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Citations to this article

Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair
Christa Maes, … , Roger Bouillon, Geert Carmeliet
Christa Maes, … , Roger Bouillon, Geert Carmeliet
Published May 1, 2006
Citation Information: J Clin Invest. 2006;116(5):1230-1242. https://doi.org/10.1172/JCI26772.
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Research Article Bone biology Article has an altmetric score of 1

Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair

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Abstract

Current therapies for delayed- or nonunion bone fractures are still largely ineffective. Previous studies indicated that the VEGF homolog placental growth factor (PlGF) has a more significant role in disease than in health. Therefore we investigated the role of PlGF in a model of semistabilized bone fracture healing. Fracture repair in mice lacking PlGF was impaired and characterized by a massive accumulation of cartilage in the callus, reminiscent of delayed- or nonunion fractures. PlGF was required for the early recruitment of inflammatory cells and the vascularization of the fracture wound. Interestingly, however, PlGF also played a role in the subsequent stages of the repair process. Indeed in vivo and in vitro findings indicated that PlGF induced the proliferation and osteogenic differentiation of mesenchymal progenitors and stimulated cartilage turnover by particular MMPs. Later in the process, PlGF was required for the remodeling of the newly formed bone by stimulating osteoclast differentiation. As PlGF expression was increased throughout the process of bone repair and all the important cell types involved expressed its receptor VEGFR-1, the present data suggest that PlGF is required for mediating and coordinating the key aspects of fracture repair. Therefore PlGF may potentially offer therapeutic advantages for fracture repair.

Authors

Christa Maes, Lieve Coenegrachts, Ingrid Stockmans, Evis Daci, Aernout Luttun, Anna Petryk, Rajaram Gopalakrishnan, Karen Moermans, Nico Smets, Catherine M. Verfaillie, Peter Carmeliet, Roger Bouillon, Geert Carmeliet

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Total citations by year

Year: 2025 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 2 5 5 8 4 3 3 4 4 4 3 3 6 1 4 6 4 2 71
Citation information
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Citations to this article in year 2015 (4)

Title and authors Publication Year
The vasculature: a vessel for bone metastasis
K Raymaekers, S Stegen, N Gastel, G Carmeliet
BoneKEy Reports 2015
The Multifaceted Role of the Vasculature in Endochondral Fracture Repair
CS Bahney, DP Hu, T Miclau, RS Marcucio
Frontiers in Endocrinology 2015
ERK1/2 and AKT are vital factors in regulation of the migration of rat Schwann cells
H YU, L ZHU, C LI, D SHA, H PAN, N WANG, S MA
Journal of Veterinary Medical Science 2015
Myeloma cell-derived Runx2 promotes myeloma progression in bone
TN Trotter, M Li, Q Pan, D Peker, PD Rowan, J Li, F Zhan, LJ Suva, A Javed, Y Yang
Blood 2015

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ISSN: 0021-9738 (print), 1558-8238 (online)

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