Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
Chia-Lin Tsou, … , Matthias Mack, Israel F. Charo
Chia-Lin Tsou, … , Matthias Mack, Israel F. Charo
Published April 2, 2007
Citation Information: J Clin Invest. 2007;117(4):902-909. https://doi.org/10.1172/JCI29919.
View: Text | PDF
Research Article Inflammation Article has an altmetric score of 13

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

  • Text
  • PDF
Abstract

Monocyte recruitment to sites of inflammation is regulated by members of the chemokine family of chemotactic cytokines. However, the mechanisms that govern the migration of monocytes from bone marrow to blood and from blood to inflamed tissues are not well understood. Here we report that CC chemokine receptor 2 (CCR2) is highly expressed on a subpopulation of blood monocytes whose numbers are markedly decreased in CCR2–/– mice. In bone marrow, however, CCR2–/– mice had an increased number of monocytes, suggesting that CCR2 is critical for monocyte egress. Intravenous infusion of ex vivo–labeled WT or CCR2–/– bone marrow into WT recipient mice demonstrated that CCR2 is necessary for efficient monocyte recruitment from the blood to inflamed tissue. Analysis of mice lacking monocyte chemoattractant protein–1 (MCP-1), MCP-3, MCP-5, or MCP-2 plus MCP-5 revealed that MCP-3 and MCP-1 are the CCR2 agonists most critical for the maintenance of normal blood monocyte counts. These findings provide evidence that CCR2 and MCP-3/MCP-1 are critical for monocyte mobilization and suggest new roles for monocyte chemoattractants in leukocyte homeostasis.

Authors

Chia-Lin Tsou, Wendy Peters, Yue Si, Sarah Slaymaker, Ara M. Aslanian, Stuart P. Weisberg, Matthias Mack, Israel F. Charo

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 12 53 44 40 42 41 30 39 39 46 39 47 35 28 38 31 34 12 3 653
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (41)

