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Noam Zelcer, Peter Tontonoz
Published March 1, 2006
Citation Information: J Clin Invest. 2006;116(3):607-614. https://doi.org/10.1172/JCI27883.
Citation Information: J Clin Invest. 2006;116(3):607-614. https://doi.org/10.1172/JCI27883.
Abstract
The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that are activated in response to elevated intracellular cholesterol levels in multiple cell types. Once activated, LXRs induce the expression of an array of genes involved in cholesterol absorption, efflux, transport, and excretion. In addition to their function in lipid metabolism, LXRs have also been found to modulate immune and inflammatory responses in macrophages. Synthetic LXR agonists promote cholesterol efflux and inhibit inflammation in vivo and inhibit the development of atherosclerosis in animal models. The ability of LXRs to integrate metabolic and inflammatory signaling makes them particularly attractive targets for intervention in human metabolic disease.
Authors
Noam Zelcer, Peter Tontonoz
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Citations to this article (427)
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Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta
YC Lien, Z Zhang, G Barila, A Green-Brown, MA Elovitz, RA Simmons |
Frontiers in physiology | 2020 |
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Extensive Changes in Transcriptomic “Fingerprints” and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis
BS Brusletto, EM Løberg, BC Hellerud, IL Goverud, JP Berg, OK Olstad, U Gopinathan, P Brandtzaeg, R Øvstebø |
Frontiers in Cellular and Infection Microbiology | 2020 |
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Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer
MT Bilotta, S Petillo, A Santoni, M Cippitelli |
Frontiers in immunology | 2020 |
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Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities
J Zhao, J Chen, M Li, M Chen, C Sun |
Viruses | 2020 |
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LXRα Phosphorylation in Cardiometabolic Disease: Insight From Mouse Models
M Voisin, MC Gage, N Becares, E Shrestha, EA Fisher, I Pineda-Torra, MJ Garabedian |
Endocrinology | 2020 |
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Yin and Yang Regulation of Liver X Receptor α Signaling Control of Cholesterol Metabolism by Poly(ADP-ribose) polymerase 1
F Zhang, C Wang, Y Jiang, K Huang, F Liu, M Du, , D Huang, K Huang |
International journal of biological sciences | 2020 |
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Lipid rafts in glial cells: role in neuroinflammation and pain processing
YI Miller, JM Navia-Pelaez, M Corr, TL Yaksh |
Journal of lipid research | 2020 |
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Epigenetic Regulation of Hepatic Lipogenesis: Role in Hepatosteatosis and Diabetes
J Viscarra, HS Sul |
Diabetes | 2020 |
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Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells
T Hu, W Huang, Z Li, MA Kane, L Zhang, SM Huang, H Wang |
Toxicology and Applied Pharmacology | 2020 |
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Proteomic analysis of platelet-rich and platelet-poor plasma
Miroshnychenko O, Chalkley RJ, Leib RD, Everts PA, Dragoo JL |
Regenerative Therapy | 2020 |
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Synthetic Alkaloid Treatment Influences the Intestinal Epithelium and Mesenteric Adipose Transcriptome in Holstein Steers
McLean KJ, Baldwin RL VI, Li CJ, Klotz JL, Edwards JL, McLeod KR |
Frontiers in Veterinary Science | 2020 |
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Advanced nanomedicines for the treatment of inflammatory diseases
Brusini R, Varna M, Couvreur P |
Advanced Drug Delivery Reviews | 2020 |
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Unilateral acute anterior uveitis is associated with ipsilateral changes in the tear fluid proteome that involves the LXR/RXR pathway
Eidet JR, Jørstad ØK, Fostad IG, Olstad OK, Sørland RØ, Moe MC, Petrovski G, Pepaj M |
Journal of Ophthalmic Inflammation and Infection | 2020 |
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Identification of Age-Specific and Common Key Regulatory Mechanisms Governing Eggshell Strength in Chicken Using Random Forests
Ramzan F, Klees S, Schmitt AO, Cavero D, Gültas M |
Genes & development | 2020 |
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Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes
Asare-Bediako B, Noothi SK, Li Calzi S, Athmanathan B, Vieira CP, Adu-Agyeiwaah Y, Dupont M, Jones BA, Wang XX, Chakraborty D, Levi M, Nagareddy PR, Grant MB |
Cells | 2020 |
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Liver X Receptor α in Sciatic Nerve Exerts an Alleviating Effect on Neuropathic Pain Behaviors Induced by Crush Injury.
Mao Z, Huang R, Xu J, Guo R, Wei X |
Neurochemical Research | 2020 |
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Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer’s disease mouse model
J Bogie, C Hoeks, M Schepers, A Tiane, A Cuypers, F Leijten, Y Chintapakorn, T Suttiyut, S Pornpakakul, D Struik, A Kerksiek, HB Liu, N Hellings, P Martinez-Martinez, JW Jonker, I Dewachter, E Sijbrands, J Walter, J Hendriks, A Groen, B Staels, D Lütjohann, T Vanmierlo, M Mulder |
Scientific Reports | 2019 |
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Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function
E Wouters, NM de Wit, J Vanmol, SM van der Pol, B van het Hof, D Sommer, M Loix, D Geerts, JA Gustafsson, KR Steffensen, T Vanmierlo, JF Bogie, JJ Hendriks, HE de Vries |
Frontiers in immunology | 2019 |
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High-Fat Diets and LXRs Expression in Rat Liver and Hypothalamus
M Rey, MS Kruse, RN Magrini-Huamán, H Coirini |
Cellular and Molecular Neurobiology | 2019 |
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Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer
J Lyu, EJ Yang, JS Shim |
Cells | 2019 |
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LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1
D Patel, F Ahmad, DM Kambach, Q Sun, AS Halim, T Kramp, KA Camphausen, JM Stommel |
Scientific Reports | 2019 |
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The Metabolic Signature of Macrophage Responses
A Viola, F Munari, R Sánchez-Rodríguez, T Scolaro, A Castegna |
Frontiers in immunology | 2019 |
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Breed, Diet, and Interaction Effects on Adipose Tissue Transcriptome in Iberian and Duroc Pigs Fed Different Energy Sources
R Benítez, N Trakooljul, Y Núñez, B Isabel, E Murani, ED Mercado, E Gómez-Izquierdo, J García-Casco, C López-Bote, K Wimmers, C Óvilo |
Genes & development | 2019 |
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Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands
AY Belorusova, E Evertsson, D Hovdal, J Sandmark, E Bratt, I Maxvall, IG Schulman, P Åkerblad, EL Lindstedt |
2019 | |
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MicroRNA 7 Impairs Insulin Signaling and Regulates Aβ Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway
MF Frutos, I Galán-Chilet, L Goedeke, B Kim, V Pardo-Marqués, A Pérez-García, JI Herrero, C Fernández-Hernando, J Kim, CM Ramírez |
Molecular and cellular biology | 2019 |
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Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages
TK Smith, Z Kahiel, ND LeBlond, P Ghorbani, E Farah, R Al-Awosi, M Cote, S Gadde, MD Fullerton |
Molecules (Basel, Switzerland) | 2019 |
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The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina
AM Petrov, AA Astafev, N Mast, A Saadane, N El-Darzi, IA Pikuleva |
Biomolecules | 2019 |
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PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells
FV Bruschi, T Claudel, M Tardelli, P Starlinger, F Marra, M Trauner |
Hepatology Communications | 2019 |
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Hepatic lipid metabolism is affected by a daily 3-meal pattern with varying dietary crude protein with a pig model
Xie C, Duan X, Long C, Wu X |
Animal Nutrition | 2019 |
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Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways
Chen YC, Chen HJ, Huang BM, Chen YC, Chang CF |
Journal of Clinical Medicine | 2019 |
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Induction of Stearoyl-CoA 9-Desaturase 1 Protects Human Mesenchymal Stromal Cells Against Palmitic Acid-Induced Lipotoxicity and Inflammation
Dalla Valle A, Vertongen P, Spruyt D, Lechanteur J, Suain V, Gaspard N, Brion JP, Gangji V, Rasschaert J |
Frontiers in Endocrinology | 2019 |
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Programmed increases in LXRα induced by paternal alcohol use enhance offspring metabolic adaptation to high-fat diet induced obesity
Chang RC, Thomas KN, Bedi YS, Golding MC |
Molecular Metabolism | 2019 |
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Promising Directions in Atherosclerosis Treatment Based on Epigenetic Regulation Using MicroRNAs and Long Noncoding RNAs
Skuratovskaia D, Vulf M, Komar A, Kirienkova E, Litvinova L |
Biomolecules | 2019 |
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Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain
Li YJ, Zhang K, Sun T, Wang J, Guo YY, Yang L, Yang Q, Li YJ, Liu SB, Zhao MG, Wu YM |
Journal of Neuroinflammation | 2019 |
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Effects of Single Probiotic- and Combined Probiotic-Fermented Milk on Lipid Metabolism in Hyperlipidemic Rats
Wa Y, Yin B, He Y, Xi W, Huang Y, Wang C, Guo F, Gu R |
Frontiers in microbiology | 2019 |
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Noncoding RNAs in cardiovascular diseases
Gurha P |
Current Opinion in Cardiology | 2019 |
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Metabolic Regulators Nampt and Sirt6 Serially Participate in the Macrophage Interferon Antiviral Cascade
Dantoft W, Robertson KA, Watkins WJ, Strobl B, Ghazal P |
Frontiers in microbiology | 2019 |
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MicroRNA-155 Promotes Heat Stress-Induced Inflammation via Targeting Liver X Receptor α in Microglia
Li P, Wang G, Zhang XL, He GL, Luo X, Yang J, Luo Z, Shen TT, Yang XS |
Frontiers in cellular neuroscience | 2019 |
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Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming
