the lungs, which constitute the tissue effector site. Reconstitution of Cd27–/– CD8+ T cells with the IL2 gene restored their accumulation to wild-type levels in the lungs, but it did not rescue their accumulation in lymphoid organs. Competition experiments showed that the IL-2 produced under the control of CD27 supported effector CD8+ T cell survival in the lungs in an autocrine manner. We conclude that CD27 signaling directs the IL-2 production that is reportedly essential to sustain survival of virus-specific CTLs in nonlymphoid tissue.

Authors

Victor Peperzak, Yanling Xiao, Elise A.M. Veraar, Jannie Borst

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Total citations by year

Year: 2024 2023 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Total
Citations: 1 5 4 4 3 6 4 2 3 8 8 5 4 5 62
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2014 (8)

Title and authors Publication Year
Regulation of Tissue-Dependent Differences in CD8+ T Cell Apoptosis during Viral Infection
VN Kapoor, HM Shin, OH Cho, LJ Berg, J Kang, RM Welsh
Journal of virology 2014
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
DA Schaer, D Hirschhorn-Cymerman, JD Wolchok
Journal for ImmunoTherapy of Cancer 2014
Epitope-Specific Regulation of Memory Programming by Differential Duration of Antigen Presentation to Influenza-Specific CD8+ T Cells
A Ballesteros-Tato, B León, BO Lee, FE Lund, TD Randall
Immunity 2014
The transcriptional program of vaccine-induced CD8+ T cell memory
R Roychoudhuri, F Lefebvre, M Honda, L Pan, Y Ji, CA Klebanoff, C Nichols, S Fourati, AN Hegazy, JP Goulet, L Gattinoni, GJ Nabel, M Gilliet, M Cameron, NP Restifo, RP Sékaly, L Flatz
2014
Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2
KK McKinstry, TM Strutt, B Bautista, W Zhang, Y Kuang, AM Cooper, SL Swain
Nature Communications 2014
Epitope Specificity Delimits the Functional Capabilities of Vaccine-Induced CD8 T Cell Populations
BJ Hill, PA Darrah, Z Ende, DR Ambrozak, KM Quinn, S Darko, E Gostick, L Wooldridge, HA van Berg, V Venturi, M Larsen, MP Davenport, RA Seder, DA Price, DC Douek
Journal of immunology (Baltimore, Md. : 1950) 2014
OX40- and CD27-Mediated Costimulation Synergizes with Anti-PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence
SL Buchan, T Manzo, B Flutter, A Rogel, N Edwards, L Zhang, S Sivakumaran, S Ghorashian, B Carpenter, CL Bennett, GJ Freeman, M Sykes, M Croft, A Al-Shamkhani, R Chakraverty
Journal of immunology (Baltimore, Md. : 1950) 2014
Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses
A Allam, M Swiecki, W Vermi, JD Ashwell, M Colonna
Journal of immunology (Baltimore, Md. : 1950) 2014

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