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PI3K integrates the action of insulin and leptin on hypothalamic neurons

Allison Wanting Xu, … , Michael W. Schwartz, Gregory S. Barsh

Allison Wanting Xu, … , Michael W. Schwartz, Gregory S. Barsh

Published April 1, 2005
Citation Information: J Clin Invest. 2005;115(4):951-958. https://doi.org/10.1172/JCI24301.

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KCNB1-Leptin receptor complexes couple electric and endocrine function in the melanocortin neurons of the hypothalamus. Forzisi-Kathera-Ibarra E, Jo C, Castillo L, Gaur A, Lad P, Bortolami A, Roser C, Venkateswaran S, Dutto S, Selby M, Sampath H, Pan PY, Sesti F	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2024
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PI3K and AKT at the Interface of Signaling and Metabolism. Solinas G, Becattini B	Current topics in microbiology and immunology	2022
CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity Qiu J, Bosch MA, Stincic TL, Hunker AC, Zweifel LS, Rønnekleiv OK, Kelly MJ	Molecular Metabolism	2022
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Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons Y Huang, Z He, Y Gao, L Lieu, T Yao, J Sun, T Liu, C Javadi, M Box, S Afrin, H Guo, KW Williams	Journal of the Endocrine Society	2018
Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons TL Stincic, OK Rønnekleiv, MJ Kelly	Hormones and Behavior	2018
TRPCing around the hypothalamus MJ Kelly, J Qiu, OK Rønnekleiv	Frontiers in Neuroendocrinology	2018
Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels J Qiu, EJ Wagner, OK Rønnekleiv, MJ Kelly	Journal of Neuroendocrinology	2018
4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1 AW Kinyua, CM Ko, KV Doan, DJ Yang, MK Huynh, SH Moh, YH Choi, KW Kim	Experimental & molecular medicine	2018
Various transgenic mouse lines to study proopiomelanocortin cells in the brain stem label disparate populations of GABAergic and glutamatergic neurons AR Rau, AR Hughes, ST Hentges	American Journal of Physiology - Regulatory, Integrative and Comparative Physiology	2018
Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation YH Lee, HC Hsu, PC Kao, YJ Shiao, SH Yeh, FS Shie, SM Hsu, CW Yeh, HK Liu, SB Yang, HJ Tsay	International journal of molecular sciences	2018
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons MA Smith, L Katsouri, S Virtue, AI Choudhury, A Vidal-Puig, ML Ashford, DJ Withers	Cell Reports	2018
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Leptin Induces Mitosis and Activates the Canonical Wnt/β-Catenin Signaling Pathway in Neurogenic Regions of Xenopus Tadpole Brain MC Bender, CJ Sifuentes, RJ Denver	Frontiers in Endocrinology	2017
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Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier E Yulyaningsih, IA Rudenko, M Valdearcos, E Dahlén, E Vagena, A Chan, A Alvarez-Buylla, C Vaisse, SK Koliwad, AW Xu	Cell Reports	2017
Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity PD Fox, ST Hentges	The Journal of neuroscience : the official journal of the Society for Neuroscience	2017
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Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance J Qiu, MA Bosch, C Meza, UV Navarro, CC Nestor, EJ Wagner, OK Rønnekleiv, MJ Kelly	Endocrinology	2017
Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity JH Lee, L Lin, P Xu, K Saito, Q Wei, AG Meadows, OY Bongmba, G Pradhan, H Zheng, Y Xu, Y Sun	Diabetes	2016
Central Leptin and Tumor Necrosis Factor-α (TNFα) in Diurnal Control of Blood Pressure and Hypertension C Han, W Wu, A Ale, MS Kim, D Cai	The Journal of biological chemistry	2016
