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SPDEF regulates goblet cell hyperplasia in the airway epithelium

Kwon-Sik Park, … , Gang Chen, Jeffrey A. Whitsett

Kwon-Sik Park, … , Gang Chen, Jeffrey A. Whitsett

Published April 2, 2007
Citation Information: J Clin Invest. 2007;117(4):978-988. https://doi.org/10.1172/JCI29176.

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Research Article Pulmonology

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Targeting Mucus Hypersecretion: New Therapeutic Opportunities for COPD? C Martin, J Frija-Masson, PR Burgel	Drugs	2014
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A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression HS Chand, G Montano, X Huang, SH Randell, Y Mebratu, H Petersen, Y Tesfaigzi		2014
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SPDEF Inhibits Prostate Carcinogenesis by Disrupting a Positive Feedback Loop in Regulation of the Foxm1 Oncogene XH Cheng, M Black, V Ustiyan, T Le, L Fulford, A Sridharan, M Medvedovic, VV Kalinichenko, JA Whitsett, TV Kalin, MS Horwitz	PLoS genetics	2014
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Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke A Oldenburger, W Timens, S Bos, M Smit, AV Smrcka, AC Laurent, J Cao, M Hylkema, H Meurs, H Maarsingh, F Lezoualc'h, M Schmidt	The FASEB Journal	2014
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins I Das, CW Png, I Oancea, SZ Hasnain, R Lourie, M Proctor, RD Eri, Y Sheng, DI Crane, TH Florin, MA McGuckin	Journal of Experimental Medicine	2013
Spdef Null Mice Lack Conjunctival Goblet Cells and Provide a Model of Dry Eye CK Marko, BB Menon, G Chen, JA Whitsett, H Clevers, IK Gipson	The American Journal of Pathology	2013
Barrier function of airway tract epithelium S Ganesan, AT Comstock, US Sajjan	Tissue Barriers	2013
The UPR and lung disease F Osorio, B Lambrecht, S Janssens	Seminars in Immunopathology	2013
Ocular Surface Development and Gene Expression SK Swamynathan	Journal of Ophthalmology	2013
Repair and remodeling of airway epithelium after injury in chronic obstructive pulmonary disease S Ganesan, US Sajjan	Current Respiratory Care Reports	2013
PDEF Promotes Luminal Differentiation and Acts as a Survival Factor for ER-Positive Breast Cancer Cells G Buchwalter, MM Hickey, A Cromer, LM Selfors, RN Gunawardane, J Frishman, R Jeselsohn, E Lim, D Chi, X Fu, R Schiff, M Brown, JS Brugge	Cancer Cell	2013
High SPDEF may identify patients who will have a prolonged response to androgen deprivation therapy: Role of SPDEF in recurrent CaP AC Haller, W Tan, R Payne-Ondracek, W Underwood, L Tian, C Morrison, F Li	The Prostate	2013
ETS2 Mediated Tumor Suppressive Function and MET Oncogene Inhibition in Human Non–Small Cell Lung Cancer M Kabbout, MM Garcia, J Fujimoto, DD Liu, D Woods, CW Chow, G Mendoza, AA Momin, BP James, L Solis, C Behrens, JJ Lee, II Wistuba, H Kadara	Clinical cancer research	2013
Understanding the role of ETS-mediated gene regulation in complex biological processes. Findlay VJ, LaRue AC, Turner DP, Watson PM, Watson DK	Advances in cancer research	2013
KRAS.G12D and NKX2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung Yutaka Maeda, Tomoshi Tsuchiya, Haiping Hao, David Tompkins, Yan Xu, Michael Mucenski, Lingling Du, Angela Keiser, Takuya Fukazawa, Yoshio Naomoto, Takeshi Nagayasu, Jeffrey Whitsett	Journal of Clinical Investigation	2012
The ER stress transducer IRE1β is required for airway epithelial mucin production MB Martino, L Jones, B Brighton, C Ehre, L Abdulah, CW Davis, D Ron, WK O'Neal, CM Ribeiro	Mucosal Immunology	2012
SAM-pointed domain ETS factor mediates epithelial cell–intrinsic innate immune signaling during airway mucous metaplasia Thomas R. Korfhagen, Joseph Kitzmiller, Gang Chen, Anusha Sridharan, Hans-Michael Haitchi, Rashmi S. Hegde, Senad Divanovic, Christopher L. Karp, Jeffrey A. Whitsett	Proceedings of the National Academy of Sciences	2012
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation X Ren, TA Shah, V Ustiyan, Y Zhang, J Shinn, G Chen, JA Whitsett, TV Kalin, VV Kalinichenko	Molecular and cellular biology	2012
The airway epithelium in asthma BN Lambrecht, H Hammad	Nature Medicine	2012
Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge A Pardo-Saganta, BM Law, M Gonzalez-Celeiro, V Vinarsky, J Rajagopal	American journal of respiratory cell and molecular biology	2012
Cross-roads in the lung: immune cells and tissue interactions as determinants of allergic asthma L Ramakrishna, VC de Vries, MA de Lafaille	Immunologic Research	2012
The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways O Boucherat, J Chakir, L Jeannotte	Biology Open	2012
The Role of Atoh1 in Mucous Cell Metaplasia Y Nakamura, Y Hamajima, M Komori, M Yokota, M Suzuki, J Lin	International Journal of Otolaryngology	2012
Wheezing and itching NL Glosson, HA Bruns, MH Kaplan	JAK-STAT	2012
Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2 S Li, Y Wang, Y Zhang, MM Lu, FJ DeMayo, JD Dekker, PW Tucker, EE Morrisey	Development (Cambridge, England)	2012
