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Citations to this article

Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
Stephan Wueest, … , Marc Y. Donath, Daniel Konrad
Stephan Wueest, … , Marc Y. Donath, Daniel Konrad
Published December 1, 2009
Citation Information: J Clin Invest. 2010;120(1):191-202. https://doi.org/10.1172/JCI38388.
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Research Article Metabolism Article has an altmetric score of 1

Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice

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Abstract

Adipose tissue inflammation is linked to the pathogenesis of insulin resistance. In addition to exerting death-promoting effects, the death receptor Fas (also known as CD95) can activate inflammatory pathways in several cell lines and tissues, although little is known about the metabolic consequence of Fas activation in adipose tissue. We therefore sought to investigate the contribution of Fas in adipocytes to obesity-associated metabolic dysregulation. Fas expression was markedly increased in the adipocytes of common genetic and diet-induced mouse models of obesity and insulin resistance, as well as in the adipose tissue of obese and type 2 diabetic patients. Mice with Fas deficiency either in all cells or specifically in adipocytes (the latter are referred to herein as AFasKO mice) were protected from deterioration of glucose homeostasis induced by high-fat diet (HFD). Adipocytes in AFasKO mice were more insulin sensitive than those in wild-type mice, and mRNA levels of proinflammatory factors were reduced in white adipose tissue. Moreover, AFasKO mice were protected against hepatic steatosis and were more insulin sensitive, both at the whole-body level and in the liver. Thus, Fas in adipocytes contributes to adipose tissue inflammation, hepatic steatosis, and insulin resistance induced by obesity and may constitute a potential therapeutic target for the treatment of insulin resistance and type 2 diabetes.

Authors

Stephan Wueest, Reto A. Rapold, Desiree M. Schumann, Julia M. Rytka, Anita Schildknecht, Ori Nov, Alexander V. Chervonsky, Assaf Rudich, Eugen J. Schoenle, Marc Y. Donath, Daniel Konrad

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 4 6 5 3 5 6 6 3 4 5 6 5 8 9 11 6 1 93
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2011 (11)

Title and authors Publication Year
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
N Alkhouri, C Carter-Kent, AE Feldstein
Expert Review of Gastroenterology & Hepatology 2011
Mechanisms of Lipotoxicity in NAFLD and Clinical Implications
SH Ibrahim, R Kohli, GJ Gores
Journal of Pediatric Gastroenterology and Nutrition 2011
Obesity, inflammation, and liver cancer
B Sun, M Karin
Journal of Hepatology 2011
B Lymphocytes Promote Insulin Resistance through Modulation of T Lymphocytes and Production of Pathogenic IgG Antibody
DA Winer, S Winer, L Shen, PP Wadia, J Yantha, G Paltser, H Tsui, P Wu, MG Davidson, MN Alonso, HX Leong, A Glassford, M Caimol, JA Kenkel, TF Tedder, T McLaughlin, DB Miklos, HM Dosch, EG Engleman
Nature Medicine 2011
The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications
C Zeng, X Shi, B Zhang, H Liu, L Zhang, W Ding, Y Zhao
Journal of Molecular Medicine 2011
Metabolic consequences of ENPP1 overexpression in adipose tissue
W Pan, E Ciociola, M Saraf, B Tumurbaatar, D Tuvdendorj, S Prasad, M Chandalia, N Abate
American journal of physiology. Endocrinology and metabolism 2011
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
H Ellingsgaard, I Hauselmann, B Schuler, AM Habib, LL Baggio, DT Meier, E Eppler, K Bouzakri, S Wueest, YD Muller, AM Hansen, M Reinecke, D Konrad, M Gassmann, F Reimann, PA Halban, J Gromada, DJ Drucker, FM Gribble, JA Ehses, MY Donath
Nature Medicine 2011
A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis
V Ratziu, MY Sheikh, AJ Sanyal, JK Lim, H Conjeevaram, N Chalasani, M Abdelmalek, A Bakken, C Renou, M Palmer, RA Levine, BR Bhandari, M Cornpropst, W Liang, B King, E Mondou, FS Rousseau, J McHutchison, M Chojkier
Hepatology 2011
Inverse regulation of basal lipolysis in perigonadal and mesenteric fat depots in mice
S Wueest, X Yang, J Liu, EJ Schoenle, D Konrad
American journal of physiology. Endocrinology and metabolism 2011
Death receptor 5 signaling promotes hepatocyte lipoapoptosis
SC Cazanave, JL Mott, SF Bronk, NW Werneburg, CD Fingas, XW Meng, N Finnberg, WS El-Deiry, SH Kaufmann, GJ Gores
The Journal of biological chemistry 2011
Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice
C Jiang, A Qu, T Matsubara, T Chanturiya, W Jou, O Gavrilova, YM Shah, FJ Gonzalez
Diabetes 2011

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