Chang RC, Wang H, Bedi Y, Golding MC |
Epigenetics & chromatin | 2019 |
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Lipid Synthesis Is Required to Resolve Endoplasmic Reticulum Stress and Limit Fibrotic Responses in the Lung
F Romero, X Hong, D Shah, CB Kallen, I Rosas, Z Guo, DL Schriner, J Barta, H Shaghaghi, JB Hoek, C Mesaros, AM Choi, NW Snyder, R Summer |
American journal of respiratory cell and molecular biology | 2018 |
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Molecular and functional heterogeneity of IL-10-producing CD4+ T cells
L Brockmann, S Soukou, B Steglich, P Czarnewski, L Zhao, S Wende, T Bedke, C Ergen, C Manthey, T Agalioti, M Geffken, O Seiz, SM Parigi, C Sorini, J Geginat, K Fujio, T Jacobs, T Roesch, JR Izbicki, AW Lohse, RA Flavell, C Krebs, JA Gustafsson, P Antonson, MG Roncarolo, EJ Villablanca, N Gagliani, S Huber |
Nature Communications | 2018 |
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Tumor necrosis factor α stimulates endogenous apolipoprotein A-I expression and secretion by human monocytes and macrophages: role of MAP-kinases, NF-κB, and nuclear receptors PPARα and LXRs
VS Shavva, DA Mogilenko, EV Nekrasova, AS Trulioff, IV Kudriavtsev, EE Larionova, AV Babina, EB Dizhe, BV Missyul, SV Orlov |
Molecular and Cellular Biochemistry | 2018 |
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Liver X Receptors Protect Dorsal Root Ganglia from Obesity-Induced Endoplasmic Reticulum Stress and Mechanical Allodynia
CK Gavini, AL Bookout, R Bonomo, L Gautron, S Lee, V Mansuy-Aubert |
Cell Reports | 2018 |
|
Lipid metabolism reprogramming and its potential targets in cancer
C Cheng, F Geng, X Cheng, D Guo |
2018 | |
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N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity
N El-Darzi, A Astafev, N Mast, A Saadane, M Lam, IA Pikuleva |
Frontiers in pharmacology | 2018 |
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Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1–Mediated Cholesterol Removal
A Saadane, N Mast, G Trichonas, D Chakraborty, S Hammer, JV Busik, MB Grant, IA Pikuleva |
The American Journal of Pathology | 2018 |
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ATP binding cassette family A protein 1 determines hexosylceramide and sphingomyelin levels in human and mouse plasma
J Iqbal, MT Walsh, SM Hammad, M Cuchel, DJ Rader, MM Hussain |
Journal of lipid research | 2018 |
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Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
T Sallam, M Jones, BJ Thomas, X Wu, T Gilliland, K Qian, A Eskin, D Casero, Z Zhang, J Sandhu, D Salisbury, P Rajbhandari, M Civelek, C Hong, A Ito, X Liu, B Daniel, AJ Lusis, J Whitelegge, L Nagy, A Castrillo, S Smale, P Tontonoz |
Nature Medicine | 2018 |
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Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production
M Viaud, S Ivanov, N Vujic, M Duta-Mare, LE Aira, T Barouillet, E Garcia, F Orange, I Dugail, I Hainault, C Stehlik, S Marchetti, L Boyer, R Guinamard, F Foufelle, A Bochem, KG Hovingh, EB Thorp, EL Gautier, D Kratky, P Dasilva-Jardine, L Yvan-Charvet |
Circulation research | 2018 |
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MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver
R Singaravelu, C Quan, MH Powdrill, TA Shaw, P Srinivasan, RK Lyn, RC Alonzi, DM Jones, R Filip, RS Russell, JP Pezacki |
Scientific Reports | 2018 |
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25-Hydroxycholesterol protects against acute lung injury via targeting MD-2
W Ouyang, H Zhou, C Liu, S Wang, Y Han, J Xia, F Xu |
Journal of Cellular and Molecular Medicine | 2018 |
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Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK–mediated pathways
Lee SE, Park SH, Oh SW, Yoo JA, Kwon K, Park SJ, Kim J, Lee HS, Cho JY, Lee J |
Scientific Reports | 2018 |
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Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s disease
Qin L, Zhu X, Liu X, Zeng M, Tao R, Zhuang Y, Zhou Y, Zhang Z, Yang Y, Li Y, Wang Y, Ye H |
Endocrine Connections | 2018 |
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Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization
Mukwaya A, Lennikov A, Xeroudaki M, Mirabelli P, Lachota M, Jensen L, Peebo B, Lagali N |
Angiogenesis | 2018 |
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Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population
Mehrad-Majd H, Ghayour-Mobarhan M, Zali MR |
Electronic Physician | 2018 |
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Orphan Nuclear Receptors in Colorectal Cancer.
Kelly ME, Mohan HM, Baird AW, Ryan EJ, Winter DC |
Pathology oncology research : POR | 2018 |
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CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
MA Alfaqih, ER Nelson, W Liu, R Safi, JS Jasper, E Macias, J Geradts, JW Thompson, LG Dubois, MR Freeman, C Chang, JT Chi, DP McDonnell, SJ Freedland |
Cancer research | 2017 |
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The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease
MB Fessler |
Pharmacology & Therapeutics | 2017 |
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ABCG1 regulates pulmonary surfactant metabolism in mice and men
TQ de Vallim, E Lee, DJ Merriott, CN Goulbourne, J Cheng, A Cheng, A Gonen, RM Allen, EN Palladino, DA Ford, T Wang, Á Baldán, EJ Tarling |
Journal of lipid research | 2017 |
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Histone Deacetylase Inhibitor SAHA Is a Promising Treatment of Cushing Disease
J Lu, GP Chatain, A Bugarini, X Wang, D Maric, S Walbridge, Z Zhuang, P Chittiboina |
The Journal of clinical endocrinology and metabolism | 2017 |
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Immunohistochemical Expression of Cyclo-oxygenase 2 and Liver X Receptor-α in Acne Vulgaris
OA Bakry |
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH | 2017 |
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Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene
EC Cook, JK Nelson, V Sorrentino, D Koenis, M Moeton, S Scheij, R Ottenhoff, B Bleijlevens, A Loregger, N Zelcer, A Moschetta |
PloS one | 2017 |
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Protective Effect of Argan and Olive Oils against LPS-Induced Oxidative Stress and Inflammation in Mice Livers
SE Kamouni, RE Kebbaj, P Andreoletti, AE Ktaibi, I Rharrassi, A Essamadi, ME Kebbaj, S Mandard, N Latruffe, J Vamecq, B Nasser, M Cherkaoui-Malki |
International journal of molecular sciences | 2017 |
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Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis
H He, Q Yuan, J Bie, RL Wallace, PJ Yannie, J Wang, MG Lancina, OY Zolotarskaya, W Korzun, H Yang, S Ghosh |
Translational Research | 2017 |
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Liver X receptors link lipid metabolism and inflammation
IG Schulman |
FEBS Letters | 2017 |
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EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol EffluxHighlights
JK Nelson, DS Koenis, S Scheij, EC Cook, M Moeton, A Santos, JM Lobaccaro, S Baron, N Zelcer |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
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Activation of liver X receptor α protects amyloid β1–40 induced inflammatory and senescent responses in human retinal pigment epithelial cells
B Dai, C Lei, R Lin, L Tao, Y Bin, H Peng, B Lei |
Inflammation Research | 2017 |
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The role of dyslipidemia in diabetic retinopathy
SS Hammer, JV Busik |
Vision research | 2017 |
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Liver X Receptor Agonist TO901317 Attenuates Paraquat-Induced Acute Lung Injury through Inhibition of NF- κ B and JNK/p38 MAPK Signal Pathways
X Hu, H Shen, Y Wang, M Zhao |
BioMed Research International | 2017 |
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Inhalation Exposure to PM2.5 Counteracts Hepatic Steatosis in Mice Fed High-fat Diet by Stimulating Hepatic Autophagy
Y Qiu, Z Zheng, H Kim, Z Yang, G Zhang, X Shi, F Sun, C Peng, Y Ding, A Wang, LC Chen, S Rajagopalan, Q Sun, K Zhang |
Scientific Reports | 2017 |
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Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense
K Gabor, M Fessler |
Current molecular pharmacology | 2017 |
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Liver X receptor α (LXRα) promoted invasion and EMT of gastric cancer cells by regulation of NF-κB activity
L Ji, B Zhang, G Zhao |
Human Cell | 2017 |
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A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH): Srivastava, Robertson, et al
J Srivastava, CL Robertson, K Ebeid, M Dozmorov, D Rajasekaran, R Mendoza, A Siddiq, MA Akiel, N Jariwala, XN Shen, JJ Windle, MA Subler, ND Mukhopadhyay, S Giashuddin, S Ghosh, Z Lai, Y Chen, PB Fisher, AK Salem, AJ Sanyal, D Sarkar |
Hepatology | 2017 |
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Liver X receptors as potential targets for cancer therapeutics (Review)
X Ju, P Huang, M Chen, Q Wang |
Oncology Letters | 2017 |
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Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling
S Ducheix, A Montagner, A Polizzi, F Lasserre, M Régnier, A Marmugi, F Benhamed, J Bertrand-Michel, L Mselli-Lakhal, N Loiseau, PG Martin, JM Lobaccaro, L Ferrier, C Postic, H Guillou, M Makishima |
PloS one | 2017 |
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Tribbles homolog 1 enhances cholesterol efflux from oxidized low-density lipoprotein-loaded THP-1 macrophages
Y Fu, Y Zhao, B Huang |
Experimental and therapeutic medicine | 2017 |
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Nuclear receptors in neural stem/progenitor cell homeostasis
D Gkikas, M Tsampoula, PK Politis |
Cellular and Molecular Life Sciences | 2017 |
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Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer
K Davalieva, S Kiprijanovska, IM Kostovska, S Stavridis, O Stankov, S Komina, G Petrusevska, M Polenakovic |
Proteomes | 2017 |
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Liver X Receptor Gene Expression is Enhanced in Children with Obstructive Sleep Apnea-Hyperpnoea Syndrome and Cyclooxygenase-2 (COX-2) is Correlated with Severity of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS).