Title and authors Publication Year
High-salt diet decreases mechanical thresholds in mice that is mediated by a CCR2-dependent mechanism
A Fan, O Oladiran, XQ Shi, J Zhang
Journal of Neuroinflammation 2020
Modulation of the chemokine/chemokine receptor axis as a novel approach for glioma therapy
GP Takacs, JA Flores-Toro, JK Harrison
Pharmacology & Therapeutics 2020
The Anti-atherogenic Role of Exercise Is Associated With the Attenuation of Bone Marrow-Derived Macrophage Activation and Migration in Hypercholesterolemic Mice
T Rentz, AC Wanschel, L de Carvalho Moi, E Lorza-Gil, JC de Souza, RR dos Santos, HC Oliveira
Frontiers in physiology 2020
miR-21 is upregulated, promoting fibrosis and blocking G2/M in irradiated rat cardiac fibroblasts
H Guo, X Zhao, H Su, C Ma, K Liu, S Kong, K Liu, H Li, J Chang, T Wang, H Guo, H Wei, Z Fu, X Lv, Y Li
PeerJ 2020
Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung
M Becerra-Diaz, M Song, N Heller
Frontiers in immunology 2020
Apoptosis of hematopoietic progenitor-derived adipose tissue–resident macrophages contributes to insulin resistance after myocardial infarction
SB Vasamsetti, E Coppin, X Zhang, J Florentin, S Koul, M Götberg, AS Clugston, F Thoma, J Sembrat, GC Bullock, D Kostka, CM Croix, A Chattopadhyay, M Rojas, SR Mulukutla, P Dutta
Science Translational Medicine 2020
Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2
EC Stahl, ER Delgado, F Alencastro, ST LoPresti, PD Wilkinson, N Roy, MJ Haschak, CD Skillen, SP Monga, AW Duncan, BN Brown
The American Journal of Pathology 2020
Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome
AJ Kim, N Xu, K Umeyama, A Hulin, SR Ponny, RJ Vagnozzi, EA Green, P Hanson, BM McManus, H Nagashima, KE Yutzey
Circulation 2020
The role of peripheral monocytes and macrophages in ischemic stroke
D Han, H Liu, Y Gao
Neurological Sciences 2020
Parallels between wound healing, epimorphic regeneration and solid tumors
AY Wong, JL Whited
Development (Cambridge, England) 2020
Immune crosstalk in cancer progression and metastatic spread: a complex conversation
H Garner, KE de Visser
Nature Reviews Immunology 2020
The Roles of Monocyte and Monocyte-Derived Macrophages in Common Brain Disorders
M Zhao, H Tuo, S Wang, L Zhao
BioMed Research International 2020
Cancer systems immunology
NE Reticker-Flynn, EG Engleman
eLife 2020
CCR2 Mediates Chronic LPS-Induced Pulmonary Inflammation and Hypoalveolarization in a Murine Model of Bronchopulmonary Dysplasia
TX Cui, AE Brady, CT Fulton, YJ Zhang, LM Rosenbloom, AM Goldsmith, BB Moore, AP Popova
Frontiers in immunology 2020
Origins and diversity of macrophages in health and disease
G Sreejit, AJ Fleetwood, AJ Murphy, PR Nagareddy
IBMS BoneKEy 2020
Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing
MA Raddatz, T Huffstater, MR Bersi, BI Reinfeld, MZ Madden, SE Booton, WK Rathmell, JC Rathmell, BR Lindman, MS Madhur, WD Merryman
Arteriosclerosis, thrombosis, and vascular biology 2020
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2
M Gheblawi, K Wang, A Viveiros, Q Nguyen, JC Zhong, AJ Turner, MK Raizada, MB Grant, GY Oudit
Circulation research 2020
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
AD Boeck, BY Ahn, C DMello, X Lun, SV Menon, MM Alshehri, F Szulzewsky, Y Shen, L Khan, NH Dang, E Reichardt, KA Goring, J King, CJ Grisdale, N Grinshtein, D Hambardzumyan, KM Reilly, MD Blough, JG Cairncross, VW Yong, MA Marra, SJ Jones, DR Kaplan, KD McCoy, EC Holland, P Bose, JA Chan, SM Robbins, DL Senger
Nature Communications 2020
Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults
SM Cho, H Lee, JS Shim, HC Kim
Diabetes & Metabolism Journal 2020
Sepsis Triggers a Late Expansion of Functionally Impaired Tissue-Vascular Inflammatory Monocytes During Clinical Recovery
CB de Chanville, BG Chousterman, P Hamon, M Laviron, N Guillou, PL Loyher, A Meghraoui-Kheddar, S Barthelemy, P Deterre, A Boissonnas, C Combadière
Frontiers in immunology 2020
Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease
MP Noz, S Bekkering, L Groh, TM Nielen, EJ Lamfers, A Schlitzer, SE Messaoudi, N van Royen, EH Huys, FW Preijers, EM Smeets, EH Aarntzen, B Zhang, Y Li, ME Bremmers, WJ van der Velden, H Dolstra, LA Joosten, ME Gomes, MG Netea, NP Riksen
