Mitochondria: pharmacological manipulation of cell death

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Abstract

Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.

Authors

Lisa Bouchier-Hayes, Lydia Lartigue, Donald D. Newmeyer