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Citations to this article

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4
Dianhua Jiang, … , Andrew D. Luster, Paul W. Noble
Dianhua Jiang, … , Andrew D. Luster, Paul W. Noble
Published May 17, 2010
Citation Information: J Clin Invest. 2010;120(6):2049-2057. https://doi.org/10.1172/JCI38644.
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Research Article Pulmonology Article has an altmetric score of 11

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

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Abstract

Pulmonary fibrosis is a progressive, dysregulated response to injury culminating in compromised lung function due to excess extracellular matrix production. The heparan sulfate proteoglycan syndecan-4 is important in mediating fibroblast-matrix interactions, but its role in pulmonary fibrosis has not been explored. To investigate this issue, we used intratracheal instillation of bleomycin as a model of acute lung injury and fibrosis. We found that bleomycin treatment increased syndecan-4 expression. Moreover, we observed a marked decrease in neutrophil recruitment and an increase in both myofibroblast recruitment and interstitial fibrosis in bleomycin-treated syndecan-4–null (Sdc4–/–) mice. Subsequently, we identified a direct interaction between CXCL10, an antifibrotic chemokine, and syndecan-4 that inhibited primary lung fibroblast migration during fibrosis; mutation of the heparin-binding domain, but not the CXCR3 domain, of CXCL10 diminished this effect. Similarly, migration of fibroblasts from patients with pulmonary fibrosis was inhibited in the presence of CXCL10 protein defective in CXCR3 binding. Furthermore, administration of recombinant CXCL10 protein inhibited fibrosis in WT mice, but not in Sdc4–/– mice. Collectively, these data suggest that the direct interaction of syndecan-4 and CXCL10 in the lung interstitial compartment serves to inhibit fibroblast recruitment and subsequent fibrosis. Thus, administration of CXCL10 protein defective in CXCR3 binding may represent a novel therapy for pulmonary fibrosis.

Authors

Dianhua Jiang, Jiurong Liang, Gabriele S. Campanella, Rishu Guo, Shuang Yu, Ting Xie, Ningshan Liu, Yoosun Jung, Robert Homer, Eric B. Meltzer, Yuejuan Li, Andrew M. Tager, Paul F. Goetinck, Andrew D. Luster, Paul W. Noble

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Total
Citations: 2 6 5 6 7 9 4 9 4 8 4 6 6 12 13 101
Citation information
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Citations to this article in year 2012 (12)

Title and authors Publication Year
Pulmonary Fibrosis: Patterns and Perpetrators
Paul W. Noble, Christina Barkauskas, Dianhua Jiang
Journal of Clinical Investigation 2012
miRNA-127 Inhibits Lung Inflammation by Targeting IgG Fcγ Receptor I
T Xie, J Liang, N Liu, Q Wang, Y Li, PW Noble, D Jiang
Journal of immunology (Baltimore, Md. : 1950) 2012
Role of the Lysophospholipid Mediators Lysophosphatidic Acid and Sphingosine 1-Phosphate in Lung Fibrosis
BS Shea, AM Tager
Proceedings of the American Thoracic Society 2012
Syndecans in cartilage breakdown and synovial inflammation
T Pap, J Bertrand
Nature Reviews Rheumatology 2012
Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis
M Weidenbusch, HJ Anders
Journal of Innate Immunity 2012
Tissues use resident dendritic cells and macrophages to maintain homeostasis and to regain homeostasis upon tissue injury: the immunoregulatory role of changing tissue environments
M Lech, R Gröbmayr, M Weidenbusch, HJ Anders
Mediators of Inflammation 2012
Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide
Y Tanino, MY Chang, X Wang, SE Gill, S Skerrett, JK McGuire, S Sato, T Nikaido, T Kojima, M Munakata, S Mongovin, WC Parks, TR Martin, TN Wight, CW Frevert
American journal of respiratory cell and molecular biology 2012
Cytokine-like factor 1 gene expression is enriched in idiopathic pulmonary fibrosis and drives the accumulation of CD4+ T cells in murine lungs: evidence for an antifibrotic role in bleomycin injury
DJ Kass, G Yu, KS Loh, A Savir, A Borczuk, R Kahloon, B Juan-Guardela, G Deiuliis, J Tedrow, J Choi, T Richards, N Kaminski, SM Greenberg
The American Journal of Pathology 2012
Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
B Hinz, SH Phan, VJ Thannickal, M Prunotto, A Desmoulière, J Varga, OD Wever, M Mareel, G Gabbiani
The American Journal of Pathology 2012
Periostin, a Matricellular Protein, Plays a Role in the Induction of Chemokines in Pulmonary Fibrosis
M Uchida, H Shiraishi, S Ohta, K Arima, K Taniguchi, S Suzuki, M Okamoto, SK Ahlfeld, K Ohshima, S Kato, S Toda, H Sagara, H Aizawa, T Hoshino, SJ Conway, S Hayashi, K Izuhara
American journal of respiratory cell and molecular biology 2012
Syndecan-2 Is a Novel Target of Insulin-Like Growth Factor Binding Protein-3 and Is Over-Expressed in Fibrosis
XD Ruiz, LR Mlakar, Y Yamaguchi, Y Su, AT Larregina, JM Pilewski, CA Feghali-Bostwick
PloS one 2012
The role of interferon-γ inducible protein-10 in a mouse model of acute liver injury post induced pluripotent stem cells transplantation
CC Chan, LY Cheng, J Lu, YH Huang, SH Chiou, PH Tsai, TI Huo, HC Lin, FY Lee
PloS one 2012

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