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Citations to this article

Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
Stephan Wueest, … , Marc Y. Donath, Daniel Konrad
Stephan Wueest, … , Marc Y. Donath, Daniel Konrad
Published December 1, 2009
Citation Information: J Clin Invest. 2010;120(1):191-202. https://doi.org/10.1172/JCI38388.
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Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice

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Abstract

Adipose tissue inflammation is linked to the pathogenesis of insulin resistance. In addition to exerting death-promoting effects, the death receptor Fas (also known as CD95) can activate inflammatory pathways in several cell lines and tissues, although little is known about the metabolic consequence of Fas activation in adipose tissue. We therefore sought to investigate the contribution of Fas in adipocytes to obesity-associated metabolic dysregulation. Fas expression was markedly increased in the adipocytes of common genetic and diet-induced mouse models of obesity and insulin resistance, as well as in the adipose tissue of obese and type 2 diabetic patients. Mice with Fas deficiency either in all cells or specifically in adipocytes (the latter are referred to herein as AFasKO mice) were protected from deterioration of glucose homeostasis induced by high-fat diet (HFD). Adipocytes in AFasKO mice were more insulin sensitive than those in wild-type mice, and mRNA levels of proinflammatory factors were reduced in white adipose tissue. Moreover, AFasKO mice were protected against hepatic steatosis and were more insulin sensitive, both at the whole-body level and in the liver. Thus, Fas in adipocytes contributes to adipose tissue inflammation, hepatic steatosis, and insulin resistance induced by obesity and may constitute a potential therapeutic target for the treatment of insulin resistance and type 2 diabetes.

Authors

Stephan Wueest, Reto A. Rapold, Desiree M. Schumann, Julia M. Rytka, Anita Schildknecht, Ori Nov, Alexander V. Chervonsky, Assaf Rudich, Eugen J. Schoenle, Marc Y. Donath, Daniel Konrad

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 4 6 5 3 5 6 6 3 4 5 6 5 8 9 11 6 1 93
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2012 (9)

Title and authors Publication Year
CCAAT/enhancer-binding protein β (C/EBPβ) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice
SM Rahman, RC Janssen, M Choudhury, KC Baquero, RM Aikens, BA de la Houssaye, JE Friedman
The Journal of biological chemistry 2012
Scavenger Receptor CD36 Expression Contributes to Adipose Tissue Inflammation and Cell Death in Diet-Induced Obesity
L Cai, Z Wang, A Ji, JM Meyer, DR van der Westhuyzen, PT Bozza
PloS one 2012
Genetically modified mouse models for the study of nonalcoholic fatty liver disease
P Nagarajan, MJ Kumar, R Venkatesan, SS Majundar, RC Juyal
World journal of gastroenterology : WJG 2012
Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging
A González-Rodríguez, JA Más-Gutierrez, M Mirasierra, A Fernandez-Pérez, YJ Lee, HJ Ko, JK Kim, E Romanos, JM Carrascosa, M Ros, M Vallejo, CM Rondinone, AM Valverde
Aging Cell 2012
Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance
R Palanivel, MD Fullerton, S Galic, J Honeyman, KA Hewitt, SB Jorgensen, GR Steinberg
Diabetologia 2012
Role of ceramides in nonalcoholic fatty liver disease
M Pagadala, T Kasumov, AJ McCullough, NN Zein, JP Kirwan
Trends in Endocrinology & Metabolism 2012
Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding
KT Chambers, Z Chen, PA Crawford, X Fu, SC Burgess, L Lai, TC Leone, DP Kelly, BN Finck
PloS one 2012
Depot-specific differences in adipocyte insulin sensitivity in mice are diet- and function-dependent
S Wueest, EJ Schoenle, D Konrad
Adipocyte 2012
Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes
RA Rapold, S Wueest, A Knoepfel, EJ Schoenle, D Konrad
Journal of lipid research 2012

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