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Usage Information

Taking aim at translation for tumor therapy
Bryan C. Barnhart, M. Celeste Simon
Bryan C. Barnhart, M. Celeste Simon
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Commentary

Taking aim at translation for tumor therapy

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Abstract

Increased cap-dependent mRNA translation rates are frequently observed in human cancers. Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic translation initiation factor 4E (eIF4E), leading to enhanced translation of numerous tumor-promoting genes. In this issue of the JCI, Graff and colleagues describe potent antitumor effects using second-generation antisense oligonucleotides for eIF4E (see the related article beginning on page 2638). If their results are recapitulated in a clinical setting, this strategy will provide a promising antitumor therapy with broad-reaching applications.

Authors

Bryan C. Barnhart, M. Celeste Simon

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Usage data is cumulative from November 2025 through November 2026.

Usage JCI PMC
Text version 520 10
PDF 261 7
Figure 170 1
Citation downloads 264 0
Totals 1,215 18
Total Views 1,233
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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