Mitochondria: pharmacological manipulation of cell death
Lisa Bouchier-Hayes, … , Lydia Lartigue, Donald D. Newmeyer
Lisa Bouchier-Hayes, … , Lydia Lartigue, Donald D. Newmeyer
Published October 3, 2005
Citation Information: J Clin Invest. 2005;115(10):2640-2647. https://doi.org/10.1172/JCI26274.
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Mitochondria: pharmacological manipulation of cell death

Abstract

Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.

Authors

Lisa Bouchier-Hayes, Lydia Lartigue, Donald D. Newmeyer

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Figure 1

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Molecular mechanisms of MOMP. The proposed models of MOMP leading to cyt...
Molecular mechanisms of MOMP. The proposed models of MOMP leading to cytochrome c release are represented. (i) Bax pore. Bax or Bak forms a pore in the MOM after activation by a BH3-only protein such as Bid. (ii) PT pore opening. Opening of the PT pore allows an influx of water and ions into the matrix, causing matrix swelling; this leads to rupture of the MOM, releasing IMS proteins such as cytochrome c. MIM, mitochondrial inner membrane; PBR, peripheral benzodiazepine receptor.