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Citations to this article

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4
Dianhua Jiang, … , Andrew D. Luster, Paul W. Noble
Dianhua Jiang, … , Andrew D. Luster, Paul W. Noble
Published May 17, 2010
Citation Information: J Clin Invest. 2010;120(6):2049-2057. https://doi.org/10.1172/JCI38644.
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Research Article Pulmonology Article has an altmetric score of 11

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

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Abstract

Pulmonary fibrosis is a progressive, dysregulated response to injury culminating in compromised lung function due to excess extracellular matrix production. The heparan sulfate proteoglycan syndecan-4 is important in mediating fibroblast-matrix interactions, but its role in pulmonary fibrosis has not been explored. To investigate this issue, we used intratracheal instillation of bleomycin as a model of acute lung injury and fibrosis. We found that bleomycin treatment increased syndecan-4 expression. Moreover, we observed a marked decrease in neutrophil recruitment and an increase in both myofibroblast recruitment and interstitial fibrosis in bleomycin-treated syndecan-4–null (Sdc4–/–) mice. Subsequently, we identified a direct interaction between CXCL10, an antifibrotic chemokine, and syndecan-4 that inhibited primary lung fibroblast migration during fibrosis; mutation of the heparin-binding domain, but not the CXCR3 domain, of CXCL10 diminished this effect. Similarly, migration of fibroblasts from patients with pulmonary fibrosis was inhibited in the presence of CXCL10 protein defective in CXCR3 binding. Furthermore, administration of recombinant CXCL10 protein inhibited fibrosis in WT mice, but not in Sdc4–/– mice. Collectively, these data suggest that the direct interaction of syndecan-4 and CXCL10 in the lung interstitial compartment serves to inhibit fibroblast recruitment and subsequent fibrosis. Thus, administration of CXCL10 protein defective in CXCR3 binding may represent a novel therapy for pulmonary fibrosis.

Authors

Dianhua Jiang, Jiurong Liang, Gabriele S. Campanella, Rishu Guo, Shuang Yu, Ting Xie, Ningshan Liu, Yoosun Jung, Robert Homer, Eric B. Meltzer, Yuejuan Li, Andrew M. Tager, Paul F. Goetinck, Andrew D. Luster, Paul W. Noble

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Total
Citations: 2 6 5 6 7 9 4 9 4 8 4 6 6 12 13 101
Citation information
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Citations to this article in year 2018 (9)

Title and authors Publication Year
FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts
M Black, D Milewski, T Le, X Ren, Y Xu, VV Kalinichenko, TV Kalin
Cell Reports 2018
Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out
J Zent, LW Guo
Cellular Physiology and Biochemistry 2018
Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands
M Metzemaekers, V Vanheule, R Janssens, S Struyf, P Proost
Frontiers in immunology 2018
Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148
K Tsoyi, SG Chu, NG Patino-Jaramillo, J Wilder, J Villalba, M Doyle-Eisele, J McDonald, X Liu, S El-Chemaly, MA Perrella, IO Rosas
American journal of respiratory cell and molecular biology 2018
Interplay between EZH2 and G9a Regulates CXCL10 Gene Repression in Idiopathic Pulmonary Fibrosis
WR Coward, OJ Brand, A Pasini, G Jenkins, AJ Knox, L Pang
American journal of respiratory cell and molecular biology 2018
Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema
WD Cornwell, C Kim, AC Lastra, C Dass, S Bolla, H Wang, H Zhao, FV Ramsey, N Marchetti, TJ Rogers, GJ Criner
Biomarkers 2018
Pulmonary immunity and extracellular matrix interactions
DN O'Dwyer, SJ Gurczynski, BB Moore
Matrix biology : journal of the International Society for Matrix Biology 2018
Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts
S Jana, H Zhang, GD Lopaschuk, DH Freed, C Sergi, PF Kantor, GY Oudit, Z Kassiri
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2018
Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction between Macrophages and Alveolar Epithelial Cells
S Choi, JK Woo, YS Jang, JH Kang, JI Hwang, JK Seong, YS Yoon, SH Oh
Scientific Reports 2018

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