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Citations to this article

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans
Carmela De Santo, … , Maria Zambon, Vincenzo Cerundolo
Carmela De Santo, … , Maria Zambon, Vincenzo Cerundolo
Published November 13, 2008
Citation Information: J Clin Invest. 2008;118(12):4036-4048. https://doi.org/10.1172/JCI36264.
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Research Article Article has an altmetric score of 12

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans

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Abstract

Infection with influenza A virus (IAV) presents a substantial threat to public health worldwide, with young, elderly, and immunodeficient individuals being particularly susceptible. Inflammatory responses play an important role in the fatal outcome of IAV infection, but the mechanism remains unclear. We demonstrate here that the absence of invariant NKT (iNKT) cells in mice during IAV infection resulted in the expansion of myeloid-derived suppressor cells (MDSCs), which suppressed IAV-specific immune responses through the expression of both arginase and NOS, resulting in high IAV titer and increased mortality. Adoptive transfer of iNKT cells abolished the suppressive activity of MDSCs, restored IAV-specific immune responses, reduced IAV titer, and increased survival rate. The crosstalk between iNKT and MDSCs was CD1d- and CD40-dependent. Furthermore, IAV infection and exposure to TLR agonists relieved the suppressive activity of MDSCs. Finally, we extended these results to humans by demonstrating the presence of myeloid cells with suppressive activity in the PBLs of individuals infected with IAV and showed that their suppressive activity is substantially reduced by iNKT cell activation. These findings identify what we believe to be a novel immunomodulatory role of iNKT cells, which we suggest could be harnessed to abolish the immunosuppressive activity of MDSCs during IAV infection.

Authors

Carmela De Santo, Mariolina Salio, S. Hajar Masri, Laurel Yong-Hwa Lee, Tao Dong, Anneliese O. Speak, Stefan Porubsky, Sarah Booth, Natacha Veerapen, Gurdyal S. Besra, Hermann-Josef Gröne, Frances M. Platt, Maria Zambon, Vincenzo Cerundolo

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 2 11 13 12 15 8 11 23 8 14 11 11 17 15 17 12 8 1 209
Citation information
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Citations to this article in year 2022 (12)

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Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models
H Wang, D Tumes, T Hercus, K Yip, C Aloe, R Vlahos, A Lopez, N Wilson, C Owczarek, S Bozinovski
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Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection
Shu-Ting Song, Meng-Li Wu, Hai-Jiao Zhang, Xiao Su, Jian-Hua Wang
Frontiers in microbiology 2022
Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention
Y Li, Z Dunn, G Garcia, C Carmona, Y Zhou, D Lee, J Yu, J Huang, J Kim, V Arumugaswami, P Wang, L Yang
Stem Cell Research & Therapy 2022
Natural killer T cell immunotherapy combined with IL-15-expressing oncolytic virotherapy and PD-1 blockade mediates pancreatic tumor regression
Nelson A, Gebremeskel S, Lichty BD, Johnston B
Journal for ImmunoTherapy of Cancer 2022
Cross Talk Between Natural Killer T and Dendritic Cells and Its Impact on T Cell Responses in Infections.
Zhao L, Yang X
Frontiers in immunology 2022
Ingestion, Immunity, and Infection: Nutrition and Viral Respiratory Tract Infections
Govers C, Calder PC, Savelkoul HF, Albers R, van Neerven RJ
Frontiers in immunology 2022
Myeloid-derived suppressor cells in COVID-19: A review
Perfilyeva YV, Ostapchuk YO, Tleulieva R, Kali A, Abdolla N, Krasnoshtanov VK, Perfilyeva AV, Belyaev NN
Clinical Immunology 2022
Adoptive Immunotherapy With Engineered iNKT Cells to Target Cancer Cells and the Suppressive Microenvironment
Delfanti G, Dellabona P, Casorati G, Fedeli M
Frontiers in Medicine 2022
Immature granulocytes: Innovative biomarker for SARS-CoV-2 infection
Georgakopoulou VE, Makrodimitri S, Triantafyllou M, Samara S, Voutsinas PM, Anastasopoulou A, Papageorgiou CV, Spandidos DA, Gkoufa A, Papalexis P, Xenou E, Chelidonis G, Sklapani P, Trakas N, Sipsas NV
Molecular medicine reports 2022
Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs
Artiaga BL, Morozov I, Ransburgh R, Kwon T, Balaraman V, Indran SV, De Carvalho Madrid DM, Gu W, Henningson J, Ma W, Richt JA, Driver JP
2022
Invariant natural killer T cells minimally influence gut microbiota composition in mice.
Lin Q, Kuypers M, Liu Z, Copeland JK, Chan D, Robertson SJ, Kontogiannis J, Guttman DS, Banks EK, Philpott DJ, Mallevaey T
Gut microbes 2022
Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.
Stavrou V, Fultang L, Booth S, De Simone D, Bartnik A, Scarpa U, Gneo L, Panetti S, Potluri S, Almowaled M, Barlow J, Jankevics A, Lloyd G, Southam A, Priestman DA, Cheng P, Dunn W, Platt F, Endou H, Craddock C, Keeshan K, Mussai F, De Santo C
Cancer Immunology, Immunotherapy 2022

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