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Pancreatic regulation of glucose homeostasis PV Röder, B Wu, Y Liu, W Han	Experimental & molecular medicine	2016
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Minireview: CNS Mechanisms of Leptin Action JN Flak, MG Myers	Molecular Endocrinology	2016
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Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver N Martinez-Lopez, M Garcia-Macia, S Sahu, D Athonvarangkul, E Liebling, P Merlo, F Cecconi, GJ Schwartz, R Singh	Cell Metabolism	2016
Neuroendocrine Regulation of Metabolism MP Cornejo, ST Hentges, M Maliqueo, H Coirini, D Becu-Villalobos, CF Elias	Journal of Neuroendocrinology	2016
Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential D Gavello, E Carbone, V Carabelli	Channels (Austin, Tex.)	2016
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Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis M Thon, T Hosoi, K Ozawa	Frontiers in Endocrinology	2016
Caloric restriction selectively reduces the GABAergic phenotype of mouse hypothalamic proopiomelanocortin neurons: Caloric restriction and POMC neurons BC Jarvie, CM King, AR Hughes, MS Dicken, CS Dennison, ST Hentges	The Journal of Physiology	2016
Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood S Nasif, FS de Souza, LE González, M Yamashita, DP Orquera, MJ Low, M Rubinstein	Proceedings of the National Academy of Sciences	2015
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis MS Kim, J Yan, W Wu, G Zhang, Y Zhang, D Cai	Nature Immunology	2015
Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity Ritu Malhotra, James P Warne, Eduardo Salas, Allison W Xu, Jayanta Debnath	Autophagy	2015
Hypothalamic PKA regulates leptin sensitivity and adiposity L Yang, GS McKnight	Nature Communications	2015
Advanced Glycation End Products (AGE) Potently Induce Autophagy through Activation of RAF Protein Kinase and Nuclear Factor κB (NF-κB) N Verma, SK Manna	The Journal of biological chemistry	2015
Leptin Monotherapy Rescues Spermatogenesis in Male Akita Type 1 Diabetic Mice EL Schoeller, M Chi, A Drury, A Bertschinger, P Esakky, KH Moley	Endocrinology	2014
Peptides and Food Intake CS Crespo, AP Cachero, LP Jiménez, V Barrios, EA Ferreiro	Frontiers in Endocrinology	2014
Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity JA Pedroso, DC Buonfiglio, LI Cardinali, IC Furigo, AM Ramos-Lobo, J Tirapegui, CF Elias, J Donato	Molecular Metabolism	2014
Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system DV Khanh, YH Choi, SH Moh, AW Kinyua, KW Kim	Frontiers in psychology	2014
Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels J Qiu, C Zhang, A Borgquist, CC Nestor, AW Smith, MA Bosch, S Ku, EJ Wagner, OK Rønnekleiv, MJ Kelly	Cell Metabolism	2014
Participation of the central melanocortin system in metabolic regulation and energy homeostasis JK Jeong, JG Kim, BJ Lee	Cellular and Molecular Life Sciences	2014
Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis HE Kocalis, SL Hagan, L George, MK Turney, MA Siuta, GN Laryea, LC Morris, LJ Muglia, RL Printz, GD Stanwood, KD Niswender	Molecular Metabolism	2014
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat HB Ruan, MO Dietrich, ZW Liu, MR Zimmer, MD Li, JP Singh, K Zhang, R Yin, J Wu, TL Horvath, X Yang	Cell	2014
The role of gastrointestinal vagal afferent fibres in obesity: Gastrointestinal vagal afferents in obesity SJ Kentish, AJ Page	The Journal of Physiology	2014