Ye XH, Chen H, Yu Q, Zhu QL |
Medical science monitor : international medical journal of experimental and clinical research | 2017 |
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Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease.
Mariani MM, Malm T, Lamb R, Jay TR, Neilson L, Casali B, Medarametla L, Landreth GE |
Scientific Reports | 2017 |
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Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats
Gong Y, Yang Y, Wu Q, Gao G, Liu Y, Xiong Y, Huang C, Wu S |
Scientific Reports | 2017 |
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Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism
Du J, Tian J, Ding L, Trac C, Xia B, Sun S, Schones DE, Huang W |
Scientific Reports | 2017 |
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Inhibition Role of Atherogenic Diet on Ethyl Carbamate Induced Lung Tumorigenesis in C57BL/6J Mice
Chen T, Lu L, Xu C, Lin X, Leung YK, Ho SM, Ruan XZ, Lian X |
Scientific Reports | 2017 |
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OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans
Sierra B, Triska P, Soares P, Garcia G, Perez AB, Aguirre E, Oliveira M, Cavadas B, Regnault B, Alvarez M, Ruiz D, Samuels DC, Sakuntabhai A, Pereira L, Guzman MG |
PLoS pathogens | 2017 |
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Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages
E Shrestha, MA Hussein, JN Savas, M Ouimet, TJ Barrett, S Leone, JR Yates, KJ Moore, EA Fisher, MJ Garabedian |
The Journal of biological chemistry | 2016 |
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Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis
T Sallam, MC Jones, T Gilliland, L Zhang, X Wu, A Eskin, J Sandhu, D Casero, TQ de Vallim, C Hong, M Katz, R Lee, J Whitelegge, P Tontonoz |
Nature | 2016 |
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Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B −/− (Wilson disease) mice: Hepatology, Vol. XX, No. X, 2015 Hamilton et al
JP Hamilton, L Koganti, A Muchenditsi, VS Pendyala, D Huso, J Hankin, RC Murphy, D Huster, U Merle, C Mangels, N Yang, JJ Potter, E Mezey, S Lutsenko |
Hepatology | 2016 |
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Obesity is associated with changes in oxysterol metabolism and levels in mice liver, hypothalamus, adipose tissue and plasma
O Guillemot-Legris, V Mutemberezi, PD Cani, GG Muccioli |
Scientific Reports | 2016 |
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Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS
AM Speen, HY Kim, RN Bauer, M Meyer, KM Gowdy, MB Fessler, KE Duncan, W Liu, NA Porter, I Jaspers |
The Journal of biological chemistry | 2016 |
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Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?
S Rudraiah, X Zhang, L Wang |
Annual Review of Pharmacology and Toxicology | 2016 |
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Dissociated sterol-based liver X receptor agonists as therapeutics for chronic inflammatory diseases
S Yu, S Li, A Henke, ED Muse, B Cheng, G Welzel, AK Chatterjee, D Wang, J Roland, CK Glass, M Tremblay |
The FASEB Journal | 2016 |
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Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment
ME Ertunc, GS Hotamisligil |
Journal of lipid research | 2016 |
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Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E–Deficient MiceCLINICAL PERSPECTIVE
Y Higashi, S Sukhanov, SY Shai, S Danchuk, R Tang, P Snarski, Z Li, P Lobelle-Rich, M Wang, D Wang, H Yu, R Korthuis, P Delafontaine |
Circulation | 2016 |
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Mesenchymal Stem Cells and Metabolic Syndrome: Current Understanding and Potential Clinical Implications
K Matsushita |
Stem Cells International | 2016 |
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Role of lipids in the metabolism and activation of immune cells
MJ Hubler, AJ Kennedy |
The Journal of Nutritional Biochemistry | 2016 |
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Role for phospholipid acyl chains and cholesterol in pulmonary infections and inflammation
SR Shaikh, MB Fessler, KM Gowdy |
Journal of leukocyte biology | 2016 |
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MicroRNA: a connecting road between apoptosis and cholesterol metabolism
YK Adlakha, N Saini |
Tumor Biology | 2016 |
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Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage
CH Wu, CC Chen, CY Lai, TH Hung, CC Lin, M Chao, SF Chen |
Journal of Neuroinflammation | 2016 |
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Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients
PJ Crick, WJ Griffiths, J Zhang, M Beibel, J Abdel-Khalik, J Kuhle, AW Sailer, Y Wang |
Molecular Neurobiology | 2016 |
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Defective cholesterol metabolism in amyotrophic lateral sclerosis
J Abdel-Khalik, E Yutuc, PJ Crick, JÅ Gustafsson, M Warner, G Roman, K Talbot, E Gray, WJ Griffiths, MR Turner, Y Wang |
Journal of lipid research | 2016 |
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Discovery of Highly Potent Liver X Receptor β Agonists
EK Kick, BB Busch, R Martin, WC Stevens, V Bollu, Y Xie, BC Boren, MC Nyman, MH Nanao, L Nguyen, A Plonowski, IG Schulman, G Yan, H Zhang, X Hou, MN Valente, R Narayanan, K Behnia, AD Rodrigues, B Brock, J Smalley, GH Cantor, J Lupisella, P Sleph, D Grimm, J Ostrowski, RR Wexler, T Kirchgessner, R Mohan |
ACS Medicinal Chemistry Letters | 2016 |
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A Mixture of Extracts of Kochia scoparia and Rosa multiflora with PPAR α/γ Dual Agonistic Effects Prevents Photoaging in Hairless Mice
H Jeon, D Kim, YH Nho, JE Park, SN Kim, E Choi |
International journal of molecular sciences | 2016 |
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MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis.
Wu H, Zhang T, Pan F, Steer CJ, Li Z, Chen X, Song G |
Journal of Hepatology | 2016 |
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Increased mortality and aggravation of heart failure in liver X receptor-α knockout mice after myocardial infarction.
Liu X, Gao J, Xia Q, Lu T, Wang F |
Heart and Vessels | 2016 |
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A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects
Ghosal K, Haag M, Verghese PB, West T, Veenstra T, Braunstein JB, Bateman RJ, Holtzman DM, Landreth GE |
2016 | |
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Cardiac LXR protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization
MV Cannon, HH Sillje, JW Sijbesma, I Vreeswijk-Baudoin, J Ciapaite, B der Sluis, J Deursen, GJ Silva, LJ de Windt, JA Gustafsson, P der Harst, WH van Gilst, RA de Boer |
EMBO Molecular Medicine | 2015 |
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Liver X receptors at the intersection of lipid metabolism and atherogenesis
SD Lee, P Tontonoz |
Atherosclerosis | 2015 |
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Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection
K Kotzamanis, A Angulo, P Ghazal |
Medical Microbiology and Immunology | 2015 |
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Molecular mechanisms of fatty liver in obesity
L Gan, W Xiang, B Xie, L Yu |
Frontiers of Medicine | 2015 |
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Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
C Cheng, P Ru, F Geng, J Liu, JY Yoo, X Wu, X Cheng, V Euthine, P Hu, JY Guo, E Lefai, B Kaur, A Nohturfft, J Ma, A Chakravarti, D Guo |
Cancer Cell | 2015 |
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Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake
JK Nelson, EC Cook, A Loregger, MA Hoeksema, S Scheij, I Kovacevic, PL Hordijk, H Ovaa, N Zelcer |
The Journal of biological chemistry | 2015 |
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A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes
A Loregger, EC Cook, JK Nelson, M Moeton, LJ Sharpe, S Engberg, M Karimova, G Lambert, AJ Brown, N Zelcer |
Molecular and cellular biology | 2015 |
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Immune Regulation of Metabolic Homeostasis in Health and Disease
JR Brestoff, D Artis |
Cell | 2015 |
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Cold Exposure Improves the Anti-diabetic Effect of T0901317 in Streptozotocin-Induced Diabetic Mice
M Gao, C Zhang, Y Ma, D Liu |
The AAPS Journal | 2015 |
|
Emerging role of liver X receptors in cardiac pathophysiology and heart failure
MV Cannon, WH van Gilst, RA de Boer |
Basic Research in Cardiology | 2015 |
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Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling
K Matsushita, F Morello, Z Zhang, T Masuda, S Iwanaga, KR Steffensen, JÅ Gustafsson, RE Pratt, VJ Dzau |
Laboratory Investigation | 2015 |
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Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure: ( A ) Regulation of selected target genes in nodose ganglia (NG) following liver X receptor (LXR) agonist treatment in vivo (left panel) n = 5–8 per group. **p < 0.005. ( B ) NG organotypic slices were prepared from LXRs Nav or LXRs fl/fl treated with GW3965 (5 μM) or vehicle for 4 hr. Quantitative PCR (qPCR) data are expressed as average fold-change relative to vehicle ± S.E.M., n = 3 independent experiments. # and *indicates p < 0.5, **p < 0.005. ( C ) Quantification of total cholesterol. Values were expressed as ng of cholesterol per NG, n = 6. ## and **p < 0.001. (right panel). Neurons isolated from LXRs Nav or control mice NG were subjected to Filipin staining (representative images of staining from 3 individual mice)
V Mansuy-Aubert, L Gautron, S Lee, AL Bookout, CM Kusminski, K Sun, Y Zhang, PE Scherer, DJ Mangelsdorf, JK Elmquist |
eLife | 2015 |
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The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and A amyloidosis
J Choi, J Gao, J Kim, C Hong, J Kim, P Tontonoz |
Science Translational Medicine | 2015 |
|
Liver X receptors contribute to periodontal pathogen-elicited inflammation and oral bone loss
N Huang, YB Shaik-Dasthagirisaheb, MP LaValley, FC Gibson |
Molecular Oral Microbiology | 2015 |
|
Age-dependent therapeutic effects of liver X receptor- activation in murine polymicrobial sepsis
G Botez, G Piraino, PW Hake, JR Ledford, M O'Connor, JA Cook, B Zingarelli |
Innate immunity | 2015 |
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Liver X receptors and cholesterol metabolism: role in ventral midbrain development and neurodegeneration
S Theofilopoulos, E Arenas |
F1000prime reports | 2015 |
|
Anti-Atherosclerotic and Anti-Inflammatory Actions of Sesame Oil
CA Narasimhulu, K Selvarajan, D Litvinov, S Parthasarathy |
Journal of Medicinal Food | 2015 |
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Targeting liver X receptors in cancer therapeutics
CY Lin, JÅ Gustafsson |
Nature Reviews Cancer | 2015 |
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Sirtuins in glucose and lipid metabolism
X Ye, M Li, T Hou, T Gao, W Zhu, Y Yang |
Oncotarget | 2015 |
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Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression.
