Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Inflammation, stress, and diabetes
Kathryn E. Wellen, Gökhan S. Hotamisligil
Kathryn E. Wellen, Gökhan S. Hotamisligil
Published May 2, 2005
Citation Information: J Clin Invest. 2005;115(5):1111-1119. https://doi.org/10.1172/JCI25102.
View: Text | PDF
Review Article has an altmetric score of 191

Inflammation, stress, and diabetes

  • Text
  • PDF
Abstract

Over the last decade, an abundance of evidence has emerged demonstrating a close link between metabolism and immunity. It is now clear that obesity is associated with a state of chronic low-level inflammation. In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes. We also consider mechanisms through which the inflammatory response may be initiated and discuss the reasons for the inflammatory response in obesity. We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease.

Authors

Kathryn E. Wellen, Gökhan S. Hotamisligil

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 31 43 67 91 80 100 101 112 77 85 71 86 95 123 93 89 59 60 34 23 4 1524
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2006 (23)

Title and authors Publication Year
CCR2 modulates inflammatory and metabolic effects of a high fat feeding
Stuart P. Weisberg, Deborah Hunter, Reid Huber, Jacob Lemieux, Sarah Slaymaker, Kris Vaddi, Isreal Charo, Rudolph L. Leibel and Anthony W. Ferrante Jr
Journal of Clinical Investigation 2006
TNF-alpha down-regulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
Alessandra Valerio, Annalisa Cardile, Valeria Cozzi, Renata Bracale, Laura Tedesco, Addolorata Pisconti, Letizia Palomba, Orazio Cantoni, Emilio Clementi, Salvador Moncada, Michele O. Carruba, and Enzo Nisoli
Journal of Clinical Investigation 2006
Absence of Bacterially-Induced RELMbeta Reduces Injury in the DSS Model of Colitis
Laila D. McVay, Sue A. Keilbaugh, Tracie M.H. Wong, Marcus E. Shin, Sonja Kierstein, Michael Lehrke, Martina I. Lefterova, D. Edward Schifflett, Sean L. Barnes, Fabio Cominelli, Steven M. Cohn, Gail Hecht, Mitchell A. Lazar, Angela Haczku, and Gary D. Wu
Journal of Clinical Investigation 2006
Toll Like Receptor 4: A link Between Innate Immunity And Fatty Acid-Induced Insulin Resistance
Hang Shi, Maia Kokoeva, Karen Inouye, Iphigenia Tzameli, Huali Yin and Jeffrey S. Flier
Journal of Clinical Investigation 2006
Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids
J Todoric, M Löffler, J Huber, M Bilban, M Reimers, A Kadl, M Zeyda, W Waldhäusl, TM Stulnig
Diabetologia 2006
Diabetes mellitus und koronare Herzkrankheit: —eine Risikokombination
V Schächinger, MB Britten, AM Zeiher
Clinical Research in Cardiology 2006
The Genetic Basis of Type 2 Diabetes
SK Das, SC Elbein
Cellscience 2006
Diet-Genotype Interactions in the Development of the Obese, Insulin-Resistant Phenotype of C57BL/6J Mice Lacking Melanocortin-3 or -4 Receptors
GM Sutton, JL Trevaskis, MW Hulver, RP McMillan, NJ Markward, MJ Babin, EA Meyer, AA Butler
Endocrinology 2006
Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin
RS Streeper, SK Koliwad, CJ Villanueva, RV Farese
American journal of physiology. Endocrinology and metabolism 2006
Is all fat the same? The role of fat in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus
E Hansen, T Hajri, NN Abumrad
Surgery 2006
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
KF Petersen, S Dufour, J Feng, D Befroy, J Dziura, CD Man, C Cobelli, GI Shulman
Proceedings of the National Academy of Sciences 2006
Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases
MA Bogoyevitch, B Kobe
Microbiology and molecular biology reviews : MMBR 2006
Inflamed fat: what starts the fire?
JG Neels, JM Olefsky
Journal of Clinical Investigation 2006
Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes
N Tiffin, E Adie, F Turner, HG Brunner, MA van Driel, M Oti, N Lopez-Bigas, C Ouzounis, C Perez-Iratxeta, MA Andrade-Navarro, A Adeyemo, ME Patti, CA Semple, W Hide
Nucleic Acids Research 2006
Metabolic syndrome and obesity in an insect
RJ Schilder, JH Marden
Proceedings of the National Academy of Sciences 2006
Stress and Wound Healing
LM Christian, JE Graham, DA Padgett, R Glaser, JK Kiecolt-Glaser
Neuroimmunomodulation 2006
The innate interferon gamma response of BALB/c and C57BL/6 mice to in vitro Burkholderia pseudomallei infection
GC Koo, YH Gan
BMC Immunology 2006
JNK1 deficiency does not enhance muscle glucose metabolism in lean mice
CA Witczak, MF Hirshman, N Jessen, N Fujii, MM Seifert, J Brandauer, GS Hotamisligil, LJ Goodyear
Biochemical and Biophysical Research Communications 2006
A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
G Tuncman, E Erbay, X Hom, ID Vivo, H Campos, EB Rimm, GS Hotamisligil
Proceedings of the National Academy of Sciences 2006
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
G Tuncman, J Hirosumi, G Solinas, L Chang, M Karin, GS Hotamisligil
Proceedings of the National Academy of Sciences 2006
The influence of yoga-based programs on risk profiles in adults with type 2 diabetes mellitus: a systematic review
KE Innes, HK Vincent
Evidence-based complementary and alternative medicine : eCAM 2006
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics.
Jope RS, Yuskaitis CJ, Beurel E
Neurochemical Research 2006
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS
Science (New York, N.Y.) 2006

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 20 news outlets
Blogged by 2
Referenced in 1 policy sources
Posted by 6 X users
Referenced in 24 patents
On 5 Facebook pages
Referenced in 7 Wikipedia pages
Mentioned in 1 Google+ posts
On 2 videos
798 readers on Mendeley
2 readers on CiteULike
See more details