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia: Airway goblet cell metaplasia P Scudieri, E Caci, S Bruno, L Ferrera, M Schiavon, E Sondo, V Tomati, A Gianotti, O Zegarra-Moran, N Pedemonte, F Rea, R Ravazzolo, LJ Galietta	The Journal of Physiology	2012
Airway Epithelial Transcription Factor NK2 Homeobox 1 Inhibits Mucous Cell Metaplasia and Th2 Inflammation Y Maeda, G Chen, Y Xu, HM Haitchi, L Du, AR Keiser, PH Howarth, DE Davies, ST Holgate, JA Whitsett	American journal of respiratory and critical care medicine	2011
Cigarette Smoke Suppresses Bik To Cause Epithelial Cell Hyperplasia and Mucous Cell Metaplasia YA Mebratu, K Schwalm, KR Smith, M Schuyler, Y Tesfaigzi	American journal of respiratory and critical care medicine	2011
Interleukin-13 (IL-13)/IL-13 Receptor α1 (IL-13Rα1) Signaling Regulates Intestinal Epithelial Cystic Fibrosis Transmembrane Conductance Regulator Channel-dependent Cl− Secretion* D Wu, R Ahrens, H Osterfeld, TK Noah, K Groschwitz, PS Foster, KA Steinbrecher, ME Rothenberg, NF Shroyer, KI Matthaei, FD Finkelman, SP Hogan	The Journal of biological chemistry	2011
Mucin dynamics and enteric pathogens MA McGuckin, SK Lindén, P Sutton, TH Florin	Nature Reviews Microbiology	2011
Notch-Dependent Differentiation of Adult Airway Basal Stem Cells JR Rock, X Gao, Y Xue, SH Randell, YY Kong, BL Hogan	Cell Stem Cell	2011
Mouse Conjunctival Forniceal Gene Expression during Postnatal Development and Its Regulation by Krüppel-like Factor 4 D Gupta, SA Harvey, N Kaminski, SK Swamynathan	Investigative ophthalmology & visual science	2011
Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development PN Tsao, SC Wei, MF Wu, MT Huang, HY Lin, MC Lee, KM Lin, IJ Wang, V Kaartinen, LT Yang, WV Cardoso	Development (Cambridge, England)	2011
Intersections between Pulmonary Development and Disease JA Whitsett, HM Haitchi, Y Maeda	American journal of respiratory and critical care medicine	2011
Molecular mechanisms of Barrett's esophagus H Chen, Y Fang, W Tevebaugh, RC Orlando, NJ Shaheen, X Chen	Digestive Diseases and Sciences	2011
Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis SJ McElroy, LS Prince, JH Weitkamp, J Reese, JC Slaughter, DB Polk	American journal of physiology. Gastrointestinal and liver physiology	2011
A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma U Sivaprasad, DJ Askew, MB Ericksen, AM Gibson, MT Stier, EB Brandt, SA Bass, MO Daines, J Chakir, KF Stringer, SE Wert, JA Whitsett, TD Cras, M Wills-Karp, GA Silverman, GK Hershey	Journal of Allergy and Clinical Immunology	2011
Aldose reductase inhibition prevents metaplasia of airway epithelial cells UC Yadav, L Aguilera-Aguirre, KV Ramana, I Boldogh, SK Srivastava	PloS one	2010
SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells TK Noah, A Kazanjian, J Whitsett, NF Shroyer	Experimental Cell Research	2010
The SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression JV DeGiulio, CD Kaufman, DA Dean	Gene Therapy	2010
Requirement of the Epithelium-specific Ets Transcription Factor Spdef for Mucous Gland Cell Function in the Gastric Antrum* D Horst, X Gu, M Bhasin, Q Yang, M Verzi, D Lin, M Joseph, X Zhang, W Chen, YP Li, RA Shivdasani, TA Libermann	The Journal of biological chemistry	2010
SPDEF is Required for Pulmonary Goblet Cell Differentiation and Regulates a Network of Genes Associated with Mucus Production Gang Chen, Thomas R. Korfhagen, Yan Xu, Joseph Kitzmiller, Susan E. Wert, Yutaka Maeda, Alexander Gregorieff, Hans Clevers, Jeffrey A. Whitsett	Journal of Clinical Investigation	2009
Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease DR Curran, L Cohn	American journal of respiratory cell and molecular biology	2009
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development JS Guseh, SA Bores, BZ Stanger, Q Zhou, WJ Anderson, DA Melton, J Rajagopal	Development (Cambridge, England)	2009
Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium AW Lange, AR Keiser, JM Wells, AM Zorn, JA Whitsett	PloS one	2009
Mechanisms of Lung Development W Shi, F Chen, WV Cardoso	Proceedings of the American Thoracic Society	2009
Airway and Lung Pathology Due to Mucosal Surface Dehydration in β-Epithelial Na + Channel-Overexpressing Mice: Role of TNF-α and IL-4Rα Signaling, Influence of Neonatal Development, and Limited Efficacy of Glucocorticoid Treatment A Livraghi, BR Grubb, EJ Hudson, KJ Wilkinson, JK Sheehan, MA Mall, WK O'Neal, RC Boucher, SH Randell	Journal of immunology (Baltimore, Md. : 1950)	2009
Resident cellular components of the lung: developmental aspects WV Cardoso, JA Whitsett	Proceedings of the American Thoracic Society	2008
Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung PN Tsao, F Chen, KI Izvolsky, J Walker, MA Kukuruzinska, J Lu, WV Cardoso	The Journal of biological chemistry	2008
Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation DE Metzger, MT Stahlman, JM Shannon	Developmental Biology	2008
Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. Kuperman DA, Schleimer RP	Current molecular medicine	2008
Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity A Kato, RP Schleimer	Current Opinion in Immunology	2007

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