Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Liver fibrosis
Ramón Bataller, David A. Brenner
Ramón Bataller, David A. Brenner
Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):209-218. https://doi.org/10.1172/JCI24282.
View: Text | PDF | Corrigendum
Science in Medicine Article has an altmetric score of 213

Liver fibrosis

  • Text
  • PDF
Abstract

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Our knowledge of the cellular and molecular mechanisms of liver fibrosis has greatly advanced. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-β1, angiotensin II, and leptin. Reversibility of advanced liver fibrosis in patients has been recently documented, which has stimulated researchers to develop antifibrotic drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans is unknown. This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current antifibrotic strategies.

Authors

Ramón Bataller, David A. Brenner

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 65 147 153 179 178 149 133 138 131 150 152 119 102 102 88 73 53 44 27 22 2 2207
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (2207)

Title and authors Publication Year
Continuous activation of C/EBPβ transcription factor prevents fibrosis resolution after alcohol cessation
Michael Schonfeld, Kruti Nataraj, Steven Weinman, Irina Tikhanovich
Cellular and molecular gastroenterology and hepatology 2025
The paradigm of stem cell secretome in tissue repair and regeneration: Present and future perspectives
Da Silva K, Kumar P, Choonara YE
Wound Repair and Regeneration 2025
NAFLD and NAFLD Related HCC: Emerging Treatments and Clinical Trials
Khare T, Liu K, Chilambe LO, Khare S
International Journal of Molecular Sciences 2025
Tubulointerstitial nephritis antigen-like 1 promotes the progression of liver fibrosis after HCV eradication with direct-acting antivirals
Lei L, Li H, Wang XK, Li JR, Sun H, Li HY, Li JY, Tang M, Xu JC, Dong B, Gong Y, Song DQ, Jiang JD, Peng ZG
International Journal of Biological Sciences 2025
Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression
Zhu Y, Chen J, Chen C, Tang R, Xu J, Shi S, Yu X
Biomarker Research 2025
NLRP3 inflammasome in health and disease (Review)
Wang H, Ma L, Su W, Liu Y, Xie N, Liu J
International Journal of Molecular Medicine 2025
Spinal cord injury induces transient activation of hepatic stellate cells in rat liver
Fernandez-Canadas I, Badajoz A, Jimenez-Gonzalez J, Wirenfeldt M, Paniagua-Torija B, Bravo-Jimenez C, Del Cerro M, Arevalo-Martin A, Garcia-Ovejero D
Scientific Reports 2025
Aurora kinase A promotes hepatic stellate cell activation and liver fibrosis through the Wnt/β-catenin pathway
Dai G, Lin J, Jiang Y, Liu X, Chen P, Zhang Y, Song Z, Zhuang X, Cong J, Li Y, Hong X, Liu Y, Xiao D, Li A, Luo Y
Frontiers in Oncology 2025
Therapeutic anti-inflammatory immune potentials of some seaweeds extracts on chemically induced liver injury in mice
Bases E, El-Sheekh MM, El Shafay SM, El-shenody R, Nassef M
Scientific Reports 2025
Impact of non-alcoholic fatty liver disease and liver fibrosis on outcomes of acute ischemic stroke: A systematic review and meta-analysis
Yang L, Han J, Qin C, Song F
Pakistan Journal of Medical Sciences 2025
Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis
Dan L, Li X, Chen S, You X, Wang D, Wang T, Li J, Liu W, Mu J, Feng Q
Frontiers in Pharmacology 2025
Discoid Domain Receptors Signaling in Macrophages-Mediated Diseases
Ma Y, Gong H, Cheng L, Zhang D
International Journal of General Medicine 2025
From Pathophysiology to Practice: Evolving Pharmacological Therapies, Clinical Complications, and Pharmacogenetic Considerations in Portal Hypertension
Porada M, Bułdak Ł
Metabolites 2025
Is There an Association Between Cigarette Smoking and Advanced Liver Fibrosis in Smokers with HIV, Heavy Drinking and High Prevalence of HCV?
Fuster D, So-Armah K, Cheng DM, Blokhina E, Patts G, Lioznov D, Gnatienko N, Long MT, Freiberg MS, Tindle H, Samet JH
Journal of Clinical Medicine 2025
Dose-Dependent PFESA-BP2 Exposure Increases Risk of Liver Toxicity and Hepatocellular Carcinoma
Kostecki G, Chuang K, Buxton A, Dakshanamurthy S
Current Issues in Molecular Biology 2025
Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells
Li W, Sparks RP, Sun C, Yang Y, Pantano L, Kirchner R, Arghiani N, Weilheimer A, Toles BJ, Chen JY, Moran SP, Barrera V, Li Z, Zhou P, Brassil ML, Wrobel D, Ho Sui SJ, Aspnes G, Schuler M, Smith J, Medoff BD, Zhou C, Boustany-Kari CM, Rippmann JF, Santos DM, Doerner JF, Mullen AC
Nature Communications 2025
Ferritinophagy: multifaceted roles and potential therapeutic strategies in liver diseases
Wu K, Zhao W, Hou Z, Zhang W, Qin L, Qiu J, Wang D, Zhuang L, Xue X, Sun D
Frontiers in Cell and Developmental Biology 2025
The relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and both MASLD and advanced liver fibrosis: evidence from NHANES 2017–2020
Li J, Kou C, Chai Y, Li Y, Liu X, Zhang L, Zhang H
Frontiers in Nutrition 2025
Chondroitin Sulfate-Based Imatinib Nanoparticles Targeting Activated Hepatic Stellate Cells Against Hepatic Fibrosis
Liu X, Fang C, Yu H, Huang L, Feng J, Luo S, Song L, Wu M, Tan Y, Dong J, Gong T, Xiao P
Pharmaceutics 2025
MEOX1-mediated transcriptional regulation of circABHD3 exacerbates hepatic fibrosis through promoting m6A/YTHDF2-dependent YPEL3 mRNA decay to activate β-catenin signaling
Chen L, Yang H, Wang J, Zhang H, Fu K, Yan Y, Liu Z
PLOS Genetics 2025
Exercise and tissue fibrosis: recent advances in therapeutic potential and molecular mechanisms
Zhao Z, Zhu Y, Wan D
Frontiers in Endocrinology 2025
Hepatotoxicity evaluation method through multiple-factor analysis using human pluripotent stem cell derived hepatic organoids
Shin DS, Yang JY, Jeong HN, Mun SJ, Kim H, Son MJ, Bae MA
Scientific Reports 2025
Non-invasive liver fibrosis markers are increased in obese individuals with non-alcoholic fatty liver disease and the metabolic syndrome
Askeland A, Rasmussen RW, Gjela M, Frøkjær JB, Højlund K, Mellergaard M, Handberg A
Scientific Reports 2025
Ablation of Hepatic Asah1 Gene Disrupts Hepatic Lipid Homeostasis and Promotes Fibrotic Nonalcoholic Steatohepatitis in Mice
Zuo R, Wang M, Wang YT, ShenTu Y, Moura AK, Zhou Y, Roudbari K, Hu JZ, Li PL, Hao J, Li X, Zhang Y
The American Journal of Pathology 2025
Danshensu Attenuates Palmitic Acid-Induced Activation of Hepatic Stellate Cells by Regulating Pyroptosis
Tseng HF, Chao HN, Lin CH, Kuo CY
International Journal of Medical Sciences 2025
A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1‐Induced LX‐2 Human Hepatic Stellate Cells
Lee S, Jang Y, Seok H, Moon Y
The FASEB Journal 2025
Hepatocellular carcinoma: pathogenesis, molecular mechanisms, and treatment advances
Ding Z, Wang L, Sun J, Zheng L, Tang Y, Tang H
Frontiers in Oncology 2025
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3
Sugimoto A, Saito Y, Wang G, Sun Q, Yin C, Lee KH, Geng Y, Rajbhandari P, Hernandez C, Steffani M, Qie J, Savage T, Goyal DM, Ray KC, Neelakantan TV, Yin D, Melms J, Lehrich BM, Yasaka TM, Liu S, Oertel M, Lan T, Guillot A, Peiseler M, Filliol A, Kanzaki H, Fujiwara N, Ravi S, Izar B, Brosch M, Hampe J, Remotti H, Argemi J, Sun Z, Kendall TJ, Hoshida Y, Tacke F, Fallowfield JA, Blockley-Powell SK, Haeusler RA, Steinman JB, Pajvani UB, Monga SP, Bataller R, Masoodi M, Arpaia N, Lee YA, Stockwell BR, Augustin HG, Schwabe RF
Nature 2025
Effect of high-altitude hypoxia on function and cytoarchitecture of rats’ liver
Ibrahim E, Sohail SK, Ihunwo A, Eid RA, Al-Shahrani Y, Rezigalla AA
Scientific Reports 2025
Molecular Landscape and Diagnostic Model of MASH: Transcriptomic, Proteomic, Metabolomic, and Lipidomic Perspectives
Chen Y, Bian S, Le J
Genes 2025
Identification of CDK1 as a Biomarker for the Treatment of Liver Fibrosis and Hepatocellular Carcinoma Through Bioinformatics Analysis
Qin J, Li Z
International Journal of Molecular Sciences 2025
The interactive role of microRNA and other non-coding RNA in hepatitis B (HBV) associated fibrogenesis.
Sartorius K, Wang Y, Sartorius B, Antwi SO, Li X, Chuturgoon A, Yu C, Lu Y, Wang Y
Functional & integrative genomics 2025
Plasma levels of soluble PD-1, TIM-3, LAG-3 and galectin-3 and the degree of liver fibrosis in CHC and the impact of successful antiviral treatment on their levels.
Osuch S, Kumorek A, Kozłowski P, Berak H, Kochanowicz AM, Cortés-Fendorf K
Scientific reports 2025
Pentadecanoic acid attenuates thioacetamide-induced liver fibrosis by modulating oxidative stress, inflammation, and ferroptosis pathways in rat.
Aabis M, Tiwari P, Kumar V, Singh G, Panghal A, Jena G
Naunyn-Schmiedeberg's archives of pharmacology 2025
Role of Essential Oils and Antioxidants in the Treatment of Fibrosis.
Sah J, Singh I
Current drug research reviews 2025
The interplay between lymphatic system and portal hypertension: a comprehensive review.
Juneja P, Yadav R, Tripathi DM, Kaur S
Hepatology international 2025
Anti-liver fibrotic effects of small extracellular vesicle microRNAs from human umbilical cord-derived mesenchymal stem cells and their differentiated hepatocyte-like cells.
Choi MS, Hong JS, Lee DH, Jang YJ, Kim JH, Lee YS
Biotechnology letters 2025
Human menstrual blood-derived stem cells secreted ECM1 directly interacts with LRP1α to ameliorate hepatic fibrosis through FoxO1 and mTOR signaling pathway
Fang Y, Chen L, Yuan Y, Zhou S, Fu J, Zhang Q, Zhang N, Huang Y, Li Y, Yuan L, Chen L, Xiang C
Stem Cell Research & Therapy 2025
A Golden Shield: The Protective Role of Curcumin against Liver Fibrosis.
Abolfazli S, Butler AE, Jamialahmadi T, Sahebkar A
Current medicinal chemistry 2025
Mechanistic Insights into the Role of MCP-1 in Diverse Liver Pathological Conditions: A Recent Update.
Dhengle S, Maharana KC, Meenakshi S, Singh S
Current pharmaceutical design 2025
Challenges of in vitro modelling of liver fibrosis.
Ros-Tarraga P, Villanueva-Badenas E, Sanchez-Gonzalez E, Gallego-Ferrer G, Donato MT, Tolosa L
Frontiers in cell and developmental biology 2025
Deciphering the Matrisome: Extracellular Matrix Remodeling in Liver Cirrhosis and Hepatocellular Carcinoma.
Chaulagain RP, Padder AM, Shrestha H, Gupta R, Bhandari R, Shrestha Y, Qasem Moqbel A, Gautam S, Lal N, Jin S
Cureus 2025
Recent Advances in Three-Dimensional In Vitro Models for Studies of Liver Fibrosis.
Chi KY, Kim G, Son JS, Han J, Kim JH
Tissue engineering and regenerative medicine 2025
Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease.
Schwabe RF, Brenner DA
Nature reviews. Gastroenterology & hepatology 2025
Single cell multiomics reveals drivers of metabolic dysfunction-associated steatohepatitis.
Elison W, Chang L, Xie Y, Miciano C, Yang Q, Mummey H, Lancione R, Corban S, Sakane S, Lucero J, Mamde S, Kim HY, Kim MJ, Melton R, Tucciarone L, Lie A, Loe T, Vashist T, Dang K, Elgamal R, Li D, Vu M, Farah EN, Seng C, Djulamsah J, Yang B, Buchanan J, Miller M, Tran M, Birrueta JO, Chi NC, Wang T, D'Antonio-Chronowska A, Wang A, Kisseleva T, Brenner D, Ren B, Gaulton KJ
medRxiv : the preprint server for health sciences 2025
Tension-induced directional migration of hepatic stellate cells potentially coordinates liver fibrosis progression.
Zhou L, Shi Z, Yang X, Zeng J, You Z, Zhang Y, Zhu Z, Liu Z, Niu Y, Yu H, He J, Long Y, Wu Z, Zhang Y, Lyu C, Deng L, Wang Y, Wu C, Du Y
Nature biomedical engineering 2025
Cellular crosstalk mediated by Meteorin-like regulating hepatic stellate cell activation during hepatic fibrosis.
Zhou Y, Wang G, Liu L, Song L, Hu L, Liu L, Xu L, Wang T, Liu L, Wang Y, Zhang T, Guo B
Cell death & disease 2025
Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis.
Zhang Y, Gai X, Li Y, Chen Z, Zhang X, Qiao W, Qiu P, Du C, Sheng S, Hao J, Zhang Y, Fan H, Li X, Liu M, Zhang J, Pan Z, Chang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025
Knowledge landscape of macrophage research in liver fibrosis: a bibliometric review of the literature from WoSCC.
Li Y, Cao Z, Lu Y, Lei C, Lyu W
Frontiers in pharmacology 2025
Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment
Cheng S, Xiao X, Wang D, Wang X, Yang M
Frontiers in Immunology 2025
MOLECULAR DISSECTION OF THE ROLE OF ACE2 IN GLUCOSE HOMEOSTASIS
Chhabra KH, Shoemaker R, Herath CB, Thomas MC, Filipeanu CM, Lazartigues E
Physiological reviews 2025
Diagnostic performance of microvascular flow imaging for noninvasive assessment of liver fibrosis in chronic liver disease
Yoo HW, Yang CJ, Yoo JJ, Chang Y, Lee SH, Jeong SW, Jang JY, Cheon GJ, Kim YS, Kim HS, Kim SG
PLOS One 2025
Evaluating the therapeutic potential of BSA-reduced mussel-derived selenium nanoparticles to mitigate copper sulfate-induced hepatic damage and neurodegeneration in a zebrafish model
Umapathy S, Pan I
Frontiers in Genetics 2025
Monocytes and Macrophages as Unique Cellular Compartments Governing Non-Alcoholic Fatty Liver Disease and Inflammation
Hemmatian G, Rostamzadeh D, Baghaei K, Shabani M
Avicenna Journal of Medical Biotechnology 2025
The Hepatoprotective Effects of Ginsenoside from Ginseng: A Review of Molecular Mechanisms and Therapeutic Potentials.
Taha SR, Fazlollahpour-Naghibi A, Zadeh MS, Bagheri K, Youshanlouei HR, Mosaddeghi-Heris R, Hejazian SS, Khalaji A, Alavi SS, Fattahi P, Mehrtabar S
Current pharmaceutical biotechnology 2025
Mechanism-guided drug development and treatment for liver fibrosis: a clinical perspective
Zeng X, Huang D, Zhu Z, Cai Q, Yang Y, Lu H, Chen J
Frontiers in Pharmacology 2025
Therapeutic potential of Janus kinase inhibitors for the management of fibrosis in inflammatory bowel disease
Su J, Lartey DA, Zanella G, Hawinkels LJ, Matteoli G, Löwenberg M, Barnhoorn MC
Journal of Crohn's & Colitis 2025
Long-term risk of chronic liver disease after pre-eclampsia
Auger N, Jutras G, Paradis G, Ayoub A, Lewin A, Maniraho A, Potter BJ
International Journal of Epidemiology 2025
Arctigenin Attenuates Hepatic Stellate Cell Activation via Endoplasmic Reticulum-Associated Degradation (ERAD)-Mediated Restoration of Lipid Homeostasis
Xia M, Li J, Martinez Aguilar LM, Wang J, Trillos Almanza MC, Li Y, Buist-Homan M, Moshage H
Journal of Agricultural and Food Chemistry 2025
Cellular crosstalk in fibrosis: Insights into macrophage and fibroblast dynamics
Froom ZS, Callaghan NI, Davenport Huyer L
The Journal of Biological Chemistry 2025
Hepatic stellate cell inhibition by angiotensin II receptor blocker mitigates liver injury and fibrosis via NF-κB-galectin-3 suppression in a rat nonalcoholic steatohepatitis model.
Kuang X, Naiki-Ito A, Kawamura H, Murakami A, Komura M, Kato H, Nagayasu Y, Takahashi S
Archives of toxicology 2025
The impact of dietary neem leaf on the growth and biochemical traits of rabbits.
Ali A, Adawy A, Ismaiel Z, Hussein M, Attaai A
Scientific reports 2025
Regression of hepatic fibrosis in gamma-irradiated rats by mycophenolate mofetil: potential role of Egr-1.
Galal SM, Mostafa DM, El Kiki SM
Naunyn-Schmiedeberg's archives of pharmacology 2025
Novel RORγt inverse agonists limit IL-17-mediated liver inflammation and fibrosis
Dabbaghizadeh A, Dion J, Maali Y, Fouda A, Bédard N, Evaristo G, Hassan GS, Tchervenkov J, Shoukry NH
The Journal of Immunology Author Choice 2025
Polygonatum sibiricum polysaccharide alleviates liver fibrosis through the TGF-β/Smad signaling pathway and reduces collagen
Yuan Y, Liu X, Zhou T, Zhou Z, Gong M, Li Y
Molecular Medicine Reports 2025
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H
Nature Communications 2024
Activated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition
Wan S, Liu X, Sun R, Liu H, Jiang J, Wu B
Cell Death and Disease 2024
Huaju Xiaoji Formula Regulates ERS-lncMGC/miRNA to Enhance the Renal Function of Hypertensive Diabetic Mice with Nephropathy.
Zhang Z, Fu X, Zhou F, Zhang D, Xu Y, Fan Z, Wen S, Shao Y, Yao Z, He Y
Journal of Diabetes Research 2024
Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment
Halimani N, Nesterchuk M, Tsitrina AA, Sabirov M, Andreichenko IN, Dashenkova NO, Petrova E, Kulikov AM, Zatsepin TS, Romanov RA, Mikaelyan AS, Kotelevtsev YV
Scientific Reports 2024
Comparative Study on the Effects of Four Plant Protein Sources on the Liver and Intestinal Health of Largemouth Bass, Micropterus salmoides
Yao S, Li W, Cai C, Wang C, Kang J, Hu H, Wu P, Cao X, Ye Y
Aquaculture Nutrition 2024
CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation.
Wang J, Zhang H, Chen L, Fu K, Yan Y, Liu Z
Journal of Gastroenterology 2024
STAT3 Decoy Oligodeoxynucleotides Suppress Liver Inflammation and Fibrosis in Liver Cancer Cells and a DDC-Induced Liver Injury Mouse Model
Choi HJ, Kim YA, Ryu J, Park KK, Lee SJ, Kim BS, Song JE, Kim JD
Molecules (Basel, Switzerland) 2024
Protective hepatocyte signals restrain liver fibrosis in metabolic dysfunction-associated steatohepatitis
Marcella Steffani, Yana Geng, Utpal Pajvani, Robert F. Schwabe1
Journal of Clinical Investigation 2024
Identification of functional genes in liver fibrosis based on bioinformatics analysis of a lncRNA-mediated ceRNA network.
Zhang F, Pei S, Xiao M
BMC Medical Genomics 2024
Endothelial anthrax toxin receptor 2 plays a protective role in liver fibrosis.
Huang X, Zhang L, Luo W, Zeng Y, Li X, Yang N, Huang W, Ding BS
Frontiers in Cell and Developmental Biology 2024
Clinical value of the fibrosis-4 index in predicting mortality in patients with right ventricular pacing.
Inoue N, Morikawa S, Ogane T, Hiramatsu T, Murohara T
PloS one 2024
Metabolomics in liver diseases: A novel alternative for liver biopsy?
Tanaka Y
World journal of hepatology 2024
The staging of nonalcoholic fatty liver disease fibrosis: A comparative study of MR elastography and the quantitative DCE-MRI exchange model.
Ren H, Yang D, Xu H, Tong X, Zhao X, Wang Q, Sun Y, Ou X, Jia J, You H, Wang Z, Yang Z
Heliyon 2024
LiveBoost: A GB-based prediction system for liver fibrosis in chronic hepatitis B patients in China - A multi-center retrospective study.
Xie G, Xiao H, Liu Q, Chen T, Chen F, Zhou K, Wang X, Liu P, Jia Z, Chen L, Deng X, Meng F, Zhang Z, Chi X, Jia W
Heliyon 2024
Structure Modification Converts the Hepatotoxic Tacrine into Novel Hepatoprotective Analogs.
Sorour AA, Aly RG, Ragab HM, Wahid A
ACS Omega 2024
The miR-3074/BMP7 axis regulates TGF-β-caused activation of hepatic stellate cells in vitro and CCl(4)-caused murine liver fibrosis in vivo.
Liu B, Xie X, Yang X, Dou C, Tang H, Liu J
Human Cell 2024
Mouse Type-I Interferon-Mannosylated Albumin Fusion Protein for the Treatment of Chronic Hepatitis
Minayoshi Y, Maeda H, Hamasaki K, Nagasaki T, Takano M, Fukuda R, Mizuta Y, Tanaka M, Sasaki Y, Otagiri M, Watanabe H, Maruyama T
Pharmaceuticals 2024
MSC-derived exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation.
Chen W, Lin F, Feng X, Yao Q, Yu Y, Gao F, Zhou J, Pan Q, Wu J, Yang J, Yu J, Cao H, Li L
Asian Journal of Pharmaceutical Sciences 2024
Liver fibrosis pathologies and potentials of RNA based therapeutics modalities.
Diwan R, Gaytan SL, Bhatt HN, Pena-Zacarias J, Nurunnabi M
Drug Delivery and Translational Research 2024
Hepatocellular Carcinoma: Old and Emerging Therapeutic Targets
Pessino G, Scotti C, Maggi M
Cancers 2024
HDAC7: a promising target in cancer.
Liu C, Zheng D, Pu X, Li S
Frontiers in Oncology 2024
Understanding Alcohol Relapse in Liver Transplant Patients With Alcohol-Related Liver Disease: A Comprehensive Review.
Shinde SS, Chakole S, Humane S
Cureus 2024
Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism.
Ouyang H, Miao H, Li Z, Wu D, Gao SC, Dai YY, Gao XD, Chai HS, Hu WY, Zhu JF
World journal of hepatology 2024
Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma
Lauer SM, Omar MH, Golkowski MG, Kenerson HL, Lee KS, Pascual BC, Lim HC, Forbush K, Smith FD, Gordan JD, Ong SE, Yeung RS, Scott JD
Cell Reports 2024
Effects of HCV Clearance with Direct-Acting Antivirals (DAAs) on Liver Stiffness, Liver Fibrosis Stage and Metabolic/Cellular Parameters
Ferreira J, Bicho M, Serejo F
Viruses 2024
Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications.
Wu Z, Zhu Y, Liu W, Balasubramanian B, Xu X, Yao J, Lei X
2024
Evaluation of the modulating effect of epidermal growth factor receptor inhibitor cetuximab in carbon-tetrachloride induce hepatic fibrosis in rats.
Alimullah M, Shuvo AUH, Jahan I, Ismail IN, Islam SMM, Sultana M, Saad MR, Raihan S, Khan F, Alam MA, Subhan N
Biochemistry and Biophysics Reports 2024
Interplay between gut microbiota and the master iron regulator, hepcidin, in the pathogenesis of liver fibrosis.
Ahmadi Badi S, Bereimipour A, Rohani P, Khatami S, Siadat SD
Pathogens and Disease 2024
Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan
Miryan M, Rashid SA, Navashenaq JG, Soleimani D, Nematy M, Moludi J
BMC Gastroenterology 2024
The role of PI3k/AKT signaling pathway in attenuating liver fibrosis: a comprehensive review
Shamsan E, Almezgagi M, Gamah M, Khan N, Qasem A, Chuanchuan L, Haining F
Frontiers in Medicine 2024
Inactivation of ERK1/2 in cancer-associated hepatic stellate cells suppresses cancer-stromal interaction by regulating extracellular matrix in fibrosis
Lin Q, Lei D, Zhong T, Zhang Y, Da Q, Chen X, Li X, Liu J, Yan Z
American journal of cancer research 2024
BMP7-Loaded Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorate Liver Fibrosis by Targeting Activated Hepatic Stellate Cells
Zhu D, Sun Z, Wei J, Zhang Y, An W, Lin Y, Li X
International Journal of Nanomedicine 2024
The role and mechanism of TXNDC5 in disease progression.
Jiao M, Zhang Y, Song X, Xu B
Frontiers in immunology 2024
Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
Wang P, Kang Q, Wu WS, Rui L
Cell Reports 2024
Combining T1rho and advanced diffusion MRI for noninvasively staging liver fibrosis: an experimental study in rats.
Guo Y, Guo T, Huang C, Sun P, Wu Z, Jin Z, Zheng C, Li X
2024
MCPIP1 Inhibits Hepatic Stellate Cell Activation in Autocrine and Paracrine Manners, Preventing Liver Fibrosis
Pydyn N, Ferenc A, Trzos K, Pospiech E, Wilamowski M, Mucha O, Major P, Kadluczka J, Rodrigues PM, Banales JM, Herranz JM, Avila MA, Hutsch T, Malczak P, Radkowiak D, Budzynski A, Jura J, Kotlinowski J
Cellular and Molecular Gastroenterology and Hepatology 2024
Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression
Osna NA, Tikhanovich I, Ortega-Ribera M, Mueller S, Zheng C, Mueller J, Li S, Sakane S, Weber RC, Kim HY, Lee W, Ganguly S, Kimura Y, Liu X, Dhar D, Diggle K, Brenner DA, Kisseleva T, Attal N, McKillop IH, Chokshi S, Mahato R, Rasineni K, Szabo G, Kharbanda KK
Biomolecules 2024
DCDC2 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing Wnt/β-catenin signaling
Liu QQ, Chen J, Ma T, Huang W, Lu CH
Scientific Reports 2024
The 90‐Day Survival Threshold: A Pivotal Determinant of Long‐Term Prognosis in HBV‐ACLF Patients – Insights from a Prospective Longitudinal Cohort Study
Xiao L, Chen J, Zhao S, Zhoudi W, He K, Qian X, Zhang F, Liu Q, Li T, Zhu D, Wu X, Pu Z, Huang J, Xie Z, Xu X
Advanced Science 2024
Low Dose of Nickel and Benzo [a] Anthracene in Rat-Diet, Induce Apoptosis, Fibrosis, and Initiate Carcinogenesis in Liver via NF-Ƙβ Pathway.
Adetutu A, Adegbola PI, Aborisade AB
Biological Trace Element Research 2024
Novel Inositol 1,4,5-Trisphosphate Receptor Inhibitor Antagonizes Hepatic Stellate Cell Activation: A Potential Drug to Treat Liver Fibrosis
Smith-Cortinez N, Heegsma J, Podunavac M, Zakarian A, Cardenas JC, Faber KN
Cells 2024
Hepatic recruitment of myeloid-derived suppressor cells upon liver injury promotes both liver regeneration and fibrosis.
Zhang Q, Yu T, Tan H, Shi H
BMC Gastroenterology 2024
Nogo-B Silencing Expedites the Senescence of Platelet-Derived Growth Factor-BB-Induced Human Hepatic Stellate Cells Via Autophagy.
Gao L, Zhuang Y, Liu Z
Molecular Biotechnology 2024
Assessing the combined impact of fatty liver-induced TGF-β1 and LPS-activated macrophages in fibrosis through a novel 3D serial section methodology
Ishiyama S, Hayatsu M, Toriumi T, Tsuda H, Watanabe K, Kasai H, Kishigami S, Mochizuki K, Mikami Y
Scientific Reports 2024
Potential Hepatoprotective Effects of Irbesartan, an Accessible Angiotensin II Receptor Blocker, Against Cisplatin-Induced Liver Injury in a Rat Model
ERTUNÇ O, ERZURUMLU Y, SAVRAN M, ÇATAKLI D, DOĞAN KIRAN E, PEKGÖZ Ş
2024
Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications
Bonadio JD, Bashiri G, Halligan P, Kegel M, Ahmed F, Wang K
Advanced Drug Delivery Reviews 2024
Hedgehog signaling is a promising target for the treatment of hepatic fibrogenesis: a new management strategy using itraconazole-loaded nanoparticles
Elmorsy EA, Saber S, Kira AY, Alghasham A, Abdel-Hamed MR, Amer MM, Mohamed EA, AlSalloom A. A, Alkhamiss AS, Hamad RS, Abdel-Reheim MA, Ellethy AT, Elsisi HA, Alsharidah M, Elghandour SR, Elnawawy T, Abdelhady R
Frontiers in pharmacology 2024
LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a.
Samuvel DJ, Lemasters JJ, Chou CJ, Zhong Z
Frontiers in pharmacology 2024
Engineered SPIONs functionalized with endothelin a receptor antagonist ameliorate liver fibrosis by inhibiting hepatic stellate cell activation
ten Hove M, Smyris A, Booijink R, Wachsmuth L, Hansen U, Alic L, Faber C, Hӧltke C, Bansal R
Bioactive Materials 2024
Stem cell-based therapy for fibrotic diseases: mechanisms and pathways
Taherian M, Bayati P, Mojtabavi N
Stem Cell Research & Therapy 2024
The adiponectin‐derived peptide ALY688 protects against the development of metabolic dysfunction‐associated steatohepatitis
Huang Z, Sung HK, Yan X, He S, Jin L, Wang Q, Wu X, Hsu HH, Pignalosa A, Crawford K, Sweeney G, Xu A
Clinical and Translational Science 2024
Profibrogenic role of IL-15 through IL-15 receptor alpha-mediated trans-presentation in the carbon tetrachloride-induced liver fibrosis model
Cloutier M, Variya B, Akbari SA, Rexhepi F, Ilangumaran S, Ramanathan S
Frontiers in immunology 2024
Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis
Chen S, Zhuang D, Jia Q, Guo B, Hu G
Biomaterials Research 2024
Implicating the cholecystokinin B receptor in liver stem cell oncogenesis
Gay MD, Drda JC, Chen W, Huang Y, Yassin AA, Duka T, Fang H, Shivapurkar N, Smith JP
AJP Gastrointestinal and Liver Physiology 2024
Using Routinely Collected Electronic Healthcare Record Data to Investigate Fibrotic Multimorbidity in England
Massen GM, Whittaker HR, Cook S, Jenkins G, Allen RJ, Wain LV, Stewart I, Quint JK
Clinical epidemiology 2024
Hemodialysis bilayer bionic blood vessels developed by the mechanical stimulation of hepatitis B viral X(HBX) gene- transfected hepatic stellate cells
Journal of Zhejiang University. Science. B 2024
Impact of mechanical cues on key cell functions and cell-nanoparticle interactions
Elblová P, Lunova M, Dejneka A, Jirsa M, Lunov O
2024
The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production
Kang Z, Wang C, Shao F, Deng H, Sun Y, Ren Z, Zhang W, Ding Z, Zhang J, Zang Y
The Journal of biological chemistry 2024
Morin hydrate ameliorates Di-2-ethylhexyl phthalate (DEHP) induced hepatotoxicity in a mouse model via TNF-α and NF-κβ signaling
Kumar V, Kumar R, Gurusubramanian G, Rathore SS, Roy VK
3 Biotech 2024
Unraveling the hepatic stellate cells mediated mechanisms in aging's influence on liver fibrosis
Wahid RM, Hassan NH, Samy W, Abdelhadi AA, Saadawy SF, Elsayed SF, Seada SG, Mohamed SR
Scientific Reports 2024
Biomarkers of Hepatic Toxicity: An Overview
Thakur S, Kumar V, Das R, Sharma V, Mehta DK
Current Therapeutic Research 2024
Alcoholic Liver Disease in China: A Disease Influenced by Complex Social Factors That Should Not Be Neglected
Feng X, Huang N, Wu Y, Gao F, Chen X, Zhang C, Zhang B, Sun T
Journal of Clinical and Translational Hepatology 2024
Depletion of Activated Hepatic Stellate Cells and Capillarized Liver Sinusoidal Endothelial Cells Using a Rationally Designed Protein for Nonalcoholic Steatohepatitis and Alcoholic Hepatitis Treatment
Mishra F, Yuan Y, Yang JJ, Li B, Chan P, Liu Z
International journal of molecular sciences 2024
Exploring Fibrosis Pathophysiology in Lean and Obese Metabolic-Associated Fatty Liver Disease: An In-Depth Comparison
Vesković M, Pejović M, Šutulović N, Hrnčić D, Rašić-Marković A, Stanojlović O, Mladenović D
International journal of molecular sciences 2024
Unlocking the Potential of Tranilast: Targeting Fibrotic Signaling Pathways for Therapeutic Benefit
Massoud G, Parish M, Hazimeh D, Moukarzel P, Singh B, Cayton Vaught KC, Segars J, Islam MS
International Immunopharmacology 2024
Factors Affecting the Evaluation of Collagen Deposition and Fibrosis In Vitro
Fathi P, Sundaresan V, Alfonso AL, Rama Varma A, Sadtler K
Tissue Engineering Part A 2024
Advanced Techniques for Liver Fibrosis Detection: Spectral Photoacoustic Imaging and Superpixel Photoacoustic Unmixing Analysis for Collagen Tracking
Sultan LR, Grasso V, Jose J, Al-Hasani M, Karmacharya MB, Sehgal CM
Sensors (Basel, Switzerland) 2024
The effects of TGF-β-induced activation and starvation of vitamin A and palmitic acid on human stem cell-derived hepatic stellate cells
Wilhelmsen I, Combriat T, Dalmao-Fernandez A, Stokowiec J, Wang C, Olsen PA, Wik JA, Boichuk Y, Aizenshtadt A, Krauss S
Stem Cell Research & Therapy 2024
Resveratrol treatment ameliorates hepatic damage via the TGF-β/SMAD signaling pathway in a phenobarbital/CCl4-induced hepatic fibrosis model
Aykaç M, Balkan E, Gedi̇kli̇ S, Öztürk N
Iranian Journal of Basic Medical Sciences 2024
Inhibition of intrahepatic monocyte recruitment by Cenicriviroc and extracellular matrix degradation by MMP1 synergistically attenuate liver inflammation and fibrogenesis in vivo
Geervliet E, Karkdijk E, Bansal R
Scientific Reports 2024
Ultrasound Shear Wave Elastography Evaluation of the Liver and Implications for Perioperative Medicine
Suffredini G, Gao WD, Dodd-o JM
Journal of Clinical Medicine 2024
Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis
Ding C, Wang Z, Dou X, Yang Q, Ning Y, Kao S, Sang X, Hao M, Wang K, Peng M, Zhang S, Han X, Cao G
Aging and disease 2024
Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives.