Preserved Energy Balance in Mice Lacking FoxO1 in Neurons of Nkx2.1 Lineage Reveals Functional Heterogeneity of FoxO1 Signaling Within the Hypothalamus G Heinrich, K Meece, SL Wardlaw, D Accili	Diabetes	2014
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Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein JP Warne, JM Varonin, SS Nielsen, LE Olofsson, CB Kaelin, S Chua, GS Barsh, SK Koliwad, AW Xu	The Journal of neuroscience : the official journal of the Society for Neuroscience	2013
PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin SM Harlan, K Rahmouni	Molecular Metabolism	2013
Leptin signaling and leptin resistance Y Zhou, L Rui	Frontiers of Medicine	2013
Insulin and glucagon signaling in the central nervous system BM Filippi, MA Abraham, JT Yue, TK Lam	Reviews in Endocrine and Metabolic Disorders	2013
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Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses G Matarese, C Procaccini, C Menale, JG Kim, JD Kim, S Diano, N Diano, VD Rosa, MO Dietrich, TL Horvath	Proceedings of the National Academy of Sciences	2013
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Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance LE Olofsson, EK Unger, CC Cheung, AW Xu	Proceedings of the National Academy of Sciences	2013
A C. elegans model to study human metabolic regulation S Hashmi, Y Wang, RS Parhar, KS Collison, W Conca, F Al-Mohanna, R Gaugler	Nutrition & Metabolism	2013
Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit T Liu, Q Wang, ED Berglund, Q Tong	Frontiers in neuroscience	2013
Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice RE Mercer, SD Michaelson, MJ Chee, TA Atallah, R Wevrick, WF Colmers	PLoS genetics	2013
Unraveling the central proopiomelanocortin neural circuits AJ Mercer, ST Hentges, CK Meshul, MJ Low	Frontiers in neuroscience	2013
Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance M Schneeberger, MO Dietrich, D Sebastián, M Imbernón, C Castaño, A Garcia, Y Esteban, A Gonzalez-Franquesa, IC Rodríguez, A Bortolozzi, PM Garcia-Roves, R Gomis, R Nogueiras, TL Horvath, A Zorzano, M Claret	Cell	2013
PI3K is an upstream regulator of the PDE3B pathway of leptin signaling that may not involve activation of Akt in the rat hypothalamus A Sahu, K Koshinaka, M Sahu	Journal of Neuroendocrinology	2013
ROCK1 in AgRP Neurons Regulates Energy Expenditure and Locomotor Activity in Male Mice H Huang, SH Lee, C Ye, IS Lima, BC Oh, BB Lowell, JM Zabolotny, YB Kim	Endocrinology	2013
An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue AK OConnor, EB Malarkey, NF Berbari, MJ Croyle, CJ Haycraft, PD Bell, P Hohenstein, RA Kesterson, BK Yoder	Cilia	2013
Inflammation during obesity is not all bad: evidence from animal and human studies J Ye, OP McGuinness	American journal of physiology. Endocrinology and metabolism	2012
Leptin signaling and circuits in puberty and fertility CF Elias, D Purohit	Cellular and Molecular Life Sciences	2012
PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction M Acosta-Martínez	Frontiers in Endocrinology	2012
Lipophagy: Connecting Autophagy and Lipid Metabolism R Singh, AM Cuervo	International Journal of Cell Biology	2012
Acute Leptin Treatment Enhances Functional Recovery after Spinal Cord Injury CM Fernández-Martos, P González, FJ Rodriguez	PloS one	2012
Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity M Schneeberger, J Altirriba, A García, Y Esteban, C Castaño, M García-Lavandeira, CV Alvarez, R Gomis, M Claret	Molecular Metabolism	2012
Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours M Guo, TY Huang, JC Garza, SC Chua, XY Lu	The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)	2012
Autophagy in the control of food intake R Singh	Adipocyte	2012