Kaneko T, Kanno C, Ichikawa-Tomikawa N, Kashiwagi K, Yaginuma N, Ohkoshi C, Tanaka M, Sugino T, Imura T, Hasegawa H, Chiba H |
Oncotarget | 2015 |
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Role of gut microbiota in the modulation of atherosclerosis-associated immune response.
Chistiakov DA, Bobryshev YV, Kozarov E, Sobenin IA, Orekhov AN |
Frontiers in microbiology | 2015 |
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Normalizing glycosphingolipid turnover restores function in SLE CD4+T cells
Georgia McDonald, Shantal Deepak, LAura Miguel, Cleo Hall, David Isenberg, Anthony Magee, Terry D. Butters, Elizabeth C Jury |
Journal of Clinical Investigation | 2014 |
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Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor
Geun Hyang Kim, Gyun-Sik Oh, Jin Yoon, Gang Gu Lee, Ki-Up Lee, Seung-Whan Kim |
Journal of Clinical Investigation | 2014 |
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Retinal and Nonocular Abnormalities in Cyp27a1−/−Cyp46a1−/− Mice with Dysfunctional Metabolism of Cholesterol
A Saadane, N Mast, CD Charvet, S Omarova, W Zheng, SS Huang, TS Kern, NS Peachey, IA Pikuleva |
The American Journal of Pathology | 2014 |
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A Computational Model for the Analysis of Lipoprotein Distributions in the Mouse: Translating FPLC Profiles to Lipoprotein Metabolism
FL Sips, CA Tiemann, MH Oosterveer, AK Groen, PA Hilbers, NA van Riel |
PLoS computational biology | 2014 |
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Cholesterol efflux is LXRα isoform-dependent in human macrophages
AZ Ma, ZY Song, Q Zhang |
BMC Cardiovascular Disorders | 2014 |
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The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis
T Sallam, A Ito, X Rong, J Kim, C Stijn, BT Chamberlain, ME Jung, LC Chao, M Jones, T Gilliland, X Wu, GL Su, RK Tangirala, P Tontonoz, C Hong |
Journal of lipid research | 2014 |
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CB1 Blockade Potentiates Down-Regulation of Lipogenic Gene Expression in Perirenal Adipose Tissue in High Carbohydrate Diet-Induced Obesity
M Vida, P Rivera, AL Gavito, J Suárez, FJ Pavón, S Arrabal, M Romero-Cuevas, D Bautista, A Martínez, FR de Fonseca, A Serrano, E Baixeras, M Alemany |
PloS one | 2014 |
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Liver X Receptor Regulation of Thyrotropin-Releasing Hormone Transcription in Mouse Hypothalamus Is Dependent on Thyroid Status
R Ghaddab-Zroud, I Seugnet, KR Steffensen, BA Demeneix, MS Clerget-Froidevaux, H Guillou |
PloS one | 2014 |
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Dietary Cholesterol Promotes Adipocyte Hypertrophy and Adipose Tissue Inflammation in Visceral, but Not in Subcutaneous, Fat in Monkeys
S Chung, H Cuffe, SM Marshall, AL McDaniel, JH Ha, K Kavanagh, C Hong, P Tontonoz, RE Temel, JS Parks |
Arteriosclerosis, thrombosis, and vascular biology | 2014 |
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Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases A 1-42 Clearance
Y Shibuya, CC Chang, LH Huang, EY Bryleva, TY Chang |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2014 |
|
Cholesterol in the retina: The best is yet to come
IA Pikuleva, CA Curcio |
Progress in Retinal and Eye Research | 2014 |
|
Transcriptional Regulation of Human Hydroxysteroid Sulfotransferase SULT2A1 by LXR
Z Ou, M Jiang, B Hu, Y Huang, M Xu, S Ren, S Li, S Liu, W Xie, M Huang |
Drug metabolism and disposition: the biological fate of chemicals | 2014 |
|
Discovery of New Liver X Receptor Agonists by Pharmacophore Modeling and Shape-Based Virtual Screening
V Temml, CV Voss, VM Dirsch, D Schuster |
Journal of Chemical Information and Modeling | 2014 |
|
Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis
XQ Zhang, O Even-Or, X Xu, M Rosmalen, L Lim, S Gadde, OC Farokhzad, EA Fisher |
Advanced Healthcare Materials | 2014 |
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Activation of Liver X Receptor Alleviates Ocular Inflammation in Experimental Autoimmune Uveitis
H Yang, S Zheng, Y Qiu, Y Yang, C Wang, P Yang, Q Li, B Lei |
Investigative ophthalmology & visual science | 2014 |
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The MYLIP p.N342S polymorphism is associated with response to lipid-lowering therapy in Brazilian patients with familial hypercholesterolemia:
PC Santos, AC Morgan, CE Jannes, JE Krieger, RD Santos, AC Pereira |
Pharmacogenetics and Genomics | 2014 |
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miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages
M Vinod, I Chennamsetty, S Colin, L Belloy, FD Paoli, H Schaider, WF Graier, S Frank, D Kratky, B Staels, G Chinetti-Gbaguidi, GM Kostner |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2014 |
|
Nuclear receptors in neurodegenerative diseases
R Skerrett, T Malm, G Landreth |
Neurobiology of Disease | 2014 |
|
Effect of garlic on lipid profile and expression of LXR alpha in intestine and liver of hypercholesterolemic mice
A Mohammadi, E Oshaghi |
Journal of Diabetes & Metabolic Disorders | 2014 |
|
Macrophage-Independent Regulation of Reverse Cholesterol Transport by Liver X Receptors
SR Breevoort, J Angdisen, IG Schulman |
Arteriosclerosis, thrombosis, and vascular biology | 2014 |
|
Human coronary heart disease: importance of blood cellular miR-2909 RNomics
M Arora, D Kaul, YP Sharma |
Molecular and Cellular Biochemistry | 2014 |
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Targeting SREBP-1-driven lipid metabolism to treat cancer.
Guo D, Bell EH, Mischel P, Chakravarti A |
Current pharmaceutical design | 2014 |
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The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice
JS Wooten, H Wu, J Raya, XD Perrard, J Gaubatz, RC Hoogeveen |
Cholesterol | 2014 |
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Development of Therapeutic Polymeric Nanoparticles for the Resolution of Inflammation
Gadde S, Even-Or O, Kamaly N, Hasija A, Gagnon PG, Adusumilli KH, Erakovic A, Pal AK, Zhang XQ, Kolishetti N, Shi J, Fisher EA, Farokhzad OC |
Advanced Healthcare Materials | 2014 |
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Cyanidin-3-O-β-glucoside inhibits lipopolysaccharide-induced inflammatory response in mouse mastitis model
Fu Y, Wei Z, Zhou E, Zhang N, Yang Z |
Journal of lipid research | 2014 |
|
Loading into Nanoparticles Improves Quercetin's Efficacy in Preventing Neuroinflammation Induced by Oxysterols
Testa G, Gamba P, Badilli U, Gargiulo S, Maina M, Guina T, Calfapietra S, Biasi F, Cavalli R, Poli G, Leonarduzzi G |
PloS one | 2014 |
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Dihydrocapsaicin down-regulates apoM expression through inhibiting Foxa2 expression and enhancing LXRα expression in HepG2 cells
Zhao JY, Hu YW, Li SF, Hu YR, Ma X, Wu SG, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q |
Lipids in Health and Disease | 2014 |
|
ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity
de Haan W, Bhattacharjee A, Ruddle P, Kang MH, Hayden MR |
Journal of lipid research | 2014 |
|
Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes
Hayashi T, Kotani H, Yamaguchi T, Taguchi K, Iida M, Ina K, Maeda M, Kuzuya M, Hattori Y, Ignarro LJ |
Proceedings of the National Academy of Sciences | 2014 |
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Potential approaches to ameliorate hepatic fat accumulation seen with MTP inhibition.