Sahoo AK, Chivukula N, Madgaonkar SR, Ramesh K, Marigoudar SR, Sharma KV, Samal A
Archives of Toxicology 2024
A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model
Rojas-Chaverra NM, Imamura R, Sato H, Passioura T, Mihara E, Nishimura T, Takagi J, Suga H, Matsumoto K, Sakai K
iScience 2024
Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications
Zhao J, Yue P, Mi N, Li M, Fu W, Zhang X, Gao L, Bai M, Tian L, Jiang N, Lu Y, Ma H, Dong C, Zhang Y, Zhang H, Zhang J, Ren Y, Suzuki A, Wong PF, Tanaka K, Rerknimitr R, Junger HH, Cheung TT, Melloul E, Demartines N, Leung JW, Yao J, Yuan J, Lin Y, Schlitt HJ, Meng W
2024
Renin-angiotensin system inhibitors and risk of hepatocellular carcinoma among patients with hepatitis B virus infection.
Chen R, Zhou S, Liu J, Li L, Su L, Li Y, Fang C, Zhang X, Luo F, Gao Q, Lin Y, Guo Z, Cao L, Xu X, Nie S
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2024
Long noncoding RNA MALAT1 as a ceRNA drives mouse fibroblast activation via the miR-335-3p/P2ry2 axis.
Chen M, Peng J, Zhu G, Qian C, Xiao Z, Song X, Yu H, Huang R, Wang W, Zheng H, Yu Y
PloS one 2024
Mechanism of Action of Dihydroquercetin in the Prevention and Therapy of Experimental Liver Injury
Wei H, Zhao T, Liu X, Ding Q, Yang J, Bi X, Cheng Z, Ding C, Liu W
Molecules (Basel, Switzerland) 2024
Cysteine sulfenylation contributes to liver fibrosis via the regulation of EphB2-mediated signaling.
Han Y, Gao Q, Xu Y, Chen K, Li R, Guo W, Wang S
Cell death & disease 2024
The Metabolomic Footprint of Liver Fibrosis
Beyoğlu D, Popov YV, Idle JR
Cells 2024
Progranulin: A promising biomarker and therapeutic target for fibrotic diseases
Yang F, Cheng MH, Pan HF, Gao J
Acta Pharmaceutica Sinica. B 2024
Comprehensive evaluation of the mechanism of human adipose mesenchymal stem cells ameliorating liver fibrosis by transcriptomics and metabolomics analysis
Ji G, Zhang Z, Wang X, Guo Q, Zhang E, Li C
Scientific Reports 2024
Noncoding RNA-Mediated Epigenetic Regulation in Hepatic Stellate Cells of Liver Fibrosis
Gao R, Mao J
Non-Coding RNA 2024
Dietary Approaches to Stop Hypertension (DASH) and mortality risk among patients with liver cirrhosis: a prospective cohort study.
Zarei A, Pashayee-Khamene F, Hekmatdoost A, Karimi S, Ahmadzadeh S, Saberifiroozi M, Hatami B, Yari Z
BMC research notes 2024
Neutrophil-secreted S100A8/A9 participates in fatty liver injury and fibrosis by promoting myofibroblast migration.
Chang N, Liu Y, Li W, Ma Y, Zhou X, Zhao X, Yang L, Li L
Journal of molecular medicine (Berlin, Germany) 2024
Lactylation signature identifies liver fibrosis phenotypes and traces fibrotic progression to hepatocellular carcinoma
Li LN, Li WW, Xiao LS, Lai WN
Frontiers in Immunology 2024
The role of Rhizoma Paridis saponins on anti-cancer: The potential mechanism and molecular targets
Ke F, Zhang R, Chen R, Guo X, Song C, Gao X, Zeng F, Liu Q
Heliyon 2024
Effect of an Autotaxin Inhibitor, 2-(4-Chlorophenyl)-7-methyl-8-pentylimidazo[1,2-a] Pyrimidin-5(8H)-one (CBT-295), on Bile Duct Ligation-Induced Chronic Liver Disease and Associated Hepatic Encephalopathy in Rats
Roy S, Chakrabarti M, Mondal T, Das TK, Sarkar T, Datta S, Kundu M, Banerjee M, Kulkarni OP
ACS Pharmacology & Translational Science 2024
Sini san regulates intestinal flora and short-chain fatty acids to ameliorate hepatocyte apoptosis and relieve CCl4-induced liver fibrosis in mice
Wu Q, Zhu F, Yao Y, Chen L, Ding Y, Su Y, Ge C
Frontiers in Pharmacology 2024
The role of 2'-5'-oligoadenylate synthase-like protein (OASL1) in biliary and hepatotoxin-induced liver injury in mice.
Leya M, Yang D, Bao THTN, Jeong H, Oh SI, Kim JH, Kim JW, Kim B
Scientific reports 2024
Effect and Mechanism of Apple Polyphenols in Regulating Intestinal Flora and Inhibiting the TLR4/NF-κB/TGF-β Signaling Pathway to Alleviate Alcoholic Liver Fibrosis.
Meng X, Ma Y, Li K, Ji M, Lin L, Xiao X, Zhao Y, Su G
Plant foods for human nutrition (Dordrecht, Netherlands) 2024
The Battle of LPS Clearance in Host Defense vs. Inflammatory Signaling
Kumar P, Schroder EA, Rajaram MV, Harris EN, Ganesan LP
Cells 2024
NADPH oxidase 4 deficiency promotes hepatocellular carcinoma arising from hepatic fibrosis by inducing M2-macrophages in the tumor microenvironment
Kim JY, Kang W, Yang S, Park SH, Ha SY, Paik YH
Scientific Reports 2024
Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism.
Li X, Liu Y, Tang Y, Xia Z
Frontiers in immunology 2024
Nanogene editing drug delivery systems in the treatment of liver fibrosis.
Wang Q, Jia S, Wang Z, Chen H, Jiang X, Li Y, Ji P
Frontiers in medicine 2024
AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice.
Shi H, Xu W, Liu Q, Li Y, Dong S, Zhao Z
Journal of cellular and molecular medicine 2024
Signaling pathways that activate hepatic stellate cells during liver fibrosis.
Zhang Y, Ren L, Tian Y, Guo X, Wei F, Zhang Y
Frontiers in medicine 2024
The Role of Zinc on Liver Fibrosis by Modulating ZIP14 Expression Throughout Epigenetic Regulatory Mechanisms.
Aksoy-Ozer ZB, Bitirim CV, Turan B, Akcali KC
Biological trace element research 2024
Deciphering Molecular Mechanisms of Carbon Tetrachloride- Induced Hepatotoxicity: A Brief Systematic Review.
Fareed MM, Khalid H, Khalid S, Shityakov S
Current molecular medicine 2024
Targeting ketone body metabolism to treat fatty liver disease.
Kwon S, Jeyaratnam R, Kim KH
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2024
Drivers of cardiovascular disease in metabolic dysfunction-associated steatotic liver disease: the threats of oxidative stress.
Minetti ET, Hamburg NM, Matsui R
Frontiers in cardiovascular medicine 2024
Artificial intelligence-based evaluation of prognosis in cirrhosis.
Zhai Y, Hai D, Zeng L, Lin C, Tan X, Mo Z, Tao Q, Li W, Xu X, Zhao Q, Shuai J, Pan J
Journal of translational medicine 2024
Liver Characterization of a Cohort of Alpha-1 Antitrypsin Deficiency Patients with and without Lung Disease
Mohammad N, Oshins R, Gu T, Clark V, Lascano J, Assarzadegan N, Marek G, Brantly M, Khodayari N
Journal of Clinical and Translational Hepatology 2024
Application of the Human Amniotic Membrane as an Adjuvant Therapy for the Treatment of Hepatocellular Carcinoma.
Abou-Shanab AM, Gaser OA, Salah RA, El-Badri N
Advances in experimental medicine and biology 2024
Cannabidiol (CBD) modulates the transcriptional profile of ethanol-exposed human dermal fibroblast cells.
Gurgul A, Żurowski J, Szmatoła T, Kucharski M, Sawicki S, Semik-Gurgul E, Ocłoń E
Journal of applied genetics 2024
Review of the Effects of Antiviral Therapy on Hepatitis B/C-Related Mortality and the Regression of Fibrosis.
Sinclair S 3rd, Shearen S, Ghobrial Y, Trad G, Abdul Basit S, Shih D, Ryan JK
Viruses 2024
Liver Fibrosis Leading to Cirrhosis: Basic Mechanisms and Clinical Perspectives.
Somnay K, Wadgaonkar P, Sridhar N, Roshni P, Rao N, Wadgaonkar R
Biomedicines 2024
Mechanisms of Metal-Induced Hepatic Inflammation.
Subramaniam NK, Mann KK
Current environmental health reports 2024
Gut‑liver axis in liver disease: From basic science to clinical treatment (Review).
Wang J, Wang X, Zhuo E, Chen B, Chan S
Molecular medicine reports 2024
Extracellular vesicle mimetics engineered from mesenchymal stem cells and curcumin promote fibrosis regression in a mouse model of thioacetamide-induced liver fibrosis.
Gopal A, Gangadaran P, Rajendran RL, Oh JM, Lee HW, Hong CM, Kalimuthu S, Han MH, Lee J, Ahn BC
Regenerative therapy 2024
Evaluating the antifibrotic potential of naringenin, asiatic acid, and icariin using murine and human precision-cut liver slices.
Luo K, Geng Y, Oosterhuis D, de Meijer VE, Olinga P
Physiological reports 2024
Therapeutic Effect of Melatonin on CCl(4)-Induced Fibrotic Liver Model by Modulating Oxidative Stress, Inflammation, and TGF-β1 Signaling Pathway in Pinealectomized Rats.
Cinar D, Altinoz E, Elbe H, Bicer Y, Cetinavci D, Ozturk I, Colak T
Inflammation 2024
Effects of Bulleyaconitine A on Extracellular Matrix Secretion and Expression of Related Proteins in Acetaldehyde-Activated Hepatic Stellate Cells.
Song QW, Yuan YP, Sun QS, Zhan XD, Jiang YX, Tang XN
Bulletin of experimental biology and medicine 2024
Network Pharmacology, Molecular Docking Analysis and Molecular Dynamics Simulation of Scutellaria baicalensis in the Treatment of Liver Fibrosis.
Wang J, Wu Z, Chen X, Sun Y, Ma S, Weng J, Zhang Y, Dong K, Shao J, Zheng S
Current pharmaceutical design 2024
Study on the Hepatotoxicity of Emodin and Its Application in the Treatment of Liver Fibrosis
Guo Y, Song J, Liu Y, Yuan M, Zhong W, Guo Y, Guo L
Molecules 2024
Metagenome-based characterization of the gut bacteriome, mycobiome, and virome in patients with chronic hepatitis B-related liver fibrosis
Chen W, Liang F, Zhang Y, Zhang Y, Lv J, Jin X, Ran Y, Li S, Sun W
Frontiers in Microbiology 2024
The NRF-2/HO-1 Signaling Pathway: A Promising Therapeutic Target for Metabolic Dysfunction-Associated Steatotic Liver Disease
Li N, Hao L, Li S, Deng J, Yu F, Zhang J, Nie A, Hu X
Journal of Inflammation Research 2024
Antrodia cinnamomea extract alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting the mTOR pathway
Lan YW, Chen CE, Huang TT, Huang TH, Chen CM, Chong KY
Biomedical Journal 2024
Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis.
Almalki WH, Almujri SS
Biogerontology 2024
Copaiba Oleoresin Improves Weight Gain and IL-10 Concentration, with No Impact on Hepatic Histology, in Liver Cirrhosis
Taffarel M, da Silva BS, Paulino AM, Telles LO, Mendonça ST, dos Santos CV, Giordani MA, Nascimento AF, Aguiar DH, Sinhorin VD, Andrighetti CR, Luvizotto RD, Bomfim GF
Biology 2024
Single-Cell Analysis Reveals the Cellular and Molecular Changes of Liver Injury and Fibrosis in Mice During the Progression of Schistosoma japonicum Infection
Lu J, Zhang X, Dong P, Mei C, Yang Y, Yu C, Song L
Current Issues in Molecular Biology 2024
Role of CALCR expression in liver cancer: Implications for the immunotherapy response
Wang S, Wang W, Zeng J
Molecular Medicine Reports 2024
Hypoxia-Inducible Factor-2α Promotes Liver Fibrosis by Inducing Hepatocellular Death
Mooli RG, Mukhi D, Watt M, Nagati V, Reed SM, Gandhi NK, Oertel M, Ramakrishnan SK
International Journal of Molecular Sciences 2024
Integrated single-cell and bulk RNA sequencing reveals immune-related SPP1+ macrophages as a potential strategy for predicting the prognosis and treatment of liver fibrosis and hepatocellular carcinoma
Li B, Hu J, Xu H
Frontiers in Immunology 2024
The Influence and Mechanisms of Natural Plant Polysaccharides on Intestinal Microbiota-Mediated Metabolic Disorders
Chen Y, Li H, Lai F, Min T, Wu H, Zhan Q
Foods 2024
Exosome-based therapies for inflammatory disorders: a review of recent advances
Saleem M, Shahzad KA, Marryum M, Singh S, Zhou Q, Du S, Wang S, Shao C, Shaikh II
Stem Cell Research & Therapy 2024
Investigating the role of Wnt3a and Wnt5a as critical factors of hepatic stellate cell activation in acute toxicant-induced liver injury
Rutt LN, Orlicky DJ, McCullough RL
Cell Biology and Toxicology 2024
Menaquinone-7 and its therapeutic potential in type 2 diabetes mellitus based on a Zucker diabetic fatty rat model
Mrosewski I, Mantel V, Urbank M, Schulze-Tanzil G, Werner C, Gögele C, Kokozidou M, Bertsch T
Heliyon 2024
The potential therapeutic role of melatonin in organ fibrosis: a comprehensive review
Huang W, Zheng J, Wang M, Du LY, Bai L, Tang H
Frontiers in Medicine 2024
Pharmacotherapy of Liver Fibrosis and Hepatitis: Recent Advances
Zhao L, Tang H, Cheng Z
Pharmaceuticals 2024
A Multi-Institutional Study on Ultrasound Image Analysis for Staging HBV-Derived Liver Fibrosis: A Potential Noninvasive Alternative to Liver Stiffness Measurement
Wang J, Cao L, Liu F, Li C, Zhao P, Li Z, Lu X, Ye X, Bao J
Clinical and Translational Gastroenterology 2024
The Hippo Signaling Pathway Manipulates Cellular Senescence
Miyajima C, Nagasaka M, Aoki H, Toriuchi K, Yamanaka S, Hashiguchi S, Morishita D, Aoyama M, Hayashi H, Inoue Y
Cells 2024
Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction
Lai TL, Park SY, Nguyen G, Pham PT, Kang SM, Hong J, Lee JH, Im SS, Choi DH, Cho EH
Endocrinology and Metabolism 2024
Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies
Di X, Li Y, Wei J, Li T, Liao B
Advanced Science 2024
Pathological Microenvironment‐Remodeling Nanoparticles to Alleviate Liver Fibrosis: Reversing Hepatocytes‐Hepatic Stellate Cells Malignant Crosstalk
Zhang L, Deng W, Wang X, Huang Q, Liang S, Ding Z, Qi L, Wang Y, Zhou T, Xing L, Lee J, Oh Y, Jiang H
Advanced Science 2024
Evaluation of liver fibrosis in HCV-infected patients using two-dimensional shear-wave elastography (2D-SWE) before and after antiviral treatment
Inglot M, Pozowski P, Misiak P, Fleischer-Stępniewska K, Lewandowski Ł, Bilski M, Zaleska-Dorobisz U
Journal of Ultrasonography 2024
Sinusoidal communication in chronic liver disease
Gibert-Ramos A, Andrés-Rozas M, Pastó R, Alfaro-Retamero P, Guixé-Muntet S, Gracia-Sancho J
Clinical and Molecular Hepatology 2024
PR/SET domain 1 targeting glutathione peroxidase 4 regulates chronic hepatitis B liver fibrosis through ferroptosis
Wu W, Ke W, Shi W, Lin T, Lin S, Lin M, Ma H, Gao H
CytoJournal 2024
Sphingosine Kinase 1 – A Therapeutic Opportunity for Alleviating Liver Fibrosis?
Teo JM, Ling GS
Cellular and Molecular Gastroenterology and Hepatology 2024
A comprehensive evaluation system for ultrasound-guided infusion of human umbilical cord-derived MSCs in liver cirrhosis patients
Zhou G, You Y, Wang B, Wang S, Feng T, Lai C, Xiang G, Yang K, Yao Y
Stem Cells Translational Medicine 2024
Neutrophil extracellular traps promote MASH fibrosis by metabolic reprogramming of HSC
Xia Y, Wang Y, Xiong Q, He J, Wang H, Islam M, Zhou X, Kim A, Zhang H, Huang H, Tsung A
Hepatology (Baltimore, Md.) 2024
Serine metabolism in aging and age-related diseases
Shan S, Hoffman JM
GeroScience 2024
Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH
Mucinski JM, Salvador AF, Moore MP, Fordham TM, Anderson JM, Shryack G, Cunningham R, Lastra G, Gaballah AH, Diaz-Arias A, Ibdah JA, Rector RS, Parks EJ
Journal of hepatology 2024
Stem cell exosomes: new hope and future potential for relieving liver fibrosis
Li L, Liu Y, Wang K, Mo J, Weng Z, Jiang H, Jin C
Clinical and Molecular Hepatology 2024
Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma
Nishimura S, Linares JF, L\u2019Hermitte A, Duran A, Cid-Diaz T, Martinez-Ordoñez A, Ruiz-Martinez M, Kudo Y, Marzio A, Heikenwalder M, Roberts LR, Diaz-Meco MT, Moscat J
Molecular cell 2024
Serum ECM1 is a promising biomarker for staging and monitoring fibrosis in patients with chronic hepatitis B.
Liu L, Zhang D, Fan R, Cheng S, Yang J, Ma L, Ling Z, Zhang Y, Hou J, Wang X, Sun B, Niu J
Science China. Life sciences 2024
Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose
Tung HC, Kim JW, Zhu J, Li S, Yan J, Liu Q, Koo I, Koshkin SA, Hao F, Zhong G, Xu M, Wang Z, Wang J, Huang Y, Xi Y, Cai X, Xu P, Ren S, Higashiyama T, Gonzalez FJ, Li S, Isoherranen N, Yang D, Ma X, Patterson AD, Xie W
Science translational medicine 2024
Modeling Porcine NAFLD by Deletion of Leptin and defining the role of AMPK in hepatic fibrosis
Tan Tan, Zhiyuan Song, Runming Wang, Shuheng Jiang, Haitao Wang, Qi Wang, Zhigang Zhang, Xiaoxiang Hu, Ning Li, Yiming Xing
Cell & Bioscience 2023
Non-invasive Assessment of Liver Fibrosis by Serum Metabolites in Non-human Primates and Human Patients
Tianhang Feng, Chunyou Lai, Qiuyun Yuan, Wanchun Yang, Mengze Du, Jin Shang, Sijia Wang, Ying Shi, Qinyan Yang, Yutong Yao, Xiaolun Huang
iScience 2023
CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis
Michal Segal-Salto, Neta Barashi, Raanan Greenman, Avi Katav, Omer Levi, Johnny Amer, Ahmad Salhab, Rifaat Safadi, Yaakov Maor, Andrew Hall, Francesca Saffioti, Massimo Pinzani, Douglas Thorburn, Ophir Hay, Inbal Mishalian, Devorah Olam, Amnon Peled, Adi Mor
JCI Insight 2023
The inhibition of YAP signaling prevents chronic biliary fibrosis in the Abcb4-/- model by modulation of hepatic stellate cell and bile duct epithelium cell pathophysiology
Liangtao Ye, Andreas Ziesch, Julia Schneider, Andrea Ofner, Hanno Nieß, Gerald Denk, Simon Hohenester, Doris Mayr, Ujjwal Mahajan, Stefan Munker, Najib Khaled, Ralf Wimmer, Alexander Gerbes, Julia Mayerle, Yulong He, Andreas Geier, Enrico Toni, Changhua Zhang, Florian Reiter
Aging and disease 2023
Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model
Cahill T, da Silveira WA, Renaud L, Wang H, Williamson T, Chung D, Chan S, Overton I, Hardiman G
Scientific Reports 2023
Metabolic Role of Autophagy in the Pathogenesis and Development of NAFLD.
An L, Wirth U, Koch D, Schirren M, Drefs M, Koliogiannis D, Niess H, Andrassy J, Guba M, Bazhin AV, Werner J, Kühn F
Metabolites 2023
The Resolvin D2-GPR18 Axis Enhances Bone Marrow Function and Limits Hepatic Fibrosis in Aging
Hannah Fitzgerald, Jesse Bonin, Sudeshna Sadhu, Masharh Lipscomb, Nirupam Biswas, Christa Decker, Melisande Nabage, Ramon Bossardi, Michael Marinello, Hebe Agustina Mena, Kurrim Gilliard, Matthew Spite, Alejandro Adam, Katherine MacNamara, Gabrielle Fredman
The American Journal of Pathology 2023
Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis
Li L, Zhu Z
Frontiers in pharmacology 2023
Iron as a therapeutic target in chronic liver disease
Kouroumalis E, Tsomidis I, Voumvouraki A
World Journal of Gastroenterology 2023
Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling
Kim HJ, Kim G, Chi KY, Kim H, Jang YJ, Jo S, Lee J, Lee Y, Woo DH, Han C, Kim SK, Park HJ, Kim JH
Stem Cell Research & Therapy 2023
Therapeutic interventions of acute and chronic liver disorders: A comprehensive review
Ali FE, Abd El-Aziz MK, Sharab EI, Bakr AG
World journal of hepatology 2023
Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is the Unifying Biochemical Basis of Murine Liver Fibrosis
Beyoğlu D, Huang P, Skelton-Badlani D, Zong C, Popov YV, Idle JR
Cells 2023
Regulatory T cells (Tregs) in liver fibrosis
Wu KJ, Qian QF, Zhou JR, Sun DL, Duan YF, Zhu X, Sartorius K, Lu YJ
Cell Death Discovery 2023
HIPK2 as a Novel Regulator of Fibrosis
Garufi A, Pistritto G, D\u2019Orazi G
Cancers 2023
Spatiotemporal regulation of cholangiocarcinoma growth and dissemination by peritumoral myofibroblasts in a Vcam1-dependent manner.
Tian C, Li L, Pan Q, Xu B, Li Y, Fan L, Brown A, Morrison M, Dey K, Yang JJ, Yu J, Glazer ES, Zhu L
Oncogene 2023
Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis.
Peng H, Zhong L, Cheng L, Chen L, Tong R, Shi J, Bai L
Frontiers in pharmacology 2023
A Pathogenic Role of Non-Parenchymal Liver Cells in Alcohol-Associated Liver Disease of Infectious and Non-Infectious Origin.
Kharbanda KK, Chokshi S, Tikhanovich I, Weinman SA, New-Aaron M, Ganesan M, Osna NA
Biology 2023
Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment.
Yang X, Li Q, Liu W, Zong C, Wei L, Shi Y, Han Z
Cellular & molecular immunology 2023
Peptide-Based siRNA Nanocomplexes Targeting Hepatic Stellate Cells
Lin CY, Mamani UF, Guo Y, Liu Y, Cheng K
Biomolecules 2023
Microfat exerts an anti-fibrotic effect on human hypertrophic scar via fetuin-A/ETV4 axis
Yu Q, Dai Q, Huang Z, Li C, Yan L, Fu X, Wang Q, Zhang Y, Cai L, Yang Z, Xiao R
Journal of Translational Medicine 2023
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells
Zheng W, Guan F, Xu G, Yu Y, Xiao J, Huang X
International journal of medical sciences 2023
Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy
Ma M, Wei N, Yang J, Ding T, Song A, Chen L, Zheng S, Jin H
Pharmaceutical Biology 2023
Inhibition of FGFR2 Signaling by Cynaroside Attenuates Liver Fibrosis
Meng Q, Luo L, Lei M, Chen Z, Sun Y, Chen X, Zhai Z, Zhang Y, Cao J, Su Z, Li F, Li J, Hong A, Chen X
Pharmaceuticals 2023
The Values and Perspectives of Organoids in the Field of Metabolic Syndrome.
Tan C, Ding M, Zheng YW
International journal of molecular sciences 2023
Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease.
Aasadollahei N, Rezaei N, Golroo R, Agarwal T, Vosough M, Piryaei A
EXCLI journal 2023
A Combination of an Angiotensin II Receptor and a Neprilysin Inhibitor Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation
Suzuki J, Kaji K, Nishimura N, Kubo T, Tomooka F, Shibamoto A, Iwai S, Tsuji Y, Fujinaga Y, Kitagawa K, Namisaki T, Akahane T, Yoshiji H
Biomedicines 2023
PPAR-γ Agonist GW1929 Targeted to Macrophages with Dendrimer–Graphene Nanostars Reduces Liver Fibrosis and Inflammation
Moreno-Lanceta A, Medrano-Bosch M, Simón-Codina B, Barber-González M, Jiménez W, Melgar-Lesmes P
Pharmaceutics 2023
Human Hepatic Stellate Cells: Isolation and Characterization.
Liu X, Brenner DA, Kisseleva T
Methods in molecular biology (Clifton, N.J.) 2023
Induced pluripotent stem cell-based therapies for organ fibrosis
Cheng W, Fan C, Song Q, Chen P, Peng H, Lin L, Liu C, Wang B, Zhou Z
Frontiers in Bioengineering and Biotechnology 2023
Fibroblasts—Warriors at the Intersection of Wound Healing and Disrepair
Roman J
Biomolecules 2023
Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model
Kim J, Lee C, Han J, Jeong H, Wang S, Choi YH, Jung Y
Cells 2023
Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling
Li J, Wu B, Zeng L, Lin Y, Chen Q, Wang H, An L, Zhang J, Chen S, Huang J, Zhan R, Zhang G
Frontiers in pharmacology 2023
Liver cell therapies: cellular sources and grafting strategies.
Zhang W, Cui Y, Du Y, Yang Y, Fang T, Lu F, Kong W, Xiao C, Shi J, Reid LM, He Z
Frontiers of Medicine 2023
RNA methylations in hepatic fibrosis, a gradually emerging new treatment strategy
Cheng C, Wu Y, Wang X, Xue Q, Huang Y, Liao F, Wang X, Duan Q, Miao C
Cell & Bioscience 2023
Extracellular Succinate: A Physiological Messenger and a Pathological Trigger
Wu KK
International journal of molecular sciences 2023
Oxoglaucine Suppresses Hepatic Fibrosis by Inhibiting TGFβ-Induced Smad2 Phosphorylation and ROS Generation
Azamov B, Lee KM, Hur J, Muradillaeva S, Shim WS, Lee C, Song P
Molecules (Basel, Switzerland) 2023
Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets.
Di X, Gao X, Peng L, Ai J, Jin X, Qi S, Li H, Wang K, Luo D
Signal Transduction and Targeted Therapy 2023
Administration of AG490 decreases the senescence of umbilical cord-mesenchymal stem cells and promotes the cytotherapeutic effect in liver fibrosis.
Jiang C, Chen H, Kang Y, He X, Huang J, Lu T, Sui X, Chen H, Xiao J, Zhang J, Zhang H, Zheng J, Yang Y, Yao J, Cai J, Zhang Y
Cell Death Discovery 2023
The Current Proceedings of PSC-Based Liver Fibrosis Therapy.
Ma L, Wu Q, Tam PK
Stem Cell Reviews and Reports 2023
The 3Rs in Experimental Liver Disease.
Martinez-Lopez S, Angel-Gomis E, Sanchez-Ardid E, Pastor-Campos A, Picó J, Gomez-Hurtado I
2023
EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs
Rubio K, Molina-Herrera A, Pérez-González A, Hernández-Galdámez HV, Piña-Vázquez C, Araujo-Ramos T, Singh I
International journal of molecular sciences 2023
Integrative Transcriptomic Analysis Reveals Upregulated Apoptotic Signaling in Wound-Healing Pathway in Rat Liver Fibrosis Models
Kim J, Lee C, Noh SG, Kim S, Chung HY, Lee H, Moon JO
Antioxidants 2023
In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and Limitations.
Lee YS, Seki E
Cellular and Molecular Gastroenterology and Hepatology 2023
KLF10 Inhibits TGF-β-Mediated Activation of Hepatic Stellate Cells via Suppression of ATF3 Expression.
Hwang S, Park S, Yaseen U, Lee HJ, Cha JY
International journal of molecular sciences 2023
Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation
Li W, Zhu S, Liu J, Liu Z, Zhou H, Zhang Q, Yang Y, Chen L, Guo X, Zhang T, Meng L, Chai D, Tang G, Li X, Yang C
Molecules (Basel, Switzerland) 2023
Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments
Petagine L, Zariwala MG, Patel VB
World Journal of Gastroenterology 2023
Patterns of IgA Autoantibody Generation, Inflammatory Responses and Extracellular Matrix Metabolism in Patients with Alcohol Use Disorder
Niemelä O, Bloigu A, Bloigu R, Nivukoski U, Kultti J, Pohjasniemi H
International journal of molecular sciences 2023
FOXC2-AS1/FOXC2 axis mediates matrix stiffness-induced trans-differentiation of hepatic stellate cells into fibrosis-promoting myofibroblasts
Sun L, Li Y, Wang H, Xiao X, Luo X, Yang R, Li J, Ma Y, Liu Q, Tu K, Shi Y
International journal of biological sciences 2023
Single‐cell RNA sequencing reveals the heterogeneity and intercellular communication of hepatic stellate cells and macrophages during liver fibrosis
Cheng S, Zou Y, Zhang M, Bai S, Tao K, Wu J, Shi Y, Wu Y, Lu Y, He K, Sun P, Su X, Hou S, Han B
2023
Correlation between SDF-1α, CD34 positive hematopoietic stem cells and CXCR4 expression with liver fibrosis in CCl4 rat model.
Abubakr S, Hazem NM, Sherif RN, Elhawary AA, Botros KG
BMC Gastroenterology 2023
Chronic Liver Disease - What's New?
Effandie E, Gupte GL
The Indian Journal of Pediatrics 2023
Non-Anticoagulant Activities of Low Molecular Weight Heparins—A Review
Feng K, Wang K, Zhou Y, Xue H, Wang F, Jin H, Zhao W
Pharmaceuticals 2023
Isolation and Biological Evaluation of Alfa-Mangostin as Potential Therapeutic Agents against Liver Fibrosis
Liao YJ, Lee CY, Twu YC, Suk FM, Lai TC, Chang YC, Lai YC, Yuan JW, Jhuang HM, Jian HR, Huang LC, Chen KP, Hsu MH
Bioengineering 2023
Senescent Cells: Dual Implications on the Retinal Vascular System
Habibi-Kavashkohie MR, Scorza T, Oubaha M
Cells 2023
Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases
Sarrand J, Soyfoo MS
International journal of molecular sciences 2023
Research Progress on the Role and Mechanism of IL-37 in Liver Diseases
Jiang B, Zhou Y, Liu Y, He S, Liao B, Peng T, Yao L, Qi L
Seminars in liver disease 2023
Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice
Luo S, Zhao X, Jiang J, Deng B, Liu S, Xu H, Tan Q, Chen Y, Zhang Z, Pan X, Wan R, Chen X, Yao Y, Li J
Theranostics 2023
Hepatic β-arrestins: potential roles in liver health and disease.
Eissa AM, Hassanin MH, Ibrahim IAAEH
Molecular Biology Reports 2023
Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma
Manfredi GF, Celsa C, John C, Jones C, Acuti N, Scheiner B, Fulgenzi CA, Korolewicz J, Pinter M, Gennari A, Mauri FA, Pirisi M, Minisini R, Vincenzi F, Burlone M, Rigamonti C, Donadon M, Cabibbo G, D\u2019Alessio A, Pinato DJ
Journal of Hepatocellular Carcinoma 2023
The Roles of NFR2-Regulated Oxidative Stress and Mitochondrial Quality Control in Chronic Liver Diseases
Park JS, Rustamov N, Roh YS
Antioxidants 2023
A Critical Analysis of the FDA’s Omics-Driven Pharmacodynamic Biomarkers to Establish Biosimilarity
Niazi SK
Pharmaceuticals 2023
Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammation and TGF-β1-mediated HSC Activation
Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang W, Brashear W, Dai Y, Li S, Sun Y, Qi Y, Guo S
Cellular and Molecular Gastroenterology and Hepatology 2023
The Origin and Fate of Liver Myofibroblasts
Kim HY, Sakane S, Eguileor A, Carvalho Gontijo Weber R, Lee W, Liu X, Lam K, Ishizuka K, Rosenthal SB, Diggle K, Brenner DA, Kisseleva T
Cellular and Molecular Gastroenterology and Hepatology 2023
Targeting necroptosis in fibrosis
Hassanein EH, Ibrahim IM, Abd El-Maksoud MS, Abd El-Aziz MK, Abd-alhameed EK, Althagafy HS
Molecular Biology Reports 2023
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis.
Hosseinzadeh A, Pourhanifeh MH, Amiri S, Sheibani M, Irilouzadian R, Reiter RJ, Mehrzadi S
Pharmacological reports : PR 2023
MiRNAs in Alcohol-Related Liver Diseases and Hepatocellular Carcinoma: A Step toward New Therapeutic Approaches?
Jouve M, Carpentier R, Kraiem S, Legrand N, Sobolewski C
Cancers 2023
Programmed cell death in hepatic fibrosis: current and perspectives.
Lu JL, Yu CX, Song LJ
Cell Death Discovery 2023
Redox Biology and Liver Fibrosis
Bellanti F, Mangieri D, Vendemiale G
International journal of molecular sciences 2023
Evaluation of the Ethanolic Leaf Extract of Abutilon indicum on Isonicotinic Acid Hydrazide-Induced Proinflammatory Marker Gene Expression Changes.
Sunil M, Vedavijaya T, Thakur RS, Sree P K, Ramana Yella V, Babu Sayana S
Cureus 2023
Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis.
Zhao Y, Dai E, Dong L, Yuan J, Zhao Y, Wu T, Kong R, Li M, Wang S, Zhou L, Yang Y, Kong H, Zhao Y, Qu H
Frontiers in Molecular Biosciences 2023
Ablation of DGKα facilitates α-smooth muscle actin expression via the Smad and PKCδ signaling pathways during the acute phase of CCl(4) -induced hepatic injury.
Seino K, Nakano T, Tanaka T, Hozumi Y, Topham MK, Goto K, Iseki K
FEBS Open Bio 2023
Effects of neddylation on viral infection: an overview.
Kayesh MEH, Kohara M, Tsukiyama-Kohara K
Archives of Virology 2023
Metabolomics in chronic hepatitis C: Decoding fibrosis grading and underlying pathways.
Ferrasi AC, Lima SVG, Galvani AF, Delafiori J, Dias-Audibert FL, Catharino RR, Silva GF, Praxedes RR, Santos DB, Almeida DTM, Lima EO
World journal of hepatology 2023
Forsythiaside A Activates AMP-Activated Protein Kinase and Regulates Oxidative Stress via Nrf2 Signaling.
Kim YE, Bak SB, Kim MJ, Bae SJ, Lee WY, Kim YW
International journal of molecular sciences 2023
Mmp2 Deficiency Leads to Defective Parturition and High Dystocia Rates in Mice.
Kalev-Altman R, Becker G, Levy T, Penn S, Shpigel NY, Monsonego-Ornan E, Sela-Donenfeld D
International journal of molecular sciences 2023
A J-shaped relationship between body mass index and the risk of elevated liver stiffness: a cross-sectional study.
Liu Y, Yuan S, Zuo J, Liu S, Tang X, Li X, Yao D, Jin Y
European Journal of Medical Research 2023
Antioxidant therapy against TGF-β/SMAD pathway involved in organ fibrosis.
Ghafouri-Fard S, Askari A, Shoorei H, Seify M, Koohestanidehaghi Y, Hussen BM, Taheri M, Samsami M
Journal of Cellular and Molecular Medicine 2023
HCV and HCC Tango-Deciphering the Intricate Dance of Disease: A Review Article.
