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Citations to this article

Gastrointestinal regulation of food intake
David E. Cummings, Joost Overduin
David E. Cummings, Joost Overduin
Published January 2, 2007
Citation Information: J Clin Invest. 2007;117(1):13-23. https://doi.org/10.1172/JCI30227.
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Review Series Article has an altmetric score of 40

Gastrointestinal regulation of food intake

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Abstract

Despite substantial fluctuations in daily food intake, animals maintain a remarkably stable body weight, because overall caloric ingestion and expenditure are exquisitely matched over long periods of time, through the process of energy homeostasis. The brain receives hormonal, neural, and metabolic signals pertaining to body-energy status and, in response to these inputs, coordinates adaptive alterations of energy intake and expenditure. To regulate food consumption, the brain must modulate appetite, and the core of appetite regulation lies in the gut-brain axis. This Review summarizes current knowledge regarding the neuroendocrine regulation of food intake by the gastrointestinal system, focusing on gastric distention, intestinal and pancreatic satiation peptides, and the orexigenic gastric hormone ghrelin. We highlight mechanisms governing nutrient sensing and peptide secretion by enteroendocrine cells, including novel taste-like pathways. The increasingly nuanced understanding of the mechanisms mediating gut-peptide regulation and action provides promising targets for new strategies to combat obesity and diabetes.

Authors

David E. Cummings, Joost Overduin

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 9 12 20 20 23 20 17 26 24 24 27 32 22 24 22 23 22 17 7 391
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2009 (22)

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N Stylopoulos, AG Hoppin, LM Kaplan
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ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy
E Ravussin, SR Smith, JA Mitchell, R Shringarpure, K Shan, H Maier, JE Koda, C Weyer
Obesity (Silver Spring, Md.) 2009
Sensing of dietary lipids by enterocytes: a new role for SR-BI/CLA-1
O Béaslas, C Cueille, F Delers, D Chateau, J Chambaz, M Rousset, V Carrière
PloS one 2009
Ghrelin and peptide YY in postpartum lactating and nonlactating women
DE Larson-Meyer, E Ravussin, L Heilbronn, L DeJonge
The American journal of clinical nutrition 2009
Salivary habituation to food stimuli in successful weight loss maintainers, obese and normal-weight adults
DS Bond, HA Raynor, JM McCaffery, RR Wing
International Journal of Obesity 2009
Imaging of brain dopamine pathways: implications for understanding obesity
GJ Wang, ND Volkow, PK Thanos, JS Fowler
Journal of addiction medicine 2009
Gut sensing mechanisms
A deFonseka, J Kaunitz
Current Gastroenterology Reports 2009
Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5
Z Kokrashvili, D Rodriguez, V Yevshayeva, H Zhou, RF Margolskee, B Mosinger
Gastroenterology 2009
Appetite responds to changes in meal content, whereas ghrelin, leptin, and insulin track changes in energy availability
KT Borer, E Wuorinen, K Ku, C Burant
The Journal of clinical endocrinology and metabolism 2009
Effect of alginate on satiation, appetite, gastric function, and selected gut satiety hormones in overweight and obesity
ST Odunsi, MI Vázquez-Roque, M Camilleri, A Papathanasopoulos, MM Clark, L Wodrich, M Lempke, S McKinzie, M Ryks, D Burton, AR Zinsmeister
Obesity (Silver Spring, Md.) 2009
A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity
A Papathanasopoulos, M Camilleri, PJ Carlson, A Vella, SJ Nord, DD Burton, ST Odunsi, AR Zinsmeister
Obesity (Silver Spring, Md.) 2009
Messenger RNA for neuropeptide Y in the arcuate nucleus increases in parallel with plasma adrenocorticotropin during sepsis in the rat
DE Carlson, W Le, WC Chiu, GE Hoffman
Neuroscience Letters 2009
Opportunities for the replacement of animals in the study of nausea and vomiting
AM Holmes, JA Rudd, FD Tattersall, Q Aziz, PL Andrews
British Journal of Pharmacology 2009
Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation
TL Davidson, K Chan, LE Jarrard, SE Kanoski, DJ Clegg, SC Benoit
Hippocampus 2009
Endocrine and metabolic response to gastric bypass
J Saliba, J Wattacheril, NN Abumrad
Current Opinion in Clinical Nutrition and Metabolic Care 2009
Upper intestinal lipids regulate energy and glucose homeostasis
GW Cheung, A Kokorovic, TK Lam
Cellular and Molecular Life Sciences 2009
Modulation of Taste Sensitivity by GLP-1 Signaling in Taste Buds
B Martin, CD Dotson, YK Shin, S Ji, DJ Drucker, S Maudsley, SD Munger
Annals of the New York Academy of Sciences 2009
Impact of Different Bariatric Surgical Procedures on Insulin Action and  -Cell Function in Type 2 Diabetes
E Ferrannini, G Mingrone
Diabetes care 2009
The role of peptide YY in appetite regulation and obesity: Peptide YY in appetite regulation and obesity
E Karra, K Chandarana, RL Batterham
The Journal of Physiology 2009
Ghrelin Does Not Predict Adaptive Hyperphagia in Patients With Short Bowel Syndrome
CW Compher, BP Kinosian, DC Metz
JPEN. Journal of parenteral and enteral nutrition 2009
Obesity, Gut Hormones, and Bariatric Surgery
DJ Pournaras, CW le Roux
World Journal of Surgery 2009

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