Long-term correction of type 1 and 2 diabetes by central leptin gene therapy independent of effects on appetite and energy expenditure M Nakano, A Asakawa, A Inui	Indian journal of endocrinology and metabolism	2012
Multiple inhibitory G-protein-coupled receptors resist acute desensitization in the presynaptic but not postsynaptic compartments of neurons RL Pennock, MS Dicken, ST Hentges	The Journal of neuroscience : the official journal of the Society for Neuroscience	2012
Regulation of GABA and glutamate release from proopiomelanocortin neuron terminals in intact hypothalamic networks MS Dicken, RE Tooker, ST Hentges	The Journal of neuroscience : the official journal of the Society for Neuroscience	2012
Genetic rescue of non-classical ERalpha signaling normalizes energy balance in obese ERalpha null mutant mice Cheryl Park, Zhen Zhao, Christine Glidewell-kenney, Milos Lazic, Pierre Chambon, Andree Krust, Jeffrey Weiss, Debbie Clegg, Andrea Dunaif, James Larry Jameson, Jon Levine	Journal of Clinical Investigation	2011
Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice M Claret, MA Smith, C Knauf, H Al-Qassab, A Woods, A Heslegrave, K Piipari, JJ Emmanuel, A Colom, P Valet, PD Cani, G Begum, A White, P Mucket, M Peters, K Mizuno, RL Batterham, KP Giese, A Ashworth, R Burcelin, ML Ashford, D Carling, DJ Withers	Diabetes	2011
Leptin and the CNS Control of Glucose Metabolism GJ Morton, MW Schwartz	Physiological reviews	2011
Expanding neurotransmitters in the hypothalamic neurocircuitry for energy balance regulation Y Xu, Q Tong	Protein & Cell	2011
Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network KW Williams, MM Scott, JK Elmquist	European Journal of Pharmacology	2011
Central nervous control of energy and glucose balance: focus on the central melanocortin system Y Xu, JK Elmquist, M Fukuda	Annals of the New York Academy of Sciences	2011
Central insulin and leptin-mediated autonomic control of glucose homeostasis JS Marino, Y Xu, JW Hill	Trends in endocrinology and metabolism: TEM	2011
Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism T Scherer, C Buettner	Reviews in Endocrine and Metabolic Disorders	2011
Metabolic syndrome as a risk factor for neurological disorders AA Farooqui, T Farooqui, F Panza, V Frisardi	Cellular and Molecular Life Sciences	2011
Hypothalamic proopiomelanocortin processing and the regulation of energy balance SL Wardlaw	European Journal of Pharmacology	2011
Hypoxia-Inducible Factor Directs POMC Gene to Mediate Hypothalamic Glucose Sensing and Energy Balance Regulation H Zhang, G Zhang, FJ Gonzalez, SM Park, D Cai	PLoS Biology	2011
Erk1/2 Mediates Leptin Receptor Signaling in the Ventral Tegmental Area R Trinko, G Gan, XB Gao, RM Sears, DJ Guarnieri, RJ DiLeone	PloS one	2011
Uncoupling Obesity-related Hypertension by Targeting Hypothalamic IKKβ/NF-κB S Purkayastha, G Zhang, D Cai	Nature Medicine	2011
Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling AS Metlakunta, M Sahu, H Yasukawa, SS Dhillon, DD Belsham, A Yoshimura, A Sahu	American Journal of Physiology - Regulatory, Integrative and Comparative Physiology	2011
Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats K Iwata, M Kinoshita, S Yamada, T Imamura, Y Uenoyama, H Tsukamura, K Maeda	The Journal of Physiological Sciences	2011
Convergence of the Insulin and Serotonin Programs in the Pancreatic -Cell Y Ohta, Y Kosaka, N Kishimoto, J Wang, SB Smith, G Honig, H Kim, RM Gasa, N Neubauer, A Liou, LH Tecott, ES Deneris, MS German	Diabetes	2011