Milosevic I, Todorovic N, Filipovic A, Simic J, Markovic M, Stevanovic O, Malinic J, Katanic N, Mitrovic N, Nikolic N
International journal of molecular sciences 2023
A Novel Bioswitchable miRNA Mimic Delivery System: Therapeutic Strategies Upgraded from Tetrahedral Framework Nucleic Acid System for Fibrotic Disease Treatment and Pyroptosis Pathway Inhibition.
Jiang Y, Li S, Shi R, Yin W, Lv W, Tian T, Lin Y
2023
Liver fibrosis classification from ultrasound using machine learning: a systematic literature review.
Punn NS, Patel B, Banerjee I
2023
Role of macrophage-to-myofibroblast transition in chronic liver injury and liver fibrosis.
Xia S, Huang Y, Zhang Y, Zhang M, Zhao K, Han P, Tian D, Liao J, Liu J
European Journal of Medical Research 2023
Inhibition of integrin binding to ligand arg-gly-asp motif induces AKT-mediated cellular senescence in hepatic stellate cells.
Kitsugi K, Noritake H, Matsumoto M, Hanaoka T, Umemura M, Yamashita M, Takatori S, Ito J, Ohta K, Chida T, Ulmasov B, Neuschwander-Tetri BA, Suda T, Kawata K
Molecular and Cellular Biochemistry 2023
The Influence of Hepatic Steatosis and Fibrosis on Postoperative Outcomes After Major Liver Resection of Perihilar Cholangiocarcinoma.
van Keulen AM, Olthof PB, Buettner S, Bednarsch J, Verheij J, Erdmann JI, Nooijen LE, Porte RJ, Minnee RC, Murad SD, Neumann UP, Heij L, Groot Koerkamp B, Doukas M
Annals of Surgical Oncology 2023
Metabolomic Phenotype of Hepatic Steatosis and Fibrosis in Mexican Children Living with Obesity.
Garibay-Nieto N, Pedraza-Escudero K, Omaña-Guzmán I, Garcés-Hernández MJ, Villanueva-Ortega E, Flores-Torres M, Pérez-Hernández JL, León-Hernández M, Laresgoiti-Servitje E, Palacios-González B, López-Alvarenga JC, Lisker-Melman M, Vadillo-Ortega F
2023
The Impressive Anti-Inflammatory Activity of Cerium Oxide Nanoparticles: More than Redox?
Corsi F, Deidda Tarquini G, Urbani M, Bejarano I, Traversa E, Ghibelli L
2023
Hepatic stellate cell-intrinsic role of SOCS1 in controlling hepatic fibrogenic response and the pro-inflammatory macrophage compartment during liver fibrosis.
Kandhi R, Yeganeh M, Yoshimura A, Menendez A, Ramanathan S, Ilangumaran S
Frontiers in immunology 2023
Exosomes: Potential Next-Generation Nanocarriers for the Therapy of Inflammatory Diseases.
Mori T, Giovannelli L, Bilia AR, Margheri F
Pharmaceutics 2023
Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets.
Massemin A, Goehrig D, Flaman JM, Jaber S, Griveau A, Djebali S, Marcos E, Payen L, Marvel J, Parent R, Adnot S, Bertolino P, Rieusset J, Tortereau A, Vindrieux D, Bernard D
Aging Cell 2023
Lycopene improves autophagy and attenuates carbon tetrachloride-induced hepatic fibrosis in rats.
Li W, Jiang Y, Yu TT, Hao W, Wang G
Croatian medical journal 2023
Using Pre-Clinical Studies to Explore the Potential Clinical Uses of Exosomes Secreted from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem cells.
Zhou AK, Jou E, Lu V, Zhang J, Chabra S, Abishek J, Wong E, Zeng X, Guo B
Tissue Engineering and Regenerative Medicine 2023
Therapeutic Effect of Prolyl Endopeptidase Inhibitor in High-fat Diet-induced Metabolic Dysfunction-associated Fatty Liver Disease.
Zhang JB, Li MT, Lin SZ, Cheng YQ, Fan JG, Chen YW
Journal of Clinical and Translational Hepatology 2023
LIGHT (TNFSF14) promotes the differentiation of human bone marrow-derived mesenchymal stem cells into functional hepatocyte-like cells.
Heo SK, Yu HM, Kim DK, Seo HJ, Shin Y, Kim SA, Kim M, Kim Y, Lee YJ, Noh EK, Jo JC
PloS one 2023
An update on liver chemical exchange saturation transfer imaging with a focus on clinical translation.
Wáng YXJ, Dou W, Shen Z, Zhang Y
Quantitative imaging in medicine and surgery 2023
Assessment of hepatic function employing hepatocyte specific contrast agent concentrations to multifactorially evaluate fibrotic remodeling.
Breit HC, Vosshenrich J, Heye T, Gehweiler J, Winkel DJ, Potthast S, Merkle EM, Boll DT
Quantitative imaging in medicine and surgery 2023
Melatonin and metformin co-loaded nanoliposomes efficiently attenuate liver damage induced by bile duct ligation in rats.
Barmoudeh Z, Fouani MH, Moslemi Z, Azizi M, Doustimotlagh AH, Bardania H
Naunyn-Schmiedeberg's Archives of Pharmacology 2023
Mangiferin for the Management of Liver Diseases: A Review.
Li L, Dong Y, Liu X, Wang M
2023
Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation.
Hammad S, Ogris C, Othman A, Erdoesi P, Schmidt-Heck W, Biermayer I, Helm B, Gao Y, Piorońska W, Holland CH, D'Alessandro LA, de la Torre C, Sticht C, Al Aoua S, Theis FJ, Bantel H, Ebert MP, Klingmüller U, Hengstler JG, Dooley S, Mueller NS
Cell Death and Disease 2023
Diagnostic potential and pathogenic performance of circulating miR-146b, miR-194, and miR-214 in liver fibrosis.
Aghajanzadeh T, Talkhabi M, Zali MR, Hatami B, Baghaei K
Non-coding RNA Research 2023
Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation.
Di Fazio P, Mielke S, Böhm IT, Buchholz M, Matrood S, Schuppan D, Wissniowski T
BMJ Open Gastroenterology 2023
The possible role of Helicobacter pylori in liver diseases.
Mohammadi M, Attar A, Mohammadbeigi M, Peymani A, Bolori S, Fardsanei F
Archives of Microbiology 2023
A Hierarchical Siamese Network for Noninvasive Staging of Liver Fibrosis Based on US Image Pairs of the Liver and Spleen.
Wang X, Song L, Zhuang Y, Han L, Chen K, Lin J, Luo Y
Sensors (Basel, Switzerland) 2023
Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway.
Yao J, Zhao Y
PeerJ 2023
Comprehensive analysis of KLF2 as a prognostic biomarker associated with fibrosis and immune infiltration in advanced hepatocellular carcinoma.
Chen XQ, Ma J, Xu D, Xiang ZL
BMC bioinformatics 2023
N6-methyladenosine RNA methylation in liver diseases: from mechanism to treatment.
Yang L, Tian S, Zheng X, Zhang M, Zhou X, Shang Y, Han Y
Journal of Gastroenterology 2023
The Influence of Sex Hormones in Liver Function and Disease.
Kasarinaite A, Sinton M, Saunders PTK, Hay DC
Cells 2023
Effects of Nelumbonucifera Gaertn. Petal Tea Extract on Hepatotoxicity and Oxidative Stress Induced by Mancozeb in Rat Model.
Nuchniyom P, Intui K, Laoung-On J, Jaikang C, Quiggins R, Photichai K, Sudwan P
Toxics 2023
Hematological Abnormalities in Cirrhosis: A Narrative Review.
Lingas EC
Cureus 2023
Dendropanoxide Alleviates Thioacetamide-induced Hepatic Fibrosis via Inhibition of ROS Production and Inflammation in BALB/(C) Mice.
Kundu A, Gali S, Sharma S, Kacew S, Yoon S, Jeong HG, Kwak JH, Kim HS
International journal of biological sciences 2023
Mulberroside A ameliorates CCl4-induced liver fibrosis in mice via inhibiting pro-inflammatory response.
Shi B, Qian J, Miao H, Zhang S, Hu Y, Liu P, Xu L
Food Science & Nutrition 2023
M6P-modified solid lipid nanoparticles loaded with matrine for the treatment of fibrotic liver.
Tan X, Hao Y, Ma N, Yang Y, Jin W, Meng Y, Zhou C, Zheng W, Zhang Y
Drug Delivery 2023
PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction.
Gou Y, Wang L, Zhao J, Xu X, Xu H, Xie F, Wang Y, Feng Y, Zhang J, Zhang Y
International journal of molecular sciences 2023
Chromatographic Scalable Method to Isolate Engineered Extracellular Vesicles Derived from Mesenchymal Stem Cells for the Treatment of Liver Fibrosis in Mice.
Domínguez LM, Bueloni B, Cantero MJ, Albornoz M, Pacienza N, Biani C, Luzzani C, Miriuka S, García M, Atorrasagasti C, Yannarelli G, Bayo J, Fiore E, Mazzolini G
International journal of molecular sciences 2023
Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration.
Rodimova S, Mozherov A, Elagin V, Karabut M, Shchechkin I, Kozlov D, Krylov D, Gavrina A, Bobrov N, Zagainov V, Zagaynova E, Kuznetsova D
International journal of molecular sciences 2023
Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways.
Chen P, Wang R, Liu F, Li S, Gu Y, Wang L, Yuan Y
Frontiers in pharmacology 2023
MicroRNA-29a-3p prevents Schistosoma japonicum-induced liver fibrosis by targeting Roundabout homolog 1 in hepatic stellate cells.
Kong H, Song Q, Hu W, Guo S, Xiang D, Huang S, Xu X, He J, Pan L, Tao R, Yu H, Huang J
Parasites & vectors 2023
The SLIT/ROBO Pathway in Liver Fibrosis and Cancer.
Basha S, Jin-Smith B, Sun C, Pi L
Biomolecules 2023
Does High-Intensity Exercise Cause Acute Liver Injury in Patients with Fontan Circulation? A Prospective Pilot Study.
Gumm A, Ginde S, Hoffman G, Liegl M, Mack C, Simpson P, Vo N, Telega G, Vitola B, Chugh A
Pediatric Cardiology 2023
Anti-Fibrotic Effects of DL-Glyceraldehyde in Hepatic Stellate Cells via Activation of ERK-JNK-Caspase-3 Signaling Axis.
Samsuzzaman M, Kim SY
Biomolecules & therapeutics 2023
Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial-mesenchymal transition.
Liu J, Xia S, Han P, Zhang M, Wu J, Liao J
2023
Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway.
Wei Y, Gao C, Wang H, Zhang Y, Gu J, Zhang X, Gong X, Hao Z
Journal of Animal Science and Biotechnology 2023
Fuzheng Huayu preparation (/) combined with tenofovir disoproxil fumarate on hepatitis B: a systematic review and Meta-analysis.
Junli Z, Ying HE, Xia Z, Hongfang FU, Xiaoyu HU
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023
Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role of Hepatoma-Derived Growth Factor, HIV, and Ethanol.
New-Aaron M, Koganti SS, Ganesan M, Kanika S, Kumar V, Wang W, Makarov E, Kharbanda KK, Poluektova LY, Osna NA
International journal of molecular sciences 2023
The Expanding Phenotype of ZTTK Syndrome Due to the Heterozygous Variant of SON Gene Focusing on Liver Involvement: Patient Report and Literature Review.
Pietrobattista A, Della Volpe L, Francalanci P, Figà Talamanca L, Monti L, Lepri FR, Basso MS, Liccardo D, Della Corte C, Mosca A, Alterio T, Veraldi S, Callea F, Novelli A, Maggiore G
Genes & development 2023
The Role of Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitors in The Attenuation of CCl(4)-Induced Liver Fibrosis in Rats.
Ghobrial DK, El-Nikhely N, Sheta E, Ragab HM, Rostom SAF, Saeed H, Wahid A
2023
Predicting Post-hepatectomy Liver Failure Preoperatively for Child-Pugh A5 Hepatocellular Carcinoma Patients by Liver Stiffness.
Huang J, Long H, Peng J, Zhong X, Shi Y, Xie X, Kuang M, Lin M
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2023
Serum MFAP4, a novel potential biomarker for liver cirrhosis screening, correlates with transient elastography in NAFLD patients.
Kanaan R, Yaghi C, Saade Riachy C, Schlosser A, Hamade A, Holmskov U, Medlej-Hashim M, Sørensen GL, Jounblat R
2023
Liver Assessment in Patients with Ataxia-Telangiectasia: Transient Elastography Detects Early Stages of Steatosis and Fibrosis.
Donath H, Wölke S, Knop V, Heß U, Duecker RP, Trischler J, Poynard T, Schubert R, Zielen S
Canadian journal of gastroenterology & hepatology 2023
LncRNA-MIAT activates hepatic stellate cells via regulating Hippo pathway and epithelial-to-mesenchymal transition.
Zhan Y, Tao Q, Meng Q, Zhang R, Lin L, Li X, Zheng L, Zheng J
Communications biology 2023
Relationship between the Mediterranean diet and risk of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A cross-sectional analysis of the RaNCD cohort.
Miryan M, Darbandi M, Moradi M, Najafi F, Soleimani D, Pasdar Y
Frontiers in Nutrition 2023
Liver fibrosis-4 score predicts outcome of patients with ischemic stroke undergoing intravenous thrombolysis.
Norata D, Lattanzi S, Broggi S, Rocchi C, Bartolini M, Silvestrini M
Frontiers in neurology 2023
Tocotrienol in the Management of Nonalcoholic Fatty Liver Disease: A Systematic Review.
Chin KY, Ekeuku SO, Chew DCH, Trias A
Nutrients 2023
Protective role of resveratrol against VCM-induced hepatotoxicity in male wistar rats.
Alshehri FS, Alorfi NM
Frontiers in pharmacology 2023
Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis.
Nokkeaw A, Thamjamrassri P, Tangkijvanich P, Ariyachet C
Cells 2023
QSM Throughout the Body.
Dimov AV, Li J, Nguyen TD, Roberts AG, Spincemaille P, Straub S, Zun Z, Prince MR, Wang Y
Journal of magnetic resonance imaging : JMRI 2023
Gut Lactobacillus and Probiotics Lactobacillus lactis/rhamnosis Ameliorate Liver Fibrosis in Prevention and Treatment.
Won SM, Lee NY, Oh KK, Gupta H, Sharma SP, Kim KH, Kim BK, Joung HC, Jeong JJ, Ganesan R, Han SH, Yoon SJ, Kim DJ, Suk KT
The Journal of Microbiology 2023
The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells.
Bachtler N, Torres S, Ortiz C, Schierwagen R, Tyc O, Hieber C, Berres ML, Meier C, Kraus N, Zeuzem S, Nijmeijer B, Pronk S, Trebicka J, Klein S
PloS one 2023
Regulators, functions, and mechanotransduction pathways of matrix stiffness in hepatic disease.
Guo T, Wantono C, Tan Y, Deng F, Duan T, Liu D
Frontiers in physiology 2023
Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism.
Zhang Z, Shang J, Yang Q, Dai Z, Liang Y, Lai C, Feng T, Zhong D, Zou H, Sun L, Su Y, Yan S, Chen J, Yao Y, Shi Y, Huang X
Journal of nanobiotechnology 2023
Diagnostic Efficacy of Serum Asialo α1-Acid Glycoprotein Levels for Advanced Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Compared to That in Healthy Subjects: A Prospective Study.
Lee Y, Bae S, Kim JH, Kwak M, Jeon SY, Kim T, Yim SY, Lee YS, Jung YK, Seo YS, Yim HJ, Yeon JE, Byun KS
Journal of Clinical Medicine 2023
Pre-clinical evidence of a dual NADPH oxidase 1/4 inhibitor (setanaxib) in liver, kidney and lung fibrosis.
Thannickal VJ, Jandeleit-Dahm K, Szyndralewiez C, Török NJ
Journal of Cellular and Molecular Medicine 2023
The systemic and hepatic alternative renin-angiotensin system is activated in liver cirrhosis, linked to endothelial dysfunction and inflammation.
Hartl L, Rumpf B, Domenig O, Simbrunner B, Paternostro R, Jachs M, Poglitsch M, Marculescu R, Trauner M, Reindl-Schwaighofer R, Hecking M, Mandorfer M, Reiberger T
Scientific Reports 2023
Low vitamin A levels are associated with liver-related mortality: a nationally representative cohort study
Song J, Jiang ZG
Hepatology Communications 2023
Development of an optimized, non-stem cell line for intranasal delivery of therapeutic cargo to the central nervous system.
El-Ayoubi A, Arakelyan A, Klawitter M, Merk L, Hakobyan S, Gonzalez-Menendez I, Quintanilla Fend L, Holm PS, Mikulits W, Schwab M, Danielyan L, Naumann U
Molecular Oncology 2023
The Role of Endoplasmic Reticulum Stress Response in Liver Regeneration.
Deshmukh K, Apte U
Seminars in liver disease 2023
Fibrosis severity scoring on Sirius red histology with multiple-instance deep learning.
Naik SN, Forlano R, Manousou P, Goldin R, Angelini ED
2023
FAT4 loss initiates hepatocarcinogenesis through the switching of canonical to noncanonical WNT signaling pathways.
Huang FY, Wong DK, Mak LY, Cheung TT, Zhang SS, Chau HT, Hui RW, Seto WK, Yuen MF
Hepatology Communications 2023
Curcumin Modulates NOX Gene Expression and ROS Production via P-Smad3C in TGF-β-Activated Hepatic Stellate Cells
Asadizade S, Hatami M, Salehipour Bavarsad S, Kabizade B, Shakerian E, Rashidi M
Iranian Biomedical Journal 2023
Hepatoprotective effects of paeonol by suppressing hepatic stellate cell activation via inhibition of SMAD2/3 and STAT3 pathways
Jeong HJ, Koo S, Kang YH, Kim TW, Kim HK, Park YJ
Food Science and Biotechnology 2023
Implication of Hypotension in the Pathogenesis of Cognitive Impairment and Brain Injury in Chronic Liver Disease.
L'Écuyer S, Charbonney E, Carrier FM, Rose CF
Neurochemical Research 2023
Inpatient Outcomes of Cirrhosis-related Cachexia in the United States.
Alabbas M, Chaar A, Gibson CA, Mohamad Alahmad MA
2023
Formation and Investigation of Cell‐Derived Nanovesicles as Potential Therapeutics against Chronic Liver Disease
Ganguin AA, Skorup I, Streb S, Othman A, Luciani P
Advanced Healthcare Materials 2023
Identification and validation of plasma AGRN as a novel diagnostic biomarker of hepatitis B Virus-related chronic hepatitis and liver fibrosis/cirrhosis.
Ai R, Li L, Yuan X, Zhao D, Miao T, Guan W, Dong S, Dong C, Dou Y, Hou M, Nan Y
Histology and histopathology 2023
Fibroblasts in liver cancer: functions and therapeutic translation
Affo S, Filliol A, Gores GJ, Schwabe RF
The lancet. Gastroenterology & hepatology 2023
Unique Estrogen-Sensitive Fibroblast Population Drives Abdominal Muscle Fibrosis in an Inguinal Hernia Mouse Model
Tanvi Potluri, Matthew J. Taylor, Jonah Stulberg, Richard L Lieber, Hong Zhao, Serdar E Bulun
JCI Insight 2022
TGF-β1 regulates peroxisomal genes/proteins via Smad signaling in IPF fibroblasts and transgenic mouse models
Gani Oruqaj, Srikanth Karnati, Lakshmi Kotarkonda, Eistine Boateng, Marek Bartkuhn, Wenming Zhang, Clemens Ruppert, Andreas Günther, Laurent Bartholin, Wei Shi, Eveline Baumgart-Vogt
The American Journal of Pathology 2022
Cell-to-Cell Communications in Alcohol-Associated Liver Disease
N Osna, A Eguchi, A Feldstein, H Tsukamoto, R Dagur, M Ganesan, M New-Aaron, M Arumugam, S Chava, M Ribeiro, G Szabo, S Mueller, S Wang, C Chen, S Weinman, K Kharbanda
Frontiers in physiology 2022
Antibody-drug conjugates targeting CD248 inhibits liver fibrosis through specific killing on myofibroblasts
S Liu, D Han, C Xu, F Yang, Y Li, K Zhang, X Zhao, J Zhang, T Lu, S Lu, C Shi, R Zhang, A Yang, A Zhao, W Qin, B Yang, W Wen
Molecular Medicine 2022
Nanotechnology in Drug Delivery for Liver Fibrosis
L Gu, F Zhang, J Wu, Y Zhuge
Frontiers in Molecular Biosciences 2022
Receptor-interacting protein kinase-1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms
M Farooq, M Eugénio, C Piquet-Pellorce, S Dion, C Raguenes-Nicol, K Santamaria, G Kara-Ali, T Larcher, M Dimanche-Boitrel, M Samson, J Seyec
Journal of Molecular Medicine 2022
Inflammation and Cancer: From the Development of Personalized Indicators to Novel Therapeutic Strategies
P Ballerini, A Contursi, A Bruno, M Mucci, S Tacconelli, P Patrignani
Frontiers in pharmacology 2022
Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells
K Kim, T Admasu, A Stolzing, A Sharma
Aging 2022
Nucleic acid biomarkers to assess graft injury after liver transplantation
E Bardhi, J McDaniels, T Rousselle, D Maluf, V Mas
2022
Galectin 1—A Key Player between Tissue Repair and Fibrosis
Hermenean A, Oatis D, Herman H, Ciceu A, D\u2019Amico G, Trotta MC
International journal of molecular sciences 2022
Risk of liver fibrosis in patients with prediabetes and diabetes mellitus
Park J, Kwon HJ, Sohn W, Cho JY, Park SJ, Chang Y, Ryu S, Kim BI, Cho YK
PloS one 2022
De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet
Winkler S, Winkler I, Figaschewski M, Tiede T, Nordheim A, Kohlbacher O
BMC bioinformatics 2022
Research Progress of Fibroblast Growth Factor 21 in Fibrotic Diseases
Jia MQ, Guan CX, Tao JH, Zhou Y
Oxidative medicine and cellular longevity 2022
Dihydromyricetin-Encapsulated Liposomes Inhibit Exhaustive Exercise-Induced Liver Inflammation by Orchestrating M1/M2 Macrophage Polarization
Zhou X, Yi L, Lang H, Zhang J, Zhang Q, Yu L, Zhu J, Mi M
Frontiers in pharmacology 2022
In vivo assessment of mechanical properties during axolotl development and regeneration using confocal Brillouin microscopy
Riquelme-Guzmán C, Beck T, Edwards-Jorquera S, Schlüßler R, Müller P, Guck J, Möllmert S, Sandoval-Guzmán T
Open Biology 2022
Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity.
Han X, Ding C, Ning Y, Shan Q, Niu M, Cai H, Xu P, Cao G
Frontiers in Nutrition 2022
Mesenchymal Stromal/Stem Cells and Their Extracellular Vesicles Application in Acute and Chronic Inflammatory Liver Diseases: Emphasizing on the Anti-Fibrotic and Immunomodulatory Mechanisms
Hazrati A, Malekpour K, Soudi S, Hashemi SM
Frontiers in immunology 2022
Roles of NRF2 in Fibrotic Diseases: From Mechanisms to Therapeutic Approaches
Hao W, Li M, Cai Q, Wu S, Li X, He Q, Hu Y
Frontiers in physiology 2022
The Role of Macrophages in Liver Fibrosis: New Therapeutic Opportunities
Binatti E, Gerussi A, Barisani D, Invernizzi P
International journal of molecular sciences 2022
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin
Qin L, Liu N, Bao CL, Yang DZ, Ma GX, Yi WH, Xiao GZ, Cao HL
Acta Pharmacologica Sinica 2022
Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma
Dai Q, Ain Q, Rooney M, Song F, Zipprich A
Frontiers in Oncology 2022
Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation
Guo R, Jia X, Ding Z, Wang G, Jiang M, Li B, Chen S, Xia B, Zhang Q, Liu J, Zheng R, Gao Z, Xie X
Theranostics 2022
Emerging Roles of the Iron Chelators in Inflammation
Di Paola A, Tortora C, Argenziano M, Marrapodi MM, Rossi F
International journal of molecular sciences 2022
Characterization and Roles of Membrane Lipids in Fatty Liver Disease
Welch M, Secunda C, Ghimire N, Martinez I, Mathus A, Patel U, Bhogoju S, Al-Mutairi M, Min K, Lawan A
Membranes 2022
Wound healing, fibroblast heterogeneity, and fibrosis
Talbott HE, Mascharak S, Griffin M, Wan DC, Longaker MT
Cell Stem Cell 2022
Pituitary Tumor-Transforming Gene 1/Delta like Non-Canonical Notch Ligand 1 Signaling in Chronic Liver Diseases.
Perramón M, Jiménez W
International journal of molecular sciences 2022
Treatment of Liver Fibrosis: A 20-Year Bibliometric and Knowledge-Map Analysis
Dai YK, Zhao ZM, Liu C
Frontiers in pharmacology 2022
Novel Insights into Alcoholic Liver Disease: Iron Overload, Iron Sensing and Hemolysis
Mueller S, Chen C, Mueller J, Wang S
Journal of Translational Internal Medicine 2022
Multiple functions of MLKL in liver fibrosis, from necroptosis to hepatic stellate cell activation
Pistorio V, Housset C, Gautheron J
Theranostics 2022
Transient Receptor Potential Vanilloid-1 (TRPV1) Alleviates Hepatic Fibrosis via TGF-β Signaling.
Qian K, Lei X, Liu G, Fang Y, Xie C, Wu X, Liu Q, Liu G, Cao Z, Zhang J, Kuang T, Yan L, Fu J, Du H, Liu Z, Chu Y, Xu G, Yamamoto H, Mori M, Liang XM, Xu X
Disease Markers 2022
Computational simulation of liver fibrosis dynamics
Yoshizawa M, Sugimoto M, Tanaka M, Sakai Y, Nishikawa M
Scientific Reports 2022
MicroRNA-223 Suppresses Human Hepatic Stellate Cell Activation Partly via Regulating the Actin Cytoskeleton and Alleviates Fibrosis in Organoid Models of Liver Injury
Ariyachet C, Chuaypen N, Kaewsapsak P, Chantaravisoot N, Jindatip D, Potikanond S, Tangkijvanich P
International journal of molecular sciences 2022
The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications
Hung CT, Tsai YW, Wu YS, Yeh CF, Yang KC
Journal of biomedical science 2022
Granulocyte-macrophage colony-stimulating factor (GM-CSF) shows therapeutic effect on dimethylnitrosamine (DMN)-induced liver fibrosis in rats
Karmacharya MB, Hada B, Park SR, Kim KH, Choi BH
PloS one 2022
Autophagy Dysregulation in Metabolic Associated Fatty Liver Disease: A New Therapeutic Target.
Chen CL, Lin YC
International journal of molecular sciences 2022
Activated Hepatic Stellate Cells Promote the M1 to M2 Macrophage Transformation and Liver Fibrosis by Elevating the Histone Acetylation Level
Chen J, Huang X, Huang Z, Cao Y
Disease Markers 2022
Pharmacological effects of Chinese medicine modulating NLRP3 inflammasomes in fatty liver treatment
Liu T, Xu G, Liang L, Xiao X, Zhao Y, Bai Z
Frontiers in pharmacology 2022
Effects of Ion-Transporting Proteins on the Digestive System Under Hypoxia
Xiang Y, Fan D, An Q, Zhang T, Wu X, Ding J, Xu X, Yue G, Tang S, Du Q, Xu J, Xie R
Frontiers in physiology 2022
Advancements in MAFLD Modeling with Human Cell and Organoid Models
Wang SX, Yan JS, Chan YS
International journal of molecular sciences 2022
S100 Proteins in Fatty Liver Disease and Hepatocellular Carcinoma
Delangre E, Oppliger E, Berkcan S, Gjorgjieva M, Correia de Sousa M, Foti M
International journal of molecular sciences 2022
Emerging Role of Nicotinamide Riboside in Health and Diseases
Sharma C, Donu D, Cen Y
Nutrients 2022
Beneficial Effects of Milk-Derived Extracellular Vesicles on Liver Fibrosis Progression by Inhibiting Hepatic Stellate Cell Activation
Reif S, Atias A, Musseri M, Koroukhov N, Gerstl RG
Nutrients 2022
Extracellular vesicles: catching the light of intercellular communication in fibrotic liver diseases
Li Y, Wu J, Liu R, Zhang Y, Li X
Theranostics 2022
High-Throughput Glycomic Methods.
Trbojević-Akmačić I, Lageveen-Kammeijer GSM, Heijs B, Petrović T, Deriš H, Wuhrer M, Lauc G
Chemical Reviews 2022
Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair.
Wang P, Huang Z, Peng Y, Li H, Lin T, Zhao Y, Hu Z, Zhou Z, Zhou W, Liu Y, Hou FF
Nature Communications 2022
NOX as a Therapeutic Target in Liver Disease.
Matuz-Mares D, Vázquez-Meza H, Vilchis-Landeros MM
2022
Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells.
Li W, Chen JY, Sun C, Sparks RP, Pantano L, Rahman RU, Moran SP, Pondick JV, Kirchner R, Wrobel D, Bieler M, Sauer A, Ho Sui SJ, Doerner JF, Rippmann JF, Mullen AC
eLife 2022
Fibrotic Scar in CNS Injuries: From the Cellular Origins of Fibroblasts to the Molecular Processes of Fibrotic Scar Formation.
Ayazi M, Zivkovic S, Hammel G, Stefanovic B, Ren Y
Cells 2022
Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis.
Shao J, Ge T, Tang C, Wang G, Pang L, Chen Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022
Nanoparticle Delivery of Novel PDE4B Inhibitor for the Treatment of Alcoholic Liver Disease.
Ma J, Kumar V, Mahato RI
Pharmaceutics 2022
Anti-fibrotic effect of extracellular vesicles derived from tea leaves in hepatic stellate cells and liver fibrosis mice.
Gong Q, Zeng Z, Jiang T, Bai X, Pu C, Hao Y, Guo Y
Frontiers in Nutrition 2022
XSSJS inhibits hepatic fibrosis by promoting the miR-29b-3p/VEGFA axis in vitro and in vivo.
Zhang T, Yang Y, Wang B, Wang L, Wang D, Cao N, Shi J
Bioscience Reports 2022
Fibrosis and hepatic regeneration mechanism.
Zuñiga-Aguilar E, Ramírez-Fernández O
Translational Gastroenterology and Hepatology 2022
Hepatic stellate cells in physiology and pathology.
Kamm DR, McCommis KS
The Journal of Physiology 2022
Microbiome-Based Metabolic Therapeutic Approaches in Alcoholic Liver Disease.
Hyun JY, Kim SK, Yoon SJ, Lee SB, Jeong JJ, Gupta H, Sharma SP, Oh KK, Won SM, Kwon GH, Cha MG, Kim DJ, Ganesan R, Suk KT
International journal of molecular sciences 2022
Influence of Lipoxin-A4 Treatment on Cytokine, Chemokine Genes Expression, and Phenotypic Distribution of Lymphocyte Subsets During Experimental Liver Fibrosis.
Karaca ZM, Kurtoğlu EL, Gül M, Kayhan B
The Eurasian Journal of Medicine 2022
Constructing biomimetic liver models through biomaterials and vasculature engineering.
Lv W, Zhou H, Aazmi A, Yu M, Xu X, Yang H, Huang YYS, Ma L
Regenerative Biomaterials 2022
Extracellular vesicles as advanced therapeutics for the resolution of organ fibrosis: Current progress and future perspectives.
Lv K, Wang Y, Lou P, Liu S, Zhou P, Yang L, Lu Y, Cheng J, Liu J
Frontiers in immunology 2022
The Hippo signalling pathway and its implications in human health and diseases.
Fu M, Hu Y, Lan T, Guan KL, Luo T, Luo M
Signal Transduction and Targeted Therapy 2022
The role of p53 in liver fibrosis.
Yu S, Ji G, Zhang L
Frontiers in pharmacology 2022
FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2
Rao J, Wang H, Ni M, Wang Z, Wang Z, Wei S, Liu M, Wang P, Qiu J, Zhang L, Wu C, Shen H, Wang X, Cheng F, Lu L
Gut 2022
Down-regulation of hepatic expression of GHR/STAT5/IGF-1 signaling pathway fosters development and aggressiveness of HCV-related hepatocellular carcinoma: Crosstalk with Snail-1 and type 2 transforming growth factor-beta receptor
Abu El-Makarem MA, Kamel MF, Mohamed AA, Ali HA, Mohamed MR, Mohamed AE, El-Said AM, Ameen MG, Hassnine AA, Hassan HA
PloS one 2022
The case for FAT10 as a novel target in fatty liver diseases
Wimalarathne MM, Wilkerson-Vidal QC, Hunt EC, Love-Rutledge ST
Frontiers in pharmacology 2022
The Role of Tβ4-POP-Ac-SDKP Axis in Organ Fibrosis.
Wang W, Jia W, Zhang C
International journal of molecular sciences 2022
Spectral computed tomography with inorganic nanomaterials: State-of-the-art.
Li Y, Younis MH, Wang H, Zhang J, Cai W, Ni D
Advanced Drug Delivery Reviews 2022
P2X7 Receptor in Alcoholic Steatohepatitis and Alcoholic Liver Fibrosis.
Xia GQ, Fang Q, Cai JN, Li ZX, Zhang FZ, Lv XW
Journal of Clinical and Translational Hepatology 2022
Polymeric nanomedicines for the treatment of hepatic diseases.
Luo F, Yu Y, Li M, Chen Y, Zhang P, Xiao C, Lv G
Journal of nanobiotechnology 2022
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
Yan L, Zhang T, Wang K, Chen Z, Yang Y, Shan B, Sun Q, Zhang M, Zhang Y, Zhong Y, Liu N, Gu J, Xu D
Nature Communications 2022
The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury.
Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E, Brenner DA, Kisseleva T
Biology 2022
Circular RNAs in organ injury: recent development.
Wong R, Zhang Y, Zhao H, Ma D
Journal of Translational Medicine 2022
Activation of primary hepatic stellate cells and liver fibrosis induced by targeting TGF-β1/Smad signaling in schistosomiasis in mice.
Huang P, Ma H, Cao Y, Zhan T, Zhang T, Wang X, Zhang Y, Xu J, Xia C
Parasites & vectors 2022
Current Perspectives of Neuroendocrine Regulation in Liver Fibrosis
Li B, Wang H, Zhang Y, Liu Y, Zhou T, Zhou B, Zhang Y, Chen R, Xing J, He L, Salinas JM, Koyama S, Meng F, Wan Y
Cells 2022
Resident macrophages of the lung and liver: The guardians of our tissues
Kulle A, Thanabalasuriar A, Cohen TS, Szydlowska M
Frontiers in immunology 2022
Exosomes of Whartons’ jelly mesenchymal stem cell reduce the NOX genes in TGF-β-induced hepatic fibrosis
Afarin R, Behdarvand T, Shakerian E, Salehipour Bavarsad S, Rashidi M
Iranian Journal of Basic Medical Sciences 2022
NAFLD and HBV interplay - related mechanisms underlying liver disease progression
Tourkochristou E, Assimakopoulos SF, Thomopoulos K, Marangos M, Triantos C
Frontiers in immunology 2022
SARS-CoV-2-mediated liver injury: pathophysiology and mechanisms of disease.
Choaib A, Issa E, El Choueiry F, Eldin JN, Shbaklo K, Alhajj M, Sawaya RT, Assi G, Nader M, Chatila R, Faour WH
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022
Role of Oxylipins in the Inflammatory-Related Diseases NAFLD, Obesity, and Type 2 Diabetes.
Misheva M, Johnson J, McCullagh J
Metabolites 2022
Cellular Senescence in Hepatocellular Carcinoma: The Passenger or the Driver?
