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Citations to this article

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
Punita Dhawan, … , M. Kay Washington, R. Daniel Beauchamp
Punita Dhawan, … , M. Kay Washington, R. Daniel Beauchamp
Published July 1, 2005
Citation Information: J Clin Invest. 2005;115(7):1765-1776. https://doi.org/10.1172/JCI24543.
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Research Article Oncology Article has an altmetric score of 4

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

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Abstract

Disruption of the cell-cell junction with concomitant changes in the expression of junctional proteins is a hallmark of cancer cell invasion and metastasis. The role of adherent junction proteins has been studied extensively in cancer, but the roles of tight junction (TJ) proteins are less well understood. Claudins are recently identified members of the tetraspanin family of proteins, which are integral to the structure and function of TJs. Recent studies show changes in expression/cellular localization of claudins during tumorigenesis; however, a causal relationship between claudin expression/localization and cancer has not been established. Here, we report an increased expression of claudin-1 in human primary colon carcinoma and metastasis and in cell lines derived from primary and metastatic tumors. We also report frequent nuclear localization of claudin-1 in these samples. Genetic manipulations of claudin-1 expression in colon cancer cell lines induced changes in cellular phenotype, with structural and functional changes in markers of epithelial-mesenchymal transition. Furthermore, we demonstrate that changes in claudin-1 expression have significant effects on growth of xenografted tumors and metastasis in athymic mice. We further provide data suggesting that the regulation of E-cadherin expression and β-catenin/Tcf signaling is a possible mechanism underlying claudin-1–dependent changes.

Authors

Punita Dhawan, Amar B. Singh, Natasha G. Deane, YiRan No, Sheng-Ru Shiou, Carl Schmidt, John Neff, M. Kay Washington, R. Daniel Beauchamp

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 8 12 13 11 22 16 20 5 15 20 16 18 16 14 10 8 15 7 7 2 255
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Citations to this article in year 2023 (13)

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Improving the response to oxaliplatin by targeting chemotherapy-induced CLDN1 in resistant metastatic colorectal cancer cells
Sara Cherradi, Véronique Garambois, Johanna Marines, Augusto Augusto Faria Andrade1,, Alexandra Fauvre, Olivia Morand, Manon Fargal, Ferial Mancouri, Adeline Ayrolles-Torro, Nadia Vezzo-Vié, MARTA Jarlier, Gérald Lossaint, Steve Huvelle, Nicolas Joubert, Thibault Mazard, Céline Gongora, Philippe Pourquier, Florence Boissière, Maguy DEL RIO
Cell & Bioscience 2023
LIN28B promotes cell invasion and colorectal cancer metastasis via the induction of CLDN1 and NOTCH3
Yasunori Masuike, Kensuke Sugiura, Kensuke Suzuki, Alice E Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter Sims, Christopher Lengner, Anil Rustgi
JCI Insight 2023
Tight Junction Protein Signaling and Cancer Biology.
Nehme Z, Roehlen N, Dhawan P, Baumert TF
Cells 2023
P62/SQSTM1 binds with claudin-2 to target for selective autophagy in stressed intestinal epithelium
Ahmad R, Kumar B, Tamang RL, Talmon GA, Dhawan P, Singh AB
Communications biology 2023
Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling
Lama Tamang R, Kumar B, Patel SM, Thapa I, Ahmad A, Kumar V, Ahmad R, Becker DF, Bastola D(, Dhawan P, Singh AB
Cells 2023
cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids
Waldow A, Beier LS, Arndt J, Schallenberg S, Vollbrecht C, Bischoff P, Farrera-Sal M, Loch FN, Bojarski C, Schumann M, Winkler L, Kamphues C, Ehlen L, Piontek J
Pharmaceutics 2023
Expression of Claudins in Preneoplastic Conditions of the Gastrointestinal Tract: A Review.
Ouban A, Arabi TZ
Cancers 2023
Aberrant Expression of Claudins in Head and Neck Carcinomas and Their Prognostic and Therapeutic Value: A Narrative Review
Arabi TZ, Algheryafi LA, Alodah NA, Enabi HM, Alshehry AA, Ouban A
Cancers 2023
Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1
Mashinson V, Webster TM, Vadukoot AK, Tolentino KT, Simeon P, Fatima I, Dhawan P, Hopkins CR
Bioorganic & Medicinal Chemistry 2023
Expression patterns of claudins in cancer
Tao D, Guan B, Li H, Zhou C
Heliyon 2023
Tight Junction Claudins and Occludin Are Differentially Regulated and Expressed in Genomically Defined Subsets of Colon Cancer
Voutsadakis IA
Current issues in molecular biology 2023
Claudin-1 interacts with EPHA2 to promote cancer stemness and chemoresistance in colorectal cancer.
Primeaux M, Liu X, Gowrikumar S, Fatima I, Fisher KW, Bastola D, Vecchio AJ, Singh AB, Dhawan P
Cancer Letters 2023
Identification and characterization of a first-generation inhibitor of claudin-1 in Colon Cancer progression and metastasis
Fatima I, Uppada JP, Chhonker YS, Gowrikumar S, Barman S, Roy S, Tolentino KT, Palermo N, Natarajan A, Beauchamp DR, Vecchio A, Murry DJ, Singh AB, Hopkins CR, Dhawan P
Biomedicine & Pharmacotherapy 2023

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