Neuropeptide Exocytosis Involving Synaptotagmin-4 and Oxytocin in Hypothalamic Programming of Body Weight and Energy Balance G Zhang, H Bai, H Zhang, C Dean, Q Wu, J Li, S Guariglia, Q Meng, D Cai	Neuron	2011
Hypothalamic lipophagy and energetic balance. Singh R	Aging	2011
PTP1B- or SHP2-deficiency in POMC neurons reciprocally regulates energy balance in mice Ryoichi Banno, Derek Zimmer, Bart De Jonghe, Marybless Atienza, Kimberly Rak, Wentian Yang, Kendra Bence	Journal of Clinical Investigation	2010
Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors KS Kim, YR Yoon, HJ Lee, S Yoon, SY Kim, SW Shin, JJ An, MS Kim, SY Choi, W Sun, JH Baik	The Journal of biological chemistry	2010
Arcuate Nucleus Proopiomelanocortin Neurons Mediate the Acute Anorectic Actions of Leukemia Inhibitory Factor via gp130 AJ Grossberg, JM Scarlett, XX Zhu, DD Bowe, AK Batra, TP Braun, DL Marks	Endocrinology	2010
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis AS Reed, EK Unger, LE Olofsson, ML Piper, MG Myers, AW Xu	Diabetes	2010
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons KW Williams, LO Margatho, CE Lee, M Choi, S Lee, MM Scott, CF Elias, JK Elmquist	The Journal of neuroscience : the official journal of the Society for Neuroscience	2010
Leptin receptor modulation of adiposity and fertility D Israel, S Chua	Trends in Endocrinology & Metabolism	2010
Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo SA Paranjape, O Chan, W Zhu, AM Horblitt, EC McNay, JA Cresswell, JS Bogan, RJ McCrimmon, RS Sherwin	Diabetes	2010
Nutritional programming in the rat is linked to long-lasting changes in nutrient sensing and energy homeostasis in the hypothalamus R Orozco-Solís, RJ Matos, O Guzmán-Quevedo, SL de Souza, A Bihouée, R Houlgatte, RM de Castro, F Bolaños-Jiménez	PloS one	2010
Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line G Honig, A Liou, M Berger, MS German, LH Tecott	Journal of Biomedical Science	2010
Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity MO Dietrich, C Antunes, G Geliang, ZW Liu, E Borok, Y Nie, AW Xu, DO Souza, Q Gao, S Diano, XB Gao, TL Horvath	The Journal of neuroscience : the official journal of the Society for Neuroscience	2010
De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance AA Pierce, AW Xu	The Journal of neuroscience : the official journal of the Society for Neuroscience	2010
Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice H Su, B Marcheva, S Meng, FA Liang, A Kohsaka, Y Kobayashi, AW Xu, J Bass, X Wang	Developmental Biology	2009
Functional role of c-Jun-N-terminal kinase in feeding regulation EK Unger, ML Piper, LE Olofsson, AW Xu	Endocrinology	2009
Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons H Al-Qassab, MA Smith, EE Irvine, J Guillermet-Guibert, M Claret, AI Choudhury, C Selman, K Piipari, M Clements, S Lingard, K Chandarana, JD Bell, GS Barsh, AJ Smith, RL Batterham, ML Ashford, B Vanhaesebroeck, DJ Withers	Cell Metabolism	2009
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons HV Lin, L Plum, H Ono, R Gutiérrez-Juárez, M Shanabrough, E Borok, TL Horvath, L Rossetti, D Accili	Diabetes	2009
Recent advances in understanding leptin signaling and leptin resistance DL Morris, L Rui	American journal of physiology. Endocrinology and metabolism	2009
Central leptin receptor action and resistance in obesity C Bjørbaek	Journal of investigative medicine : the official publication of the American Federation for Clinical Research	2009
Oleic acid directly regulates POMC neuron excitability in the hypothalamus YH Jo, Y Su, R Gutierrez-Juarez, S Chua	Journal of neurophysiology	2009
Hypothalamic reactive oxygen species are required for insulin-induced food intake inhibition: an NADPH oxidase-dependent mechanism T Jaillard, M Roger, A Galinier, P Guillou, A Benani, C Leloup, L Casteilla, L Pénicaud, A Lorsignol	Diabetes	2009