Cai X, Guillot A, Liu H
Cells 2022
Gemigliptin Alleviates Succinate-Induced Hepatic Stellate Cell Activation by Ameliorating Mitochondrial Dysfunction.
Nguyen G, Park SY, Do DV, Choi DH, Cho EH
2022
Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis.
Pandey SP, Bender MJ, McPherson AC, Phelps CM, Sanchez LM, Rana M, Hedden L, Sangani KA, Chen L, Shapira JH, Siller M, Goel C, Verdú EF, Jabri B, Chang A, Chandran UR, Mullett SJ, Wendell SG, Singhi AD, Tilstra JS, Pierre JF, Arteel GE, Hinterleitner R, Meisel M
Cell Host & Microbe 2022
Subclinical versus advanced forms of alcohol-related liver disease: Need for early detection
Gómez-Medina C, Melo L, Martí-Aguado D, Bataller R
Clinical and Molecular Hepatology 2022
Role of platelet factor 4 in arteriovenous fistula maturation failure: What do we know so far?
Xiao Y, Vazquez-Padron RI, Martinez L, Singer HA, Woltmann D, Salman LH
The Journal of Vascular Access 2022
Exploring the constituent mechanisms of hepatitis: a dynamical systems approach
Dunster JL, Gibbins JM, Nelson MR
Mathematical Medicine and Biology 2022
Plasticity of monocytes and macrophages in cirrhosis of the liver
Geng A, Flint E, Bernsmeier C
2022
Oxidative Stress and Redox Signaling in the Pathophysiology of Liver Diseases
Mooli RG, Mukhi D, Ramakrishnan SK
Comprehensive Physiology 2022
Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis
Charan HV, Dwivedi DK, Khan S, Jena G
Genes & Diseases 2022
Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy.
Li H, Liu T, Yang Y, Cho WC, Flynn RJ, Harandi MF, Song H, Luo X, Zheng Y
Genes & Diseases 2022
Nicotinamide N-methyltransferase and liver diseases.
Liang G, Li Y, Lin Y, Yang X, Yang J, Hu S, Liu A
Genes & Diseases 2022
Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS
Zhou M, Zhao X, Liao L, Deng Y, Liu M, Wang J, Xue X, Li Y
Oxidative medicine and cellular longevity 2022
Roles of hepatic stellate cells in NAFLD: From the perspective of inflammation and fibrosis
Wang M, Li L, Xu Y, Du J, Ling C
Frontiers in pharmacology 2022
Danshensu attenuated lipopolysaccharide-induced LX-2 and T6 cells activation through regulation of ferroptosis.
Wang C, Su Z, Xu JH, Ko CY
Food Science & Nutrition 2022
Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease.
Bukke VN, Moola A, Serviddio G, Vendemiale G, Bellanti F
World Journal of Gastroenterology 2022
The Efficacy of Combination Therapy Involving Excision Followed by Intralesional 5-Fluorouracil and Betamethasone, and Radiotherapy in the Treatment of Keloids: A Randomized Controlled Trial.
Li Y, Zhang D, Hang B, Wang H
Clinical, cosmetic and investigational dermatology 2022
Identification of Liver Fibrosis-Related MicroRNAs in Human Primary Hepatic Stellate Cells Using High-Throughput Sequencing.
Liu X, Ma H, Wu R, Wang H, Xu H, Li S, Wang G, Lv G, Niu J
Genes & development 2022
T (1)-T (2) dual-modal magnetic resonance contrast-enhanced imaging for rat liver fibrosis stage.
Lu F, Du L, Chen W, Jiang H, Yang C, Pu Y, Wu J, Zhu J, Chen T, Zhang X, Wu C
RSC Advances 2022
Association of liver fibrosis biomarkers with overall and CVD mortality in the Korean population: The Dong-gu study.
Choi SW, Kweon SS, Lee YH, Ryu SY, Nam HS, Shin MH
PloS one 2022
Utility of Human Relevant Preclinical Animal Models in Navigating NAFLD to MAFLD Paradigm.
Chua D, Low ZS, Cheam GX, Ng AS, Tan NS
International journal of molecular sciences 2022
LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation.
Gao H, Wang X, Ma H, Lin S, Zhang D, Wu W, Liao Z, Chen M, Ye H, Li Q, Lin M, Li D
Scientific Reports 2022
Association between History of Pregnancy and Liver Fibrosis Using Fibrosis-4 Index in Korean Postmenopausal Women: A Nationwide Population-Based Study.
Ahn JJ, Park JH, Kim DH, Kim HJ, Ko HS, Kwon JY, Koh YS, Jung JH, Lee GN, Han K
Korean Journal of Family Medicine 2022
Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications.
Yepmo M, Potier JB, Pinget M, Grabarz A, Bouzakri K, Dumond Bourie A
Frontiers in Endocrinology 2022
Intra-individual comparison of liver stiffness measurements by magnetic resonance elastography and two-dimensional shear-wave elastography in 888 patients.
Ichikawa H, Yasuda E, Kumada T, Takeshima K, Ogawa S, Tsunekawa A, Goto T, Nakaya K, Akita T, Tanaka J
2022
Acute Hepatic Injury Associated with Acute Administration of Synthetic Cannabinoid XLR-11 in Mouse Animal Model.
Alzu'bi A, Zoubi MSA, Al-Trad B, AbuAlArjah MI, Shehab M, Alzoubi H, Albals D, Abdelhady GT, El-Huneidi W
Toxics 2022
CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma.
Zhao J, Li R, Li J, Chen Z, Lin Z, Zhang B, Deng L, Chen G, Wang Y
Journal of Translational Medicine 2022
[Hydroxynitone suppresses hepatic stellate cell activation by inhibiting TGF-β1 phosphorylation to alleviate CCl(4)-induced liver fibrosis in rats].
Zhao Z, Dong H, Li B, Shen B, Guo Y, Gu T, Qu Y, Cai X, Lu L
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2022
Increased Natural Killer Cells Are Associated with Alcohol Liver Fibrosis and with T Cell and Cytotoxic Subpopulations Change.
Zuluaga P, Teniente-Serra A, Fuster D, Quirant-Sánchez B, Hernandez-Rubio A, Martínez-Cáceres E, Muga R
Journal of Clinical Medicine 2022
Probiotics counteract the expression of hepatic profibrotic genes via the attenuation of TGF-β/SMAD signaling and autophagy in hepatic stellate cells.
Kanmani P, Kim H
PloS one 2022
Liver fibrosis quantification.
Venkatesh SK, Torbenson MS
2022
Extracellular Vesicles from miR-148a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Relieve Hepatic Fibrosis by Targeting Smad4.
Xuan J, Xu H, Li H, Chen D, Qiu Y, Chen X, Shao M, Xia X
Molecular Biotechnology 2022
Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis.
Zhang Q, Qu Y, Zhang Q, Li F, Li B, Li Z, Dong Y, Lu L, Cai X
Cell Biology and Toxicology 2022
A strategy of vascular-targeted therapy for liver fibrosis.
Lin Y, Dong MQ, Liu ZM, Xu M, Huang ZH, Liu HJ, Gao Y, Zhou WJ
Hepatology 2022
Clinical relevance of shear wave elastography compared with transient elastography and other markers of liver fibrosis.
Ayonrinde OT, Zelesco M, Welman CJ, Abbott S, Adris N
Internal Medicine Journal 2022
Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey.
Zhu T, Lu XT, Liu ZY, Zhu HL
Frontiers in Nutrition 2022
Inhomogeneous liver fibrosis distribution revealed by macromolecular proton fraction quantification based on spin-lock MRI.
Qian Y, Wong VW, Hou J, Jiang B, Chu WC, Chen W
Quantitative imaging in medicine and surgery 2022
Identification of Gut Microbiome Metabolites via Network Pharmacology Analysis in Treating Alcoholic Liver Disease.
Oh KK, Choi YR, Gupta H, Ganesan R, Sharma SP, Won SM, Jeong JJ, Lee SB, Cha MG, Kwon GH, Kim DJ, Suk KT
Current issues in molecular biology 2022
Residual Level, Histology, and Blood Biochemistry of Tebuconazole: A Repeated Dose 28-Day Oral Toxicity Study in Pigs.
Jeong JY, Kim M, Park SH, Kim B, Oh SI, Kim E, Jung H
2022
Calotropis gigantea stem bark extracts inhibit liver cancer induced by diethylnitrosamine.
Sawong S, Pekthong D, Suknoppakit P, Winitchaikul T, Kaewkong W, Somran J, Intapa C, Parhira S, Srisawang P
Scientific Reports 2022
Systemic inflammation is linked to liver fibrogenesis in patients with advanced chronic liver disease.
Simbrunner B, Villesen IF, Königshofer P, Scheiner B, Bauer D, Paternostro R, Schwabl P, Timelthaler G, Ramazanova D, Wöran K, Stift J, Eigenbauer E, Stättermayer AF, Marculescu R, Pinter M, Møller S, Trauner M, Karsdal M, Leeming DJ, Reiberger T, Mandorfer M
Liver international : official journal of the International Association for the Study of the Liver 2022
Phenolic composition, antioxidant and anti-fibrotic effects of Sesbania grandiflora L. (Agastya) - An edible medicinal plant.
Arthanari S, Periyasamy P
AYU (An International Quarterly Journal of Research in Ayurveda) 2022
Grevillea robusta Delayed the Progression of Experimentally Induced Hepatic Fibrosis and Cirrhosis in Wistar Rats by Attenuating the Expression of Smooth Muscle Actin, Collagen, and TGF-β.
Hameed S, Ur Rehman A, Massey S, Syed NI, Anwar F, Ahmed D, Ahmad S
Frontiers in pharmacology 2022
The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis.
Sun R, Tian X, Li Y, Zhao Y, Wang Z, Hu Y, Zhang L, Wang Y, Gao D, Zheng S, Yao J
Redox Biology 2022
RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1 downregulation.
Song LJ, Yin XR, Guan SW, Gao H, Dong PP, Mei CJ, Yang YY, Zhang Y, Yu CX, Hua ZC
Signal Transduction and Targeted Therapy 2022
The Role of Extracellular Vesicles in Liver Pathogenesis.
Liu G, Yin XM
The American Journal of Pathology 2022
MCD Diet Rat Model Induces Alterations in Zinc and Iron during NAFLD Progression from Steatosis to Steatohepatitis.
Palladini G, Di Pasqua LG, Cagna M, Croce AC, Perlini S, Mannucci B, Profumo A, Ferrigno A, Vairetti M
International journal of molecular sciences 2022
Ferulic Acid Combined With Bone Marrow Mesenchymal Stem Cells Attenuates the Activation of Hepatic Stellate Cells and Alleviates Liver Fibrosis.
Zhang R, Li W, Jiang X, Cui X, You H, Tang Z, Liu W
Frontiers in pharmacology 2022
Prevalence and Prognostic Significance of Liver Fibrosis in Patients With Aneurysmal Subarachnoid Hemorrhage.
Li T, Wang P, Gong X, Chong W, Hai Y, You C, Kang J, Fang F, Zhang Y
Frontiers in neurology 2022
A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus.
Melin N, Yarahmadov T, Sanchez-Taltavull D, Birrer FE, Brodie TM, Petit B, Felser A, Nuoffer JM, Montani M, Vozenin MC, Herrmann E, Candinas D, Aebersold DM, Stroka D
2022
Assessment of liver cirrhosis severity with extracellular volume fraction MRI.
Mesropyan N, Kupczyk PA, Dold L, Praktiknjo M, Chang J, Isaak A, Endler C, Kravchenko D, Bischoff LM, Sprinkart AM, Pieper CC, Kuetting D, Jansen C, Attenberger UI, Luetkens JA
Scientific Reports 2022
Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice.
Liu QW, Ying YM, Zhou JX, Zhang WJ, Liu ZX, Jia BB, Gu HC, Zhao CY, Guan XH, Deng KY, Xin HB
Stem Cell Research & Therapy 2022
Correlation between Fibroscan and laboratory tests in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis patients for assessing liver fibrosis.
Al Danaf L, Hussein Kamareddine M, Fayad E, Hussain A, Farhat S
World journal of hepatology 2022
Retrospective Evaluation of Non-Invasive Assessment Based on Routine Laboratory Markers for Assessing Advanced Liver Fibrosis in Chronic Hepatitis B Patients.
Wang Z, Zhou Y, Yu P, Liu Y, Mei M, Bian Z, Shao W, Lv J, Li X, Lu W, Xu L
International journal of general medicine 2022
Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide.
Liu L, Wu Q, Chen Y, Gu G, Gao R, Peng B, Wang Y, Li A, Guo J, Xu X, Shao X, Li L, Shen Y, Sun J
Molecules (Basel, Switzerland) 2022
Empagliflozin Reduces the Progression of Hepatic Fibrosis in a Mouse Model and Inhibits the Activation of Hepatic Stellate Cells via the Hippo Signalling Pathway.
Heo YJ, Lee N, Choi SE, Jeon JY, Han SJ, Kim DJ, Kang Y, Lee KW, Kim HJ
Biomedicines 2022
NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers.
Hurtado-Navarro L, Angosto-Bazarra D, Pelegrín P, Baroja-Mazo A, Cuevas S
2022
Safety, tolerability, and anti-fibrotic efficacy of the CBP/β-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1/2a study.
Kimura K, Kanto T, Shimoda S, Harada K, Kimura M, Nishikawa K, Imamura J, Ogawa E, Saio M, Ikura Y, Okusaka T, Inoue K, Ishikawa T, Ieiri I, Kishimoto J, Todaka K, Kamisawa T
EBioMedicine 2022
Fucoxanthin Attenuates the Reprogramming of Energy Metabolism during the Activation of Hepatic Stellate Cells.
Bae M, Kim MB, Lee JY
Nutrients 2022
Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review.
Shokravi S, Borisov V, Zaman BA, Niazvand F, Hazrati R, Khah MM, Thangavelu L, Marzban S, Sohrabi A, Zamani A
Stem Cell Research & Therapy 2022
Quantitative Magnetization EXchange MRI Measurement of Liver Fibrosis Model in Rodents.
Wilczynski E, Sasson E, Eliav U, Navon G, Nevo U
Journal of magnetic resonance imaging : JMRI 2022
Gadd45 in Senescence.
Zaidi MR, Liebermann DA
Advances in experimental medicine and biology 2022
miR-654-5p Contributes to the Activation and Proliferation of Hepatic Stellate Cells by Targeting RXRα.
Ma H, Wang X, Liu X, Wang C, Gao X, Niu J
Frontiers in Cell and Developmental Biology 2022
S-Acetyl-Glutathione Attenuates Carbon Tetrachloride-Induced Liver Injury by Modulating Oxidative Imbalance and Inflammation.
Di Paola R, Modafferi S, Siracusa R, Cordaro M, D'Amico R, Ontario ML, Interdonato L, Salinaro AT, Fusco R, Impellizzeri D, Calabrese V, Cuzzocrea S
International journal of molecular sciences 2022
Proteoglycans in Cancer: Friends or Enemies? A Special Focus on Hepatocellular Carcinoma.
Dituri F, Gigante G, Scialpi R, Mancarella S, Fabregat I, Giannelli G
Cancers 2022
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z
Bioengineered 2022
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
Luo J, Li L, Chang B, Zhu Z, Deng F, Hu M, Yu Y, Lu X, Chen Z, Zuo D, Zhou J
Cellular and Molecular Gastroenterology and Hepatology 2022
Hydrostatic pressure induces profibrotic properties in hepatic stellate cells via the RhoA/ROCK signaling pathway.
Huang Z, Khalifa MO, Gu W, Li TS
FEBS Open Bio 2022
Radiomics analysis of contrast-enhanced CT for staging liver fibrosis: an update for image biomarker.
Wang J, Tang S, Mao Y, Wu J, Xu S, Yue Q, Chen J, He J, Yin Y
Hepatology International 2022
Lycorine Ameliorates Thioacetamide-Induced Hepatic Fibrosis in Rats: Emphasis on Antioxidant, Anti-Inflammatory, and STAT3 Inhibition Effects.
Alkreathy HM, Esmat A
Pharmaceuticals (Basel, Switzerland) 2022
Safety and Pharmacokinetic Assessment of Oral Proglumide in Those with Hepatic Impairment.
Hsu CC, Bansal S, Cao H, Smith CI, He AR, Gay MD, Li Y, Cheema A, Smith JP
Pharmaceutics 2022
Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro.
Kanabekova P, Kadyrova A, Kulsharova G
Micromachines 2022
FibROAD: a manually curated resource for multi-omics level evidence integration of fibrosis research.
Sun YZ, Hu YF, Zhang Y, Wei SY, Yang BL, Xu YP, Rong ZL, Wang D, Yang B
Database : the journal of biological databases and curation 2022
Astaxanthin Attenuates the Changes in the Expression of MicroRNAs Involved in the Activation of Hepatic Stellate Cells.
Bae M, Kim MB, Lee JY
Nutrients 2022
Trimetazidine inhibits liver fibrosis and hepatic stellate cell proliferation and blocks transforming growth factor-β (TGFβ)/Smad signaling in vitro and in vivo.
Ding W, Zhou D, Zhang S, Qian J, Yang L, Tang L
Bioengineered 2022
Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis.
Tan Y, Sun X, Xu Y, Tang B, Xu S, Lu D, Ye Y, Luo X, Diao X, Li F, Wang T, Chen J, Xu Q, Wu X
Nucleic Acids Research 2022
Cumulative Betel Quid Chewing and the Risk of Significant Liver Fibrosis in Subjects With and Without Metabolic Syndrome.
Chou YT, Sun ZJ, Shen WC, Yang YC, Lu FH, Chang CJ, Li CY, Wu JS
Frontiers in Nutrition 2022
Analysis of Liver Responses to Non-alcoholic Steatohepatitis by mRNA-Sequencing.
Green CD, Dozmorov MG, Spiegel S
Methods in molecular biology (Clifton, N.J.) 2022
The Lactobacillus as a Probiotic: Focusing on Liver Diseases.
Jeong JJ, Park HJ, Cha MG, Park E, Won SM, Ganesan R, Gupta H, Gebru YA, Sharma SP, Lee SB, Kwon GH, Jeong MK, Min BH, Hyun JY, Eom JA, Yoon SJ, Choi MR, Kim DJ, Suk KT
Microorganisms 2022
From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation.
Liu Q, Lv C, Jiang Y, Luo K, Gao Y, Liu J, Zhang X, Mohammad Omar J, Jin S
PeerJ 2022
ECM1 modified HF-MSCs targeting HSC attenuate liver cirrhosis by inhibiting the TGF-β/Smad signaling pathway.
Liu Q, Lv C, Huang Q, Zhao L, Sun X, Ning D, Liu J, Jiang Y, Jin S
Cell Death Discovery 2022
Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway.
Huang T, Li YQ, Zhou MY, Hu RH, Zou GL, Li JC, Feng S, Liu YM, Xin CQ, Zhao XK
World Journal of Gastroenterology 2022
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor.
Liu Z, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JJ, Hernandez-Benitez R, Shyh-Chang N, Belmonte JCI, Zhang W, Qu J, Liu GH
Cell Discovery 2022
Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats.
M Soliman S, Mosallam S, Mamdouh MA, Hussein MA, M Abd El-Halim S
Drug Delivery 2022
GANE can Improve Lung Fibrosis by Reducing Inflammation via Promoting p38MAPK/TGF-β1/NF-κB Signaling Pathway Downregulation.
Mohamad EA, Mohamed ZN, Hussein MA, Elneklawi MS
ACS Omega 2022
Intraindividual comparison of MRI-derived liver surface nodularity score at 1.5 T and 3 T.
Jang W, Song JS, Kim TH, Yoon KH
2022
miR-488-5p mitigates hepatic stellate cell activation and hepatic fibrosis via suppressing TET3 expression
Qiu J, Wu S, Wang P, Zhou Y, Wang Z, Sun Y, Jiang C
Hepatology International 2022
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Torres S, Ortiz C, Bachtler N, Gu W, Grünewald LD, Kraus N, Schierwagen R, Hieber C, Meier C, Tyc O, Joseph Brol M, Uschner FE, Nijmeijer B, Welsch C, Berres M, Garcia\u2010Ruiz C, Fernandez\u2010Checa JC, Trautwein C, Vogl TJ, Zeuzem S, Trebicka J, Klein S
Hepatology 2022
Safety and Dosing Study of a Cholecystokinin Receptor Antagonist in Non‐alcoholic Steatohepatitis
Rabiee A, Gay MD, Shivapurkar N, Cao H, Nadella S, Smith CI, Lewis JH, Bansal S, Cheema A, Kwagyan J, Smith JP
Clinical Pharmacology & Therapeutics 2022
Evidence of Renin–Angiotensin System Receptors in Deep Fascia: A Role in Extracellular Matrix Remodeling and Fibrogenesis?
Pirri C, Caroccia B, Angelini A, Petrelli L, Piazza M, Biz C, Ruggieri P, De Caro R, Stecco C
Biomedicines 2022
Single-Cell Chromatin Accessibility Data Combined with GWAS Improves Detection of Relevant Cell Types in 59 Complex Phenotypes
Das AC, Foroutan A, Qian B, Hosseini Naghavi N, Shabani K, Shooshtari P
International journal of molecular sciences 2022
Human stem cells for decompensated cirrhosis in adults
Aung HH, Aye SN, Htet NH, El-Nakeep S, Kew ST, Pavlov CS
The Cochrane Database of Systematic Reviews 2022
Bibliometric-analysis visualization and review of non-invasive methods for monitoring and managing the portal hypertension
Sun X, Ni HB, Xue J, Wang S, Aljbri A, Wang L, Ren TH, Li X, Niu M
Frontiers in Medicine 2022
Protective Effect of SeMet on Liver Injury Induced by Ochratoxin A in Rabbits
Zhang Z, Xu J, Zhang X, Wang J, Xie H, Sun Y, Zhang Q, Chang Z, Liu Y
Toxins 2022
Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model
Vargas-Pozada EE, Ramos-Tovar E, Rodriguez-Callejas JD, Cardoso-Lezama I, Galindo-Gómez S, Talamás-Lara D, Vásquez-Garzón VR, Arellanes-Robledo J, Tsutsumi V, Villa-Treviño S, Muriel P
International journal of molecular sciences 2022
Higher cardiovascular risk scores and liver fibrosis risk estimated by biomarkers in patients with metabolic-dysfunction-associated fatty liver disease
Salgado Alvarez GA, Pinto Galvez SM, Garcia Mora U, Cano Contreras AD, Durán Rosas C, Priego-Parra BA, Triana Romero A, Amieva Balmori M, Roesch Dietlen F, Martinez Vazquez SE, Mendez Guerrero IO, Chi-Cervera LA, Bernal Reyes R, Martinez Roriguez LA, Icaza Chavez ME, Remes Troche JM
World journal of hepatology 2022
Involvement of Ferroptosis in Diabetes-Induced Liver Pathology
Stancic A, Velickovic K, Markelic M, Grigorov I, Saksida T, Savic N, Vucetic M, Martinovic V, Ivanovic A, Otasevic V
International journal of molecular sciences 2022
Label-free metabolic imaging of non-alcoholic-fatty-liver-disease (NAFLD) liver by volumetric dynamic optical coherence tomography
Mukherjee P, Fukuda S, Lukmanto D, Yamashita T, Okada K, Makita S, Abd El-Sadek I, Miyazawa A, Zhu L, Morishita R, Lichtenegger A, Oshika T, Yasuno Y
Biomedical Optics Express 2022
From MAFLD to hepatocellular carcinoma and everything in between
Bae SD, George J, Qiao L
Chinese Medical Journal 2022
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease
Wang Y, Abrol R, Mak JY, Das Gupta K, Ramnath D, Karunakaran D, Fairlie DP, Sweet MJ
The FEBS journal 2022
The role of interleukin-33 in organ fibrosis.
Di Carmine S, Scott MM, McLean MH, McSorley HJ
2022
Magnesium and Its Role in Primary Open Angle Glaucoma; A Novel Therapeutic?
Elghobashy M, Lamont HC, Morelli-Batters A, Masood I, Hill LJ
2022
Decoding liver fibrogenesis with single-cell technologies
Zhou T, Kiran M, Lui KO, Ding Q
Life Medicine 2022
GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells
Noelia Arroyo, Laura Villamayor, I Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramon Muñoz-Chapuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martin, David A. Cano, Anabel Rojas
JCI Insight 2021
Interleukin-24 protects against liver injury in mouse models
HH Wang, JH Huang, MH Sue, WC Ho, YH Hsu, KC Chang, MS Chang
EBioMedicine 2021
Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation
HM Huang, XR Zhou, YJ Liu, SJ Fan, LP Liao, J Huang, CC Shi, L Yu, JJ Pen, C Luo, YY Zhang, GM Li
Molecular medicine reports 2021
Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis
E Kostallari, B Wei, D Sicard, J Li, SA Cooper, J Gao, M Dehankar, Y Li, S Cao, M Yin, DJ Tschumperlin, VH Shah
AJP Gastrointestinal and Liver Physiology 2021
Involvement of Autophagy in Ageing and Chronic Cholestatic Diseases
C Pinto, E Ninfole, A Benedetti, M Marzioni, L Maroni
Cells 2021
Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice
J Baglieri, C Zhang, S Liang, X Liu, T Nishio, SB Rosenthal, D Dhar, H Su, M Cong, J Jia, M Hosseini, M Karin, T Kisseleva, DA Brenner
The American Journal of Pathology 2021
Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases
G Casals, M Perramón, E Casals, I Portolés, G Fernández-Varo, M Morales-Ruiz, V Puntes, W Jiménez
Antioxidants 2021
Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis
Y Wu, Y Cao, K Xu, Y Zhu, Y Qiao, Y Wu, J Chen, C Li, R Zeng, G Ge
Cell Death and Disease 2021
Effects of blocking chemokine receptor CCR1 with BX471 in two models of fibrosis prevention and rescue in mice
SN Weber, I Nowak, F Grünhage, F Lammert
Biochemistry and Biophysics Reports 2021
Liver macrophages and inflammation in physiology and physiopathology of non‐alcoholic fatty liver disease
R Thibaut, MC Gage, I PinedaTorra, G Chabrier, N Venteclef, F Alzaid
The FEBS journal 2021
Fibrotic Events in the Progression of Cholestatic Liver Disease
H Wu, C Chen, S Ziani, LJ Nelson, MA Ávila, YA Nevzorova, FJ Cubero
Cells 2021
NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis
AJ Quenum, A Shukla, F Rexhepi, M Cloutier, A Ghosh, TA Kufer, S Ramanathan, S Ilangumaran
Frontiers in immunology 2021
Organ Fibrosis and Autoimmunity: The Role of Inflammation in TGFβ-Dependent EMT
M Sisto, D Ribatti, S Lisi
Biomolecules 2021
Retinoic Acid: A New Old Friend of IL-17A in the Immune Pathogeny of Liver Fibrosis
DM Kartasheva-Ebertz, S Pol, S Lagaye
Frontiers in immunology 2021
Immunobiology and pathogenesis of hepatitis B virus infection
M Iannacone, LG Guidotti
Nature Reviews Immunology 2021
Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression
A Caligiuri, A Gentilini, M Pastore, S Gitto, F Marra
Cells 2021
The miR-23–27–24 cluster: an emerging target in NAFLD pathogenesis
L Ru, X Wang, J Niu
Acta Pharmacologica Sinica 2021
Cellular Protein Markers, Therapeutics, and Drug Delivery Strategies in the Treatment of Diabetes-Associated Liver Fibrosis
CY Lin, P Adhikary, K Cheng
Advanced Drug Delivery Reviews 2021
Interleukin-10 Attenuates Liver Fibrosis Exacerbated by Thermoneutrality
HT Nga, JS Moon, J Tian, HY Lee, SH Kim, YS Lee, JH Jeon, HS Yi
Frontiers in Medicine 2021
Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways
Z Li, Z Wang, F Dong, W Shi, W Dai, J Zhao, Q Li, Z Fang, L Ren, T Liu, Z Wei, W Mou, L Lin, Y Yang, X Xiao, L Ma, Z Bai
Frontiers in pharmacology 2021
Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
P Mukherjee, A Miyazawa, S Fukuda, T Yamashita, D Lukmanto, K Okada, IA El-Sadek, L Zhu, S Makita, T Oshika, Y Yasuno
Scientific Reports 2021
Modulation of Liver Inflammation and Fibrosis by Interleukin-37
S Mountford, M Effenberger, H Noll-Puchta, L Griessmair, A Ringleb, S Haas, G Denk, FP Reiter, D Mayr, CA Dinarello, H Tilg, P Bufler
Frontiers in immunology 2021
Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis
C Lee, M Kim, J Han, M Yoon, Y Jung
Biomedicines 2021
Targeting Certain Interleukins as Novel Treatment Options for Liver Fibrosis
SY An, AD Petrescu, S DeMorrow
Frontiers in pharmacology 2021
Cellular Mechanisms of Liver Fibrosis
P Acharya, K Chouhan, S Weiskirchen, R Weiskirchen
Frontiers in pharmacology 2021
Fibrotic Scar After Spinal Cord Injury: Crosstalk With Other Cells, Cellular Origin, Function, and Mechanism
Z Li, S Yu, X Hu, Y Li, X You, D Tian, L Cheng, M Zheng, J Jing
Frontiers in cellular neuroscience 2021
Cell and Tissue Therapy for the Treatment of Chronic Liver Disease
Y Bram, DH Nguyen, V Gupta, J Park, C Richardson, V Chandar, RE Schwartz
Annual Review of Biomedical Engineering 2021
Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer
DA Patten, AL Wilkinson, A O'Keeffe, S Shetty
Seminars in liver disease 2021
Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment
RC Turaga, G Satyanarayana, M Sharma, JJ Yang, S Wang, C Liu, S Li, H Yang, H Grossniklaus, AB Farris, J Gracia-Sancho, ZR Liu
2021
Till Death Do Us Part—The Multifaceted Role of Platelets in Liver Diseases
M Mussbacher, L Brunnthaler, A Panhuber, P Starlinger, A Assinger
International journal of molecular sciences 2021
Regenerative Potential of Mesenchymal Stem Cells’ (MSCs) Secretome for Liver Fibrosis Therapies
SR Ignat, S Gharbia, A Hermenean, S Dinescu, M Costache
International journal of molecular sciences 2021
Hepatic stellate cells – from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology
RT Sufleţel, CS Melincovici, BA Gheban, Z Toader, CM Mihu
Romanian Journal of Morphology and Embryology 2021
Exosomal miR-500 Derived From Lipopolysaccharide-Treated Macrophage Accelerates Liver Fibrosis by Suppressing MFN2
L Chen, Y Huang, Z Duan, P Huang, H Yao, Y Zhou, Q Ji, X Liu
Frontiers in Cell and Developmental Biology 2021
Pathophysiology and Management of Variceal Bleeding
SA Alqahtani, S Jang
Drugs 2021
Cyclam-Modified Polyethyleneimine for Simultaneous TGFβ siRNA Delivery and CXCR4 Inhibition for the Treatment of CCl4-Induced Liver Fibrosis
A Ullah, G Chen, A Hussain, H Khan, A Abbas, Z Zhou, M Shafiq, S Ahmad, U Ali, M Usman, F Raza, A Ahmed, Z Qiu, M Zheng, D Liu
International Journal of Nanomedicine 2021
Extracellular PKM2 facilitates organ-tissue fibrosis progression
H Han, Y Zhang, G Peng, L Li, J Yang, Y Yuan, Y Xu, ZR Liu
iScience 2021
Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis
I Hwang, EJ Lee, H Park, D Moon, HS Kim
Cell & Bioscience 2021
Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift
M Migdał, E Tralle, KA Nahia, Ł Bugajski, KZ Kędzierska, F Garbicz, K Piwocka, CL Winata, M Pawlak
BMC Genomics 2021
The Combination of Schisandrol B and Wedelolactone Synergistically Reverses Hepatic Fibrosis Via Modulating Multiple Signaling Pathways in Mice
Y Ai, W Shi, X Zuo, X Sun, Y Chen, Z Wang, R Li, X Song, W Dai, W Mu, K Ding, Z Li, Q Li, X Xiao, X Zhan, Z Bai
Frontiers in pharmacology 2021
Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options: An Update
K Duspara, K Bojanic, JI Pejic, L Kuna, TO Kolaric, V Nincevic, R Smolic, A Vcev, M Glasnovic, IB Curcic, M Smolic
Journal of Clinical and Translational Hepatology 2021
Quantitative evaluation of hepatic fibrosis by fibro Scan and Gd-EOB-DTPA-enhanced T1 mapping magnetic resonance imaging in chronic hepatitis B
Q Li, T Chen, N Shi, W Ye, M Yuan, Y Shi
Abdominal Radiology 2021
PNPLA3 Genotype, Arachidonic Acid Intake, and Unsaturated Fat Intake Influences Liver Fibrosis in Hispanic Youth with Obesity
RB Jones, L Arenaza, C Rios, JF Plows, PK Berger, TL Alderete, JL Fogel, K Nayak, P Mohamed, D Hwang, S Palmer, F Sinatra, H Allayee, R Kohli, MI Goran
Nutrients 2021
Immune cell-mediated features of non-alcoholic steatohepatitis
T Huby, EL Gautier
Nature Reviews Immunology 2021
Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation
Y Yan, J Zeng, L Xing, C Li
Biomedicines 2021
Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies
W Qu, T Ma, J Cai, X Zhang, P Zhang, Z She, F Wan, H Li
Frontiers in Medicine 2021
Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives
GF Vasse, M Nizamoglu, IH Heijink, M Schlepütz, P Rijn, MJ Thomas, JK Burgess, BN Melgert
The Journal of Pathology 2021
The combined induction of liver progenitor cells and the suppression of stellate cells by small molecules reverts chronic hepatic dysfunction
WJ Huang, X Zhou, GB Fu, M Ding, HP Wu, M Zeng, HD Zhang, LY Xu, Y Gao, HY Wang, HX Yan
Theranostics 2021
Oncofetal Protein CRIPTO Is Involved in Wound Healing and Fibrogenesis in the Regenerating Liver and Is Associated with the Initial Stages of Cardiac Fibrosis
S Karkampouna, D van der Helm, M Scarpa, B van Hoek, HW Verspaget, MJ Goumans, MJ Coenraad, BP Kruithof, MK Julio
Cells 2021
Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured?
