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Citations to this article

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans
Carmela De Santo, … , Maria Zambon, Vincenzo Cerundolo
Carmela De Santo, … , Maria Zambon, Vincenzo Cerundolo
Published November 13, 2008
Citation Information: J Clin Invest. 2008;118(12):4036-4048. https://doi.org/10.1172/JCI36264.
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Research Article Article has an altmetric score of 12

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans

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Abstract

Infection with influenza A virus (IAV) presents a substantial threat to public health worldwide, with young, elderly, and immunodeficient individuals being particularly susceptible. Inflammatory responses play an important role in the fatal outcome of IAV infection, but the mechanism remains unclear. We demonstrate here that the absence of invariant NKT (iNKT) cells in mice during IAV infection resulted in the expansion of myeloid-derived suppressor cells (MDSCs), which suppressed IAV-specific immune responses through the expression of both arginase and NOS, resulting in high IAV titer and increased mortality. Adoptive transfer of iNKT cells abolished the suppressive activity of MDSCs, restored IAV-specific immune responses, reduced IAV titer, and increased survival rate. The crosstalk between iNKT and MDSCs was CD1d- and CD40-dependent. Furthermore, IAV infection and exposure to TLR agonists relieved the suppressive activity of MDSCs. Finally, we extended these results to humans by demonstrating the presence of myeloid cells with suppressive activity in the PBLs of individuals infected with IAV and showed that their suppressive activity is substantially reduced by iNKT cell activation. These findings identify what we believe to be a novel immunomodulatory role of iNKT cells, which we suggest could be harnessed to abolish the immunosuppressive activity of MDSCs during IAV infection.

Authors

Carmela De Santo, Mariolina Salio, S. Hajar Masri, Laurel Yong-Hwa Lee, Tao Dong, Anneliese O. Speak, Stefan Porubsky, Sarah Booth, Natacha Veerapen, Gurdyal S. Besra, Hermann-Josef Gröne, Frances M. Platt, Maria Zambon, Vincenzo Cerundolo

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 2 11 13 12 15 8 11 23 8 14 11 11 17 15 17 12 8 1 209
Citation information
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Citations to this article in year 2020 (8)

Title and authors Publication Year
Off-the-Shelf Allogeneic T Cell Therapies for Cancer: Opportunities and Challenges Using Naturally Occurring “Universal” Donor T Cells
C Perez, I Gruber, C Arber
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Modulation of Immune Responses to Influenza A Virus Vaccines by Natural Killer T Cells
JP Driver, DM de Carvalho Madrid, W Gu, BL Artiaga, JA Richt
Frontiers in immunology 2020
Pharmaco-Immunomodulatory Therapy in COVID-19
JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie, Y Rizk, DN Forthal
Drugs 2020
Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells
P Riese, S Trittel, RD Pathirana, F Klawonn, RJ Cox, CA Guzmán
Human vaccines 2020
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
J Schulte-Schrepping, N Reusch, D Paclik, K Baßler, S Schlickeiser, B Zhang, B Krämer, T Krammer, S Brumhard, L Bonaguro, ED Domenico, D Wendisch, M Grasshoff, TS Kapellos, M Beckstette, T Pecht, A Saglam, O Dietrich, HE Mei, AR Schulz, C Conrad, D Kunkel, E Vafadarnejad, CJ Xu, A Horne, M Herbert, A Drews, C Thibeault, M Pfeiffer, S Hippenstiel, A Hocke, H Müller-Redetzky, KM Heim, F Machleidt, A Uhrig, LB de Jarcy, L Jürgens, M Stegemann, CR Glösenkamp, HD Volk, C Goffinet, M Landthaler, E Wyler, P Georg, M Schneider, C Dang-Heine, N Neuwinger, K Kappert, R Tauber, V Corman, J Raabe, KM Kaiser, MT Vinh, G Rieke, C Meisel, T Ulas, M Becker, R Geffers, M Witzenrath, C Drosten, N Suttorp, C von Kalle, F Kurth, K Händler, JL Schultze, AC Aschenbrenner, Y Li, J Nattermann, B Sawitzki, AE Saliba, LE Sander, A Angelov, R Bals, A Bartholomäus, A Becker, D Bezdan, E Bonifacio, P Bork, T Clavel, M Colome-Tatche, A Diefenbach, A Dilthey, N Fischer, K Förstner, JS Frick, J Gagneur, A Goesmann, T Hain, M Hummel, S Janssen, J Kalinowski, R Kallies, B Kehr, A Keller, S Kim-Hellmuth, C Klein, O Kohlbacher, JO Korbel, I Kurth, M Landthaler, Y Li, K Ludwig, O Makarewicz, M Marz, A McHardy, C Mertes, M Nöthen, P Nürnberg, U Ohler, S Ossowski, J Overmann, S Peter, K Pfeffer, AR Poetsch, A Pühler, N Rajewsky, M Ralser, O Rieß, S Ripke, UN da Rocha, P Rosenstiel, AE Saliba, LE Sander, B Sawitzki, P Schiffer, EC Schulte, JL Schultze, A Sczyrba, O Stegle, J Stoye, F Theis, J Vehreschild, J Vogel, M von Kleist, A Walker, J Walter, D Wieczorek, J Ziebuhr
Cell 2020
Recent advances in myeloid-derived suppressor cell biology
MM Yaseen, NM Abuharfeil, H Darmani, A Daoud
Frontiers of Medicine 2020
Prostaglandin D2 as a mediator of lymphopenia and a therapeutic target in COVID-19 disease
Gupta A, Chander Chiang K
Medical Hypotheses 2020
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis
Zeng X, Zhou J, Xiong Z, Sun H, Yang W, Mok MT, Wang J, Li J, Liu M, Tang W, Feng Y, Wang HK, Tsang SW, Chow KL, Yeung PC, Wong J, Lai PB, Chan AW, To KF, Chan SL, Xia Q, Xue J, Chen X, Yu J, Peng S, Sung JJ, Kuang M, Cheng AS
Cellular and Molecular Immunology 2020

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