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Citations to this article

Inflammation, stress, and diabetes
Kathryn E. Wellen, Gökhan S. Hotamisligil
Kathryn E. Wellen, Gökhan S. Hotamisligil
Published May 2, 2005
Citation Information: J Clin Invest. 2005;115(5):1111-1119. https://doi.org/10.1172/JCI25102.
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Inflammation, stress, and diabetes

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Abstract

Over the last decade, an abundance of evidence has emerged demonstrating a close link between metabolism and immunity. It is now clear that obesity is associated with a state of chronic low-level inflammation. In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes. We also consider mechanisms through which the inflammatory response may be initiated and discuss the reasons for the inflammatory response in obesity. We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease.

Authors

Kathryn E. Wellen, Gökhan S. Hotamisligil

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 30 43 67 91 80 100 101 112 77 85 71 86 95 123 93 89 59 60 34 23 4 1523
Citation information
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