A Khanam, PG Saleeb, S Kottilil
Cells 2021
Non-alcoholic Steatohepatitis Pathogenesis, Diagnosis, and Treatment
B Zhu, SL Chan, J Li, K Li, H Wu, K Cui, H Chen
Frontiers in Cardiovascular Medicine 2021
ADAM 17 and Epithelial-to-Mesenchymal Transition: The Evolving Story and Its Link to Fibrosis and Cancer
M Sisto, D Ribatti, S Lisi
Journal of Clinical Medicine 2021
MCLR-elicited hepatic fibrosis and carcinogenic gene expression changes persist in rats with diet-induced nonalcoholic steatohepatitis through a 4-week recovery period
T Arman, JA Baron, KD Lynch, LA White, J Aldan, JD Clarke
Toxicology 2021
Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders
AM Sofias, FD Lorenzi, Q Peña, AA Shalmani, M Vucur, JW Wang, F Kiessling, Y Shi, L Consolino, G Storm, T Lammers
Advanced Drug Delivery Reviews 2021
Hepatic BRD4 Is Upregulated in Liver Fibrosis of Various Etiologies and Positively Correlated to Fibrotic Severity
C Wu, D Cheng, Y Peng, Y Li, C Fu, Y Wang, L Fu, S Peng, X Ni
Frontiers in Medicine 2021
The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis
H Fuji, G Miller, T Nishio, Y Koyama, K Lam, V Zhang, R Loomba, D Brenner, T Kisseleva
Frontiers in Molecular Biosciences 2021
Insights into the molecular mechanisms of Huangqi decoction on liver fibrosis via computational systems pharmacology approaches
B Wang, Z Wu, W Li, G Liu, Y Tang
Chinese medicine 2021
Novel Therapeutic Targets in Liver Fibrosis
J Zhang, Q Liu, J He, Y Li
Frontiers in Molecular Biosciences 2021
Association of cell death mechanisms and fibrosis in visceral white adipose tissue with pathological alterations in the liver of morbidly obese patients with NAFLD
AS Leven, RK Gieseler, M Schlattjan, T Schreiter, M Niedergethmann, T Baars, HA Baba, MK Özçürümez, JP Sowa, A Canbay
Adipocyte 2021
Gardeniae Fructus Attenuates Thioacetamide-Induced Liver Fibrosis in Mice via Both AMPK/SIRT1/NF-κB Pathway and Nrf2 Signaling
MR Shin, JA Lee, M Kim, S Lee, M Oh, J Moon, JW Nam, H Choi, YJ Mun, SS Roh
Antioxidants 2021
Potential therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis: a study of network pharmacology
Y Fan, X Yin
Annals of translational medicine 2021
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration
CE Dorrier, D Aran, EA Haenelt, RN Sheehy, KK Hoi, L Pintarić, Y Chen, CO Lizama, KM Cautivo, GA Weiner, B Popko, SP Fancy, TD Arnold, R Daneman
Nature Neuroscience 2021
Neoagarooligosaccharide Protects against Hepatic Fibrosis via Inhibition of TGF-β/Smad Signaling Pathway
JH Yang, SK Ku, IL Cho, JH Lee, CS Na, SH Ki
International journal of molecular sciences 2021
Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress
W Dai, Q Qin, Z Li, L Lin, R Li, Z Fang, Y Han, W Mu, L Ren, T Liu, X Zhan, X Xiao, Z Bai
Frontiers in Cell and Developmental Biology 2021
Exosomal microRNAs as diagnostic and therapeutic biomarkers in non-malignant liver diseases
S Hwang, YM Yang
Archives of Pharmacal Research 2021
Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis
L An, Y Lin, L Li, M Kong, Y Lou, J Wu, Z Liu
Frontiers in pharmacology 2021
Induction of liver fibrosis by CCl4 mediates pathological alterations in the spleen and lymph nodes: The potential therapeutic role of propolis
EA Sayed, G Badr, KA Hassan, H Waly, B Ozdemir, MH Mahmoud, S Alamery
Saudi Journal of Biological Sciences 2021
Review: Challenges of In Vitro CAF Modelling in Liver Cancers
A Herrero, E Knetemann, I Mannaerts
Cancers 2021
The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases
Z Wang, N Chen, Z Li, G Xu, X Zhan, J Tang, X Xiao, Z Bai
Frontiers in Cell and Developmental Biology 2021
Identification of hepatic fibrosis inhibitors through morphometry analysis of a hepatic multicellular spheroids model
Y Song, S Kim, J Heo, D Shum, SY Lee, M Lee, AR Kim, HR Seo
Scientific Reports 2021
Antifibrotic Effects of Kangxian Ruangan Capsule on Rats with Nonalcoholic Fatty Liver Fibrosis and Hepatic Stellate Cells through Regulation of TGF-β and TLR4 Signaling Pathways
L Liu, Y Zhou, D Dai, H Xia, K Zhao, J Zhang, SM Silvestre
Evidence-Based Complementary and Alternative Medicine 2021
Pathophysiological Role of Purinergic P2X Receptors in Digestive System Diseases
Q An, G Yue, X Yang, J Lou, W Shan, J Ding, Z Jin, Y Hu, Q Du, Q Liao, R Xie, J Xu
Frontiers in physiology 2021
Nobiletin Alleviates Non-alcoholic Steatohepatitis in MCD-Induced Mice by Regulating Macrophage Polarization
S Wang, T Lan, H Sheng, F Zheng, M Lei, L Wang, H Chen, C Xu, F Zhang
Frontiers in physiology 2021
Tissue mechanics in stem cell fate, development, and cancer
M Hayward, J Muncie, V Weaver
Developmental Cell 2021
Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect
, L Yu, M Zhou, P Hou, L Yi, M Mi
Nutrition & Metabolism 2021
(Pro)renin Receptor Knockdown Attenuates Liver Fibrosis Through Inactivation of ERK/TGF-β1/SMAD3 Pathway.
Hsieh YC, Lee KC, Lei HJ, Lan KH, Huo TI, Lin YT, Chan CC, Schnabl B, Huang YH, Hou MC, Lin HC
Cellular and Molecular Gastroenterology and Hepatology 2021
Safety pharmacology of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG), a novel siRNA nanoparticle platform.
Kim TR, Kim HY, Kim IH, Kim KC, Ko Y, Park JH, Yun S, Lee IC, Kim SH, Park HO
Toxicology Reports 2021
Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)-A Condition Associated with Heightened Sympathetic Activation.
Carnagarin R, Tan K, Adams L, Matthews VB, Kiuchi MG, Marisol Lugo Gavidia L, Lambert GW, Lambert EA, Herat LY, Schlaich MP
International journal of molecular sciences 2021
Truncated Milk Fat Globule-EGF-like Factor 8 Ameliorates Liver Fibrosis via Inhibition of Integrin-TGFβ Receptor Interaction.
An GH, Lee J, Jin X, Chung J, Kim JC, Park JH, Kim M, Han C, Kim JH, Woo DH
Biomedicines 2021
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4
TJ Humpton, H Hall, C Kiourtis, C Nixon, W Clark, A Hedley, R Shaw, TG Bird, K Blyth, KH Vousden
Cell Death and Differentiation 2021
Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway
NS Younis, AM Ghanim, MA Elmorsy, HA Metwaly
Scientific Reports 2021
Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis
CH Ho, JH Huang, MS Sun, IS Tzeng, YC Hsu, CY Kuo, S Perveen
Evidence-Based Complementary and Alternative Medicine 2021
Targeting myosin 1c inhibits murine hepatic fibrogenesis
E Arif, C Wang, MK Swiderska-Syn, AK Solanki, B Rahman, PP Manka, JD Coombes, A Canbay, S Papa, D Nihalani, P Aspichueta, JH Lipschutz, WK Syn
AJP Gastrointestinal and Liver Physiology 2021
sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p
J Kim, C Lee, Y Shin, S Wang, J Han, M Kim, JM Kim, SC Shin, BJ Lee, TJ Kim, Y Jung
Molecular Therapy 2021
Inhibiting Th1/2 cells influences hepatic capillarization by adjusting sinusoidal endothelial fenestrae through Rho-ROCK-myosin pathway
Y Zhong, M Xu, J Hu, , N Lin, M Deng
Aging 2021
Identification of Common Genes and Pathways in Eight Fibrosis Diseases
C Gu, X Shi, X Dang, J Chen, C Chen, Y Chen, X Pan, T Huang
Frontiers in Genetics 2021
Disruption of myofibroblastic Notch signaling attenuates liver fibrosis by modulating fibrosis progression and regression
Z Yue, Z Jiang, B Ruan, J Duan, P Song, J Liu, H Han, L Wang
International journal of biological sciences 2021
PROLIDASE: A Review from Discovery to its Role in Health and Disease.
Eni-Aganga I, Lanaghan ZM, Balasubramaniam M, Dash C, Pandhare J
Frontiers in Molecular Biosciences 2021
Shugan Huoxue Huayu Fang (疏肝活血化瘀方) attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting transforming growth factor-β1/Smad signaling
LIU L, GUO H, SHAO C, WANG L, XU Y, ZHOU Y
Journal of Traditional Chinese Medicine 2021
Role of the Inflammasome in Liver Disease.
de Carvalho Ribeiro M, Szabo G
Annual review of pathology 2021
Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis.
Tang M, Chen Y, Li B, Sugimoto H, Yang S, Yang C, LeBleu VS, McAndrews KM, Kalluri R
The FASEB Journal 2021
Knockdown of TRIM15 inhibits the activation of hepatic stellate cells.
Zhang J, Chen Y, Tian Y, Chen S, Liu H
Journal Of Molecular Histology 2021
SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury.
Getachew A, Abbas N, You K, Yang Z, Hussain M, Huang X, Cheng Z, Tan S, Tao J, Yu X, Chen Y, Yang F, Pan T, Xu Y, Xu G, Zhuang Y, Wu F, Li Y
iScience 2021
Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells.
Wu X, Shu L, Zhang Z, Li J, Zong J, Cheong LY, Ye D, Lam KSL, Song E, Wang C, Xu A, Hoo RLC
2021
Activity Components from Gynostemma pentaphyllum for Preventing Hepatic Fibrosis and of Its Molecular Targets by Network Pharmacology Approach.
Zhang Y, Shi G, Luo Z, Wang J, Wu S, Zhang X, Zhao Y
Molecules (Basel, Switzerland) 2021
Lack of Association Between Recent Cannabis Use and Advanced Liver Fibrosis Among HIV-positive Heavy Drinkers.
Fuster D, So-Armah K, Cheng DM, Coleman SM, Gnatienko N, Lioznov D, Krupitsky EM, Freiberg MS, Samet JH
Current HIV research 2021
It's all about the spaces between cells: role of extracellular matrix in liver fibrosis.
Khurana A, Sayed N, Allawadhi P, Weiskirchen R
Annals of translational medicine 2021
The roles and mechanisms of hypoxia in liver fibrosis.
Cai J, Hu M, Chen Z, Ling Z
Journal of Translational Medicine 2021
Silencing of CD147 inhibits hepatic stellate cells activation related to suppressing aerobic glycolysis via hedgehog signaling.
Li H, Yang L, Sun Y, Zhang Y, Chai J, Liu B, Ye Y
Cytotechnology 2021
Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment.
Flamini S, Sergeev P, Viana de Barros Z, Mello T, Biagioli M, Paglialunga M, Fiorucci C, Prikazchikova T, Pagano S, Gagliardi A, Riccardi C, Zatsepin T, Migliorati G, Bereshchenko O, Bruscoli S
Cell Death and Disease 2021
TGF-β1 can be regulated by NDRG2 via the NF-κB pathway in hypoxia-induced liver fibrosis.
Ba HZ, Liang ZH, Kim HS, Cao W
Annals of translational medicine 2021
Magnetic resonance quantitative susceptibility mapping in the evaluation of hepatic fibrosis in chronic liver disease: a feasibility study.
Qu Z, Yang S, Xing F, Tong R, Yang C, Guo R, Huang J, Lu F, Fu C, Yan X, Hectors S, Gillen K, Wang Y, Liu C, Zhan S, Li J
Quantitative imaging in medicine and surgery 2021
A Positive Relationship between Betel Nut Chewing and Significant Liver Fibrosis in NAFLD Subjects, but Not in Non-NAFLD Ones.
Chou YT, Li CH, Sun ZJ, Shen WC, Yang YC, Lu FH, Chang CJ, Wu JS
Nutrients 2021
Role of FAT1 in health and disease.
Peng Z, Gong Y, Liang X
Oncology Letters 2021
N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice.
Shen DF, Cheng H, Cai BZ, Cai WF, Wang B, Zhu Q, Wu YB, Liu M, Chen RJ, Gao FF, Zhang YM, Niu YD, Shi GG
Acta Pharmacologica Sinica 2021
Inhibition of miR-188-5p alleviates hepatic fibrosis by significantly reducing the activation and proliferation of HSCs through PTEN/PI3K/AKT pathway.
Riaz F, Chen Q, Lu K, Osoro EK, Wu L, Feng L, Zhao R, Yang L, Zhou Y, He Y, Zhu L, Du X, Sadiq M, Yang X, Li D
Journal of Cellular and Molecular Medicine 2021
Imaging-Based Staging of Hepatic Fibrosis in Patients with Hepatitis B: A Dynamic Radiomics Model Based on Gd-EOB-DTPA-Enhanced MRI.
Zheng R, Shi C, Wang C, Shi N, Qiu T, Chen W, Shi Y, Wang H
Biomolecules 2021
Exosomes Secreted from Amniotic Membrane Contribute to Its Anti-Fibrotic Activity.
Mao Y, Jacob V, Singal A, Lei S, Park MS, Lima MRN, Li C, Dhall S, Sathyamoorthy M, Kohn J
International journal of molecular sciences 2021
Taxifolin, Extracted from Waste Larix olgensis Roots, Attenuates CCl(4)-Induced Liver Fibrosis by Regulating the PI3K/AKT/mTOR and TGF-β1/Smads Signaling Pathways.
Liu X, Liu W, Ding C, Zhao Y, Chen X, Ling D, Zheng Y, Cheng Z
Drug design, development and therapy 2021
Endoplasmic reticulum stress and autophagy are involved in adipocyte-induced fibrosis in hepatic stellate cells.
Liu Y, Wu X, Wang Y, Guo Y
Molecular and Cellular Biochemistry 2021
Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis.
Bu FT, Zhu Y, Chen X, Wang A, Zhang YF, You HM, Yang Y, Yang YR, Huang C, Li J
2021
A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma.
Diesinger T, Lautwein A, Bergler S, Buckert D, Renz C, Dvorsky R, Buko V, Kirko S, Schneider E, Kuchenbauer F, Kumar M, Günes C, Genze F, Büchele B, Simmet T, Haslbeck M, Masur K, Barth T, Müller-Enoch D, Wirth T, Haehner T
Canadian journal of gastroenterology & hepatology 2021
Automated Analysis of Multiparametric Magnetic Resonance Imaging/Magnetic Resonance Elastography Exams for Prediction of Nonalcoholic Steatohepatitis.
Dzyubak B, Li J, Chen J, Mara KC, Therneau TM, Venkatesh SK, Ehman RL, Allen AM, Yin M
Journal of magnetic resonance imaging : JMRI 2021
Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system.
Pirola CJ, Salatino A, Sookoian S
World Journal of Gastroenterology 2021
Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
Dat NQ, Thuy LTT, Hieu VN, Hai H, Hoang DV, Thi Thanh Hai N, Thuy TTV, Komiya T, Rombouts K, Dong MP, Hanh NV, Hoang TH, Sato-Matsubara M, Daikoku A, Kadono C, Oikawa D, Yoshizato K, Tokunaga F, Pinzani M, Kawada N
Hepatology 2021
Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways.
Ji J, Yu Q, Dai W, Wu L, Feng J, Zheng Y, Li Y, Guo C
PPAR Research 2021
Hepatoprotective effect of bone marrow-derived mesenchymal stromal cells in CCl(4)-induced liver cirrhosis.
Aithal AP, Bairy LK, Seetharam RN, Kumar N
3 Biotech 2021
Role of long non‑coding RNAs and related epigenetic mechanisms in liver fibrosis (Review).
Ganguly N, Chakrabarti S
International journal of molecular medicine 2021
Integrin Linked Kinase (ILK) and its Role in Liver Pathobiology.
Martucci N, Michalopoulos GK, Mars WM
Gene expression 2021
Period1 mediates rhythmic metabolism of toxins by interacting with CYP2E1.
Ge W, Wang T, Zhao Y, Yang Y, Sun Q, Yang X, Gao Y, Xu X, Zhang J
Cell Death and Disease 2021
Liver Fibrosis Biomarkers Accurately Exclude Advanced Fibrosis and Are Associated with Higher Cardiovascular Risk Scores in Patients with NAFLD or Viral Chronic Liver Disease.
Ballestri S, Mantovani A, Baldelli E, Lugari S, Maurantonio M, Nascimbeni F, Marrazzo A, Romagnoli D, Targher G, Lonardo A
2021
Comparison of MR-PWI quantitative and semi-quantitative parameters for the evaluation of liver fibrosis.
Ding K, Liu M, Wei X, Huang R, Chen J, Lu S, Wang D, Lu W
BMC medical imaging 2021
STAT3 Promotes Schistosome-Induced Liver Injury by Inflammation, Oxidative Stress, Proliferation, and Apoptosis Signal Pathway.
Zhao J, Liu X, Chen Y, Zhang LS, Zhang YR, Ji DR, Liu SM, Jia MZ, Zhu YH, Qi YF, Lu FM, Yu YR
Infection and immunity 2021
KRT17 Promotes the Activation of HSCs via EMT in Liver Fibrosis.
Chen J, Ge SJ, Feng HJ, Wu SZ, Ji R, Huang WR, Huang W, Lu CH
Journal of Clinical and Translational Hepatology 2021
Potential role of noninvasive biomarkers during liver fibrosis
Kaur N, Goyal G, Garg R, Tapasvi C, Chawla S, Kaur R
World journal of hepatology 2021
Deep Learning in the Classification of Stage of Liver Fibrosis in Chronic Hepatitis B with Magnetic Resonance ADC Images
Zhu Z, Lv D, Zhang X, Wang SH, Zhu G
Contrast Media & Molecular Imaging 2021
Transcriptome analysis reveals the molecular mechanism of Yiqi Rougan decoction in reducing CCl4-induced liver fibrosis in rats
Xiong Y, Hu J, Xuan C, Tian J, Tan K, Chen Z, Luo Y, Du X, Cheng J, Zhang L, Cao W
Chinese medicine 2021
The Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration
Zheng Z, Wang B
Frontiers in immunology 2021
Drug Induced Liver Injury: Perspective of the Adverse Drug Reaction Reports to the Portuguese Pharmacovigilance System from 2010 to 2019
Nunes DR, Breton MC, Monteiro CS, dos Santos JL
Healthcare 2021
Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann–Pick Type C Disease
Van Hoecke L, Van Cauwenberghe C, Börger V, Bruggeman A, Castelein J, Van Imschoot G, Van Wonterghem E, Dittrich R, Claeys W, Xie J, Giebel B, Vandenbroucke RE
Biomedicines 2021
Preparation and Characterization of Silymarin-Conjugated Gold Nanoparticles with Enhanced Anti-Fibrotic Therapeutic Effects against Hepatic Fibrosis in Rats: Role of MicroRNAs as Molecular Targets
Abdullah AS, El Sayed IE, El-Torgoman AM, Alghamdi NA, Ullah S, Wageh S, Kamel MA
Biomedicines 2021
UDP-glucuronosyltransferases mediate coffee-associated reduction of liver fibrosis in bile duct ligated humanized transgenic UGT1A mice
Landerer S, Kalthoff S, Strassburg CP
Hepatobiliary surgery and nutrition 2021
Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
Cai Q, Gan C, Tang C, Wu H, Gao J
Frontiers in pharmacology 2021
Effect of miR-183-5p on Cholestatic Liver Fibrosis by Regulating Fork Head Box Protein O1 Expression
Wang Y, Chen B, Xiao C, Yu J, Bu X, Jiang F, Ding W, Ge Z
Frontiers in physiology 2021
Comprehensive Analysis of the Transcriptome-Wide m6A Methylation Modification Difference in Liver Fibrosis Mice by High-Throughput m6A Sequencing
Fan C, Ma Y, Chen S, Zhou Q, Jiang H, Zhang J, Wu F
Frontiers in Cell and Developmental Biology 2021
HLA-G Is Widely Expressed by Mast Cells in Regions of Organ Fibrosis in the Liver, Lung and Kidney
Mouchet N, Vu N, Turlin B, Rioux-Leclercq N, Jouneau S, Samson M, Amiot L
International journal of molecular sciences 2021
Naringenin: A Promising Therapeutic Agent against Organ Fibrosis
Du Y, Ma J, Fan Y, Wang X, Zheng S, Feng J, Li J, Fan Z, Li G, Ye Q
Oxidative medicine and cellular longevity 2021
p70 Ribosomal Protein S6 Kinase Is a Checkpoint of Human Hepatic Stellate Cell Activation and Liver Fibrosis in Mice
Reiter FP, Ye L, Ofner A, Schiergens TS, Ziesch A, Brandl L, Ben Khaled N, Hohenester S, Wimmer R, Artmann R, He Y, Lee SM, Mayr D, Zhang C, Gerbes AL, Mayerle J, Denk G, De Toni EN
Cellular and Molecular Gastroenterology and Hepatology 2021
Human Liver Stem Cell-Derived Extracellular Vesicles Target Hepatic Stellate Cells and Attenuate Their Pro-fibrotic Phenotype
Chiabotto G, Ceccotti E, Tapparo M, Camussi G, Bruno S
Frontiers in Cell and Developmental Biology 2021
The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways
Abdelhamid AM, Selim A, Zaafan MA
Frontiers in Molecular Biosciences 2021
Magnetic resonance quantification of non-Gaussian water diffusion in hepatic fibrosis staging: a pilot study of diffusion kurtosis imaging to identify reversible hepatic fibrosis
Liu T, Hu J, Liu Y, Chen H, Guo D
Annals of translational medicine 2021
Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion
Zhang Y, Guo A, Lyu C, Bi R, Wu Z, Li W, Zhao P, Niu Y, Na J, Xi JJ, Du Y
iScience 2021
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation
Lu ZN, Niu WX, Zhang N, Ge MX, Bao YY, Ren Y, Guo XL, He HW
Acta Pharmacologica Sinica 2021
Hyaluronic acid as a potential marker for assessment of fibrosis regression after direct acting antiviral drugs in chronic hepatitis C patients
Rewisha E, Salman T, Alhaddad O, Raia GA, Naguib M, Rashad S, Abdelfattah A, Metwally K, Abdelsameea E
Clinical and Experimental Hepatology 2021
Liver Impairment—The Potential Application of Volatile Organic Compounds in Hepatology
Stavropoulos G, van Munster K, Ferrandino G, Sauca M, Ponsioen C, van Schooten FJ, Smolinska A
Metabolites 2021
Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as Fibrosis-Specific Extracellular Biomarkers and Promoters of HSC Activation
Messner CJ, Schmidt S, Özkul D, Gaiser C, Terracciano L, Krähenbühl S, Suter-Dick L
International journal of molecular sciences 2021
Glucosylceramide synthase regulates hepatocyte repair after concanavalin A-induced immune-mediated liver injury
Gan J, Gao Q, Wang LL, Tian AP, Zhu LD, Zhang LT, Zhou W, Mao XR, Li JF
PeerJ 2021
The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1
Xi Y, Li Y, Xu P, Li S, Liu Z, Tung HC, Cai X, Wang J, Huang H, Wang M, Xu M, Ren S, Li S, Zhang M, Lee YJ, Huang L, Yang D, He J, Huang Z, Xie W
Science Advances 2021
Cholbam® and Zellweger spectrum disorders: treatment implementation and management
Anderson JN, Ammous Z, Eroglu Y, Hernandez E, Heubi J, Himes R, Palle S
Orphanet Journal of Rare Diseases 2021
Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment
El-Khateeb E, Achour B, Al-Majdoub ZM, Barber J, Rostami-Hodjegan A
Molecular Pharmaceutics 2021
Markers of Monocyte Activation, Inflammation, and Microbial Translocation Are Associated with Liver Fibrosis in Alcohol Use Disorder
Fuster D, Garcia-Calvo X, Farré O, Zuluaga P, Bolao F, Leis A, Hernández-Rubio A, Rivas I, Muga R
Journal of Clinical Medicine 2021
Somatostatin Therapy Improves Stellate Cell Activation and Early Fibrogenesis in a Preclinical Model of Extended Major Hepatectomy
Hessheimer AJ, Vengohechea J, Martínez de la Maza L, Muñoz J, Vendrell M, Sanahuja JM, Torroella A, Adel Al Shwely F, Riquelme F, Muñoz C, García R, Taurá P, Fondevila C
Cancers 2021
White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice
Gallego P, Luque-Sierra A, Falcon G, Carbonero P, Grande L, Bautista JD, Martín F, Del Campo JA
Foods 2021
miRNA‐130b‐5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression
Wang H, Wang Z, Wang Y, Li X, Yang W, Wei S, Shi C, Qiu J, Ni M, Rao J, Cheng F
Journal of Cellular and Molecular Medicine 2021
Identification of New Biomarker for Prediction of Hepatocellular Carcinoma Development in Early-Stage Cirrhosis Patients
Ning G, Li Y, Chen W, Tang W, Shou D, Luo Q, Chen H, Zhou Y
Journal of Oncology 2021
Progress and Challenges in the Use of a Liver-on-a-Chip for Hepatotropic Infectious Diseases
Kulkeaw K, Pengsart W
Micromachines 2021
Death-Associated Protein 6 (Daxx) Alleviates Liver Fibrosis by Modulating Smad2 Acetylation
Kim SM, Hur WH, Kang BY, Lee SW, Roh PR, Park DJ, Sung PS, Yoon SK
Cells 2021
Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling
He Y, Guo X, Lan T, Xia J, Wang J, Li B, Peng C, Chen Y, Hu X, Meng Z
Stem Cell Research & Therapy 2021
Abbreviated MR Protocols for chronic liver disease and liver cancer
Carbonell G, Taouli B
Magnetic resonance imaging clinics of North America 2021
Preclinical Pharmacokinetics and Pharmacodynamics of Coptidis Preparation in Combination with Lovastatin in High-Fat Diet-Induced Hyperlipidemic Rats
Peng WY, Huang AC, Ting CT, Tsai TH
ACS Omega 2021
Integrated MicroRNA Expression Profile Reveals Dysregulated miR-20a-5p and miR-200a-3p in Liver Fibrosis
Ye M, Wang S, Sun P, Qie J
BioMed Research International 2021
Assessment of liver disease in patients with chronic hepatitis C and unhealthy alcohol use
Fuster D, García-Calvo X, Zuluaga P, Bolao F, Muga R
World Journal of Gastroenterology 2021
Hepatoprotective effect of Saccharomyces Cervisciae Cell Wall Extract against thioacetamide-induced liver fibrosis in rats
El-Gendy ZA, El-Marasy SA, Ahmed RF, El-Batran SA, Abd El-Rahman SS, Ramadan A, Youssef SA
Heliyon 2021
Using vibration controlled transient elastography and FIB-4 to assess liver cirrhosis in a hepatitis C virus infected population
Saleem N, Miller LS, Dadabhai AS, Cartwright EJ
Medicine 2021
Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring.
Mennitti LV, Carpenter AAM, Loche E, Pantaleão LC, Fernandez-Twinn DS, Schoonejans JM, Blackmore HL, Ashmore TJ, Pisani LP, Tadross JA, Hargreaves I, Ozanne SE
International Journal of Obesity 2021
FGF21 ameliorates hepatic fibrosis by multiple mechanisms.
Meng F, Khoso MH, Kang K, He Q, Cao Y, Jiang X, Xiao W, Li D
Molecular Biology Reports 2021
Pentraxin-3: A Novel Marker for Indicating Liver Fibrosis in Chronic Hepatitis B Patients?
Balin ŞÖ, Cabalak M, Sağmak Tartar A, Kazancı Ü, Telo S, Demirdağ K, Akbulut A
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2021
Suppressor CD4(+) T cells expressing HLA-G are expanded in the peripheral blood from patients with acute decompensation of cirrhosis.
Khamri W, Gudd C, Liu T, Nathwani R, Krasniqi M, Azam S, Barbera T, Trovato FM, Possamai L, Triantafyllou E, Seoane RC, Lebosse F, Singanayagam A, Kumar N, Bernsmeier C, Mukherjee S, McPhail M, Weston CJ, Antoniades CG, Thursz MR
Gut 2021
Noninvasive staging of liver fibrosis: review of current quantitative CT and MRI-based techniques.
Im WH, Song JS, Jang W
2021
An ultrasound image-based deep multi-scale texture network for liver fibrosis grading in patients with chronic HBV infection.
Ruan D, Shi Y, Jin L, Yang Q, Yu W, Ren H, Zheng W, Chen Y, Zheng N, Zheng M
Liver international : official journal of the International Association for the Study of the Liver 2021
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1.
Luo P, Liu D, Zhang Q, Yang F, Wong YK, Xia F, Zhang J, Chen J, Tian Y, Yang C, Dai L, Shen HM, Wang J
Acta pharmaceutica Sinica. B 2021
Vibration-controlled Transient Elastography for Assessment of Liver Fibrosis at a USA Academic Medical Center.
Shen M, Lee A, Lefkowitch JH, Worman HJ
Journal of Clinical and Translational Hepatology 2021
Combined effect of hydrogen sulfide and mesenchymal stem cells on mitigating liver fibrosis induced by bile duct ligation: Role of anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-fibrotic biomarkers.
Mohammed RA, Shawky HM, Rashed LA, Elhanbuli HM, Abdelhafez DN, Said ES, Shamardan RM, Mahmoud RH
Iranian Journal of Basic Medical Sciences 2021
[(18)F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models.
Shao T, Chen Z, Rong J, Belov V, Chen J, Jeyarajan A, Deng X, Fu H, Yu Q, Rwema SH, Lin W, Papisov M, Josephson L, Chung RT, Liang SH
Acta pharmaceutica Sinica. B 2021
Second hits exacerbate alcohol-related organ damage: an update.
Osna NA, Ganesan M, Seth D, Wyatt TA, Kidambi S, Kharbanda KK
Alcohol and alcoholism (Oxford, Oxfordshire) 2021
Hepatoprotective Effect of Probiotic Lactic Acid Bacteria on Thioacetamide-Induced Liver Fibrosis in Rats.
