Citations to this article
Citation Information: J Clin Invest. 2007;117(1):50-59. https://doi.org/10.1172/JCI30082.
Abstract
Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine stimuli and share many features with their hepatic counterparts, studies of which have helped further our understanding of PaSC biology. Activation of PaSCs induces them to proliferate, to migrate to sites of tissue damage, to contract and possibly phagocytose, and to synthesize ECM components to promote tissue repair. Sustained activation of PaSCs has an increasingly appreciated role in the fibrosis that is associated with chronic pancreatitis and with pancreatic cancer. Therefore, understanding the biology of PaSCs offers potential therapeutic targets for the treatment and prevention of these diseases.
Authors
M. Bishr Omary, Aurelia Lugea, Anson W. Lowe, Stephen J. Pandol
Total citations by year
Citations to this article in year 2007 (2)
| Title and authors | Publication | Year |
|---|---|---|
|
Intro to GI Disorders series
Juanita L Merchant |
Journal of Clinical Investigation | 2007 |
|
Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis
CW Michalski, A Gorbachevski, M Erkan, C Reiser, S Deucker, F Bergmann, T Giese, M Weigand, NA Giese, H Friess, J Kleeff |
Journal of Translational Medicine | 2007 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)