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Citations to this article

Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment
Yves Levy, … , Michel Morre, Jean-François Delfraissy
Yves Levy, … , Michel Morre, Jean-François Delfraissy
Published March 16, 2009
Citation Information: J Clin Invest. 2009;119(4):997-1007. https://doi.org/10.1172/JCI38052.
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Research Article AIDS/HIV Article has an altmetric score of 7

Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment

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Abstract

HIV infection results in CD4+ T cell deficiency, but efficient combination antiretroviral therapy (c-ART) restores T cells and decreases morbidity and mortality. However, immune restoration by c-ART remains variable, and prolonged T cell deficiency remains in a substantial proportion of patients. In a prospective open-label phase I/IIa trial, we evaluated the safety and efficacy of administration of the T cell regulator IL-7. The trial included 13 c-ART–treated HIV-infected patients whose CD4+ cell counts were between 100 and 400 cells/μl and plasma HIV RNA levels were less than 50 copies/ml. Patients received a total of 8 subcutaneous injections of 2 different doses of recombinant human IL-7 (rhIL-7; 3 or 10 μg/kg) 3 times per week over a 16-day period. rhIL-7 was well tolerated and induced a sustained increase of naive and central memory CD4+ and CD8+ T cells. In the highest dose group, 4 patients experienced transient increases in viral replication. However, functional assays showed that the expanded T cells responded to HIV antigen by producing IFN-γ and/or IL-2. In conclusion, in lymphopenic HIV-infected patients, rhIL-7 therapy induced substantial functional and quantitative changes in T cells for 48 weeks. Therefore, patients may benefit from intermittent therapy with IL-7 in combination with c-ART.

Authors

Yves Levy, Christine Lacabaratz, Laurence Weiss, Jean-Paul Viard, Cecile Goujard, Jean-Daniel Lelièvre, François Boué, Jean-Michel Molina, Christine Rouzioux, Véronique Avettand-Fénoêl, Thérèse Croughs, Stéphanie Beq, Rodolphe Thiébaut, Geneviève Chêne, Michel Morre, Jean-François Delfraissy

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 2 5 7 5 14 12 8 10 6 11 10 14 16 31 15 15 8 189
Citation information
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Citations to this article in year 2011 (15)

Title and authors Publication Year
Cumulative Mechanisms of Lymphoid Tissue Fibrosis and T Cell Depletion in Immunodeficiency Virus Infections
Ming Zeng, Anthony Smith, Stephen Wietgrefe, Peter Southern, Timothy Schacker, Cavan Reilly, Jacob Estes, Gregory Burton, Guido Silvestri, Jeffrey Lifson, John Carlis, Ashley Haase
Journal of Clinical Investigation 2011
Interleukin-7 inhibits tumor-induced CD27−CD28− suppressor T-cells: implications for cancer immunotherapy
Y Zhang, LW Pfannenstiel, E Bolesta, CL Montes, X Zhang, AI Chapoval, RB Gartenhaus, SE Strome, BR Gastman
Clinical cancer research 2011
HIV controllers: A multifactorial phenotype of spontaneous viral suppression
J Thèze, LA Chakrabarti, B Vingert, F Porichis, DE Kaufmann
Clinical Immunology 2011
Harnessing the biology of IL-7 for therapeutic application
CL Mackall, TJ Fry, RE Gress
Nature Reviews Immunology 2011
HIV-1 viruses detected during episodic blips following interleukin-7 administration are similar to the viruses present before and after interleukin-7 therapy:
H Imamichi, G DeGray, DM Asmuth, MA Fischl, AL Landay, MM Lederman, I Sereti
AIDS 2011
Finding a cure for HIV: will it ever be achievable?
SR Lewin, VA Evans, JH Elliott, B Spire, N Chomont
Journal of the International AIDS Society 2011
Immunotherapeutic effects of IL-7 during a chronic viral infection in mice
SG Nanjappa, EH Kim, M Suresh
Blood 2011
Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication
S Pallikkuth, K Rogers, F Villinger, M DosterII, M Vaccari, G Franchini, R Pahwa, S Pahwa
Vaccine 2011
True story about HIV: theory of viral sequestration and reserve infection
SS Barasa
HIV/AIDS (Auckland, N.Z.) 2011
IL-7 Promotes CD95-Induced Apoptosis in B Cells via the IFN-γ/STAT1 Pathway
S Sammicheli, VP Dang, N Ruffin, HT Pham, R Lantto, N Vivar, F Chiodi, B Rethi
PloS one 2011
Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
JS Boomer, K To, KC Chang, O Takasu, DF Osborne, AH Walton, TL Bricker, SD 2nd, D Kreisel, AS Krupnick, A Srivastava, PE Swanson, JM Green, RS Hotchkiss
Journal of the American Medical Association 2011
Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study
JA Casotti, LN Passos, FJ Oliveira, C Cerutti
BMC Infectious Diseases 2011
Advances in the management of sepsis and the understanding of key immunologic defects
LP Skrupky, PW Kerby, RS Hotchkiss
Anesthesiology 2011
Validation of a gene expression-based subclassification strategy for pediatric septic shock
HR Wong, NZ Cvijanovich, GL Allen, NJ Thomas, RJ Freishtat, N Anas, K Meyer, PA Checchia, R Lin, TP Shanley, MT Bigham, DS Wheeler, LA Doughty, K Tegtmeyer, SE Poynter, JM Kaplan, RS Chima, E Stalets, RK Basu, BM Varisco, FE Barr
Critical Care Medicine 2011
Improved survival of HIV-1-infected patients with progressive multifocal leukoencephalopathy receiving early 5-drug combination antiretroviral therapy.
Gasnault J, Costagliola D, Hendel-Chavez H, Dulioust A, Pakianather S, Mazet AA, de Goer de Herve MG, Lancar R, Lascaux AS, Porte L, Delfraissy JF, Taoufik Y
PloS one 2011

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