Monocyte recruitment to sites of inflammation is regulated by members of the chemokine family of chemotactic cytokines. However, the mechanisms that govern the migration of monocytes from bone marrow to blood and from blood to inflamed tissues are not well understood. Here we report that CC chemokine receptor 2 (CCR2) is highly expressed on a subpopulation of blood monocytes whose numbers are markedly decreased in CCR2–/– mice. In bone marrow, however, CCR2–/– mice had an increased number of monocytes, suggesting that CCR2 is critical for monocyte egress. Intravenous infusion of ex vivo–labeled WT or CCR2–/– bone marrow into WT recipient mice demonstrated that CCR2 is necessary for efficient monocyte recruitment from the blood to inflamed tissue. Analysis of mice lacking monocyte chemoattractant protein–1 (MCP-1), MCP-3, MCP-5, or MCP-2 plus MCP-5 revealed that MCP-3 and MCP-1 are the CCR2 agonists most critical for the maintenance of normal blood monocyte counts. These findings provide evidence that CCR2 and MCP-3/MCP-1 are critical for monocyte mobilization and suggest new roles for monocyte chemoattractants in leukocyte homeostasis.
Chia-Lin Tsou, Wendy Peters, Yue Si, Sarah Slaymaker, Ara M. Aslanian, Stuart P. Weisberg, Matthias Mack, Israel F. Charo
Title and authors | Publication | Year |
---|---|---|
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Delayed CCL23 response is associated with poor outcomes after cardiac arrest
deKay JT, Chepurko E, Chepurko V, Knudsen L, Lord C, Searight M, Tsibulnikov S, Robich MP, Sawyer DB, Gagnon DJ, May T, Riker R, Seder DB, Ryzhov S |
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Human monocyte subtype expression of neuroinflammation and regeneration-related genes is linked to age and sex
Tampé JF, Monni E, Palma-Tortosa S, Brogårdh E, Böiers C, Lindgren AG, Kokaia Z |
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Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.
Kocher D, Cao L, Guiho R, Langhammer M, Lai YL, Becker P, Hamdi H, Friedel D, Selt F, Vonhören D, Zaman J, Valinciute G, Herter S, Picard D, Rettenmeier J, Maass KK, Pajtler KW, Remke M, von Deimling A, Pusch S, Pfister SM, Oehme I, Jones DTW, Halbach S, Brummer T, Martinez-Barbera JP, Witt O, Milde T, Sigaud R |
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Monocytes predict prognosis and successful treatment in older patients with miliary tuberculosis.
Shima Y, Masuda T, Miwa N, Kida Y, Koketsu R, Kamiryo H, Sakurai T, Tada K |
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Monocytes and macrophages: Origin, homing, differentiation, and functionality during inflammation
Dash SP, Gupta S, Sarangi PP |
Heliyon | 2024 |
C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain.
Winkler CW, Evans AB, Carmody AB, Lack JB, Woods TA, Peterson KE |
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CCR2 antagonist attenuates calcium oxalate-induced kidney oxidative stress and inflammation by regulating macrophage activation.
Wang X, Xie L, Liu C |
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Origin and Function of Monocytes in Inflammatory Bowel Disease
Liao X, Liu J, Guo X, Meng R, Zhang W, Zhou J, Xie X, Zhou H |
Journal of inflammation research | 2024 |
CCR2+ monocytes replenish border-associated macrophages in the diseased mouse brain
Wang L, Zheng J, Zhao S, Wan Y, Wang M, Bosco DB, Kuan CY, Richardson JR, Wu LJ |
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Discrepant Phenotyping of Monocytes Based on CX3CR1 and CCR2 Using Fluorescent Reporters and Antibodies
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Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets.
Chen R, Zhang H, Tang B, Luo Y, Yang Y, Zhong X, Chen S, Xu X, Huang S, Liu C |
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Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level.
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Hayes BW, Choi HW, Rathore AP, Bao C, Shi J, Huh Y, Kim MW, Mencarelli A, Bist P, Ng LG, Shi C, Nho JH, Kim A, Yoon H, Lim D, Hannan JL, Todd Purves J, Hughes FM Jr, Ji RR, Abraham SN |
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Microglia and infiltrating macrophages in ictogenesis and epileptogenesis
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Medina-Ruiz L, Bartolini R, Mathie H, Halawa HA, Cunningham M, Graham GJ |
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CCR2+ monocytes/macrophages drive steroid hormone imbalance-related prostatic fibrosis
Popovics P, Silver SV, Uchtmann KS, Arendt LM, Vezina CM, Ricke WA |
Scientific Reports | 2024 |
A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism
Ysasi AB, Engler AE, Bawa PS, Wang F, Conrad RD, Yeung AK, Rock JR, Beane-Ebel J, Mazzilli SA, Franklin RA, Mizgerd JP, Murphy GJ |
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Macrophage heterogeneity in myocardial infarction: Evolution and implications for diverse therapeutic approaches
Kanuri B, Sreejit G, Biswas P, Murphy AJ, Nagareddy PR |
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Role of circulating inflammatory protein in the development of diabetic renal complications: proteome-wide Mendelian randomization and colocalization analyses.
Liu W, Zhang J, Zhang D, Zhang L |
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Role of macrophage polarization in heart failure and traditional Chinese medicine treatment
Zhu Z, Wang M, Lu S, Dai S, Liu J |
Frontiers in pharmacology | 2024 |
Deep skin fibroblast-mediated macrophage recruitment supports acute wound healing.