Jantararussamee C, Rodniem S, Taweechotipatr M, Showpittapornchai U, Pradidarcheep W
Probiotics and Antimicrobial Proteins 2021
Angiotensin Converting Enzyme‐2 Therapy Improves Liver Fibrosis and Glycemic Control in Diabetic Mice With Fatty Liver
Rajapaksha IG, Gunarathne LS, Asadi K, Laybutt R, Andrikopoulous S, Alexander IE, Watt MJ, Angus PW, Herath CB
Hepatology Communications 2021
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis
Xu L, Yang TY, Zhou YW, Wu MF, Shen J, Cheng JL, Liu QX, Cao SY, Wang JQ, Zhang L
Acta Pharmacologica Sinica 2021
Protective effects of Longhu Rendan on chronic liver injury and fibrosis in mice
Yang G, Li S, Jin J, Xuan Y, Ding L, Huang M, Liu J, Wang B, Lan T
Liver Research 2021
Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer
Peter Dietrich, Laura Wormser, Valerie Fritz, Tatjana Seitz, Monica De Maria, Alexandra Schambony, Andreas E. Kremer, Claudia Günther, Timo Itzel, Wolfgang E. Thasler, Andreas Teufel, Jonel Trebicka, Arndt Hartmann, Markus F. Neurath, Stephan von Hörsten, Anja Bosserhoff, Claus Hellerbrand
Journal of Clinical Investigation 2020
Blockade of lL17 signaling reverses alcohol-induced liver and brain injury, and excessive alcohol drinking in mice
Jun Xu, Hsiao-Yen Ma, Xiao Liu, Sara Brin Rosenthal, Jacopo Baglieri, Ryan McCubbin, Mengxi Sun, Yukinori Koyama, Cedric G Geoffroy, Kaoru Saijo, Linshan Shang, Takahiro Nishio, Igor Maricic, Max Kreifeldt, Praveen Kusumanchi, Amanda Roberts, Binhai Zheng, Vipin Kumar, Karsten Zengler, Donald P Pizzo, Mojgan Hosseini, Candice Contet, Christopher K. Glass, Suthat Liangpunsakul, Hidekazu Tsukamoto, Bin Gao, Michael Karin, David A. Brenner, George F. Koob, Tatiana Kisseleva
JCI Insight 2020
Hepatic stellate cell–specific knockout of transcriptional intermediary factor 1γ aggravates liver fibrosis
EJ Lee, I Hwang, JY Lee, JN Park, KC Kim, I Kim, D Moon, H Park, SY Lee, HS Kim, DW Jun, SH Park, HS Kim
Journal of Experimental Medicine 2020
PKM2 tetramerization protects against hepatic stellate cell activation, liver fibrosis, and hepatocellular carcinoma
Dandan Zheng, Chen Qu, Kaishun Hu, Hui Yuan, Lu He, Peng Chen, Yuchuan Jiang, Jinying Li, Mengxian Tu, Shuang Peng, Wenyu Lin, Raymond Chung, Jian Hong
The American Journal of Pathology 2020
Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection
G Xie, X Wang, R Wei, J Wang, A Zhao, T Chen, Y Wang, H Zhang, Z Xiao, X Liu, Y Deng, L Wong, C Rajani, S Kwee, H Bian, X Gao, P Liu, W Jia
BMC Medicine 2020
Proteoglycan-4 is correlated with longer survival in HCC patients and enhances sorafenib and regorafenib effectiveness via CD44 in vitro
F Dituri, R Scialpi, TA Schmidt, M Frusciante, S Mancarella, LG Lupo, E Villa, G Giannelli
Cell Death and Disease 2020
The fibrotic tumor stroma
B Piersma, MK Hayward, VM Weaver
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2020
Ceramide and Sphingosine 1-Phosphate in Liver Diseases
Woo-Jae Park, Jae-Hwi Song, Goon-Tae Kim, Tae-Sik Park
Molecules and Cells 2020
Oncogenic driver genes and tumor microenvironment determine the type of liver cancer
G Wang, Q Wang, N Liang, H Xue, T Yang, X Chen, Z Qiu, C Zeng, T Sun, W Yuan, C Liu, Z Chen, X He
Cell Death and Disease 2020
Role of immune cells in the removal of deleterious senescent cells
A Kale, A Sharma, A Stolzing, PY Desprez, J Campisi
Immunity & Ageing 2020
The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix
M Matsuda, E Seki
Food and Chemical Toxicology 2020
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis
J Leslie, MG Macia, S Luli, JC Worrell, WJ Reilly, HL Paish, A Knox, BS Barksby, LM Gee, MY Zaki, AL Collins, RA Burgoyne, R Cameron, C Bragg, X Xu, GW Chung, CD Brown, AD Blanchard, CB Nanthakumar, M Karsdal, SM Robinson, DM Manas, G Sen, J French, SA White, S Murphy, M Trost, JL Zakrzewski, U Klein, RF Schwabe, I Mederacke, C Nixon, T Bird, LA Teuwen, L Schoonjans, P Carmeliet, J Mann, AJ Fisher, NS Sheerin, LA Borthwick, DA Mann, F Oakley
2020
Hepatic Stellate Cell–Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis
M Matsuda, E Seki
Seminars in liver disease 2020
Therapeutic efficiency of bone marrow-derived mesenchymal stem cells for liver fibrosis: A systematic review of in vivo studies
Z Al-Dhamin, LD Liu, DD Li, SY Zhang, SM Dong, YM Nan
World journal of gastroenterology : WJG 2020
Idiopathic Pulmonary Fibrosis: Pathogenesis and the Emerging Role of Long Non-Coding RNAs
MR Hadjicharalambous, MA Lindsay
International journal of molecular sciences 2020
Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein
DY Yu
Laboratory animal research 2020
Long-Term Exposure to Low-Dose Di-(2-ethylhexyl) Phthalate Impairs Cholesterol Metabolism in Hepatic Stellate Cells and Exacerbates Liver Librosis
CY Lee, FM Suk, YC Twu, YJ Liao
International journal of environmental research and public health 2020
S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemness
Y Li, J Wang, K Song, S Liu, H Zhang, F Wang, C Ni, W Zhai, J Liang, Z Qin, J Zhang
OncoImmunology 2020
Impaired liver regeneration and lipid homeostasis in CCl4 treated WDR13 deficient mice
AP Mishra, AB Siva, C Gurunathan, Y Komala, BJ Lakshmi
Laboratory animal research 2020
Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-β1-miR29a in mice
XY Xu, Y Du, X Liu, Y Ren, Y Dong, HY Xu, JS Shi, D Jiang, X Xu, L Li, ZH Xu, Y Geng
Cell Communication and Signaling 2020
Cirrhotic portal hypertension: From pathophysiology to novel therapeutics
LS Gunarathne, H Rajapaksha, N Shackel, PW Angus, CB Herath
World journal of gastroenterology : WJG 2020
Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis
LT Thuy, H Hai, N Kawada
Clinical and Molecular Hepatology 2020
Molecular and cellular mechanisms of liver fibrosis and its regression
T Kisseleva, D Brenner
Nature Reviews Gastroenterology & Hepatology 2020
The Endothelium as a Driver of Liver Fibrosis and Regeneration
E Lafoz, M Ruart, A Anton, A Oncins, V Hernández-Gea
Cells 2020
Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis
P Ramachandran, KP Matchett, R Dobie, JR Wilson-Kanamori, NC Henderson
Nature Reviews Gastroenterology & Hepatology 2020
The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders
JD Gregorio, I Robuffo, S Spalletta, G Giambuzzi, VD Iuliis, E Toniato, S Martinotti, P Conti, V Flati
Frontiers in Cell and Developmental Biology 2020
Mechanisms of liver fibrosis and its role in liver cancer
D Dhar, J Baglieri, T Kisseleva, DA Brenner
Experimental biology and medicine (Maywood, N.J.) 2020
Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway
Z Wang, ZX Cheng, ST Abrams, ZQ Lin, ED Yates, Q Yu, WP Yu, PS Chen, CH Toh, GZ Wang
World journal of gastroenterology : WJG 2020
Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma
C Mittermeier, A Konopa, S Muehlich
Cells 2020
Deletion of KLF10 Leads to Stress-Induced Liver Fibrosis upon High Sucrose Feeding
J Lee, AR Oh, HY Lee, YA Moon, HJ Lee, JY Cha
International journal of molecular sciences 2020
Advances in Functional and Molecular MRI Technologies in Chronic Liver Diseases
IY Zhou, OA Catalano, P Caravan
Journal of Hepatology 2020
Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis
A Claveria-Cabello, L Colyn, I Uriarte, MU Latasa, M Arechederra, JM Herranz, L Alvarez, JM Urman, ML Martinez-Chantar, JM Banales, B Sangro, K Rombouts, J Oyarzabal, JJ Marin, C Berasain, MA Avila, MG Fernandez-Barrena
Cancers 2020
Cellular Interplay as a Consequence of Inflammatory Signals Leading to Liver Fibrosis Development
SR Ignat, S Dinescu, A Hermenean, M Costache
Cells 2020
The Differential and Dynamic Progression of Hepatic Inflammation and Immune Responses During Liver Fibrosis Induced by Schistosoma japonicum or Carbon Tetrachloride in Mice
LJ Song, XR Yin, SS Mu, JH Li, H Gao, Y Zhang, PP Dong, CJ Mei, ZC Hua
Frontiers in immunology 2020
Metabolic dysfunction and inflammatory disease: the role of stromal fibroblasts
H Farah, SP Young, C Mauro, SW Jones
The FEBS journal 2020
Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis
B Baeza-Raja, A Goodyear, X Liu, K Lam, L Yamamoto, Y Li, GS Dodson, T Takeuchi, T Kisseleva, DA Brenner, K Dabbagh, MA Avila
PloS one 2020
Loss of hepatocyte cell division leads to liver inflammation and fibrosis
MR Dewhurst, JR Ow, G Zafer, NK van Hul, H Wollmann, X Bisteau, D Brough, H Choi, P Kaldis, GS Barsh
PLoS genetics 2020
Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12
JP Arab, D Cabrera, TS Sehrawat, N Jalan-Sakrikar, VK Verma, D Simonetto, S Cao, U Yaqoob, J Leon, M Freire, JI Vargas, TM Assuncao, JH Kwon, Y Guo, E Kostallari, Q Cai, T Kisseleva, Y Oh, M Arrese, RC Huebert, VH Shah
Journal of Hepatology 2020
Hepatic Stellate Cell Regulation of Liver Regeneration and Repair
LJ Kitto, NC Henderson
Hepatology Communications 2020
Role of spleen tyrosine kinase in liver diseases
DW Kurniawan, G Storm, J Prakash, R Bansal
World journal of gastroenterology : WJG 2020
Liver progenitor cell-driven liver regeneration
J So, A Kim, SH Lee, D Shin
Experimental & molecular medicine 2020
Role of B Cell Lymphoma 2 in the Regulation of Liver Fibrosis in miR-122 Knockout Mice
KY Teng, JM Barajas, P Hu, ST Jacob, K Ghoshal
Biology : open access journal 2020
Molecular and Functional Roles of MicroRNAs in the Progression of Hepatocellular Carcinoma—A Review
K Oura, A Morishita, T Masaki
International journal of molecular sciences 2020
Emerging Roles of SIRT1 in Alcoholic Liver Disease
R Ren, Z Wang, M Wu, H Wang
International journal of biological sciences 2020
Tyrosine kinase inhibitor neratinib attenuates liver fibrosis by targeting activated hepatic stellate cells
YJ Park, HT An, JS Park, O Park, AJ Duh, K Kim, KH Chung, KC Lee, Y Oh, S Lee
Scientific Reports 2020
Hepatic alterations during the development and progression of cancer cachexia
ME Rosa-Caldwell, JL Brown, DE Lee, MP Wiggs, RA Perry, WS Haynie, AR Caldwell, TA Washington, WJ Lo, NP Greene
Applied Physiology, Nutrition, and Metabolism 2020
Irisin Regulates the Functions of Hepatic Stellate Cells
HN Dong, SY Park, CT Le, DH Choi, EH Cho
Endocrinology and Metabolism 2020
Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation
E You, P Ko, J Jeong, S Keum, JW Kim, YJ Seo, WK Song, S Rhee
Cellular and Molecular Life Sciences 2020
Astaxanthin inhibits the reduction of glycolysis during the activation of hepatic stellate cells
M Bae, Y Lee, TX Pham, S Hu, YK Park, JY Lee
Life Sciences 2020
Liver fibrosis: Pathophysiology and clinical implications
J Berumen, J Baglieri, T Kisseleva, K Mekeel
Wiley interdisciplinary reviews. Systems biology and medicine 2020
Isochlorogenic Acid A Attenuates the Progression of Liver Fibrosis Through Regulating HMGB1/TLR4/NF-κB Signaling Pathway
X Liu, K Huang, RJ Zhang, D Mei, B Zhang
Frontiers in pharmacology 2020
Hepatoprotective effect of Xiayuxue decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells
D Zhang, L Zhang, G Chen, Y Xu, H Yang, Z Xiao, J Chen, Y Mu, H Zhang, W Liu, P Liu
Pharmaceutical Biology 2020
Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver
A Adhyatmika, L Beljaars, KS Putri, H Habibie, CE Boorsma, C Reker-Smit, T Luangmonkong, B Guney, A Haak, KA Mangnus, E Post, K Poelstra, K Ravnskjaer, P Olinga, BN Melgert
Pharmaceutics 2020
SPOCK1 overexpression induced by platelet-derived growth factor-BB promotes hepatic stellate cell activation and liver fibrosis through the integrin α5β1/PI3K/Akt signaling pathway
Z Du, Z Lin, Z Wang, D Liu, D Tian, L Xia
Laboratory Investigation 2020
Elastography for Longitudinal Assessment of Liver Fibrosis after Antiviral Therapy: A Review
H Wei, B Song
Journal of Clinical and Translational Hepatology 2020
Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma
J Zhang, C Gu, Q Song, M Zhu, Y Xu, M Xiao, W Zheng
Cell & Bioscience 2020
Ginsenosides: potential therapeutic source for fibrosis-associated human diseases
X Li, N Mo, Z Li
Journal of Ginseng Research 2020
Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine
DD Huang, SB Gibeley, C Xu, Y Xiao, O Celik, HN Ginsberg, KW Leong
Advanced Functional Materials 2020
Brucella abortus Infection Elicited Hepatic Stellate Cell-Mediated Fibrosis Through Inflammasome-Dependent IL-1β Production
PC Benitez, AI Viglietti, MT Gomes, SC Oliveira, JF Quarleri, GH Giambartolomei, MV Delpino
Frontiers in immunology 2020
Hepatoprotective Potency of Chrysophanol 8-O-Glucoside from Rheum palmatum L. against Hepatic Fibrosis via Regulation of the STAT3 Signaling Pathway
YJ Park, KH Lee, MS Jeon, YH Lee, YJ Ko, C Pang, B Kim, KH Chung, KH Kim
International journal of molecular sciences 2020
The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension
Y Yuan, H Naito, K Kitamori, S Hashimoto, T Asano, T Nakajima, U Vespasiani-Gentilucci
PloS one 2020
Development of Scaffolds with Adjusted Stiffness for Mimicking Disease-Related Alterations of Liver Rigidity
M Ruoß, S Rebholz, M Weimer, C Grom-Baumgarten, K Athanasopulu, R Kemkemer, H Käß, S Ehnert, AK Nussler
Journal of Functional Biomaterials 2020
Oridonin ameliorates carbon tetrachloride‐induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome
D Liu, H Qin, B Yang, B Du, X Yun
Drug Development Research 2020
Photoacoustic Imaging for Assessing Tissue Oxygenation Changes in Rat Hepatic Fibrosis
MB Karmacharya, LR Sultan, BM Kirkham, AK Brice, AK Wood, CM Sehgal
Diagnostics 2020
Glycyrrhetinic Acid -Induced MiR-663a Alleviates Hepatic Stellate Cell Activation by Attenuating the TGF- β /Smad Signaling Pathway
XX Guo, WN Yang, BS Dong, JW Shang, SB Su, XL Yan, H Zhang
Evidence-Based Complementary and Alternative Medicine 2020
Obeticholic acid and INT-767 modulate collagen deposition in a NASH in vitro model
B Anfuso, C Tiribelli, L Adorini, N Rosso
Scientific Reports 2020
Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy
D Beyoğlu, JR Idle
Metabolites 2020
Hepatocellular Senescence: Immunosurveillance and Future Senescence-Induced Therapy in Hepatocellular Carcinoma
P Liu, Q Tang, M Chen, W Chen, Y Lu, Z Liu, Z He
Frontiers in Oncology 2020
Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/ MAPK Pathway of Hepatic Stellate Cells
YC Yoon, Z Fang, JE Lee, JH Park, JK Ryu, KH Jung, SS Hong
Biomolecules and Therapeutics 2020
Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture
S Hamada-Tsutsumi, M Onishi, K Matsuura, M Isogawa, K Kawashima, Y Sato, Y Tanaka
International journal of molecular sciences 2020
Potential role of transforming growth factor‐beta 1/Smad signaling in secondary lymphedema after cancer surgery
M Sano, S Hirakawa, M Suzuki, J Sakabe, M Ogawa, S Yamamoto, T Hiraide, T Sasaki, N Yamamoto, K Inuzuka, H Tanaka, T Saito, R Sugisawa, K Katahashi, T Yata, T Kayama, T Urano, Y Tokura, K Sato, M Setou, H Takeuchi, H Konno, N Unno
Cancer Science 2020
hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
L Dong, Y Pu, X Chen, X Qi, L Zhang, L Xu, W Li, Y Ma, S Zhou, J Zhu, Y Li, X Wang, C Su
Stem Cell Research & Therapy 2020
Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis
Chen X, Li HD, Bu FT, Li XF, Chen Y, Zhu S, Wang JN, Chen SY, Sun YY, Pan XY, Yin NN, Xu JJ, Huang C, Li J
Theranostics 2020
ColXV Aggravates Adipocyte Apoptosis by Facilitating Abnormal Extracellular Matrix Remodeling in Mice
Xia T, Shen Z, Cai J, Pan M, Sun C
International journal of molecular sciences 2020
Quantitative Evaluation of Liver Fibrosis on T1 Relaxometry in Comparison with Fibroscan
2020
Liver-related effects of chronic hepatitis C antiviral treatment
TL Laursen, TD Sandahl, K Kazankov, J George, H Grønbæk
World journal of gastroenterology : WJG 2020
Hydrogen selenide, a vital metabolite of sodium selenite, uncouples the sulfilimine bond and promotes the reversal of liver fibrosis
D Luan, Z Zhao, D Xia, Q Zheng, X Gao, K Xu, B Tang
Science China Life Sciences 2020
Targeting the Cholecystokinin Receptor: A Novel Approach for Treatment and Prevention of Hepatocellular Cancer
MD Gay, A Safronenka, H Cao, FH Liu, ZX Malchiodi, RD Tucker, A Kroemer, N Shivapurkar, JP Smith
Cancer prevention research (Philadelphia, Pa.) 2020
Mallotus furetianus extract protects against ethanol‐induced liver injury via the activation of the cAMP‐PKA pathway
E Yoshikawa, I MatsuiYuasa, X Huang, Y Kobayashi, A KojimaYuasa
Food Science & Nutrition 2020
Collagen receptor- and metalloproteinase-dependent hypertensive stress response in mesangial and glomerular endothelial cells
S Majumder, M Amin, S Pushpakumar, U Sen
Molecular and Cellular Biochemistry 2020
Tissue Engineering in Liver Regenerative Medicine: Insights into Novel Translational Technologies
Z Heydari, M Najimi, H Mirzaei, A Shpichka, M Ruoss, Z Farzaneh, L Montazeri, A Piryaei, P Timashev, R Gramignoli, A Nussler, H Baharvand, M Vosough
Cells 2020
Cellular Interactions in the Human Fatty Liver
Silvia Sovaila, Adrian Purcarea, Dan Gheonea, Sanziana Ionescu, Tudorel Ciurea
Journal of medicine and life 2020
The antimicrobial peptide YD attenuates inflammation via miR-155 targeting CASP12 during liver fibrosis.
Yan Z, Wang D, An C, Xu H, Zhao Q, Shi Y, Song N, Deng B, Guo X, Rao J, Cheng L, Zhang B, Mou L, Yang W, Jiang X, Xie J
Acta pharmaceutica Sinica. B 2020
The Role of the Gut Microbiome in Liver Cirrhosis Treatment.
Lee NY, Suk KT
International journal of molecular sciences 2020
Use of a convolutional neural network and quantitative ultrasound for diagnosis of fatty liver.
Nguyen TN, Podkowa AS, Park TH, Miller RJ, Do MN, Oelze ML
Ultrasound in Medicine & Biology 2020
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model.
Li W, Li P, Li N, Du Y, Lü S, Elad D, Long M
American journal of physiology. Gastrointestinal and liver physiology 2020
Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis.
Kim J, Kang W, Kang SH, Park SH, Kim JY, Yang S, Ha SY, Paik YH
Scientific Reports 2020
Prevalence and Factors Associated With Liver Fibrosis Among Adult HIV-Infected Patients Attending Urban and Rural Care Clinics in Uganda.
Wekesa C, Kirk GD, Aizire J, Benson EM, Karabarinde A, Parkes-Ratanshi R, Ocama P
Open Forum Infectious Diseases 2020
Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice.
Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T, Brenner DA, Kisseleva T
2020
Convolutional neuronal networks combined with X-ray phase-contrast imaging for a fast and observer-independent discrimination of cartilage and liver diseases stages.
Stroebel J, Horng A, Armbruster M, Mittone A, Reiser M, Bravin A, Coan P
Scientific Reports 2020
Simultaneous Induction of Glycolysis and Oxidative Phosphorylation during Activation of Hepatic Stellate Cells Reveals Novel Mitochondrial Targets to Treat Liver Fibrosis.
Smith-Cortinez N, van Eunen K, Heegsma J, Serna-Salas SA, Sydor S, Bechmann LP, Moshage H, Bakker BM, Faber KN
Cells 2020
Foxp3+ Regulatory T Cells Inhibit CCl(4)-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity.
Ikeno Y, Ohara D, Takeuchi Y, Watanabe H, Kondoh G, Taura K, Uemoto S, Hirota K
Frontiers in immunology 2020
Lodoxamide Attenuates Hepatic Fibrosis in Mice: Involvement of GPR35.
Kim MJ, Park SJ, Nam SY, Im DS
Biomolecules & therapeutics 2020
Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver Injury.
Cox CR, Lynch S, Goldring C, Sharma P
2020
Evaluation of fibrosis in chronic hepatitis C patients treated with direct-acting antivirals.
Tufan AG, Hakim GD, Akar H, Akarsu M
2020
Quantitative assessment of disease severity of primary sclerosing cholangitis with T1 mapping and extracellular volume imaging.
Evrimler S, Swensson JK, Are VS, Tirkes T, Vuppalanchi R, Akisik F
2020
Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target?
Claveria-Cabello A, Colyn L, Arechederra M, Urman JM, Berasain C, Avila MA, Fernandez-Barrena MG
Cells 2020
Literature review of the causes of pain following total knee replacement surgery: prosthesis, inflammation and arthrofibrosis.
Li CY, Ng Cheong Chung KJ, Ali OME, Chung NDH, Li CH
EFORT Open Reviews 2020
Liver Fibrosis Is Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke.
Yuan CX, Ruan YT, Zeng YY, Cheng HR, Cheng QQ, Chen YB, He WL, Huang GQ, He JC
Frontiers in neurology 2020
Integrated quantitative susceptibility and R(2) * mapping for evaluation of liver fibrosis: An ex vivo feasibility study.
Jafari R, Hectors SJ, Koehne de González AK, Spincemaille P, Prince MR, Brittenham GM, Wang Y
NMR in Biomedicine 2020
The Role of Lymphatics in Cholestasis: A Comprehensive Review.
O'Brien A, Gasheva O, Alpini G, Zawieja D, Gashev A, Glaser S
Seminars in liver disease 2020
The anti-fibrotic effect of human fetal skin-derived stem cell secretome on the liver fibrosis.
Yao X, Wang J, Zhu J, Rong X
Stem Cell Research & Therapy 2020
Editorial: Advances in Liver Inflammation and Fibrosis Due to Infectious Diseases.
Oliveira SC, Delpino MV, Giambartolomei GH, Quarleri J, Splitter G
Frontiers in immunology 2020
Preclinical Evidence of Curcuma longa and Its Noncurcuminoid Constituents against Hepatobiliary Diseases: A Review.
An S, Jang E, Lee JH
Evidence-based complementary and alternative medicine : eCAM 2020
Antioxidant and hepatoprotective effects of Korean ginseng extract GS-KG9 in a D-galactosamine-induced liver damage animal model.
Jo YH, Lee H, Oh MH, Lee GH, Lee YJ, Lee JS, Kim MJ, Kim WY, Kim JS, Yoo DS, Cho SW, Cha SW, Pyo MK
Nutrition Research and Practice 2020
Interleukin-1α and -1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C.
Surlin P, Gheorghe DN, Popescu DM, Martu AM, Solomon S, Roman A, Lazar L, Stratul SI, Rusu D, Foia L, Boldeanu MV, Boldeanu L, Danilescu M, Rogoveanu I
Experimental and therapeutic medicine 2020
Histochemical and Immunohistochemical Characterizations of Hepatic Trematodiasis in Odontocetes.
Nakagun S, Kobayashi Y
Frontiers in Veterinary Science 2020
Peroxisome Proliferator-Activated Receptor Gamma Agonist Attenuates Liver Fibrosis by Several Fibrogenic Pathways in an Animal Model of Cholestatic Fibrosis.
Alatas FS, Matsuura T, Pudjiadi AH, Wijaya S, Taguchi T
Pediatric Gastroenterology Hepatology & Nutrition 2020
Mechanistic insights into the effects of SREBP1c on hepatic stellate cell and liver fibrosis.
Su S, Tian H, Jia X, Zhu X, Wu J, Zhang Y, Chen Y, Li Z, Zhou Y
Journal of Cellular and Molecular Medicine 2020
Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation In Vivo.
Sun Y, Pan H, Shen S, Xia Z, Yu Z, Li C, Sun P, Xin C
Medical science monitor : international medical journal of experimental and clinical research 2020
IL-6/STAT3 and adipokine modulation using tocilizumab in rats with fructose-induced metabolic syndrome.
Yahia H, Hassan A, El-Ansary MR, Al-Shorbagy MY, El-Yamany MF
Naunyn-Schmiedeberg's Archives of Pharmacology 2020
Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice.
Li X, Shao S, Li H, Bi Z, Zhang S, Wei Y, Bai J, Zhang R, Ma X, Ma B, Zhang L, Xie C, Ning W, Zhou H, Yang C
Journal of Cellular and Molecular Medicine 2020
MicroRNA-98 Inhibits Hepatic Stellate Cell Activation and Attenuates Liver Fibrosis by Regulating HLF Expression.
Wang Q, Wei S, Zhou H, Li L, Zhou S, Shi C, Shi Y, Qiu J, Lu L
Frontiers in Cell and Developmental Biology 2020
Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis.
Zehra M, Curry JC, Pillai SS, Lakhani HV, Edwards CE, Sodhi K
International journal of molecular sciences 2020
miR-7-5p Promotes Hepatic Stellate Cell Activation by Targeting Fibroblast Growth Factor Receptor 4.
Tian S, Chen M, Wang B, Han Y, Shang H, Chen J
Gastroenterology Research and Practice 2020
Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
Tan S, Zhao J, Sun Z, Cao S, Niu K, Zhong Y, Wang H, Shi L, Pan H, Hu J, Qian L, Liu N, Yuan J
Proceedings of the National Academy of Sciences 2020
Hydralazine Sensitizes to the Antifibrotic Effect of 5-Aza-2'-deoxycytidine in Hepatic Stellate Cells.
Asada K, Kaji K, Sato S, Seki K, Shimozato N, Kawaratani H, Takaya H, Sawada Y, Nakanishi K, Furukawa M, Kitade M, Moriya K, Namisaki T, Noguchi R, Akahane T, Yoshiji H
Biology 2020
Hepatoprotective effect and possible mechanism of phytoestrogen calycosin on carbon tetrachloride-induced liver fibrosis in mice.
Zhang M, Wang Y, Zhu G, Sun C, Wang J
Naunyn-Schmiedeberg's Archives of Pharmacology 2020
Expression of hepatic stellate cell activation-related genes in HBV-, HCV-, and nonalcoholic fatty liver disease-associated fibrosis.
He L, Yuan H, Liang J, Hong J, Qu C
PloS one 2020
Effect of hepato-toxins in the acceleration of hepatic fibrosis in hepatitis B mice.
Poilil Surendran S, George Thomas R, Moon MJ, Park R, Kim DH, Kim KH, Jeong YY
PloS one 2020
Disease Severity-Associated Gene Expression in Canine Myxomatous Mitral Valve Disease Is Dominated by TGFβ Signaling.
Markby GR, Macrae VE, Summers KM, Corcoran BM
Frontiers in Genetics 2020
Elevated liver stiffness without histological evidence of liver fibrosis in rural Ugandans.
Tibuakuu M, Jjingo C, Kirk GD, Thomas DL, Gray R, Ssempijja V, Nalugoda F, Serwadda D, Ocama P, Opio CK, Kleiner DE, Quinn TC, Reynolds SJ
Journal of Viral Hepatitis 2020
EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats.
Kundu A, Dey P, Park JH, Kim IS, Kwack SJ, Kim HS
Cells 2020
Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip.
Goto K, Roca Suarez AA, Wrensch F, Baumert TF, Lupberger J
International journal of molecular sciences 2020
GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress.
Kim HJ, Lee Y, Fang S, Kim W, Kim HJ, Kim JW
BMB Reports 2020
Diagnostic Value of Serum Procollagen III N-Terminal Peptide for Liver Fibrosis in Infantile Cholestasis.
Wang Y, Pan W, Zhao D, Chen Y, Chen X, Xia H
Frontiers in Pediatrics 2020
Aspirin alleviates hepatic fibrosis by suppressing hepatic stellate cells activation via the TLR4/NF-κB pathway.
Liu Y, Nong L, Jia Y, Tan A, Duan L, Lu Y, Zhao J
Aging 2020
Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling.
Xia Z, Ding L, Zheng J, Xu Y, Jin W, Sheng X, Wu J
Drug design, development and therapy 2020
Dendrobium officinale Polysaccharide Protected CCl(4)-Induced Liver Fibrosis Through Intestinal Homeostasis and the LPS-TLR4-NF-κB Signaling Pathway.
Wang K, Yang X, Wu Z, Wang H, Li Q, Mei H, You R, Zhang Y
Frontiers in pharmacology 2020
Clinical Characteristics, Serum Biochemical Changes, and Expression Profile of Serum Cfa-miRNAs in Dogs Confirmed to Have Congenital Portosystemic Shunts Accompanied by Liver Pathologies.
El-Sebaey AM, Abramov PN, Abdelhamid FM
Veterinary Sciences 2020
Evaluation of liver function using the hepatocyte enhancement fraction based on gadoxetic acid-enhanced MRI in patients with chronic hepatitis B.
Liu MT, Zhang XQ, Lu J, Zhang T, Chen Q, Jiang JF, Ding D, Du S, Chen WB
2020
CD47 Deficiency in Mice Exacerbates Chronic Fatty Diet-Induced Steatohepatitis Through Its Role in Regulating Hepatic Inflammation and Lipid Metabolism.
Tao HC, Chen KX, Wang X, Chen B, Zhao WO, Zheng Y, Yang YG
Frontiers in immunology 2020
Genetic and Genomic Advances in Developmental Models: Applications for Nutrition Research.
Chowanadisai W, Hart MD, Strong MD, Graham DM, Rucker RB, Smith BJ, Keen CL, Messerli MA
Advances in nutrition (Bethesda, Md.) 2020
Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connetive Tissue Growth Factor.
Seo HY, Lee SH, Lee JH, Kang YN, Hwang JS, Park KG, Kim MK, Jang BK
Cells 2020
Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook.
Singh L, Joshi T, Tewari D, Echeverría J, Mocan A, Sah AN, Parvanov E, Tzvetkov NT, Ma ZF, Lee YY, Poznański P, Huminiecki L, Sacharczuk M, Jóźwik A, Horbańczuk JO, Feder-Kubis J, Atanasov AG
Frontiers in pharmacology 2020
The Roles and Mechanisms of lncRNAs in Liver Fibrosis.
He Z, Yang D, Fan X, Zhang M, Li Y, Gu X, Yang M
International journal of molecular sciences 2020
Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking.
Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK
Science Advances 2020
FIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C.
So-Armah KA, Lim JK, Lo Re V 3rd, Tate JP, Chang CH, Butt AA, Gibert CL, Rimland D, Marconi VC, Goetz MB, Ramachandran V, Brittain E, Long M, Nguyen KL, Rodriguez-Barradas MC, Budoff MJ, Tindle HA, Samet JH, Justice AC, Freiberg MS
Progress in Cardiovascular Diseases 2020
Simultaneous multislice rapid magnetic resonance elastography of the liver.
Majeed W, Kalra P, Kolipaka A
NMR in Biomedicine 2020
AT-MSCs Antifibrotic Activity is Improved by Eugenol through Modulation of TGF-β/Smad Signaling Pathway in Rats.
Fathy M, Okabe M, Saad Eldien HM, Yoshida T
Molecules (Basel, Switzerland) 2020
Tumor-Stroma Crosstalk Enhances REG3A Expressions that Drive the Progression of Hepatocellular Carcinoma.
Cho Y, Park MJ, Kim K, Park JY, Kim J, Kim W, Yoon JH
International journal of molecular sciences 2020
T1 mapping, T2 mapping and MR elastography of the liver for detection and staging of liver fibrosis.
Hoffman DH, Ayoola A, Nickel D, Han F, Chandarana H, Shanbhogue KP
2020
Natural History of Hepatic and Extrahepatic Hepatitis C Virus Diseases and Impact of Interferon-Free HCV Therapy.
Negro F
Cold Spring Harbor Perspectives in Medicine 2020
Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells
Zhang J, Li Y, Liu Q, Huang Y, Li R, Wu T, Zhang Z, Zhou J, Huang H, Tang Q, Huang C, Zhao Y, Zhang G, Jiang W, Mo L, Zhang J, Xie W, He J
Hepatology 2020
Major Histocompatibility Complex Class I‐Related Chain A Alleles and Histology of Nonalcoholic Fatty Liver Disease
Karrar A, Rajput B, Hariharan S, Abdelatif D, Houry M, Moosvi A, Ali I, Tan D, Noor S, Esmaeili D, Felix S, Alaparthi L, Otgonsuren M, Lam B, Goodman ZD, Younossi ZM
Hepatology Communications 2020
Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis—A multicentre study
Bannaga AS, Metzger J, Kyrou I, Voigtländer T, Book T, Melgarejo J, Latosinska A, Pejchinovski M, Staessen JA, Mischak H, Manns MP, Arasaradnam RP
EBioMedicine 2020
A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression
Zhang N, Zhao SS, Zhang YX, Wang YC, Shao RG, Wang JX, He HW
Acta Pharmacologica Sinica 2020
Low-energy extracorporeal shock wave therapy for a model of liver cirrhosis ameliorates liver fibrosis and liver function
Ujiie N, Nakano T, Yamada M, Sato C, Nakanishi C, Fujishima F, Ito K, Shindo T, Shimokawa H, Kamei T
Scientific Reports 2020
Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo
Du G, Wang J, Zhang T, Ding Q, Jia X, Zhao X, Dong J, Yang X, Lu S, Zhang C, Liu Z, Zeng Z, Safadi R, Qi R, Zhao X, Hong Z, Lu Y
Cell Death and Disease 2020
Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling
J Li, Y Wang, M Ma, S Jiang, X Zhang, Y Zhang, X Yang, C Xu, G Tian, Q Li, Y Wang, L Zhu, H Nie, M Feng, Q Xia, J Gu, Q Xu, Z Zhang
EBioMedicine 2019
Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways underlying human hepatic fibrogenesis and fibrosis
Z Liu, N Chalasani, J Lin, S Gawrieh, Y He, YJ Tseng, W Liu
Journal of Bio-X Research 2019
The Role of Myeloid-Derived Cells in the Progression of Liver Disease
CJ Weston, HW Zimmermann, DH Adams
Frontiers in immunology 2019
Effects of apoptosis on liver aging
SJ Hu, SS Jiang, J Zhang, D Luo, B Yu, LY Yang, HH Zhong, MW Yang, LY Liu, FF Hong, SL Yang
World journal of clinical cases 2019
Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis
S Rothweiler, L Feldbrügge, ZG Jiang, E Csizmadia, MS Longhi, K Vaid, K Enjyoji, YV Popov, SC Robson
Purinergic Signalling 2019
Clusterin Attenuates Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Downregulating the Smad3 Signaling Pathway
Seo, Lee, Lee, Kang, Choi, Hwang, Park, Jang, Kim
Cells 2019
Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis
YM Yang, M Noureddin, C Liu, K Ohashi, SY Kim, D Ramnath, EE Powell, MJ Sweet, YS Roh, IF Hsin, N Deng, Z Liu, J Liang, E Mena, D Shouhed, RF Schwabe, D Jiang, SC Lu, PW Noble, E Seki
Science Translational Medicine 2019
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
Dewidar, Meyer, Dooley, MB
Cells 2019
Beneficial and Deleterious Effects of Female Sex Hormones, Oral Contraceptives, and Phytoestrogens by Immunomodulation on the Liver
LE Soria-Jasso, R Cariño-Cortés, VM Muñoz-Pérez, E Pérez-Hernández, N Pérez-Hernández, E Fernández-Martínez
International journal of molecular sciences 2019
Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner
R Meier, J Meyer, E Montanari, S Lacotte, A Balaphas, Y Muller, S Clément, F Negro, C Toso, P Morel, L Buhler
International journal of molecular sciences 2019
Iron and liver fibrosis: Mechanistic and clinical aspects
KJ Mehta, SJ Farnaud, PA Sharp
World journal of gastroenterology : WJG 2019
Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice
F Hempel, M Roderfeld, R Savai, A Sydykov, K Irungbam, R Schermuly, R Voswinckel, K Köhler, Y Churin, L Kiss, J Bier, J Pons-Kühnemann, E Roeb
Cells 2019
Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis
LM Norona, DG Nguyen, DA Gerber, SC Presnell, M Mosedale, PB Watkins, P Mukhopadhyay
PloS one 2019
The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia–Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats
J Iwasaki, M Afify, C Bleilevens, U Klinge, R Weiskirchen, J Steitz, M Vogt, S Yagi, K Nagai, S Uemoto, RH Tolba
International journal of molecular sciences 2019
CD5L is a pleiotropic player in liver fibrosis controlling damage, fibrosis and immune cell content
C Bárcena, G Aran, L Perea, L Sanjurjo, É Téllez, A Oncins, H Masnou, I Serra, M García-Gallo, L Kremer, M Sala, C Armengol, P Sancho-Bru, MR Sarrias
EBioMedicine 2019
The Role of Stabilin-1 in Lymphocyte Trafficking and Macrophage Scavenging in the Liver Microenvironment
Patten, Shetty
Biomolecules 2019
Human Amnion Epithelial Cell Therapy for Chronic Liver Disease
N Andrewartha, G Yeoh
Stem Cells International 2019
Shared and distinct mechanisms of fibrosis
JH Distler, AH Györfi, M Ramanujam, ML Whitfield, M Königshoff, R Lafyatis
Nature Reviews Rheumatology 2019
Metabolic Signature of Hepatic Fibrosis: From Individual Pathways to Systems Biology
ML Chang, SS Yang
Cells 2019
MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H+ Transporting V1 Subunit C1
F Jing, Y Geng, XY Xu, HY Xu, JS Shi, ZH Xu
International journal of molecular sciences 2019
MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation
YH Huang, HC Kuo, YL Yang, FS Wang
International journal of medical sciences 2019
Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model
MR Park, MS Wong, MJ Araúzo-Bravo, H Lee, D Nam, SY Park, HD Seo, SM Lee, HF Zeilhofer, H Zaehres, HR Schöler, JB Kim, LA van Grunsven
PloS one 2019
Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis
N JalanSakrikar, TM Assuncao, G Shi, SO Aseem, C Chi, VH Shah, RC Huebert
Hepatology 2019
Eosinophils and Macrophages within the Th2-Induced Granuloma: Balancing Killing and Healing in a Tight Space
A Ariyaratne, CA Finney, AJ Bäumler
Infection and immunity 2019
Liver‐Targeted Angiotensin Converting Enzyme 2 Therapy Inhibits Chronic Biliary Fibrosis in Multiple Drug‐Resistant Gene 2‐Knockout Mice
IG Rajapaksha, LS Gunarathne, K Asadi, SC Cunningham, A Sharland, IE Alexander, PW Angus, CB Herath
Hepatology Communications 2019
Mediator MED23 regulates inflammatory responses and liver fibrosis
Z Wang, D Cao, C Li, L Min, G Wang, LA Noon
PLoS Biology 2019
The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma
J Baglieri, D Brenner, T Kisseleva
International journal of molecular sciences 2019
A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease
J Lambrecht, S Verhulst, I Mannaerts, JP Sowa, J Best, A Canbay, H Reynaert, LA van Grunsven
EBioMedicine 2019
Ability to Suppress TGF-β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
R Shao, F Wang, M Lyu, J Yang, P Zhang, Y Zhu
Frontiers in pharmacology 2019
Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover
J Simon, A Ouro, L Ala-Ibanibo, N Presa, TC Delgado, ML Martínez-Chantar
International journal of molecular sciences 2019
Roles of mTOR Signaling in Tissue Regeneration
Wei, Luo, Chen
Cells 2019
The Crosstalk of miRNA and Oxidative Stress in the Liver: From Physiology to Pathology and Clinical Implications
Klieser, Mayr, Kiesslich, Wissniowski, Fazio, Neureiter, Ocker
International journal of molecular sciences 2019
Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma
P Papoutsoglou, C Louis, C Coulouarn
Cells 2019
Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review
T Kanda, T Goto, Y Hirotsu, M Moriyama, M Omata
International journal of molecular sciences 2019
The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis
HM Flood, C Bolte, N Dasgupta, A Sharma, Y Zhang, CR Gandhi, TV Kalin, VV Kalinichenko
Biology Open 2019
Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis
M Barcena-Varela, L Colyn, MG Fernandez-Barrena
International journal of molecular sciences 2019
LOXL2—A New Target in Antifibrogenic Therapy?