eLife 2020
B Lymphocyte–Derived CCL7 Augments Neutrophil and Monocyte Recruitment, Exacerbating Acute Kidney Injury
A Inaba, ZK Tuong, AM Riding, RJ Mathews, JL Martin, K Saeb-Parsy, MR Clatworthy
Journal of immunology (Baltimore, Md. : 1950) 2020
Lymph node stromal CCL2 limits antibody responses
DC Dasoveanu, HJ Park, CL Ly, WD Shipman, S Chyou, V Kumar, D Tarlinton, B Ludewig, BJ Mehrara, TT Lu
Science Immunology 2020
In‐depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis
S Mao, Y Liang, P Chen, Y Zhang, X Yin, M Zhang
Journal of Cellular and Molecular Medicine 2020
Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma
JL Ross, Z Chen, CJ Herting, Y Grabovska, F Szulzewsky, M Puigdelloses, L Monterroza, J Switchenko, NR Wadhwani, PJ Cimino, A Mackay, C Jones, RD Read, TJ MacDonald, M Schniederjan, OJ Becher, D Hambardzumyan
Brain 2020
Monocyte recruitment and fate specification after myocardial infarction
KI Mentkowski, LM Euscher, A Patel, BR Alevriadou, JK Lang
American journal of physiology. Cell physiology 2020
Single-cell mass cytometry reveals cross-talk between inflammation-dampening and inflammation-amplifying cells in osteoarthritic cartilage
FC Grandi, R Baskar, P Smeriglio, S Murkherjee, PF Indelli, DF Amanatullah, S Goodman, C Chu, S Bendall, N Bhutani
Science Advances 2020
Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX 3 CR1 + Macrophages in Tissue Repair
A Zaid, K Tharmarajah, H Mostafavi, JR Freitas, KC Sheng, SS Foo, W Chen, J Vider, X Liu, NP West, LJ Herrero, A Taylor, LK Mackay, DR Getts, NJ King, S Mahalingam, TE Morrison
mBio 2020
Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection
JP Auger, S Rivest, MO Benoit-Biancamano, M Segura, M Gottschalk, GH Palmer
Infection and immunity 2020
Cell-Free Fetal DNA Increases Prior to Labor at Term and in a Subset of Preterm Births
N Gomez-Lopez, R Romero, G Schwenkel, V Garcia-Flores, B Panaitescu, A Varrey, F Ayoub, SS Hassan, M Phillippe
Reproductive sciences (Thousand Oaks, Calif.) 2020
Neuroprotective Properties and Therapeutic Potential of Bone Marrow–Derived Microglia in Alzheimer’s Disease
C Li, YH Chen, K Zhang
American journal of Alzheimer's disease and other dementias 2020
Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation?
SM Parsadaniantz, AR Goazigo, A Sapienza, C Habas, C Baudouin
Cells 2020
Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
J Park, JY Chang, JY Kim, JE Lee
Frontiers in neurology 2020
Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae
D Liu, Z Chen, Y Yuan, H Jing, J Zou, X Zhang, , W Zhang, Q Zou, J Zhang, S Taurone
Journal of Immunology Research 2020
Polarization of Human Monocyte-Derived Cells With Vitamin D Promotes Control of Mycobacterium tuberculosis Infection
JR Muvva, VR Parasa, M Lerm, M Svensson, S Brighenti
Frontiers in immunology 2020
CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic Hedgehog-Medulloblastoma model
IL Tan, RD Arifa, H Rallapalli, V Kana, Z Lao, RM Sanghrajka, NS Bayin, A Tanne, A Wojcinski, A Korshunov, N Bhardwaj, M Merad, DH Turnbull, JJ Lafaille, AL Joyner
Oncogene 2020
The Molecular and Cellular Mechanisms Associated with a Microvascular Inflammation in the Pathogenesis of Heart Failure with Preserved Ejection Fraction
AG Ovchinnikov, TI Arefieva, AV Potekhina, AY Filatova, FT Ageev, SА Boytsov
Acta Naturae 2020
Teaching Old Dogs New Tricks? The Plasticity of Lung Alveolar Macrophage Subsets
J Kulikauskaite, A Wack
Trends in Immunology 2020
Proinflammatory macrophage-derived microvesicles exhibit tumor tropism dependent on CCL2/CCR2 signaling axis and promote drug delivery via SNARE-mediated membrane fusion
Guo L, Zhang Y, Wei R, Zhang X, Wang C, Feng M
Theranostics 2020
Local polynomial regression for pooled response data
Wang D, Mou X, Li X, Huang X
Journal of Nonparametric Statistics 2020
Cytokine Profiles and the Effect of Intravitreal Aflibercept Treatment on Experimental Choroidal Neovascularization
Wang C, Zhang R, Zhang Q, Jin H, Wei C, Wu C, Mei L, Liu Y, Zhang P
Ophthalmic Research 2020

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 14 patents
Referenced in 3 Wikipedia pages
Highlighted by 1 platforms
626 readers on Mendeley
1 readers on CiteULike
See more details