Where Does Insulin Resistance Start?: The brain U Pagotto	Diabetes care	2009
Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels K Ning, LC Miller, HA Laidlaw, KR Watterson, J Gallagher, C Sutherland, ML Ashford	The Journal of biological chemistry	2009
Control of CNS neuronal excitability by estrogens via membrane-initiated signaling MJ Kelly, OK Rønnekleiv	Molecular and Cellular Endocrinology	2009
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status EC Villanueva, H Münzberg, D Cota, RL Leshan, K Kopp, R Ishida-Takahashi, JC Jones, DC Fingar, RJ Seeley, MG Myers	Endocrinology	2009
Hormone and glucose signalling in POMC and AgRP neurons: PI3K and K ATP in the arcuate nucleus BF Belgardt, T Okamura, JC Brüning	The Journal of Physiology	2009
Cross-Talk Between Membrane-Initiated and Nuclear-Initiated Oestrogen Signalling in the Hypothalamus TA Roepke, J Qiu, MA Bosch, OK Rønnekleiv, MJ Kelly	Journal of Neuroendocrinology	2009
Signal Transduction Pathways for Leptin: An Embarrassment of Riches S Chua	Diabetes	2009
Central leptin receptor action and resistance in obesity. Bjørbaek C	Journal of investigative medicine : the official publication of the American Federation for Clinical Research	2009
Acute effects of leptin require PI3K signaling in hypothalamic POMC neurons Jennifer W. Hill, Kevin Williams, Chianping Ye, Ji Luo, Nina Balthasar, Roberto Coppari, Michael A. Cowley, Lewis C. Cantley, Bradford B. Lowell, Joel K. Elmquist	Journal of Clinical Investigation	2008
Monitoring FoxO1 localization in chemically identified neurons M Fukuda, JE Jones, D Olson, J Hill, CE Lee, L Gautron, M Choi, JM Zigman, BB Lowell, JK Elmquist	The Journal of neuroscience : the official journal of the Society for Neuroscience	2008
Leptin receptor signaling and the regulation of mammalian physiology EC Villanueva, MG Myers	International Journal of Obesity	2008
Glucose regulates the effects of leptin on hypothalamic POMC neurons X Ma, L Zubcevic, FM Ashcroft	Proceedings of the National Academy of Sciences	2008
Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis L Gong, F Yao, K Hockman, HH Heng, GJ Morton, K Takeda, S Akira, MJ Low, M Rubinstein, RG MacKenzie	Endocrinology	2008
Specific Physiological Roles for Signal Transducer and Activator of Transcription 3 in Leptin Receptor-Expressing Neurons ML Piper, EK Unger, MG Myers, AW Xu	Molecular Endocrinology	2008
Functional consequences of the human leptin receptor (LEPR) Q223R transversion G Stratigopoulos, CA LeDuc, N Matsuoka, R Gutman, R Rausch, SA Robertson, MG Myers, WK Chung, SC Chua, RL Leibel	Obesity (Silver Spring, Md.)	2008
Hypothalamic pathways linking energy balance and reproduction JW Hill, JK Elmquist, CF Elias	American journal of physiology. Endocrinology and metabolism	2008
Effects of leptin on rat ventromedial hypothalamic neurons BG Irani, CL Foll, A Dunn-Meynell, BE Levin	Endocrinology	2008
Brain regulation of appetite and satiety RS Ahima, DA Antwi	Endocrinology and metabolism clinics of North America	2008
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity X Zhang, G Zhang, H Zhang, M Karin, H Bai, D Cai	Cell	2008
Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels W Huang, M Acosta-Martínez, TH Horton, JE Levine	American journal of physiology. Endocrinology and metabolism	2008
Membrane-initiated estrogen signaling in hypothalamic neurons MJ Kelly, OK Rønnekleiv	Molecular and Cellular Endocrinology	2008
Leptin increases adult hippocampal neurogenesis in vivo and in vitro JC Garza, M Guo, W Zhang, XY Lu	The Journal of biological chemistry	2008
Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene KY Ryu, JC Garza, XY Lu, GS Barsh, RR Kopito	Proceedings of the National Academy of Sciences	2008
AMPK is essential for energy homeostasis regulation and glucose-sensing by POMC and AgRP neurons Marc Claret, Mark A. Smith, Rachel L. Batterham, Colin Selman, Agharul I Choudhury, Lee G.D. Fryer, Melanie Clements, Hind Al-Qassab, Helen Heffron, Allison W. Xu, John R. Speakman, Gregory S. Barsh, Benoit Viollet, Sophie Vaulont, Michael L.J. Ashford, David Carling and Dominic J. Withers	Journal of Clinical Investigation	2007
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion E de Wall, R Leshan, AW Xu, N Balthasar, R Coppari, SM Liu, YH Jo, RG MacKenzie, DB Allison, NJ Dun, J Elmquist, BB Lowell, GS Barsh, C Luca, MG Myers, GJ Schwartz, SC Chua	Endocrinology	2007
Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice AS Metlakunta, M Sahu, A Sahu	Endocrinology	2007
Appropriate Inhibition of Orexigenic Hypothalamic Arcuate Nucleus Neurons Independently of Leptin Receptor/STAT3 Signaling H Munzberg, EE Jobst, SH Bates, J Jones, E Villanueva, R Leshan, M Bjornholm, J Elmquist, M Sleeman, MA Cowley, MG Myers	The Journal of neuroscience : the official journal of the Society for Neuroscience	2007
Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney Disease JR Davenport, AJ Watts, VC Roper, MJ Croyle, T Groen, JM Wyss, TR Nagy, RA Kesterson, BK Yoder	Current Biology	2007
Enhanced PIP3 Signaling in POMC Neurons Causes Neuronal Silencing via KATP Channel Activation and Leads to Diet-sensitive Obesity Leona Plum, Xiaosong Ma, Brigitte Hampel, Nina Balthasar, Roberto Coppari, Heike Münzberg, Denis Burdakov, Eva Rother, Ruth Janoschek, Jens Alber, Bengt F. Belgardt, Jost Seibler, Frieder Schwenk, Csaba Fekete, Akira Suzuki, Tak W. Mak, Wilhelm Krone, Tamas L. Horvath, Frances M. Ashcroft, Jens C. Brüning	Journal of Clinical Investigation	2006
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells K Ning, LC Miller, HA Laidlaw, LA Burgess, NM Perera, CP Downes, NR Leslie, ML Ashford	The EMBO Journal	2006
Pancreatic signals controlling food intake; insulin, glucagon and amylin SC Woods, TA Lutz, N Geary, W Langhans	Philosophical Transactions of the Royal Society B: Biological Sciences	2006
Central insulin action in energy and glucose homeostasis L Plum, BF Belgardt, JC Brüning	Journal of Clinical Investigation	2006
The role of insulin receptor substrate (Irs) 2 in hypothalamic and beta cell function Agharul I. Choudhury, Helen Heffron, Mark A. Smith, Hind Al-Qassab, Allison W. Xu, Colin Selman, Marcus Simmgen, Melanie Clements, Marc Claret, Gavin MacColl, , Kazunari Hisadome, Ivan Diakonov, Vazira Moosajee, Jimmy D Bell, John R. Speakman, Rachel L. Batterham, Gregory S. Barsh, Michael L. J. Ashford, Dominic J. Withers	Journal of Clinical Investigation	2005
Reduced Anorexigenic Efficacy of Leptin, But Not of the Melanocortin Receptor Agonist Melanotan-II, Predicts Diet-Induced Obesity in Rats G van Dijk, K de Vries, C Nyakas, B Buwalda, T Adage, F Kuipers, MJ Kas, RA Adan, CW Wilkinson, TE Thiele, AJ Scheurink	Endocrinology	2005
Effects of hypothalamic neurodegeneration on energy balance AW Xu, CB Kaelin, GJ Morton, K Ogimoto, K Stanhope, J Graham, DG Baskin, P Havel, MW Schwartz, GS Barsh	PLoS Biology	2005
Insulin Inhibits Neuropeptide Y Gene Expression in the Arcuate Nucleus through GABAergic Systems I Sato	The Journal of neuroscience : the official journal of the Society for Neuroscience	2005

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