Lin M, Zhao S, Shen L, Xu D |
Drug Safety | 2014 |
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The Oxysterol Receptor LXRβ has Cardiovascular Protective Function in Endothelial Cells through a Non-nuclear Mechanism Mediated by Estrogen Receptor α
Tomonori Ishikawa, Ivan Yuhanna, Junko Umetani, Wan-Ru Lee, Kenneth S. Korach, Philip Warren Shaul, Michihisa Umetani |
Journal of Clinical Investigation | 2013 |
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Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism
T Nguyen-Vu, LL Vedin, K Liu, P Jonsson, JZ Lin, NR Candelaria, LP Candelaria, S Addanki, C Williams, JÅ Gustafsson, KR Steffensen, CY Lin |
Breast Cancer Research | 2013 |
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Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes
R Kones |
Vascular Health and Risk Management | 2013 |
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Nuclear Receptors and Their Selective Pharmacologic Modulators
TP Burris, LA Solt, Y Wang, C Crumbley, S Banerjee, K Griffett, T Lundasen, T Hughes, DJ Kojetin, DM Perez |
Pharmacological reviews | 2013 |
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Lipid metabolism emerges as a promising target for malignant glioma therapy
D Guo, EH Bell, A Chakravarti |
CNS Oncology | 2013 |
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Tumor metabolism of malignant gliomas
P Ru, TM Williams, A Chakravarti, D Guo |
Cancers | 2013 |
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The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation
V Sorrentino, JK Nelson, E Maspero, AR Marques, L Scheer, S Polo, N Zelcer |
Journal of lipid research | 2013 |
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Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer
B Grattan |
Nutrients | 2013 |
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, JG Bode, J Bolleyn, C Borner, J Böttger, A Braeuning, RA Budinsky, B Burkhardt, NR Cameron, G Camussi, CS Cho, YJ Choi, JC Rowlands, U Dahmen, G Damm, O Dirsch, MT Donato, J Dong, S Dooley, D Drasdo, R Eakins, KS Ferreira, V Fonsato, J Fraczek, R Gebhardt, A Gibson, M Glanemann, CE Goldring, MJ Gómez-Lechón, GM Groothuis, L Gustavsson, C Guyot, D Hallifax, S Hammad, A Hayward, D Häussinger, C Hellerbrand, P Hewitt, S Hoehme, HG Holzhütter, JB Houston, J Hrach, K Ito, H Jaeschke, V Keitel, JM Kelm, BK Park, C Kordes, GA Kullak-Ublick, EL LeCluyse, P Lu, J Luebke-Wheeler, A Lutz, DJ Maltman, M Matz-Soja, P McMullen, I Merfort, S Messner, C Meyer, J Mwinyi, DJ Naisbitt, AK Nussler, P Olinga, F Pampaloni, J Pi, L Pluta, SA Przyborski, A Ramachandran, V Rogiers, C Rowe, C Schelcher, K Schmich, M Schwarz, B Singh, EH Stelzer, B Stieger, R Stöber, Y Sugiyama, C Tetta, WE Thasler, T Vanhaecke, M Vinken, TS Weiss, A Widera, CG Woods, JJ Xu, KM Yarborough, JG Hengstler |
Archives of Toxicology | 2013 |
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Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells
V Mulay, P Wood, M Manetsch, M Darabi, R Cairns, M Hoque, KC Chan, M Reverter, A Álvarez-Guaita, KA Rye, C Rentero, J Heeren, C Enrich, T Grewal, X Ai |
PloS one | 2013 |
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Hormonal modulators of glial ABCA1 and apoE levels
J Fan, Y Shimizu, J Chan, A Wilkinson, A Ito, P Tontonoz, E Dullaghan, LA Galea, T Pfeifer, CL Wellington |
Journal of lipid research | 2013 |
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Fluid-Phase Pinocytosis of LDL by Macrophages: A Novel Target to Reduce Macrophage Cholesterol Accumulation in Atherosclerotic Lesions
H Kruth |
Current pharmaceutical design | 2013 |
|
Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice
M Patel, XX Wang, L Magomedova, R John, A Rasheed, H Santamaria, W Wang, R Tsai, L Qiu, A Orellana, A Advani, M Levi, CL Cummins |
Diabetologia | 2013 |
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Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance
SW Beaven, A Matveyenko, K Wroblewski, L Chao, D Wilpitz, TW Hsu, J Lentz, B Drew, AL Hevener, P Tontonoz |
Cell Metabolism | 2013 |
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LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice
A Archer, E Stolarczyk, ML Doria, L Helguero, R Domingues, JK Howard, A Mode, M Korach-André, JÅ Gustafsson |
Journal of lipid research | 2013 |
|
MicroRNA modulation of lipid metabolism and oxidative stress in cardiometabolic diseases
JF Aranda, J Madrigal-Matute, N Rotllan, C Fernández-Hernando |
Free radical biology & medicine | 2013 |
|
Nuclear receptors in inflammation control: Repression by GR and beyond
Y Chinenov, R Gupte, I Rogatsky |
Molecular and Cellular Endocrinology | 2013 |
|
Association of RXR-Gamma Gene Variants with Familial Combined Hyperlipidemia: Genotype and Haplotype Analysis
F Sentinelli, I Minicocci, A Montali, L Nanni, S Romeo, M Incani, MG Cavallo, A Lenzi, M Arca, MG Baroni |
Journal of Lipids | 2013 |
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Inhibition of LXRα/SREBP-1c-Mediated Hepatic Steatosis by Jiang-Zhi Granule
M Wang, S Sun, T Wu, L Zhang, H Song, W Hao, P Zheng, L Xing, G Ji |
Evidence-Based Complementary and Alternative Medicine | 2013 |
|
An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK
TH Kim, JS Eom, CG Lee, YM Yang, YS Lee, SG Kim |
British Journal of Pharmacology | 2013 |
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Effects of NR1H3 Genetic Variation on the Expression of Liver X Receptor α and the Progression of Alzheimer's Disease
Natunen T, Martiskainen H, Sarajärvi T, Helisalmi S, Pursiheimo JP, Viswanathan J, Laitinen M, Mäkinen P, Kauppinen T, Rauramaa T, Leinonen V, Alafuzoff I, Haapasalo A, Soininen H, Hiltunen M |
PloS one | 2013 |
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Blood cellular mutant LXR-α protein stability governs initiation of coronary heart disease
Arora M, Kaul D, Sharma YP |
World journal of cardiology | 2013 |
|
Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations
Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ, Zhu X, Kooperberg C, Li Y, Reiner AP, Tang H |
The American Journal of Human Genetics | 2013 |
|
Association of liver X receptors (LXRs) genetic variants to gallbladder cancer susceptibility.
