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Citations to this article

CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production
Victor Peperzak, … , Elise A.M. Veraar, Jannie Borst
Victor Peperzak, … , Elise A.M. Veraar, Jannie Borst
Published December 1, 2009
Citation Information: J Clin Invest. 2010;120(1):168-178. https://doi.org/10.1172/JCI40178.
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Research Article Immunology Article has an altmetric score of 1

CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production

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Abstract

Immunity to infections relies on clonal expansion of CD8+ T cells, their maintenance as effector CTLs, and their selection into a memory population. These processes rely on delivery of survival signals to activated CD8+ T cells. We here reveal the mechanism by which costimulatory CD27-CD70 interactions sustain survival of CD8+ effector T cells in infected tissue. By unbiased genome-wide gene expression analysis, we identified the Il2 gene as the most prominent CD27 target gene in murine CD8+ T cells. In vitro, CD27 directed IL-2 expression and promoted clonal expansion of primed CD8+ T cells exclusively by IL-2–dependent survival signaling. In mice intranasally infected with influenza virus, Cd27–/– CD8+ effector T cells displayed reduced IL-2 production, accompanied by impaired accumulation in lymphoid organs and in the lungs, which constitute the tissue effector site. Reconstitution of Cd27–/– CD8+ T cells with the IL2 gene restored their accumulation to wild-type levels in the lungs, but it did not rescue their accumulation in lymphoid organs. Competition experiments showed that the IL-2 produced under the control of CD27 supported effector CD8+ T cell survival in the lungs in an autocrine manner. We conclude that CD27 signaling directs the IL-2 production that is reportedly essential to sustain survival of virus-specific CTLs in nonlymphoid tissue.

Authors

Victor Peperzak, Yanling Xiao, Elise A.M. Veraar, Jannie Borst

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Total citations by year

Year: 2024 2023 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Total
Citations: 1 5 4 4 3 6 4 2 3 8 8 5 4 5 62
Citation information
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Citations to this article in year 2013 (8)

Title and authors Publication Year
Re-adapting T cells for cancer therapy: from mouse models to clinical trials
IM Stromnes, TM Schmitt, AG Chapuis, SR Hingorani, PD Greenberg
Immunological Reviews 2013
The nature of activatory and tolerogenic dendritic cell-derived signal II
G Bakdash, SP Sittig, T Dijk, CG Figdor, IJ de Vries
Frontiers in immunology 2013
A Cell-Intrinsic Requirement for NF- B-Inducing Kinase in CD4 and CD8 T Cell Memory
AM Rowe, SE Murray, HP Raue, Y Koguchi, MK Slifka, DC Parker
2013
Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway
JM Coquet, JC Ribot, N Babala, S Middendorp, G der Horst, Y Xiao, JF Neves, D Fonseca-Pereira, H Jacobs, DJ Pennington, B Silva-Santos, J Borst
Journal of Experimental Medicine 2013
Role of dendritic cells in the regulation of antitumor immunity
N Wathelet, M Moser
OncoImmunology 2013
Epigenetic Modifications Induced by Blimp-1 Regulate CD8+ T Cell Memory Progression during Acute Virus Infection
HM Shin, VN Kapoor, T Guan, SM Kaech, RM Welsh, LJ Berg
Immunity 2013
CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection
SP Welten, A Redeker, KL Franken, CA Benedict, H Yagita, FM Wensveen, J Borst, CJ Melief, RA van Lier, KP van Gisbergen, R Arens
Journal of virology 2013
Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy
JA Chacon, RC Wu, P Sukhumalchandra, JJ Molldrem, A Sarnaik, S Pilon-Thomas, J Weber, P Hwu, L Radvanyi
PloS one 2013

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