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Lisa Bouchier-Hayes, … , Lydia Lartigue, Donald D. Newmeyer
Published October 3, 2005
Citation Information: J Clin Invest. 2005;115(10):2640-2647. https://doi.org/10.1172/JCI26274.
Citation Information: J Clin Invest. 2005;115(10):2640-2647. https://doi.org/10.1172/JCI26274.
Abstract
Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.
Authors
Lisa Bouchier-Hayes, Lydia Lartigue, Donald D. Newmeyer
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Subdivisions of Bcl-2–family proteins, based on function and sequence homology
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