A Puente, J Fortea, J Cabezas, MA Loste, P Iruzubieta, S Llerena, P Huelin, E Fábrega, J Crespo
International journal of molecular sciences 2019
Dual TBK1/IKKɛ inhibitor amlexanox attenuates the severity of hepatotoxin‐induced liver fibrosis and biliary fibrosis in mice
Z Zhou, J Qi, J Zhao, CW Lim, JW Kim, B Kim
Journal of Cellular and Molecular Medicine 2019
Creosote bush-derived NDGA attenuates molecular and pathological changes in a novel mouse model of non-alcoholic steatohepatitis (NASH)
L Han, S Bittner, D Dong, Y Cortez, H Dulay, S Arshad, WJ Shen, FB Kraemer, S Azhar
Molecular and Cellular Endocrinology 2019
Matrix Mechanics as Regulatory Factors and Therapeutic Targets in Hepatic Fibrosis
G Chen, B Xia, Q Fu, X Huang, F Wang, Z Chen, Y Lv
International journal of biological sciences 2019
Stevioside inhibits experimental fibrosis by down-regulating profibrotic Smad pathways and blocking hepatic stellate cell activation
S Casas-Grajales, D Alvarez-Suarez, E Ramos-Tovar, LD Buendía-Montaño, K Reyes-Gordillo, J Camacho, V Tsutsumi, MR Lakshman, P Muriel
Basic & Clinical Pharmacology & Toxicology 2019
Fibrosis in Chronic Liver Disease: An Update on Diagnostic and Treatment Modalities
P Manka, A Zeller, WK Syn
Drugs 2019
Hepatocarcinoma–intestine–pancreas/pancreatitis-associated protein (HIP/PAP) confers protection against hepatic fibrosis through downregulation of transforming growth factor β receptor II
Q Li, H Li, Y Lv, Q Zhang, X Zhang, S Li, X Zheng, Y Wang, Z Hao
Laboratory Investigation 2019
Hepatic gene expression explains primary drug toxicity in bipolar disorder
AM Birkl-Toeglhofer, C Birkl, IC Llenos, S Weis, J Haybaeck
Translational Psychiatry 2019
Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol‐Inducible Cytochrome P450‐2E1–Mediated Oxidative and Nitrative Stress
YE Cho, DK Kim, W Seo, B Gao, SH Yoo, BJ Song
Hepatology 2019
High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway
H Moon, K Cho, S Shin, D Kim, KH Han, S Ro
International journal of molecular sciences 2019
Regional Differences following Partial Salivary Gland Resection
KJ OKeefe, KA DeSantis, AL Altrieth, DA Nelson, EZ Taroc, AR Stabell, MT Pham, M Larsen
Journal of dental research 2019
HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells
J Hyun, RS McMahon, AL Lang, JS Edwards, AD Badilla, ME Greene, GW Stone, S Pallikkuth, M Stevenson, DM Dykxhoorn, S Kottilil, S Pahwa, E Thomas, DC Douek
PLoS pathogens 2019
MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage
P Sousa-Victor, J Neves, W Cedron-Craft, PB Ventura, CY Liao, RR Riley, I Soifer, N van Bruggen, GA Kolumam, SA Villeda, DA Lamba, H Jasper
2019
Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases
I García-Ruiz, NB Ruiz, P Rada, V Pardo, L Ruiz, A Blas-García, MP Valdecantos, MG Sanz, JA Herruzo, ÁM Valverde
Redox Biology 2019
Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis
S Lachiondo-Ortega, M Mercado-Gómez, M Serrano-Maciá, F Lopitz-Otsoa, TB Salas-Villalobos, M Varela-Rey, TC Delgado, ML Martínez-Chantar
Cells 2019
Role of microRNAs in the development of hepatocellular carcinoma and drug resistance
Tricoli L, Niture S, Chimeh U, Ressom H, Kumar D
2019
KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation.
Legaz I, Bolarín JM, Navarro E, Campillo JA, Moya R, Pérez-Cárceles MD, Luna A, Osuna E, Miras M, Muro M, Minguela A, Alvarez López R
Archives of Medical Science : AMS 2019
Liver
de Miranda AS, Simões e Silva AC
2019
Current therapies and novel approaches for biliary diseases
IG Rajapaksha, PW Angus, CB Herath
World journal of gastrointestinal pathophysiology 2019
Histological and biochemical evaluation of transforming growth factor-β activation and its clinical significance in patients with chronic liver disease
H Yokoyama, T Masaki, I Inoue, M Nakamura, Y Mezaki, C Saeki, T Oikawa, M Saruta, H Takahashi, M Ikegami, H Hano, K Ikejima, S Kojima, T Matsuura
Heliyon 2019
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis
MM Heintz, R Kumar, MM Rutledge, WS Baldwin
The Journal of Nutritional Biochemistry 2019
Graptopetalum paraguayense Inhibits Liver Fibrosis by Blocking TGF-β Signaling In Vivo and In Vitro
WH Hsu, SC Liao, YJ Chyan, KW Huang, SL Hsu, YC Chen, ML Siu, CC Chang, YS Chung, CY Huang
International journal of molecular sciences 2019
miR‐193a/b‐3p relieves hepatic fibrosis and restrains proliferation and activation of hepatic stellate cells
B Ju, Y Nie, X Yang, X Wang, F Li, M Wang, C Wang, H Zhang
Journal of Cellular and Molecular Medicine 2019
The Hepatic Microenvironment and TRAIL-R2 Impact Outgrowth of Liver Metastases in Pancreatic Cancer after Surgical Resection
L Miarka, C Hauser, O Helm, D Holdhof, S Beckinger, JH Egberts, JP Gundlach, L Lenk, S Rahn, W Mikulits, A Trauzold, S Sebens
Cancers 2019
Plantamajoside exerts antifibrosis effects in the liver by inhibiting hepatic stellate cell activation
Y Wang, D Yan
Experimental and therapeutic medicine 2019
Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice
HJ Wimborne, K Takemoto, PM Woster, DC Rockey, JJ Lemasters, Z Zhong
Free radical biology & medicine 2019
Magnesium and liver disease
M Liu, H Yang, Y Mao
Annals of translational medicine 2019
Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53
Leu JI, Murphy ME, George DL
Proceedings of the National Academy of Sciences 2019
Hepatocellular Carcinoma: Etiology and Current and Future Drugs
Jindal A, Thadi A, Shailubhai K
Journal of Clinical and Experimental Hepatology 2019
The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Baik M, Kim SU, Nam HS, Heo JH, Kim YD
Frontiers in neurology 2019
Use of Electronic Noses for Diagnosis of Digestive and Respiratory Diseases through the Breath
Sánchez C, Santos JP, Lozano J
Biosensors 2019
Elimination of Wnt Secretion From Stellate Cells Is Dispensable for Zonation and Development of Liver Fibrosis Following Hepatobiliary Injury
Zhang R, Kikuchi AT, Nakao T, Russell JO, Preziosi ME, Poddar M, Singh S, Bell AW, England SG, Monga SP
Gene expression 2019
Diagnostic accuracy of red blood cell distribution width to platelet ratio for predicting staging liver fibrosis in chronic liver disease patients: A systematic review and meta-analysis
Cai Y, Liu D, Cui J, Sha Y, Zhou H, Tang N, Wang N, Huang A, Xia J
Medicine 2019
Vitronectins produced by human cirrhotic liver and CCl4‐treated rats differ in their glycosylation pattern and tissue remodeling activity
Date K, Suzuki R, Oda\u2010Tamai S, Ogawa H
FEBS Open Bio 2019
Dendropanax morbifera Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-β1/Smads Pathways
Yang HY, Kim KS, Lee YH, Park JH, Kim JH, Lee SY, Kim YM, Kim IS, Kacew S, Lee BM, Kwak JH, Yoon K, Kim HS
International journal of biological sciences 2019
Red Quinoa Bran Extracts Protects against Carbon Tetrachloride-Induced Liver Injury and Fibrosis in Mice via Activation of Antioxidative Enzyme Systems and Blocking TGF-β1 Pathway
Lin TA, Ke BJ, Cheng CS, Wang JJ, Wei BL, Lee CL
Nutrients 2019
Fast spectrally encoded Mueller optical scanning microscopy
Rivet S, Dubreuil M, Bradu A, Le Grand Y
Scientific Reports 2019
Dynamic changes of key metabolites during liver fibrosis in rats
Yu J, He JQ, Chen DY, Pan QL, Yang JF, Cao HC, Li LJ
World Journal of Gastroenterology 2019
Understanding the impact of neurologic complications in patients with cirrhosis
Allampati SK, Mullen KD
SAGE Open Medicine 2019
Shenqi Fuzheng Injection impairs bile duct ligation-induced cholestatic liver injury in vivo
Cao F, Liu P, Zhang X, Hu Y, Dong X, Bao H, Kong L, Wang L, Gong P
Bioscience Reports 2019
Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System
Akil A, Endsley M, Shanmugam S, Saldarriaga O, Somasunderam A, Spratt H, Stevenson HL, Utay NS, Ferguson M, Yi M
Scientific Reports 2019
Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes
Luo XY, Meng XJ, Cao DC, Wang W, Zhou K, Li L, Guo M, Wang P
Stem Cell Research & Therapy 2019
Differential proteomics for studying action mechanisms of traditional Chinese medicines
Yang YY, Yang FQ, Gao JL
Chinese medicine 2019
Influence of hepatic fibrosis and inflammation: Correlation between histopathological changes and Gd-EOB-DTPA-enhanced MR imaging.
Verloh N, Probst U, Utpatel K, Zeman F, Brennfleck F, Werner JM, Fellner C, Stroszczynski C, Evert M, Wiggermann P, Haimerl M
PloS one 2019
A bioactive product lipoxin A4 attenuates liver fibrosis in an experimental model by regulating immune response and modulating the expression of regeneration genes.
Kurtoğlu EL, Kayhan B, Gül M, Kayhan B, Akdoğan Kayhan M, Karaca ZM, Yeşilada E, Yılmaz S
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2019
Determination of liver fibrosis stages in Egyptian chronic hepatitis B patients by a noninvasive tool.
Serag WM, Mohamed MM, Elsayed BE, Abd-Elhamed SM
2019
Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats.
Lee YH, Son JY, Kim KS, Park YJ, Kim HR, Park JH, Kim KB, Lee KY, Kang KW, Kim IS, Kacew S, Lee BM, Kim HS
International journal of molecular sciences 2019
Context-Dependent Role of NF-κB Signaling in Primary Liver Cancer-from Tumor Development to Therapeutic Implications.
Czauderna C, Castven D, Mahn FL, Marquardt JU
Cancers 2019
Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling.
Pan XY, You HM, Wang L, Bi YH, Yang Y, Meng HW, Meng XM, Ma TT, Huang C, Li J
Theranostics 2019
SCARNA10, a nuclear-retained long non-coding RNA, promotes liver fibrosis and serves as a potential biomarker.
Zhang K, Han Y, Hu Z, Zhang Z, Shao S, Yao Q, Zheng L, Wang J, Han X, Zhang Y, Chen T, Yao Z, Han T, Hong W
Theranostics 2019
The prognostic role of liver stiffness in patients with chronic liver disease: a systematic review and dose-response meta-analysis.
Shen Y, Wu SD, Wu L, Wang SQ, Chen Y, Liu LL, Li J, Yang CQ, Wang JY, Jiang W
Hepatology International 2019
[Antiviral and antifibrotic therapies reduce occurrence of hepatocellular carcinoma in patients with chronic hepatitis B and liver fibrosis: a 144-week prospective cohort study].
Zhou Y, Hu C, Yuan G, Liu J, Ren Y, Tang C, Yang S, Dai L, Li Y, Yang D
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019
Puerarin alleviates liver fibrosis via inhibition of the ERK1/2 signaling pathway in thioacetamide-induced hepatic fibrosis in rats.
Li X, Zhang H, Pan L, Zou H, Miao X, Cheng J, Wu Y
Experimental and therapeutic medicine 2019
Fluorofenidone affects hepatic stellate cell activation in hepatic fibrosis by targeting the TGF-β1/Smad and MAPK signaling pathways.
Peng Y, Li L, Zhang X, Xie M, Yang C, Tu S, Shen H, Hu G, Tao L, Yang H
Experimental and therapeutic medicine 2019
Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers.
van der Helm D, Barnhoorn MC, de Jonge-Muller ESM, Molendijk I, Hawinkels LJAC, Coenraad MJ, van Hoek B, Verspaget HW
Journal of Cellular and Molecular Medicine 2019
Imaging fibrosis in inflammatory diseases: targeting the exposed extracellular matrix.
Beziere N, Fuchs K, Maurer A, Reischl G, Brück J, Ghoreschi K, Fehrenbacher B, Berrio DC, Schenke-Layland K, Kohlhofer U, Quintanilla-Martinez L, Gawaz M, Kneilling M, Pichler B
Theranostics 2019
Salvianolic acid A attenuates CCl(4)-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways.
Wang R, Song F, Li S, Wu B, Gu Y, Yuan Y
Drug design, development and therapy 2019
Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells.
Genz B, Coleman MA, Irvine KM, Kutasovic JR, Miranda M, Gratte FD, Tirnitz-Parker JEE, Olynyk JK, Calvopina DA, Weis A, Cloonan N, Robinson H, Hill MM, Al-Ejeh F, Ramm GA
Scientific Reports 2019
Rap1 regulates hepatic stellate cell migration through the modulation of RhoA activity in response to TGF‑β1.
Moon MY, Kim HJ, Kim MJ, Uhm S, Park JW, Suk KT, Park JB, Kim DJ, Kim SE
International journal of molecular medicine 2019
Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice.
Yan J, Tung HC, Li S, Niu Y, Garbacz WG, Lu P, Bi Y, Li Y, He J, Xu M, Ren S, Monga SP, Schwabe RF, Yang D, Xie W
Gastroenterology 2019
A Simple Index for Nonalcoholic Steatohepatitis-HUFA-Based on Routinely Performed Blood Tests.
Culafic M, Vezmar Kovacevic S, Dopsaj V, Stulic M, Vlaisavljevic Z, Miljkovic B, Culafic D
2019
miR-455-3p Alleviates Hepatic Stellate Cell Activation and Liver Fibrosis by Suppressing HSF1 Expression.
Wei S, Wang Q, Zhou H, Qiu J, Li C, Shi C, Zhou S, Liu R, Lu L
2019
Comparison of Carotenoids for Their Antifibrogenic Effects in Hepatic Stellate Cells.
Bae M, Kim MB, Kang H, Park YK, Lee JY
Lipids 2019
Evaluation of rat liver with ARFI elastography: In vivo and ex vivo study.
Carbonell G, Berná-Serna JD, Oltra L, Martínez CM, Garcia-Carrillo N, Guzmán-Aroca F, Salazar FJ, Tudela J, Berná-Mestre JD
PloS one 2019
Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model.
Graus-Nunes F, Santos FO, Marinho TS, Miranda CS, Barbosa-da-Silva S, Souza-Mello V
World journal of hepatology 2019
MicroRNA-146a regulates the transformation from liver fibrosis to cirrhosis in patients with hepatitis B via interleukin-6.
Yang Z, Peng Y, Yang S
Experimental and therapeutic medicine 2019
Myofibroblast-specific YY1 promotes liver fibrosis.
Liu H, Zhang S, Xu S, Koroleva M, Small EM, Jin ZG
Biochemical and Biophysical Research Communications 2019
Collagen Fibrils Mechanically Contribute to Tissue Contraction in an In Vitro Wound Healing Scenario.
Brauer E, Lippens E, Klein O, Nebrich G, Schreivogel S, Korus G, Duda GN, Petersen A
2019
Liver fibrosis imaging: A clinical review of ultrasound and magnetic resonance elastography.
Zhang YN, Fowler KJ, Ozturk A, Potu CK, Louie AL, Montes V, Henderson WC, Wang K, Andre MP, Samir AE, Sirlin CB
Journal of magnetic resonance imaging : JMRI 2019
Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis.
Lehmann J, Praktiknjo M, Nielsen MJ, Schierwagen R, Meyer C, Thomas D, Violi F, Strassburg CP, Bendtsen F, Møller S, Krag A, Karsdal MA, Leeming DJ, Trebicka J
Liver international : official journal of the International Association for the Study of the Liver 2019
Salacia chinensis L. Stem Extract Exerts Antifibrotic Effects on Human Hepatic Stellate Cells through the Inhibition of the TGF-β1-Induced SMAD2/3 Signaling Pathway
Phaosri M, Jantrapirom S, Na Takuathung M, Soonthornchareonnon N, Sireeratawong S, Buacheen P, Pitchakarn P, Nimlamool W, Potikanond S
International journal of molecular sciences 2019
Meta-analysis of influences of Biejiajian Pill combined with entecavir on serum liver fibrosis markers of compensatory period of hepatitis b cirrhosis: Protocol of systematic review and meta-analysis
Zhang T, Yang Y, Wang B, Zheng X, Wang L, Feng X, Li G, Shi J, Cao N
Medicine 2019
Radiation exposure alters airway deformability and bony structure displacement during laryngoscopy
Rees CA, Wu X, Eisen EA, Pastel DA, Halter RJ, Paydarfar JA
Laryngoscope Investigative Otolaryngology 2019
Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis
Milito A, Brancaccio M, D\u2019Argenio G, Castellano I
Cells 2019
Assessment of liver fibrosis using 2-dimensional shear wave elastography: a prospective study of intra- and inter-observer repeatability and comparison with point shear wave elastography
Yoo J, Lee JM, Joo I, Yoon JH
Ultrasonography 2019
The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation
Yuan K, Lai C, Wei L, Feng T, Yang Q, Zhang T, Lan T, Yao Y, Xiang G, Huang X
Stem Cells International 2019
Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review
Yuan K, Li X, Lu Q, Zhu Q, Jiang H, Wang T, Huang G, Xu A
Frontiers in pharmacology 2019
Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine-functionalized magnetic iron oxide nanoparticles on LX-2 cells
Yu Q, Xiong X, Zhao L, Xu T, Wang Q
Molecular medicine reports 2019
Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
Ho CH, Chang TT, Chien RN
PloS one 2019
Clinical significance of the immune cell landscape in hepatocellular carcinoma patients with different degrees of fibrosis
Tang X, Shu Z, Zhang W, Cheng L, Yu J, Zhang M, Zheng S
Annals of translational medicine 2019
Characterization of the Roles of Vimentin in Regulating the Proliferation and Migration of HSCs during Hepatic Fibrogenesis
Wang PW, Wu TH, Lin TY, Chen MH, Yeh CT, Pan TL
Cells 2019
TGR5 Activation Modulates an Inhibitory Effect on Liver Fibrosis Development Mediated by Anagliptin in Diabetic Rats
Kaya D, Kaji K, Tsuji Y, Yamashita S, Kitagawa K, Ozutsumi T, Fujinaga Y, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H
Cells 2019
Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC
Modica TM, Dituri F, Mancarella S, Pisano C, Fabregat I, Giannelli G
Cancers 2019
Hepatic disease and the risk of mortality of Vibrio vulnificus necrotizing skin and soft tissue infections: A systematic review and meta-analysis
Chuang PY, Yang TY, Huang TW, Tsai YH, Huang KC, Weng HH
PloS one 2019
Durability of Sustained Virologic Response and Improvement of Fibrosis Markers after Daclatasvir and Asunaprevir Treatment in Genotype 1b Hepatitis C Virus-Infected Patients: a Real Life and Multicenter Study
Shin SK, Lee JW, Ra H, Kwon OS, Shin JB, Jin YJ, Lee S, Han KJ, Kim YN, Kim TH, Kim YS, Kim JH
Journal of Korean Medical Science 2019
Programmed increases in LXRα induced by paternal alcohol use enhance offspring metabolic adaptation to high-fat diet induced obesity
Chang RC, Thomas KN, Bedi YS, Golding MC
Molecular Metabolism 2019
Progranulin attenuates liver fibrosis by downregulating the inflammatory response
Yoo W, Lee J, Noh KH, Lee S, Jung D, Kabir MH, Park D, Lee C, Kwon KS, Kim JS, Kim S
Cell Death and Disease 2019
Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats
Gunarathne LS, Angus PW, Herath CB
Frontiers in physiology 2019
Gas6/TAM Signaling Components as Novel Biomarkers of Liver Fibrosis
Smirne C, Rigamonti C, De Benedittis C, Sainaghi PP, Bellan M, Burlone ME, Castello LM, Avanzi GC
Disease Markers 2019
Active Ingredients and Action Mechanisms of Yi Guan Jian Decoction in Chronic Hepatitis B Patients with Liver Fibrosis
Li G, Zhou Y, Sze DM, Liu C, Zhang Q, Wang Z, Yu H, Chan G, Wu Z, Su S, Hu Y
Evidence-based complementary and alternative medicine : eCAM 2019
Carvacrol Downregulates Lysyl Oxidase Expression and Ameliorates Oxidative Stress in the Liver of Rats with Carbon Tetrachloride-Induced Liver Fibrosis.
Mohseni R, Karimi J, Tavilani H, Khodadadi I, Hashemnia M
Indian journal of clinical biochemistry : IJCB 2019
Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study.
Tiwari-Heckler S, Jiang ZG, Popov Y, J Mukamal K
Journal of Biomedical Research 2019
HCV infection causes cirrhosis in human by step-wise regulation of host genes involved in cellular functioning and defense during fibrosis: Identification of bio-markers.
Ijaz B, Ahmad W, Das T, Shabbiri K, Husnain T, Hassan S
Genes & Diseases 2019
(-)-Catechin-7-O-β-d-Apiofuranoside Inhibits Hepatic Stellate Cell Activation by Suppressing the STAT3 Signaling Pathway.
Park YJ, Kim DM, Jeong MH, Yu JS, So HM, Bang IJ, Kim HR, Kwon SH, Kim KH, Chung KH
Cells 2019
Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
Eubanks HB, Lavoie EG, Goree J, Kamykowski JA, Gokden N, Fausther M, Dranoff JA
Gene expression 2019
Dual-source dual-energy CT in the evaluation of hepatic fractional extracellular space in cirrhosis.
Bottari A, Silipigni S, Carerj ML, Cattafi A, Maimone S, Marino MA, Mazziotti S, Pitrone A, Squadrito G, Ascenti G
La radiologia medica 2019
Comparison of non-invasive methods of assessing liver fibrosis in combination ART-experienced Zimbabweans.
Nherera B, Mhandire K, Nyazika TK, Makura A, Musarurwa C, Mapondera PT, Stray-Pedersen B, Matarira HT
Southern African journal of HIV medicine 2019
Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes
Divya Ramnath, Katharine Irvine, Samuel W Lukowski, Leigh Horsfall, Zhixuan Loh, Andrew D Clouston, Preya J Patel, Kevin Fagan, Abishek Iyer, Guy Lampe, Jennifer Stow, Kate Schroder, David P. Fairlie, Joseph Powell, Elizabeth E Powell, Matthew Sweet
JCI Insight 2018
Extracellular matrix as a consequence and driver of progressive fibrosis
Jeremy Herrera, Craig Henke, Peter Bitterman
Journal of Clinical Investigation 2018
The balancing act of the liver: tissue regeneration vs fibrosis
Lucía Cordero-Espinoza, Meritxell Huch
Journal of Clinical Investigation 2018
The innate immune receptor TREM-1 promotes liver injury and fibrosis
Anh Thu Nguyen-Lefebvre, Ashwin Ajith, Vera Portik-Dobos, Daniel Horuzsko, Ali Arbab, Amiran Dzutsev, Ramses Sadek, Giorgio Trinchieri, Anatolij Horuzsko
Journal of Clinical Investigation 2018
Neutrophils alleviate fibrosis in the CCl 4 -induced mouse chronic liver injury model: Saijou et al
E Saijou, Y Enomoto, M Matsuda, CY Kok, S Akira, M Tanaka, A Miyajima
Hepatology Communications 2018
Inflammasome: A Double-Edged Sword in Liver Diseases
J Luan, D Ju
Frontiers in immunology 2018
Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension
KY Shim, YW Eom, MY Kim, SH Kang, SK Baik
The Korean Journal of Internal Medicine 2018
p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine
J Krstic, M Galhuber, T Schulz, M Schupp, A Prokesch
International journal of molecular sciences 2018
Current Perspectives Regarding Stem Cell-Based Therapy for Liver Cirrhosis
KA Kwak, HJ Cho, JY Yang, YS Park
Canadian journal of gastroenterology & hepatology 2018
Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis: CUI et al
G Cui, J Chen, Z Wu, H Huang, L Wang, Y Liang, P Zeng, J Yang, T Uede, H Diao
Journal of Cellular Physiology 2018
Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z
S Sciacchitano, L Lavra, A Morgante, A Ulivieri, F Magi, GD Francesco, C Bellotti, L Salehi, A Ricci
International journal of molecular sciences 2018
Low hepcidin in liver fibrosis and cirrhosis; a tale of progressive disorder and a case for a new biochemical marker
D Vela
Molecular Medicine 2018
Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations
MJ Schafer, AJ Haak, DJ Tschumperlin, NK LeBrasseur
Current Rheumatology Reports 2018
Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice
ME Guicciardi, CE Trussoni, A Krishnan, SF Bronk, MJ Pisarello, SP O'Hara, PL Splinter, Y Gao, P Vig, A Revzin, NF LaRusso, GJ Gores
Journal of Hepatology 2018
Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2
T Lan, C Li, G Yang, Y Sun, L Zhuang, Y Ou, H Li, G Wang, T Kisseleva, D Brenner, J Guo
Hepatology 2018
Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology
JO Russell, SP Monga
Annual review of pathology 2018
TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice
SC Yanguas, T da Silva, I Pereira, J Willebrords, M Maes, MS Nogueira, IA de Castro, I Leclercq, G Romualdo, L Barbisan, L Leybaert, B Cogliati, M Vinken
International journal of molecular sciences 2018
Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs
K Nishikawa, Y Osawa, K Kimura
International journal of molecular sciences 2018
Combatting Fibrosis: Exosome‐Based Therapies in the Regression of Liver Fibrosis
L Chen, DA Brenner, T Kisseleva
Hepatology Communications 2018
Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice
JL Duan, B Ruan, XC Yan, L Liang, P Song, ZY Yang, Y Liu, KF Dou, H Han, L Wang
Hepatology 2018
Myeloid Cells and Chronic Liver Disease: a Comprehensive Review
M Lian, C Selmi, ME Gershwin, X Ma
Clinical Reviews in Allergy & Immunology 2018
Frequency and risk factors for liver disease following pancreatitis: A population-based cohort study
SK Chand, SA Pendharkar, SH Bharmal, AS Bartlett, SJ Pandol, MS Petrov
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2018
Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis
M Praktiknjo, J Lehmann, MJ Nielsen, R Schierwagen, FE Uschner, C Meyer, D Thomas, CP Strassburg, F Bendtsen, S Møller, A Krag, MA Karsdal, DJ Leeming, J Trebicka
Hepatology Communications 2018
Accumulation of citrullinated glial fibrillary acidic protein in a mouse model of bile duct ligation-induced hepatic fibrosis
SE Kim, JW Park, MJ Kim, B Jang, YC Jeon, HJ Kim, A Ishigami, HS Kim, KT Suk, DJ Kim, CK Park, EK Choi, MK Jang, LA van Grunsven
PloS one 2018
Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis
S Al-Fayoumi, T Hashiguchi, Y Shirakata, J Mascarenhas, JW Singer
Journal of Experimental Pharmacology 2018
Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies
S Cannito, C Milani, A Cappon, M Parola, M Strazzabosco, M Cadamuro
International journal of molecular sciences 2018
Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat
Aliasghar Parvaresh Anbar, Tayyebeh Piran, Mehrdad Farhadi, Pouran Karimi
Iranian Journal of Basic Medical Sciences 2018
Liver fibrosis
MM Aydin, KC Akcali
TURK J GASTROENTEROL 2018
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis
D Fernández-Ramos, P Fernández-Tussy, F Lopitz-Otsoa, V Gutiérrez-de-Juan, N Navasa, L Barbier-Torres, I Zubiete-Franco, J Simón, AF Fernández, A Arbelaiz, AM Aransay, JL Lavín, N Beraza, MJ Perugorria, JM Banales, E Villa, MF Fraga, J Anguita, MA Avila, C Berasain, P Iruzibieta, J Crespo, SC Lu, M Varela-Rey, JM Mato, TC Delgado, ML Martínez-Chantar
Cell Death and Disease 2018
Ambiguous roles of innate lymphoid cells in chronic development of liver diseases
Y Shen, J Li, SQ Wang, W Jiang
World journal of gastroenterology : WJG 2018
Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells Through TGF-β-Smad2 Dependent Signaling
Y Wu, W Wang, X Peng, Y He, Y Xiong, H Liang, L Chu, B Zhang, Z Ding, X Chen
Frontiers in pharmacology 2018
Involvement of epithelial-mesenchymal transition in liver fibrosis
K Yu, Q Li, G Shi, N Li
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 2018
Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis
I Fabregat, D Caballero-Díaz
Frontiers in Oncology 2018
Hepatitis C virus: Morphogenesis, infection and therapy
VA Morozov, S Lagaye
World journal of hepatology 2018
Lactobacillus Aggravate Bile Duct Ligation-Induced Liver Inflammation and Fibrosis in Mice
YS Roh, A Cho, YS Cha, SH Oh, CW Lim, B Kim
Toxicological Research 2018
Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis
X Wu, F Zhi, W Lun, Q Deng, W Zhang
International journal of molecular medicine 2018
Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease
B Kleuser
International journal of molecular sciences 2018
MicroRNA-194 protects against chronic hepatitis B-related liver damage by promoting hepatocyte growth via ACVR2B
X Gao, P Zhao, J Hu, H Zhu, J Zhang, Z Zhou, J Zhao, F Tang
Journal of Cellular and Molecular Medicine 2018
MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression
L Ma, X Yang, R Wei, T Ye, JK Zhou, M Wen, R Men, P Li, B Dong, L Liu, X Fu, H Xu, RI Aqeilan, YQ Wei, L Yang, Y Peng
Cell Death and Disease 2018
Tyrosine Kinase SYK is a Potential Therapeutic Target for Liver Fibrosis
C Qu, D Zheng, S Li, Y Liu, A Lidofsky, JA Holmes, J Chen, L He, L Wei, Y Liao, H Yuan, Q Jin, Z Lin, Q Hu, Y Jiang, M Tu, X Chen, W Li, W Lin, BC Fuchs, RT Chung, J Hong
Hepatology 2018
miRNA Signature in NAFLD: A Turning Point for a Non-Invasive Diagnosis
P Dongiovanni, M Meroni, M Longo, S Fargion, A Fracanzani
International journal of molecular sciences 2018
Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics
D Cook, S Achanta, JB Hoek, BA Ogunnaike, R Vadigepalli
BMC Systems Biology 2018
Actin Depolymerization in Dedifferentiated Liver Sinusoidal Endothelial Cells Promotes Fenestrae Re-Formation: Hepatology Communications
JD Martino, P Mascalchi, P Legros, S Lacomme, E Gontier, P Bioulac-Sage, C Balabaud, V Moreau, F Saltel
Hepatology Communications 2018
Succinate as a Regulator of Hepatic Stellate Cells in Liver Fibrosis
EH Cho
Frontiers in Endocrinology 2018
Hepatic fibrosis: Avenues of investigation and clinical implications: Hepatic Fibrosis
JE Shay, JP Hamilton
Clinical Liver Disease 2018
Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development
YC Sung, YC Liu, PH Chao, CC Chang, PR Jin, TT Lin, JA Lin, HT Cheng, J Wang, CP Lai, LH Chen, AY Wu, TL Ho, T Chiang, DY Gao, DG Duda, Y Chen
Theranostics 2018
Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium
R Evers, M Piquette-Miller, JW Polli, FG Russel, JA Sprowl, K Tohyama, JA Ware, SN de Wildt, W Xie, KL Brouwer
Clinical Pharmacology & Therapeutics 2018
Liver fibrosis in biliary atresia
WJ Shen, G Chen, M Wang, S Zheng
World Journal of Pediatrics 2018
Oral Dysbiosis in Pancreatic Cancer and Liver Cirrhosis: A Review of the Literature
H Mohammed, E Varoni, A Cochis, M Cordaro, P Gallenzi, R Patini, E Staderini, C Lajolo, L Rimondini, V Rocchetti
Biomedicines 2018
Liver-Derived Exosomes and Their Implications in Liver Pathobiology
S Sung, J Kim, Y Jung
International journal of molecular sciences 2018
Platelet TGF-β1 deficiency decreases liver fibrosis in a mouse model of liver injury
S Ghafoory, R Varshney, T Robison, K Kouzbari, S Woolington, B Murphy, L Xia, J Ahamed
Blood Advances 2018
Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review)
M Katoh
International journal of molecular medicine 2018
Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model
J Allen, J Zhang, MD Quickel, M Kennett, AD Patterson, PA Hankey-Giblin
Journal of Proteome Research 2018
Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN/AKT pathway
P Kumar, R Raeman, DM Chopyk, T Smith, K Verma, Y Liu, FA Anania
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018
The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway
F Dong, S Jiang, J Li, Y Wang, L Zhu, Y Huang, X Jiang, X Hu, Q Zhou, Z Zhang, Z Bao
EBioMedicine 2018
Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways
J Fan, Q Chen, L Wei, X Zhou, R Wang, H Zhang
Drug design, development and therapy 2018
Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-β Signaling Pathway Activation in Type 2 Diabetic Rats.
Hou B, Zhao Y, Qiang G, Yang X, Xu C, Chen X, Liu C, Wang X, Zhang L, Du G
Oxidative medicine and cellular longevity 2018
CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways.
