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Citations to this article

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
Punita Dhawan, … , M. Kay Washington, R. Daniel Beauchamp
Punita Dhawan, … , M. Kay Washington, R. Daniel Beauchamp
Published July 1, 2005
Citation Information: J Clin Invest. 2005;115(7):1765-1776. https://doi.org/10.1172/JCI24543.
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Research Article Oncology Article has an altmetric score of 4

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

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Abstract

Disruption of the cell-cell junction with concomitant changes in the expression of junctional proteins is a hallmark of cancer cell invasion and metastasis. The role of adherent junction proteins has been studied extensively in cancer, but the roles of tight junction (TJ) proteins are less well understood. Claudins are recently identified members of the tetraspanin family of proteins, which are integral to the structure and function of TJs. Recent studies show changes in expression/cellular localization of claudins during tumorigenesis; however, a causal relationship between claudin expression/localization and cancer has not been established. Here, we report an increased expression of claudin-1 in human primary colon carcinoma and metastasis and in cell lines derived from primary and metastatic tumors. We also report frequent nuclear localization of claudin-1 in these samples. Genetic manipulations of claudin-1 expression in colon cancer cell lines induced changes in cellular phenotype, with structural and functional changes in markers of epithelial-mesenchymal transition. Furthermore, we demonstrate that changes in claudin-1 expression have significant effects on growth of xenografted tumors and metastasis in athymic mice. We further provide data suggesting that the regulation of E-cadherin expression and β-catenin/Tcf signaling is a possible mechanism underlying claudin-1–dependent changes.

Authors

Punita Dhawan, Amar B. Singh, Natasha G. Deane, YiRan No, Sheng-Ru Shiou, Carl Schmidt, John Neff, M. Kay Washington, R. Daniel Beauchamp

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 6 12 13 11 22 16 20 5 15 20 16 18 16 14 10 8 15 7 7 2 253
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Citations to this article in year 2020 (16)

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P Uc, J Miranda, A RayaSandino, L Alarcn, M Roldn, R OcadizDelgado, E CortsMalagn, B ChvezMungua, G Ramrez, R Asomoza, L Shoshani, P Gariglio, L GonzlezMariscal
International journal of oncology 2020
Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications
W Jin
Cancers 2020

The Expression and Prognostic Significance of Claudin-8 and Androgen Receptor in Breast Cancer


Y Zhang, A Zheng, H Lu, Z Jin, Z Peng, F Jin
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Tight Junction Proteins and the Biology of Hepatobiliary Disease
N Roehlen, AA Suarez, HE Saghire, A Saviano, C Schuster, J Lupberger, TF Baumert
International journal of molecular sciences 2020
Claudin-1, A Double-Edged Sword in Cancer
AA Bhat, N Syed, L Therachiyil, S Nisar, S Hashem, MA Macha, SK Yadav, R Krishnankutty, S Muralitharan, H Al-Naemi, P Bagga, R Reddy, P Dhawan, A Akobeng, S Uddin, MP Frenneaux, W El-Rifai, M Haris
International journal of molecular sciences 2020

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H Zhu, C Wang
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A Drapala, M Szudzik, D Chabowski, I Mogilnicka, K Jaworska, K Kraszewska, E Samborowska, M Ufnal
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Claudins: New Players in Human Fertility and Reproductive System Cancers
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Tzu Chi Medical Journal 2020
Role of Nuclear Claudin-4 in Renal Cell Carcinoma
T Owari, T Sasaki, K Fujii, R Fujiwara-Tani, S Kishi, S Mori, T Mori, K Goto, I Kawahara, Y Nakai, M Miyake, Y Luo, N Tanaka, M Kondoh, K Fujimoto, H Kuniyasu
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Cell adhesion & migration 2020

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