Sharma KL, Misra S, Kumar A, Mittal B |
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 2013 |
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CCAAT/enhancer-binding protein β (C/EBPβ) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice
SM Rahman, RC Janssen, M Choudhury, KC Baquero, RM Aikens, BA de la Houssaye, JE Friedman |
The Journal of biological chemistry | 2012 |
|
Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice
M González-Granillo, KR Steffensen, O Granados, N Torres, M Korach-André, V Ortíz, C Aguilar-Salinas, T Jakobsson, A Díaz-Villaseñor, A Loza-Valdes, R Hernandez-Pando, JÅ Gustafsson, AR Tovar |
Diabetologia | 2012 |
|
A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors
Y Zhang, Z Gan, P Huang, L Zhou, T Mao, M Shao, X Jiang, Y Chen, H Ying, M Cao, J Li, J Li, WJ Zhang, L Yang, Y Liu |
The Journal of biological chemistry | 2012 |
|
Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes
S Hazra, A Rasheed, A Bhatwadekar, X Wang, LC Shaw, M Patel, S Caballero, L Magomedova, N Solis, Y Yan, W Wang, JS Thinschmidt, A Verma, Q Li, M Levi, CL Cummins, MB Grant |
Diabetes | 2012 |
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Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice
T Yamamoto, M Harada-Shiba, M Nakatani, S Wada, H Yasuhara, K Narukawa, K Sasaki, MA Shibata, H Torigoe, T Yamaoka, T Imanishi, S Obika |
Molecular Therapy — Nucleic Acids | 2012 |
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MicroRNAs in metabolism and metabolic disorders
V Rottiers, AM Näär |
Nature Reviews Molecular Cell Biology | 2012 |
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Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice
ZH Yang, H Miyahara, J Takeo, M Katayama |
Diabetology & metabolic syndrome | 2012 |
|
Nutrition and Nonalcoholic Fatty Liver Disease: The Significance of Cholesterol
M Enjoji, K Yasutake, M Kohjima, M Nakamuta |
International Journal of Hepatology | 2012 |
|
25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells
A Koarai, S Yanagisawa, H Sugiura, T Ichikawa, T Kikuchi, K Furukawa, K Akamatsu, T Hirano, M Nakanishi, K Matsunaga, Y Minakata, M Ichinose |
Respiratory Research | 2012 |
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Lipopolysaccharide represses the expression of ATP-binding cassette transporter G1 and scavenger receptor class B, type I in murine macrophages
Y Park, TX Pham, J Lee |
Inflammation Research | 2012 |
|
Transcription of Liver X Receptor Is Down-Regulated by 15-Deoxy-Δ12,14-Prostaglandin J2 through Oxidative Stress in Human Neutrophils
G Alba, ME Reyes, C Santa-María, R Ramírez, I Geniz, J Jiménez, J Martín-Nieto, E Pintado, F Sobrino, PT Bozza |
PloS one | 2012 |
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Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
AC Calkin, P Tontonoz |
Nature Reviews Molecular Cell Biology | 2012 |
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Fatty liver in men is associated with high serum levels of small, dense low-density lipoprotein cholesterol
K Hosoyamada, H Uto, Y Imamura, Y Hiramine, E Toyokura, Y Hidaka, T Kuwahara, K Kusano, K Saito, M Oketani, A Ido, H Tsubouchi |
Diabetology & metabolic syndrome | 2012 |
|
Regulation of foam cells by adenosine
AB Reiss, BN Cronstein |
Arteriosclerosis, thrombosis, and vascular biology | 2012 |
|
Liver X Receptors Regulate the Transcriptional Activity of the Glucocorticoid Receptor: Implications for the Carbohydrate Metabolism
N Nader, SS Ng, Y Wang, BS Abel, GP Chrousos, T Kino |
PloS one | 2012 |
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LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice
C Hong, MN Bradley, X Rong, X Wang, A Wagner, V Grijalva, LW Castellani, J Salazar, S Realegeno, R Boyadjian, AM Fogelman, BJ van Lenten, ST Reddy, AJ Lusis, RK Tangirala, P Tontonoz |
Journal of lipid research | 2012 |
|
MicroRNA Regulation of Cholesterol Metabolism
N Rotllan, C Fernández-Hernando |
Cholesterol | 2012 |
|
cAMP response element binding protein H mediates fenofibrate-induced suppression of hepatic lipogenesis
AK Min, JY Jeong, Y Go, YK Choi, YD Kim, IK Lee, KG Park |
Diabetologia | 2012 |
|
Identification of Biological Markers of Liver X Receptor (LXR) Activation at the Cell Surface of Human Monocytes
C Rébé, R Filomenko, M Raveneau, A Chevriaux, M Ishibashi, L Lagrost, JL Junien, P Gambert, D Masson |
PloS one | 2012 |
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Carbon Source Metabolism and Its Regulation in Cancer Cells
Yin C, Qie S, Sang N |
Critical reviews in eukaryotic gene expression | 2012 |
|
2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models
Go JT, Belisle SE, Tchitchek N, Tumpey TM, Ma W, Richt JA, Safronetz D, Feldmann H, Katze MG |
BMC Genomics | 2012 |
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Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.
Theofilopoulos S, Wang Y, Kitambi SS, Sacchetti P, Sousa KM, Bodin K, Kirk J, Saltó C, Gustafsson M, Toledo EM, Karu K, Gustafsson JÅ, Steffensen KR, Ernfors P, Sjövall J, Griffiths WJ, Arenas E |
Nature Chemical Biology | 2012 |
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Nuclear receptors take center stage in Th17 cell–mediated autoimmunity
Liang Zhou, Jennifer J. Heller, Ju Qui |
Journal of Clinical Investigation | 2011 |
|
An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway
D Guo, F Reinitz, M Youssef, C Hong, D Nathanson, D Akhavan, D Kuga, AN Amzajerdi, H Soto, S Zhu, I Babic, K Tanaka, J Dang, A Iwanami, B Gini, J DeJesus, DD Lisiero, TT Huang, RM Prins, PY Wen, HI Robins, MD Prados, LM DeAngelis, IK Mellinghoff, MP Mehta, CD James, A Chakravarti, TF Cloughesy, P Tontonoz, PS Mischel |
Cancer Discovery | 2011 |
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Critical Role of Astroglial Apolipoprotein E and Liver X Receptor- Expression for Microglial A Phagocytosis
D Terwel, KR Steffensen, PB Verghese, MP Kummer, JA Gustafsson, DM Holtzman, MT Heneka |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2011 |
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Macrophage Mal1 Deficiency Suppresses Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Activating Peroxisome Proliferator-Activated Receptor-γ–Regulated Genes
VR Babaev, RP Runner, D Fan, L Ding, Y Zhang, H Tao, E Erbay, CZ Görgün, S Fazio, GS Hotamisligil, MR Linton |
Arteriosclerosis, thrombosis, and vascular biology | 2011 |
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Cholesterol metabolism in Huntington disease
JM Karasinska, MR Hayden |
Nature Reviews Neurology | 2011 |
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Hepatic ABCA1 and VLDL triglyceride production
M Liu, S Chung, GS Shelness, JS Parks |
Biochimica et Biophysica Acta | 2011 |
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The Role of MicroRNAs in Cholesterol Efflux and Hepatic Lipid Metabolism
KJ Moore, KJ Rayner, Y Suárez, C Fernández-Hernando |
Annual Review of Nutrition | 2011 |
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Histone Deacetylases: the Biology and Clinical Implication
TP Yao, E Seto |
2011 | |
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Effect of Synthetic Ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the Fatty Acid Composition of Phospholipids in Mice
K Weiss, J Mihály, G Liebisch, T Marosvölgyi, G Schmitz, T Decsi, R Rühl |
Lipids | 2011 |
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Sterol regulation of metabolism, homeostasis, and development
J Wollam, A Antebi |
Annual Review of Biochemistry | 2011 |
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Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages
T Zou, O Garifulin, R Berland, VL Boyartchuk, SM Payne |
Infection and immunity | 2011 |
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Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease
V Andersen, J Christensen, A Ernst, BA Jacobsen, A Tjønneland, HB Krarup, U Vogel |
World journal of gastroenterology : WJG | 2011 |
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Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels
J der Hoorn, D Lindén, U Lindahl, M Bekkers, M Voskuilen, R Nilsson, J Oscarsson, E Lindstedt, H Princen |
British Journal of Pharmacology | 2011 |
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Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice
SP Saini, B Zhang, Y Niu, M Jiang, J Gao, Y Zhai, JH Lee, H Uppal, H Tian, MA Tortorici, SM Poloyac, W Qin, R Venkataramanan, W Xie |
Hepatology | 2011 |
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MicroRNA hsa-miR-613 Targets the Human LXRα Gene and Mediates a Feedback Loop of LXRα Autoregulation
Z Ou, T Wada, R Gramignoli, S Li, SC Strom, M Huang, W Xie |
Molecular Endocrinology | 2011 |
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Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target
C Hong, R Walczak, H Dhamko, MN Bradley, C Marathe, R Boyadjian, JV Salazar, P Tontonoz |
Journal of lipid research | 2011 |
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Lactobacillus rhamnosus BFE 5264 and Lactobacillus plantarum NR74 Promote Cholesterol Excretion Through the Up-Regulation of ABCG5/8 in Caco-2 Cells
H Yoon, J Ju, H Kim, J Lee, H Park, Y Ji, H Shin, MS Do, J Lee, W Holzapfel |
Probiotics and Antimicrobial Proteins | 2011 |
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Hyperglycemic Ins2AkitaLdlr−/− mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease[S]
C Zhou, B Pridgen, N King, J Xu, JL Breslow |
Journal of lipid research | 2011 |
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Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis
M Blanc, WY Hsieh, KA Robertson, S Watterson, G Shui, P Lacaze, M Khondoker, P Dickinson, G Sing, S Rodríguez-Martín, P Phelan, T Forster, B Strobl, M Müller, R Riemersma, T Osborne, MR Wenk, A Angulo, P Ghazal |
PLoS Biology | 2011 |
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Identification of MIG12 as a Mediator for Stimulation of Lipogenesis by LXR Activation
J Inoue, K Yamasaki, E Ikeuchi, S Satoh, Y Fujiwara, T Nishimaki-Mogami, M Shimizu, R Sato |
Molecular Endocrinology | 2011 |
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Distinct Functional Domains Contribute to Degradation of the Low Density Lipoprotein Receptor (LDLR) by the E3 Ubiquitin Ligase Inducible Degrader of the LDLR (IDOL)
Sorrentino V, Scheer L, Santos A, Reits E, Bleijlevens B, Zelcer N |
The Journal of biological chemistry | 2011 |
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Synthetic LXR Agonist Suppresses Endogenous Cholesterol Biosynthesis and Efficiently Lowers Plasma Cholesterol
Pfeifer T, Buchebner M, Chandak PG, Patankar J, Kratzer A, Obrowsky S, Rechberger GN, Kadam RS, Kompella UB, Kostner GM, Kratky D, Levak-Frank S |
Current pharmaceutical biotechnology | 2011 |
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Group X Secretory Phospholipase A2 Enhances Toll-Like Receptor 4 Signaling in Macrophages
Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
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Virus-Induced Differential Expression of Nuclear Receptors and Coregulators in Dendritic Cells: Implication in Interferon Production
Man Ng SS, Chang TH, Tailor P, Ozato K, Kino T |
FEBS Letters | 2011 |
|
The genomic landscapes of inflammation
Natoli G, Ghisletti S, Barozzi I |
Genes & development | 2011 |
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Activation of liver X receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels.
Cui W, Sun Y, Wang Z, Xu C, Xu L, Wang F, Chen Z, Peng Y, Li R |
Neurochemical Research | 2011 |
|
Bifidobacteria can protect from enteropathogenic infection through production of acetate.
Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H |
Nature | 2011 |
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Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in Apoe-deficient mice
Fei Wang, Yasuo Okamoto, Isao Inoki, Kazuaki Yoshioka, Wa Du, Xun Qi, Noriko Takuwa, Koichi Gonda, Yasuhiko Yamamoto, Ryunosuke Ohkawa, Takumi Nishiuchi, Naotoshi Sugimoto, Yutaka Yatomi, Kunitoshi Mitsumori, Masahide Asano, Makoto Kinoshita, Yoh Takuwa |
Journal of Clinical Investigation | 2010 |
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LXR promotes maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression
Jonathan Feig, Ines Pineda-Torra, Marie Sanson, Michelle Bradley, Yuliya Vengrenyuk, Dushun Bogunovic, Emmanuel Gautier, Daniel Rubinstein, Cynthia Hong, Jianhua Liu, Nico van Rooijen, Nina Bhardwaj, Michael Garabedian, Peter Tontonoz, Edward A. Fisher |
Journal of Clinical Investigation | 2010 |
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LXRbeta is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice
Rucha Patel, Monika Patel, Ricky Tsai, Vicky Lin, Angie Bookout, Yuan Zhang, Lilia Magomedova, Tingting Li, Jessica Chan, Conrad Budd, David Mangelsdorf, Carolyn Cummins |
Journal of Clinical Investigation | 2010 |
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RanBP2-mediated neuroprotection is associated with the modulation of functionally diverse but linked pathways in response to oxidative stress
Kyoung-in Cho, Haiqing Yi, Nomingerel Tserentsoodol, Kelly Searle, Andrew Yeh, Paulo Ferreira |
2010 | |
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Tgif1 represses apolipoprotein gene expression in liver
TA Melhuish, DD Chung, GA Bjerke, D Wotton |
Journal of Cellular Biochemistry | 2010 |
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PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
A Majdalawieh, HS Ro |
Nuclear receptor signaling | 2010 |
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A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion
S Chung, AK Gebre, J Seo, GS Shelness, JS Parks |
Journal of lipid research | 2010 |
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Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation
J Yu, J Auwerx |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2010 |
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Biliary cholesterol secretion: more than a simple ABC
A Dikkers, UJ Tietge |
World journal of gastroenterology : WJG | 2010 |
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LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model
N Li, MA Rivéra-Bermúdez, M Zhang, J Tejada, SS Glasson, LA Collins-Racie, ER Lavallie, Y Wang, KC Chang, S Nagpal, EA Morris, CR Flannery, Z Yang |
Proceedings of the National Academy of Sciences | 2010 |
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Genetic causes of high and low serum HDL-cholesterol
D Weissglas-Volkov, P Pajukanta |
Journal of lipid research | 2010 |
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Targeted PPAR{gamma} deficiency in alveolar macrophages disrupts surfactant catabolism
AD Baker, A Malur, BP Barna, S Ghosh, MS Kavuru, AG Malur, MJ Thomassen |
Journal of lipid research | 2010 |
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Carboxylesterases: dual roles in lipid and pesticide metabolism
MK Ross, TM Streit, KL Herring, S Xie |
Journal of Pesticide Science | 2010 |
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Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
ED Bischoff, CL Daige, M Petrowski, H Dedman, J Pattison, J Juliano, AC Li, IG Schulman |
Journal of lipid research | 2010 |
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Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-β peptides in the cerebral spinal fluid of rats
S Suon, J Zhao, SA Villarreal, N Anumula, M Liu, LM Carangia, JJ Renger, CV Zerbinatti |
Molecular Neurodegeneration | 2010 |
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LXR deficiency confers increased protection against visceral Leishmania infection in mice
KW Bruhn, C Marathe, AC Maretti-Mira, H Nguyen, J Haskell, TA Tran, V Vanchinathan, U Gaur, ME Wilson, P Tontonoz, N Craft |
PLoS neglected tropical diseases | 2010 |
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Role of unfolded protein response in lipogenesis
Z Zheng, C Zhang, K Zhang |
World journal of hepatology | 2010 |
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Lysosomes, cholesterol and atherosclerosis
WG Jerome |
Clinical Lipidology | 2010 |
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A Comparative Study of Genome-Wide Transcriptional Profiles of Primary Hepatocytes in Collagen Sandwich and Monolayer Cultures
Y Kim, CD Lasher, LM Milford, TM Murali, P Rajagopalan |
Tissue engineering. Part C, Methods | 2010 |
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NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology.
Zhao Y, Bruemmer D |
Arteriosclerosis, thrombosis, and vascular biology | 2010 |
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Acetylation and Nuclear Receptor Action
Wang C, Tian L, Popov VM, Pestell RG |
The Journal of Steroid Biochemistry and Molecular Biology | 2010 |
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Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)
Solaas K, Legry V, Retterstol K, Berg PR, Holven KB, Ferrières J, Amouyel P, Lien S, Romeo J, Valtueña J, Widhalm K, Ruiz JR, Dallongeville J, Tonstad S, Rootwelt H, Halvorsen B, Nenseter MS, Birkeland KI, Thorsby PM, Meirhaeghe A, Nebb HI |
BMC Medical Genetics | 2010 |
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Retinoid X receptor α controls innate inflammatory responses through the up-regulation of chemokine expression
Núñez V, Alameda D, Rico D, Mota R, Gonzalo P, Cedenilla M, Fischer T, Boscá L, Glass CK, Arroyo AG, Ricote M |
Proceedings of the National Academy of Sciences | 2010 |
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Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells
Rough JJ, Monroy MA, Yerrum S, Daly JM |
Journal of Ovarian Research | 2010 |
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The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2
Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, Boyadjian R, Rodenburg KW, Foley E, Korhonen L, Lindholm D, Nimpf J, van Berkel TJ, Tontonoz P, Zelcer N |
The Journal of biological chemistry | 2010 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease
MP Marzolo, G Bu |
Seminars in Cell & Developmental Biology | 2009 |
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NR4A Orphan Nuclear Receptors in Cardiovascular Biology
Y Zhao, D Bruemmer |
Drug discovery today. Disease mechanisms | 2009 |
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Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone
K Hashimoto, E Ishida, S Matsumoto, S Okada, M Yamada, T Satoh, T Monden, M Mori |
Endocrinology | 2009 |
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Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
U Diczfalusy, KE Olofsson, AM Carlsson, M Gong, DT Golenbock, O Rooyackers, U Fläring, H Björkbacka |
Journal of lipid research | 2009 |
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The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor
C Tang, Y Liu, PS Kessler, AM Vaughan, JF Oram |
The Journal of biological chemistry | 2009 |
|
Nuclear receptors as therapeutic targets in cholestatic liver diseases
G Zollner, M Trauner |
British Journal of Pharmacology | 2009 |
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LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export
L Zhou, HY Choi, WP Li, F Xu, J Herz |
PloS one | 2009 |
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Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF- B signalling
S Wu, R Yin, R Ernest, Y Li, O Zhelyabovska, J Luo, Y Yang, Q Yang |
Cardiovascular Research | 2009 |
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Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo
M Civelek, GR Grant, CR Irolla, C Shi, RJ Riley, OA Chiesa, CJ Stoeckert, JW Karanian, WF Pritchard, PF Davies |
American journal of physiology. Heart and circulatory physiology | 2009 |
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Liver X Receptor Agonists Augment Human Islet Function through Activation of Anaplerotic Pathways and Glycerolipid/Free Fatty Acid Cycling
Ogihara T, Chuang JC, Vestermark GL, Garmey JC, Ketchum RJ, Huang X, Brayman KL, Thorner MO, Repa JJ, Mirmira RG, Evans-Molina C |
The Journal of biological chemistry | 2009 |
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Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARγ signaling as potential mechanism for the negative relationships between immune response and lipid metabolism
Moyes KM, Drackley JK, Morin DE, Bionaz M, Rodriguez-Zas SL, Everts RE, Lewin HA, Loor JJ |
BMC Genomics | 2009 |
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LXR Regulates Cholesterol Uptake through Idol-dependent Ubiquitination of the LDL Receptor
Zelcer N, Hong C, Boyadjian R, Tontonoz P |
Science (New York, N.Y.) | 2009 |
|
Editorial: Liver X receptor α (LXRα) as a therapeutic target in chronic lymphocytic leukemia (CLL)
Christopherson KW II, Landay A |
Journal of leukocyte biology | 2009 |
|
Negative Regulation of Hedgehog Signaling by Liver X Receptors
Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F |
Molecular Endocrinology | 2009 |
|
Deficiency of the NR4A Orphan Nuclear Receptor NOR1 attenuates Neointima Formation Following Vascular Injury
Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D |
Circulation | 2009 |
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OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids
Hynynen R, Suchanek M, Spandl J, Bäck N, Thiele C, Olkkonen VM |
Journal of lipid research | 2009 |
|
A role for nuclear receptors in mammalian hibernation
Nelson CJ, Otis JP, Carey HV |
The Journal of Physiology | 2009 |
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Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles – a cohort study
Dahlman I, Nilsson M, Gu HF, Lecoeur C, Efendic S, Östenson CG, Brismar K, Gustafsson JÅ, Froguel P, Vaxillaire M, Dahlman-Wright K, Steffensen KR |
BMC Medical Genetics | 2009 |
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Mylip makes an Idol turn into regulation of LDL receptor.