Amuso VM, Haas MR, Cooper PO, Chatterjee R, Hafiz S, Salameh S, Gohel C, Mazumder MF, Josephson V, Khorsandi K, Horvath A, Rahnavard A, Shook BA |
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Orchestration of antiviral responses within the infected central nervous system
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Bonin JL, Torres SR, Marcinkiewicz AL, Duhamel GE, Yang X, Pal U, DiSpirito JM, Nowak TA, Lin YP, MacNamara KC |
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Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis
Unterman A, Zhao AY, Neumark N, Schupp JC, Ahangari F, Cosme C Jr, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida TS, Gomez JL, Herazo-Maya JD, Dela Cruz CS, Herzog EL, Kaminski N |
American Journal of Respiratory and Critical Care Medicine | 2024 |
Lung-innervating nociceptor sensory neurons promote pneumonic sepsis during carbapenem-resistant Klebsiella pneumoniae lung infection
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Association of plasma proteomics with mortality in individuals with and without type 2 diabetes: Results from two population-based KORA cohort studies
Luo H, Petrera A, Hauck SM, Rathmann W, Herder C, Gieger C, Hoyer A, Peters A, Thorand B |
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Lee MG, Song Y, Kang H |
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Watanabe H, Rana M, Son M, Chiu PY, Fei-Bloom Y, Choi K, Diamond B, Sherry B |
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Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade.
Cruz Tleugabulova M, Melo SP, Wong A, Arlantico A, Liu M, Webster JD, Lau J, Lechner A, Corak B, Hodgins JJ, Garlapati VS, De Simone M, Korin B, Avraham S, Lund J, Jeet S, Reiss A, Bender H, Austin CD, Darmanis S, Modrusan Z, Brightbill H, Durinck S, Diamond MS, Schneider C, Shaw AS, Nitschké M |
Nature communications | 2024 |
Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages.
Barone L, Cucchiara M, Palano MT, Bassani B, Gallazzi M, Rossi F, Raspanti M, Zecca PA, De Antoni G, Pagiatakis C, Papait R, Bernardini G, Bruno A, Gornati R |
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CCR2+ monocytes promote white matter injury and cognitive dysfunction after myocardial infarction
Thorp EB, Filipp M, Dima M, Tan C, Feinstein M, Popko B, DeBerge M |
Brain, behavior, and immunity | 2024 |
Coronavirus disease 2019–related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging abnormalities
Ćorović A, Zhao X, Huang Y, Newland SR, Gopalan D, Harrison J, Giakomidi D, Chen S, Yarkoni NS, Wall C, Peverelli M, Sriranjan R, Gallo A, Graves MJ, Sage A, Lyons PA, Sithole N, Bennett MR, Rudd JH, Mallat Z, Zhao TX, Nus M, Tarkin JM |
Cardiovascular Research | 2024 |
Unveiling immune cell response disparities in human primary cancer-associated fibroblasts between two- and three-dimensional cultures
Yang JP, Kulkarni NN, Yamaji M, Shiraishi T, Pham T, Do H, Aiello N, Shaw M, Nakamura T, Abiru A, Gavva NR, Horman SR |
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Circulating Plasma Proteins in Aortic Stenosis: Associations With Severity, Myocardial Response, and Clinical Outcomes
Tan ES, Choi H, DeFilippi CR, Oon Y, Chan S, Gong L, Lunaria JB, Liew O, Chong JP, Tay EL, Soo W, Yip JW, Yong QW, Lee EM, Daniel Yeo PS, Ding ZP, Tang HC, Ewe SH, Chin CW, Chai SC, Goh PP, Ling LF, Ong HY, Richards AM, Ling L |
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CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis
Ai S, Arutyunov A, Liu J, Hill JD, Jiang X, Klein RS |
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IL1R2 Acts as a Negative Regulator of Monocyte Recruitment During Inflammation
Cros A, Segura E |
European Journal of Immunology | 2024 |
C-C Motif Ligand 7 and C-C Motif Chemokine Receptor 3 Dysregulation in Patients With Scrub Typhus and Association With Mortality
Ueland T, Astrup E, Otterdal K, Lekva T, Janardhanan J, Michelsen AE, Aukrust P, Varghese GM, Damås JK |
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Listeria monocytogenes use multiple mechanisms to disseminate from the intestinal lamina propria to the mesenteric lymph nodes
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Microbiology Spectrum | 2024 |
Therapeutic implications for the PD-1 axis in cerebrovascular injury
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Mouse and human macrophages and their roles in cardiovascular health and disease.
Gallerand A, Han J, Ivanov S, Randolph GJ |
Nature cardiovascular research | 2024 |
Fibroblast-Mediated Macrophage Recruitment Supports Acute Wound Healing.
Amuso VM, Haas MR, Cooper PO, Chatterjee R, Hafiz S, Salameh S, Gohel C, Mazumder MF, Josephson V, Kleb SS, Khorsandi K, Horvath A, Rahnavard A, Shook BA |
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The acid-sensing receptor GPR65 on tumor macrophages drives tumor growth in obesity.
Bagchi S, Yuan R, Huang HL, Zhang W, Chiu DK, Kim H, Cha SL, Tolentino L, Lowitz J, Liu Y, Moshnikova A, Andreev O, Plevritis S, Engleman EG |
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