Lindholm D, Bornhauser BC, Korhonen L |
Cellular and molecular life sciences : CMLS | 2009 |
|
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in liver
Pierre-Damien Denechaud, Pascale Bossard, Jean-Marc A. Lobaccaro, Lesley Millatt, Bart Staels, Jean Girard and Catherine Postic |
Journal of Clinical Investigation | 2008 |
|
Hepatic glucose sensing. Does flux matter?
Masakazu Shiota1 and Mark A. Magnuson2 |
Journal of Clinical Investigation | 2008 |
|
Cholesterol in islet dysfunction and type 2 diabetes
Liam R. Brunham, Janine K. Kruit, C. Bruce Verchere and Michael R. Hayden |
Journal of Clinical Investigation | 2008 |
|
Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression
C Gabbi, HJ Kim, K Hultenby, D Bouton, G Toresson, M Warner, JA Gustafsson |
Proceedings of the National Academy of Sciences | 2008 |
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Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons
X Fan, HJ Kim, D Bouton, M Warner, JA Gustafsson |
Proceedings of the National Academy of Sciences | 2008 |
|
Liver X receptors as therapeutic targets in metabolism and atherosclerosis
T Nomiyama, D Bruemmer |
Current Atherosclerosis Reports | 2008 |
|
Nuclear Receptors and Inflammatory Diseases
K Wang, YJ Wan |
Experimental biology and medicine (Maywood, N.J.) | 2008 |
|
Why lipids are important for Alzheimer disease?
V Hirsch-Reinshagen, BL Burgess, CL Wellington |
Molecular and Cellular Biochemistry | 2008 |
|
The Role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in Alzheimer’s Disease: Therapeutic Implications
Q Jiang, M Heneka, GE Landreth |
CNS Drugs | 2008 |
|
Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz syndrome
ML Lindegaard, CA Wassif, B Vaisman, M Amar, EV Wasmuth, R Shamburek, LB Nielsen, AT Remaley, FD Porter |
Human Molecular Genetics | 2008 |
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Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha
Y Wang, PM Rogers, C Su, G Varga, KR Stayrook, TP Burris |
The Journal of biological chemistry | 2008 |
|
New approaches to target microsomal triglyceride transfer protein
MM Hussain, A Bakillah |
Current Opinion in Lipidology | 2008 |
|
Treatment with LXR agonists after focal cerebral ischemia prevents brain damage
L Sironi, N Mitro, M Cimino, P Gelosa, U Guerrini, E Tremoli, E Saez |
FEBS Letters | 2008 |
|
Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors
C Hong, P Tontonoz |
Current Opinion in Genetics & Development | 2008 |
|
Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice
D Peng, RA Hiipakka, Q Dai, J Guo, CA Reardon, GS Getz, S Liao |
The Journal of pharmacology and experimental therapeutics | 2008 |
|
Differential anti-atherosclerotic effects in the innominate artery and aortic sinus by the liver X receptor agonist T0901317
D Peng, RA Hiipakka, CA Reardon, GS Getz, S Liao |
Atherosclerosis | 2008 |
|
Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary
S Matsumoto, K Hashimoto, M Yamada, T Satoh, J Hirato, M Mori |
Molecular Endocrinology | 2008 |
|
Androgen deprivation by activating the liver X receptor
JH Lee, H Gong, S Khadem, Y Lu, X Gao, S Li, J Zhang, W Xie |
Endocrinology | 2008 |
|
Transcriptional diversity during monocyte to macrophage differentiation
H Liu, B Shi, CC Huang, P Eksarko, RM Pope |
Immunology Letters | 2008 |
|
ApoE Promotes the Proteolytic Degradation of Aβ
Q Jiang, CY Lee, S Mandrekar, B Wilkinson, P Cramer, N Zelcer, K Mann, B Lamb, TM Willson, JL Collins, JC Richardson, JD Smith, TA Comery, D Riddell, DM Holtzman, P Tontonoz, GE Landreth |
Neuron | 2008 |
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Liver X Receptor: Crosstalk Node for the Signaling of Lipid Metabolism, Carbohydrate Metabolism, and Innate Immunity.
Fessler MB |
Current signal transduction therapy | 2008 |
|
TLR/MyD88 and LXRα Signaling Pathways Reciprocally Control Chlamydia Pneumoniae-Induced Acceleration of Atherosclerosis
Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation.
Chen S, Sorrentino R, Shimada K, Bulut Y, Doherty TM, Crother TR, Arditi M |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
Phosphorylation of Liver X Receptor α Selectively Regulates Target Gene Expression in Macrophages
IP Torra, N Ismaili, JE Feig, CF Xu, C Cavasotto, R Pancratov, I Rogatsky, TA Neubert, EA Fisher, MJ Garabedian |
Molecular and cellular biology | 2008 |
|
Dyslipidaemia as a predictor of hypertension in middle-aged men
Laaksonen DE, Niskanen L, Nyyssönen K, Lakka TA, Laukkanen JA, Salonen JT |
European Heart Journal | 2008 |
|
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Jakkula E, Coin L, Hoggart C, Collins A, Turunen H, Gabriel S, Elliot P, McCarthy MI, Daly MJ, Järvelin MR, Freimer NB, Peltonen L |
Nature Genetics | 2008 |
|
Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function
Szatmari I, Nagy L |
The EMBO Journal | 2008 |
|
Adopting New Orphans into the Family of Metabolic Regulators
Hummasti S, Tontonoz P |
Molecular Endocrinology | 2008 |
|
Activating Signal Cointegrator-2 Is an Essential Adaptor to Recruit Histone H3 Lysine 4 Methyltransferases MLL3 and MLL4 to the Liver X Receptors
Lee S, Lee J, Lee SK, Lee JW |
Molecular Endocrinology | 2008 |
|
The Nuclear Receptor Rev-erbα Is a Liver X Receptor (LXR) Target Gene Driving a Negative Feedback Loop on Select LXR-Induced Pathways in Human Macrophages
Fontaine C, Rigamonti E, Pourcet B, Duez H, Duhem C, Fruchart JC, Chinetti-Gbaguidi G, Staels B |
Molecular Endocrinology | 2008 |
|
Ligand activation of LXRbeta reverses atherosclerosis and cellular cholesterol overload in LXRalpha-/-ApoE-/- mice
Michelle N. Bradley, Cynthia Hong, Mingyi Chen, Sean B. Joseph, Damien C. Wilpitz, Xuping Wang, Aldons J. Lusis, Allan Collins, Willa A. Hseuh, Jon L. Collins, Rajendra K. Tangirala, and Peter Tontonoz |
Journal of Clinical Investigation | 2007 |
|
Tissue- and Nuclear Receptor-Specific Function of the C-Terminal LXXLL Motif of Coactivator NCoA6/AIB3 in Mice
Q Li, MJ Chu, J Xu |
Molecular and cellular biology | 2007 |
|
Cholesterol: from feeding to gene regulation
C Martini, V Pallottini |
Genes & Nutrition | 2007 |
|
Transcriptional regulation of peroxisome proliferator-activated receptors and liver X receptors
L Villacorta, MT Garcia-Barrio, YE Chen |
Current Atherosclerosis Reports | 2007 |
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Lipoprotein metabolism in chronic renal insufficiency
JM Saland, HN Ginsberg |
Pediatric Nephrology | 2007 |
|
TGFbeta1 expression in colonic mucosa: modulation by dietary lipids
F Biasi, C Mascia, G Poli |
Genes & Nutrition | 2007 |
|
GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats
CE Leik, NL Carson, JK Hennan, MD Basso, QY Liu, DL Crandall, P Nambi |
British Journal of Pharmacology | 2007 |
|
Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140
T Jakobsson, W Osman, JA Gustafsson, J Zilliacus, A Wärnmark |
Biochemical Journal | 2007 |
|
The Nuclear Receptor Cofactor, Receptor-Interacting Protein 140, Is Required for the Regulation of Hepatic Lipid and Glucose Metabolism by Liver X Receptor
B Herzog, M Hallberg, A Seth, A Woods, R White, MG Parker |
Molecular Endocrinology | 2007 |
|
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ
Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK |
Molecular Cell | 2007 |
|
Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment
Lefterov I, Bookout A, Wang Z, Staufenbiel M, Mangelsdorf D, Koldamova R |
Molecular Neurodegeneration | 2007 |
|
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, Tontonoz P |
Proceedings of the National Academy of Sciences | 2007 |
|
Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκB
Lee HC, Ziegler SF |
Proceedings of the National Academy of Sciences | 2007 |
|
PGC-1alpha controls hepatitis B virus through nutritional signals
A Shlomai, N Paran, Y Shaul |
Proceedings of the National Academy of Sciences | 2006 |
|
Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells
MD Linder, RL Uronen, M Hölttä-Vuori, P der Sluijs, J Peränen, E Ikonen |
Molecular biology of the cell | 2006 |
|
Liver X receptor opens a new gateway to StAR and to steroid hormones
CR Jefcoate |
Journal of Clinical Investigation | 2006 |
|
The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands
WF Reynolds, AP Kumar, FJ Piedrafita |
Biochemical and Biophysical Research Communications | 2006 |
|
Going nuclear in metabolic and cardiovascular disease
CK Glass |
Journal of Clinical Investigation | 2006 |
|
Polyunsaturated fatty acids: From diet to binding to ppars and other nuclear receptors
A Bordoni, M Nunzio, F Danesi, PL Biagi |
Genes & Nutrition | 2006 |
|
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis
DW Nebert, TP Dalton |
Nature Reviews Cancer | 2006 |
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