Lin IY, Chiou YS, Wu LC, Tsai CY, Chen CT, Chuang WC, Lee MC, Lin CC, Lin TT, Chen SC, Pan MH, Ma N
Journal of Food and Drug Analysis 2018
Biliverdin reductase and bilirubin in hepatic disease
L Weaver, A Hamoud, DE Stec, TD Hinds
AJP Gastrointestinal and Liver Physiology 2018
11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis
X Zou, P Ramachandran, TJ Kendall, A Pellicoro, E Dora, RL Aucott, K Manwani, TY Man, KE Chapman, NC Henderson, SJ Forbes, SP Webster, JP Iredale, BR Walker, Z Michailidou
Hepatology 2018
Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function
YH Wang, YC Twu, CK Wang, FZ Lin, CY Lee, YJ Liao
International journal of molecular sciences 2018
Artesunate may inhibit liver fibrosis via the FAK/Akt/β-catenin pathway in LX-2 cells
J Lv, R Bai, L Wang, J Gao, H Zhang
BMC Pharmacology and Toxicology 2018
MicroRNA-96 Promotes Schistosomiasis Hepatic Fibrosis in Mice by Suppressing Smad7
X Luo, D Zhang, J Xie, Q Su, X He, R Bai, G Gao, W Pan
Molecular Therapy — Methods & Clinical Development 2018
Alcoholic liver disease: Utility of animal models
A Lamas-Paz, F Hao, LJ Nelson, MT Vázquez, S Canals, MG del Moral, E Martínez-Naves, YA Nevzorova, FJ Cubero
World journal of gastroenterology : WJG 2018
Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice
BJ Lim, WK Lee, HW Lee, KS Lee, JK Kim, HY Chang, JI Lee
Cell Communication and Signaling 2018
An Inhibitor of Arginine-Glycine-Aspartate-Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis: HEPATOLOGY COMMUNICATIONS
B Ulmasov, H Noritake, P Carmichael, K Oshima, DW Griggs, BA Neuschwander-Tetri
Hepatology Communications 2018
Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs
Golder MR, Liu J, Andersen JN, Shipitsin MV, Vohidov F, Nguyen HV, Ehrlich DC, Huh SJ, Vangamudi B, Economides KD, Neenan AM, Ackley JC, Baddour J, Paramasivan S, Brady SW, Held EJ, Reiter LA, Saucier-Sawyer JK, Kopesky PW, Chickering DE, Blume-Jensen P, Johnson JA
Nature Biomedical Engineering 2018
Quantitative analysis of core fucosylation of serum proteins in liver diseases by LC-MS-MRM
Ma J, Sanda M, Wei R, Zhang L, Goldman R
Journal of Proteomics 2018
4 in 1: Antibody‐free protocol for isolating the main hepatic cells from healthy and cirrhotic single rat livers
Fernández\u2010Iglesias A, Ortega\u2010Ribera M, Guixé\u2010Muntet S, Gracia\u2010Sancho J
Journal of Cellular and Molecular Medicine 2018
α-lipoic acid protects against carbon tetrachloride-induced liver cirrhosis through the suppression of the TGF-β/Smad3 pathway and autophagy
Liu G, Liu J, Pian L, Gui S, Lu B
Molecular medicine reports 2018
Slit2-Robo2 signaling modulates the fibrogenic activity and migration of hepatic stellate cells
Zeng Z, Wu Y, Cao Y, Yuan Z, Zhang Y, Zhang DY, Hasegawa D, Friedman SL, Guo J
Life Sciences 2018
Protective Effect of Phaleria macrocarpa Water Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF-α and TGF-β1
Sundari N, Soetikno V, Louisa M, Wardhani BW, Tjandrawinata RR
Journal of Toxicology 2018
Integration of high-throughput data of microRNA and mRNA expression profiles reveals novel insights into the mechanism of liver fibrosis
Zhang Y, Liu J, Ma Y, Wang J, Zhu J, Liu J, Zhang J
Molecular medicine reports 2018
Tissue Intrinsic Fluorescence Spectra-Based Digital Pathology of Liver Fibrosis by Marker-Controlled Segmentation
Saitou T, Takanezawa S, Ninomiya H, Watanabe T, Yamamoto S, Hiasa Y, Imamura T
Frontiers in Medicine 2018
Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions
Méndez-Sánchez N, Zamarripa-Dorsey F, Panduro A, Purón-González E, Coronado-Alejandro EU, Cortez-Hernández CA, Higuera de la Tijera F, Pérez-Hernández JL, Cerda-Reyes E, Rodríguez-Hernández H, Cruz-Ramón VC, Ramírez-Pérez OL, Aguilar-Olivos NE, Rodríguez-Martínez OF, Cabrera-Palma S, Cabrera-Álvarez G
World journal of clinical cases 2018
Diagnostic performance of Gd-EOB-DTPA-enhanced MRI for evaluation of liver dysfunction: a multivariable analysis of 3T MRI sequences
Verloh N, Utpatel K, Zeman F, Fellner C, Schlitt HJ, Müller M, Stroszczynski C, Evert M, Wiggermann P, Haimerl M
Oncotarget 2018
Anti-hepatofibrosis effect of Allium senescens in activated hepatic stellate cells and thioacetamide-induced fibrosis rat model
Shin GM, Koppula S, Chae YJ, Kim HS, Lee JD, Kim MK, Song M
Pharmaceutical Biology 2018
3,5-Diethoxy-3′-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury
Lee PJ, Park HJ, Cho N, Kim HP
Molecules (Basel, Switzerland) 2018
Alpha Mangostin Inhibits the Proliferation and Activation of Acetaldehyde Induced Hepatic Stellate Cells through TGF-β and ERK 1/2 Pathways
Lestari N, Louisa M, Soetikno V, Suwana AG, Ramadhan PA, Akmal T, Arozal W
Journal of Toxicology 2018
Anti-fibrosis activity of combination therapy with epigallocatechin gallate, taurine and genistein by regulating glycolysis, gluconeogenesis, and ribosomal and lysosomal signaling pathways in HSC-T6 cells
Li Y, Zhu M, Huo Y, Zhang X, Liao M
Experimental and therapeutic medicine 2018
Identification of the Toxicity Pathways Associated With Thioacetamide-Induced Injuries in Rat Liver and Kidney
Schyman P, Printz RL, Estes SK, Boyd KL, Shiota M, Wallqvist A
Frontiers in pharmacology 2018
3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling
Ma X, Liu J, Zhu W, Tang M, Lawrence N, Yu C, Gou M, Chen S
Advanced Drug Delivery Reviews 2018
Antifibrotic Effect of Smad Decoy Oligodeoxynucleotide in a CCl4-Induced Hepatic Fibrosis Animal Model
Gwon MG, Kim JY, An HJ, Kim WH, Gu H, Kim MK, Pak SC, Park KK
2018
Role of canonical Hedgehog signaling pathway in liver
Gao L, Zhang Z, Zhang P, Yu M, Yang T
International journal of biological sciences 2018
Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model
van der Helm D, Groenewoud A, de Jonge-Muller ES, Barnhoorn MC, Schoonderwoerd MJ, Coenraad MJ, Hawinkels LJ, Snaar-Jagalska BE, van Hoek B, Verspaget HW
Scientific Reports 2018
Adiponectin as a novel biomarker for liver fibrosis
Udomsinprasert W, Honsawek S, Poovorawan Y
World journal of hepatology 2018
Yinchenhao Decoction Alleviates Liver Fibrosis by Regulating Bile Acid Metabolism and TGF-β/Smad/ERK Signalling Pathway
Cai FF, Wu R, Song YN, Xiong AZ, Chen XL, Yang MD, Yang L, Hu Y, Sun MY, Su SB
Scientific Reports 2018
Evaluation of elastography combined with serological indexes for hepatic fibrosis in patients with chronic hepatitis B
Xu B, Zhou NM, Cao WT, Li XJ
World Journal of Gastroenterology 2018
Stiffness reconstruction methods for MR elastography
Fovargue D, Nordsletten D, Sinkus R
NMR in Biomedicine 2018
Dysregulated bile transporters and impaired tight junctions during chronic liver injury in mice
Pradhan-Sundd T, Vats R, Russell JM, Singh S, Michael AA, Molina L, Kakar S, Cornuet P, Poddar M, Watkins SC, Nejak-Bowen KN, Monga SP, Sundd P
Gastroenterology 2018
Prevention of lipid peroxidation-derived cyclic DNA adduct and mutation in high fat diet-induced hepatocarcinogenesis by Theaphenon E
Coia H, Ma N, Hou Y, Dyba MD, Fu Y, Cruz MI, Benitez C, Graham GT, McCutcheon JN, Zheng YL, Sun B, Kallakury BV, Ma J, Fang HB, Berry DL, Muralidaran V, Chung FL
Cancer prevention research (Philadelphia, Pa.) 2018
LncRNA-MEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212
Yu F, Geng W, Dong P, Huang Z, Zheng J
Cell Death and Disease 2018
Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis
Chen X, Li WX, Chen Y, Li XF, Li HD, Huang HM, Bu FT, Pan XY, Yang Y, Huang C, Meng XM, Li J
Cell Death and Disease 2018
Candidate Biomarkers of Liver Fibrosis: A Concise, Pathophysiology-oriented Review
Bellan M, Castello LM, Pirisi M
Journal of Clinical and Translational Hepatology 2018
Effects of FGF21‐secreting adipose‐derived stem cells in thioacetamide‐induced hepatic fibrosis
Kang H, Seo E, Park J, Han N, Lee H, Jun H
Journal of Cellular and Molecular Medicine 2018
Clinical prediction of HBV and HCV related hepatic fibrosis using machine learning
Wei R, Wang J, Wang X, Xie G, Wang Y, Zhang H, Peng CY, Rajani C, Kwee S, Liu P, Jia W
EBioMedicine 2018
Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis
Yu J, Hu Y, Gao Y, Li Q, Zeng Z, Li Y, Chen H
Cell Death Discovery 2018
Progress in mesenchymal stem cell–based therapy for acute liver failure
Wang YH, Wu DB, Chen B, Chen EQ, Tang H
Stem Cell Research & Therapy 2018
Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells
Kumar P, Smith T, Raeman R, Chopyk DM, Brink H, Liu Y, Sulchek T, Anania FA
The Journal of biological chemistry 2018
Polyphenols from Tamarix nilotica: LC–ESI-MSn Profiling and In Vivo Antifibrotic Activity
Sekkien A, Swilam N, Ebada SS, Esmat A, El-Khatib AH, Linscheid MW, Singab AN
2018
Diagnostic Value of Hepatic Vein Ultrasound in Early Detection of Liver Cirrhosis
Zare Marzouni H, Davachi B, Rezazadeh M, Salehi Milani M, Matinfard S
Galen medical journal 2018
Phenytoin-induced chronic liver enzyme elevation and hepatic fibrosis: A case report.
Curry B, Mican L, Smith TL
2018
Thymosin β4 Prevents Oxidative Stress, Inflammation, and Fibrosis in Ethanol- and LPS-Induced Liver Injury in Mice.
Shah R, Reyes-Gordillo K, Cheng Y, Varatharajalu R, Ibrahim J, Lakshman MR
Oxidative medicine and cellular longevity 2018
Glibenclamide protects against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation.
Dwivedi DK, Jena GB
Naunyn-Schmiedeberg's Archives of Pharmacology 2018
Thymosin β4 inhibits PDGF-BB induced activation, proliferation, and migration of human hepatic stellate cells via its actin-binding domain.
Shah R, Reyes-Gordillo K, Rojkind M
Expert Opinion on Biological Therapy 2018
Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Ohara M, Ohnishi S, Hosono H, Yamamoto K, Fu Q, Maehara O, Suda G, Sakamoto N
Frontiers in pharmacology 2018
IL-1α correlates with severity of hepatitis C virus-related liver diseases.
Tawfik AK, Amin AM, Yousef M, El-Sayd NM, Elashry H, Elkadeem M, Abd-Elsalam S
Journal of inflammation research 2018
The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis.
Huang YH, Yang YL, Wang FS
International journal of molecular sciences 2018
Sorafenib and praziquantel synergistically attenuate Schistosoma japonicum-induced liver fibrosis in mice.
Ma Z, Liu X, Dong H, Xia D, Wang L, Chen Y, Xiong Y
Parasitology Research 2018
Taking advantage of the potential of mesenchymal stromal cells in liver regeneration: Cells and extracellular vesicles as therapeutic strategies.
Fiore EJ, Domínguez LM, Bayo J, García MG, Mazzolini GD
World Journal of Gastroenterology 2018
DNA Methylation of PTGIS Enhances Hepatic Stellate Cells Activation and Liver Fibrogenesis.
Pan XY, Yang Y, Meng HW, Li HD, Chen X, Huang HM, Bu FT, Yu HX, Wang Q, Huang C, Meng XM, Li J
Frontiers in pharmacology 2018
Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging.
Kyung EJ, Kim HB, Hwang ES, Lee S, Choi BK, Kim JW, Kim HJ, Lim SM, Kwon OI, Woo EJ
Mediators of Inflammation 2018
Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1/Smad Signaling Pathway.
Yuan X, Gong Z, Wang B, Guo X, Yang L, Li D, Zhang Y
Evidence-based complementary and alternative medicine : eCAM 2018
Aldehyde dehydrogenase 2 activation ameliorates CCl(4) -induced chronic liver fibrosis in mice by up-regulating Nrf2/HO-1 antioxidant pathway.
Ma X, Luo Q, Zhu H, Liu X, Dong Z, Zhang K, Zou Y, Wu J, Ge J, Sun A
Journal of Cellular and Molecular Medicine 2018
Quantitative assessment of hepatic fibrosis in chronic hepatitis B and C: T1 mapping on Gd-EOB-DTPA-enhanced liver magnetic resonance imaging.
Pan S, Wang XQ, Guo QY
World Journal of Gastroenterology 2018
Improved hemodynamic and liver function in portal hypertensive cirrhotic rats after administration of B. pseudocatenulatum CECT 7765.
Gómez-Hurtado I, Zapater P, Portune K, Juanola O, Fernández-Iglesias A, González-Navajas JM, Gracia-Sancho J, Sanz Y, Francés R
European Journal of Nutrition 2018
Detection of a lipid peroxidation-induced DNA adduct across liver disease stages.
Coia H, Ma N, He AR, Kallakury B, Berry DL, Permaul E, Makambi KH, Fu Y, Chung FL
Hepatobiliary surgery and nutrition 2018
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.
Lin L, Li R, Cai M, Huang J, Huang W, Guo Y, Yang L, Yang G, Lan T, Zhu K
Oxidative medicine and cellular longevity 2018
Emodin Alleviates Liver Fibrosis of Mice by Reducing Infiltration of Gr1(hi) Monocytes.
Zhao XA, Chen G, Liu Y, Wu H, Chen J, Xiong Y, Tian C, Jia B, Wang G, Xia J, Chen Y, Wang J, Yan X, Zhang Z, Huang R, Wu C
Evidence-based complementary and alternative medicine : eCAM 2018
Beneficial effects of naringenin in liver diseases: Molecular mechanisms.
Hernández-Aquino E, Muriel P
World Journal of Gastroenterology 2018
Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
Prasad B, Bhatt DK, Johnson K, Chapa R, Chu X, Salphati L, Xiao G, Lee C, Hop CECA, Mathias A, Lai Y, Liao M, Humphreys WG, Kumer SC, Unadkat JD
Drug metabolism and disposition: the biological fate of chemicals 2018
PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling.
Zhang Q, Xiang S, Liu Q, Gu T, Yao Y, Lu X
PPAR Research 2018
IL13Rα2 expression identifies tissue-resident IL-22-producing PLZF(+) innate T cells in the human liver.
Paquin-Proulx D, Greenspun BC, Pasquet L, Strunz B, Aleman S, Falconer K, Terabe M, Berzofsky JA, Sandberg JK, Melum E, Nixon DF, Björkström NK
European Journal of Immunology 2018
Diagnosis and staging of fibrosis in patients with chronic hepatitis C: comparison and critical overview of current strategies.
Mendes LC, Stucchi RS, Vigani AG
Hepatic medicine : evidence and research 2018
Inhibitory Effects of Angiotensin II Receptor Blockade on Human Tenon Fibroblast Migration and Reactive Oxygen Species Production in Cell Culture.
Kim D, Pattamatta U, Kelly E, Healey PR, Carnt N, Zoellner H, White AJR
Translational Vision Science & Technology 2018
CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis.
Shi WP, Ju D, Li H, Yuan L, Cui J, Luo D, Chen ZN, Bian H
International journal of molecular sciences 2018
Exploring the Mechanism of Dangguiliuhuang Decoction Against Hepatic Fibrosis by Network Pharmacology and Experimental Validation.
Cao H, Li S, Xie R, Xu N, Qian Y, Chen H, Hu Q, Quan Y, Yu Z, Liu J, Xiang M
Frontiers in pharmacology 2018
Desmin- and vimentin-mediated hepatic stellate cell-targeting radiotracer (99m)Tc-GlcNAc-PEI for liver fibrosis imaging with SPECT.
Zhang D, Zhuang R, Guo Z, Gao M, Huang L, You L, Zhang P, Li J, Su X, Wu H, Chen X, Zhang X
Theranostics 2018
The risk of cirrhosis in non-alcohol drinkers is greater in female than male betel nut chewers.
Chu YH, Wang L, Ko PC, Lan SJ, Liaw YP
Oncotarget 2018
Oleanolic Acid-amino Acids Derivatives: Design, Synthesis, and Hepatoprotective Evaluation In Vitro and In Vivo.
Chu F, Zhang W, Guo W, Wang Z, Yang Y, Zhang X, Fang K, Yan M, Wang P, Lei H
Molecules (Basel, Switzerland) 2018
Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury.
Konishi T, Schuster RM, Lentsch AB
American journal of physiology. Gastrointestinal and liver physiology 2018
Salvianolic Acid B Enhances Hepatic Differentiation of Human Embryonic Stem Cells Through Upregulation of WNT Pathway and Inhibition of Notch Pathway.
Chen J, Tschudy-Seney B, Ma X, Zern MA, Liu P, Duan Y
Stem Cells and Development 2018
Global Gene Expression Profiling of Dimethylnitrosamine-Induced Liver Fibrosis: From Pathological and Biochemical Data to Microarray Analysis
Su LJ, Hsu SL, Yang JS, Tseng HH, Huang SF, Huang CY
Gene expression 2018
MicroRNA-125b Promotes Hepatic Stellate Cell Activation and Liver Fibrosis by Activating RhoA Signaling
You K, Li SY, Gong J, Fang JH, Zhang C, Zhang M, Yuan Y, Yang J, Zhuang SM
2018
Exosome - miR-335 as a novel therapeutic strategy in hepatocellular carcinoma
Wang F, Li L, Piontek K, Sakaguchi M, Selaru FM
Hepatology 2018
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics
Billington S, Ray AS, Salphati L, Xiao G, Chu X, Humphreys WG, Liao M, Lee CA, Mathias A, Hop CE, Rowbottom C, Evers R, Lai Y, Kelly EJ, Prasad B, Unadkat JD
Drug Metabolism and Disposition 2018
SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway.
Zhang J, Li Y, Liu Q, Li R, Pu S, Yang L, Feng Y, Ma L
RSC Advances 2018
2-Methoxyestradiol attenuates liver fibrosis in mice: implications for M2 macrophages.
Neamatallah T, Abdel-Naim AB, Eid BG, Hasan A
Naunyn-Schmiedeberg's Archives of Pharmacology 2018
Mesothelin-Mucin16 signaling regulates cholestatic liver fibrosis
Yukinori Koyama, Ping Wang, Shuang Liang, Keiko Iwaisako, Xiao Liu, Jun Xu, Mingjun Zhang, Mengxi Sun, Min Cong, Daniel Karin, Kojiro Taura, Chris Benner, Sven Heinz, Tapan K. Bera, David A. Brenner, Tatiana Kisseleva
Journal of Clinical Investigation 2017
Liver inflammation and fibrosis
Yukinori Koyama, David Brenner
Journal of Clinical Investigation 2017
Microbiota, cirrhosis, and the emerging oral-liver-gut axis
Chathur Acharya, Sinem Esra Sahingur, Jasmohan Bajaj
JCI Insight 2017
Pentraxin-3 modulates lipopolysaccharide-induced inflammatory response and attenuates liver injury: Perea et al
L Perea, M Coll, L Sanjurjo, D Blaya, AE Taghdouini, D Rodrigo-Torres, J Altamirano, I Graupera, B Aguilar-Bravo, M Llopis, J Vallverdú, J Caballeria, LA van Grunsven, MR Sarrias, P Ginès, P Sancho-Bru
Hepatology 2017
FOXA2 alleviates CCl4-induced liver fibrosis by protecting hepatocytes in mice
W Wang, LJ Yao, W Shen, K Ding, PM Shi, F Chen, J He, J Ding, X Zhang, WF Xie
Scientific Reports 2017
Anti-fibrotic Effects of Synthetic Oligodeoxynucleotide for TGF-β1 and Smad in an Animal Model of Liver Cirrhosis
JY Kim, HJ An, WH Kim, MG Gwon, H Gu, YY Park, KK Park
Molecular Therapy - Nucleic Acids 2017
Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis
X Li, L Wang, C Chen
Scientific Reports 2017
Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways
E Hernández-Aquino, N Zarco, S Casas-Grajales, E Ramos-Tovar, RE Flores-Beltrán, J Arauz, M Shibayama, L Favari, V Tsutsumi, J Segovia, P Muriel
World journal of gastroenterology : WJG 2017
Myocardial fibrosis in congenital and pediatric heart disease
J Tian, X An, L Niu
Experimental and therapeutic medicine 2017
Can a fibrotic liver afford epithelial-mesenchymal transition?
S Munker, YL Wu, HG Ding, R Liebe, HL Weng
World journal of gastroenterology : WJG 2017
Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases
D Kim, GS Cho, C Han, DH Park, HK Park, DH Woo, JH Kim
Tissue Engineering and Regenerative Medicine 2017
Renin angiotensin system in liver diseases: Friend or foe?
AC Silva, AS Miranda, NP Rocha, AL Teixeira
World journal of gastroenterology : WJG 2017
Endoglin in human liver disease and murine models of liver fibrosis-A protective factor against liver fibrosis
M Alsamman, V Sterzer, SK Meurer, H Sahin, U Schaeper, D Kuscuoglu, P Strnad, R Weiskirchen, C Trautwein, D Scholten
Liver International 2017
Invasive Intraneural Interfaces: Foreign Body Reaction Issues
F Lotti, F Ranieri, G Vadalà, L Zollo, GD Pino
Frontiers in neuroscience 2017
The role of T helper 17 cells in the pathogenesis of hepatitis B virus-related liver cirrhosis (Review)
S Bao, J Zheng, G Shi
Molecular medicine reports 2017
Reversal of liver cirrhosis: current evidence and expectations
YK Jung, HJ Yim
The Korean Journal of Internal Medicine 2017
Platelets prime hematopoietic–vascular niche to drive angiocrine-mediated liver regeneration
K Shido, D Chavez, Z Cao, JL Ko, S Rafii, BS Ding
Signal Transduction and Targeted Therapy 2017
Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients
J Shi, J Zhao, X Zhang, Y Cheng, J Hu, Y Li, X Zhao, Q Shang, Y Sun, B Tu, L Shi, B Gao, FS Wang, Z Zhang
Scientific Reports 2017
The Injury-Related Activation of Hedgehog Signaling Pathway Modulates the Repair-Associated Inflammation in Liver Fibrosis
X Shen, Y Peng, H Li
Frontiers in immunology 2017
Thymic NF-κB-inducing Kinase (NIK) Regulates CD4+ T Cell-elicited Liver Injury and Fibrosis in Mice
H Shen, L Sheng, Y Xiong, YH Kim, L Jiang, Z Chen, Y Liu, K Pyaram, CH Chang, L Rui
Journal of Hepatology 2017
Activation of Insulin-PI3K/Akt-p70S6K Pathway in Hepatic Stellate Cells Contributes to Fibrosis in Nonalcoholic Steatohepatitis
CX Cai, H Buddha, S Castelino-Prabhu, Z Zhang, RS Britton, BR Bacon, BA Neuschwander-Tetri
Digestive Diseases and Sciences 2017
Effects of Liver Fibrosis Progression on Tissue Relaxation Times in Different Mouse Models Assessed by Ultrahigh Field Magnetic Resonance Imaging
A Müller, K Hochrath, J Stroeder, K Hittatiya, G Schneider, F Lammert, A Buecker, P Fries
BioMed Research International 2017
Diethylcarbamazine attenuates the expression of pro-fibrogenic markers and hepatic stellate cells activation in carbon tetrachloride-induced liver fibrosis
ME de França, SW Rocha, WH Oliveira, LA Santos, AG de Oliveira, KP Barbosa, AK Nunes, GB Rodrigues, DB Lós, CA Peixoto
Inflammopharmacology 2017
Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis
V Prestigiacomo, A Weston, S Messner, F Lampart, L Suter-Dick, P Mukhopadhyay
PloS one 2017
eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet
WG Choi, J Han, JH Kim, MJ Kim, JW Park, B Song, HJ Cha, HS Choi, HT Chung, IK Lee, TS Park, M Hatzoglou, HS Choi, HJ Yoo, RJ Kaufman, SH Back
Nutrition & Metabolism 2017
The neglected avian hepatotropic virus induces acute and chronic hepatitis in ducks: an alternative model for hepatology
X Ou, S Mao, J Cao, Y Ma, G Ma, A Cheng, M Wang, D Zhu, S Chen, R Jia, M Liu, K Sun, Q Yang, Y Wu, X Chen
Oncotarget 2017
Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo
F Yang, L Luo, ZD Zhu, X Zhou, Y Wang, J Xue, J Zhang, X Cai, ZL Chen, Q Ma, YF Chen, YJ Wang, YY Luo, P Liu, L Zhao
Frontiers in pharmacology 2017
Brucella abortus Promotes a Fibrotic Phenotype in Hepatic Stellate Cells, with Concomitant Activation of the Autophagy Pathway
PC Benitez, AI Viglietti, CK Herrmann, VA Dennis, DJ Comerci, GH Giambartolomei, MV Delpino, SM Payne
Infection and immunity 2017
The spleen in liver cirrhosis: revisiting an old enemy with novel targets
L Li, M Duan, W Chen, A Jiang, X Li, J Yang, Z Li
Journal of Translational Medicine 2017
Tissue Force Programs Cell Fate and Tumor Aggression
JJ Northey, L Przybyla, VM Weaver
Cancer Discovery 2017
Curcumin enhances liver SIRT3 expression in the rat model of cirrhosis
Sara Chenari, Fatemeh Safari, Ali Moradi
Iranian Journal of Basic Medical Sciences 2017
Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β- and PDGF-like signals in hepatic stellate cells
MH Wu, YL Chen, KH Lee, CC Chang, TM Cheng, SY Wu, CC Tu, WL Tsui
Scientific Reports 2017
Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis
Z Cao, T Ye, Y Sun, G Ji, K Shido, Y Chen, L Luo, F Na, X Li, Z Huang, JL Ko, V Mittal, L Qiao, C Chen, FJ Martinez, S Rafii, BS Ding
Science Translational Medicine 2017
TGF-β-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice
X Tu, Y Zhang, X Zheng, J Deng, H Li, Z Kang, Z Cao, Z Huang, Z Ding, L Dong, J Chen, Y Zang, J Zhang
Scientific Reports 2017
AMP-activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy
M Chen, J Liu, L Yang, W Ling
FEBS Open Bio 2017
Lipopolysaccharide mediates hepatic stellate cell activation by regulating autophagy and retinoic acid signaling
M Chen, J Liu, W Yang, W Ling
Autophagy 2017
MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis
G Lou, Y Yang, F Liu, B Ye, Z Chen, M Zheng, Y Liu
Journal of Cellular and Molecular Medicine 2017
NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6
F Yu, Z Jiang, B Chen, P Dong, J Zheng
Journal of Molecular Medicine 2017
Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury
Y Wan, K McDaniel, N Wu, S Ramos-Lorenzo, T Glaser, J Venter, H Francis, L Kennedy, K Sato, T Zhou, K Kyritsi, Q Huang, T Annable, C Wu, S Glaser, G Alpini, F Meng
The American Journal of Pathology 2017
Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity
JJ Sutherland, YW Webster, JA Willy, GH Searfoss, KM Goldstein, AR Irizarry, DG Hall, JL Stevens
The Pharmacogenomics Journal 2017
SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis
V Natarajan, EN Harris, S Kidambi
BioMed Research International 2017
Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling
Y Wu, Y Li, M Shang, Y Jian, C Wang, AS Bardeesi, Z Li, T Chen, L Zhao, L Zhou, A He, Y Huang, Z Lv, X Yu, X Li
Parasites & vectors 2017
miR-96-5p prevents hepatic stellate cell activation by inhibiting autophagy via ATG7
K Yu, N Li, Q Cheng, J Zheng, M Zhu, S Bao, M Chen, G Shi
Journal of Molecular Medicine 2017
IL‑32γ promotes integrin αvβ6 expression through the activation of NF‑κB in HSCs
H Liu, X Pan, H Cao, X Shu, H Sun, J Lu, J Liang, K Zhang, F Zhu, G Li, Q Zhang
Experimental and therapeutic medicine 2017
Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways
Q Chen, H Zhang, Y Cao, Y Li, S Sun, J Zhang, G Zhang
Drug design, development and therapy 2017
Thunbergia laurifolia Exhibits Antifibrotic Effects in Human Hepatic Stellate Cells
R Namsen, N Rojanasthien, S Sireeratawong, P Rojsanga, W Nimlamool, S Potikanond
Evidence-Based Complementary and Alternative Medicine 2017
Gd-EOB-DTPA-enhanced MR relaxometry for the detection and staging of liver fibrosis
M Haimerl, K Utpatel, N Verloh, F Zeman, C Fellner, D Nickel, A Teufel, S Fichtner-Feigl, M Evert, C Stroszczynski, P Wiggermann
Scientific Reports 2017
ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice
Q Sun, Y Wang, J Zhang, J Lu
Scientific Reports 2017
Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway
L Zhou, X Dong, L Wang, L Shan, T Li, W Xu, Y Ding, M Lai, X Lin, M Dai, X Bai, C Jia, H Zheng
Oncotarget 2017
Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling
J Kim, J Hyun, S Wang, C Lee, JW Lee, EY Moon, H Cha, AM Diehl, Y Jung
Scientific Reports 2017
Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice
T Aoyama, K Kuwahara-Arai, A Uchiyama, K Kon, H Okubo, S Yamashina, K Ikejima, S Kokubu, A Miyazaki, S Watanabe
Laboratory Investigation 2017
CCN1/Cyr61 enhances the function of hepatic stellate cells in promoting the progression of hepatocellular carcinoma
ZQ Li, WR Wu, C Zhao, C Zhao, XL Zhang, Z Yang, J Pan, WK Si
International journal of molecular medicine 2017
Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology
T Rohrbach, M Maceyka, S Spiegel
Critical Reviews in Biochemistry and Molecular Biology 2017
Liver myofibroblasts of murine origins express mesothelin: Identification of novel rat mesothelin splice variants*
M Fausther, EG Lavoie, JA Dranoff, H Francis
PloS one 2017
Effect of ginseng extract on the TGF-β1 signaling pathway in CCl4-induced liver fibrosis in rats
MM Hafez, SS Hamed, MF El-Khadragy, ZK Hassan, SS Rejaie, MM Sayed-Ahmed, NO Al-Harbi, KA Al-Hosaini, MM Al-Harbi, AR Alhoshani, OA Al-Shabanah, SD Alsharari
BMC complementary and alternative medicine 2017
Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery
H Zhang, F Chen, X Fan, C Lin, Y Hao, H Wei, W Lin, Y Jiang, F He
Scientific Reports 2017
Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models
S Caddeo, M Boffito, S Sartori
Frontiers in Bioengineering and Biotechnology 2017
Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism
J Li, M Ghazwani, K Liu, Y Huang, N Chang, J Fan, F He, L Li, S Bu, W Xie, X Ma, S Li, MA Avila
PloS one 2017
Platelets in liver disease, cancer and regeneration
T Kurokawa, N Ohkohchi
World journal of gastroenterology : WJG 2017
No significant impact of Foxf1 siRNA treatment in acute and chronic CCl 4 liver injury
K Abshagen, T Rotberg, B Genz, B Vollmar
Experimental biology and medicine (Maywood, N.J.) 2017
Platelet-derived growth factor receptor α in hepatocellular carcinoma is a prognostic marker independent of underlying liver cirrhosis
JH Yu, JM Kim, JK Kim, SJ Choi, KS Lee, JW Lee, HY Chang, JI Lee
Oncotarget 2017
Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment
RG de la Garza, LA Morales-Garza, I Martin-Estal, I Castilla-Cortazar
Journal of clinical medicine research 2017
Human hepatic stellate cell isolation and characterization
L Shang, M Hosseini, X Liu, T Kisseleva, DA Brenner
Journal of Gastroenterology 2017
Influence of resveratrol on liver fibrosis induced by dimethylnitrosamine in male rats
Abdu SB, Al-Bogami FM
Saudi Journal of Biological Sciences 2017
Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease
Pulli B, Wojtkiewicz G, Iwamoto Y, Ali M, Zeller MW, Bure L, Wang C, Choi Y, Masia R, Guimaraes AR, Corey KE, Chen JW
Radiology 2017
Portal fibroblasts marked by the surface antigen Thy1 contribute to fibrosis in mouse models of cholestatic liver injury.
Katsumata LW, Miyajima A, Itoh T
Hepatology Communications 2017
Positive Feedback Regulation between Transglutaminase 2 and Toll-Like Receptor 4 Signaling in Hepatic Stellate Cells Correlates with Liver Fibrosis Post Schistosoma japonicum Infection.
Wen Z, Ji X, Tang J, Lin G, Xiao L, Liang C, Wang M, Su F, Ferrandon D, Li Z
Frontiers in immunology 2017
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Sang L, Wang XM, Xu DY, Sang LX, Han Y, Jiang LY
World Journal of Gastroenterology 2017
The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.
Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S
OncoImmunology 2017
Estrogen receptor‑β‑dependent effects of saikosaponin‑d on the suppression of oxidative stress‑induced rat hepatic stellate cell activation.
Que R, Shen Y, Ren J, Tao Z, Zhu X, Li Y
International journal of molecular medicine 2017
Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo.
Lv X, Fang C, Yin R, Qiao B, Shang R, Wang J, Song W, He Y, Chen Y
Oncotarget 2017
Comparison of bone marrow-vs. adipose tissue-derived mesenchymal stem cells for attenuating liver fibrosis.
Hao T, Chen J, Zhi S, Zhang Q, Chen G, Yu F
Experimental and therapeutic medicine 2017
Periostin cross-reacts with the renin-angiotensin system during liver fibrosis development
Takeda K, Noguchi R, Kitade M, Namisaki T, Moriya K, Kawaratani H, Okura Y, Kaji K, Aihara Y, Douhara A, Nishimura N, Sawada Y, Seki K, Yoshiji H
Molecular medicine reports 2017
Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study
Amer MG, Mazen NF, Mohamed AM
International journal of immunopathology and pharmacology 2017
D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress
Zhao SS, Li NR, Zhao WL, Liu H, Ge MX, Zhang YX, Zhao LY, You XF, He HW, Shao RG
Acta Pharmacologica Sinica 2017
Antioxidant, antiapoptotic and amino acid balance regulating activities of 1,7-dihydroxy-3,4,8-trimethoxyxanthone against dimethylnitrosamine-induced liver fibrosis
Zheng XY, Zhao X, Yang YF, Jiang HJ, Li W, Sun Y, Pu XP
PloS one 2017
Computational Modeling in Liver Surgery
Christ B, Dahmen U, Herrmann KH, König M, Reichenbach JR, Ricken T, Schleicher J, Ole Schwen L, Vlaic S, Waschinsky N
Frontiers in physiology 2017
MicroRNA‐30a ameliorates hepatic fibrosis by inhibiting Beclin1‐mediated autophagy
Chen J, Yu Y, Li S, Liu Y, Zhou S, Cao S, Yin J, Li G
Journal of Cellular and Molecular Medicine 2017
MMP‐13 deletion decreases profibrogenic molecules and attenuates N‐nitrosodimethylamine‐induced liver injury and fibrosis in mice
George J, Tsutsumi M, Tsuchishima M
Journal of Cellular and Molecular Medicine 2017
Identification of Hepatoprotective Constituents in Limonium tetragonum and Development of Simultaneous Analysis Method using High-performance Liquid Chromatography
Lee JS, Kim YN, Kim NH, Heo JD, Yang MH, Rho JR, Jeong EJ
Pharmacognosy magazine 2017
20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1-AMP-activated protein kinase activation.
Park SM, Jung EH, Kim JK, Jegal KH, Park CA, Cho IJ, Kim SC
Journal of Ginseng Research 2017
Non-alcoholic fatty liver disease, to struggle with the strangle: Oxygen availability in fatty livers.
Anavi S, Madar Z, Tirosh O
Redox Biology 2017
Enhanced antiviral and antifibrotic effects of short hairpin RNAs targeting HBV and TGF-β in HBV-persistent mice.
Ye L, Kan F, Yan T, Cao J, Zhang L, Wu Z, Li W
Scientific Reports 2017
The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis.
Yan C, Li B, Fan F, Du Y, Ma R, Cheng XD, Li XY, Zhang B, Yu Q, Wang YG, Tang RX, Zheng KY
Scientific Reports 2017
M2-like Kupffer cells in fibrotic liver may protect against acute insult.
Zheng QF, Bai L, Duan ZP, Han YP, Zheng SJ, Chen Y, Li JS
World Journal of Gastroenterology 2017
Transplantation of human bone marrow mesenchymal stromal cells reduces liver fibrosis more effectively than Wharton's jelly mesenchymal stromal cells.
Rengasamy M, Singh G, Fakharuzi NA, Siddikuzzaman, Balasubramanian S, Swamynathan P, Thej C, Sasidharan G, Gupta PK, Das AK, Rahman AZA, Fakiruddin KS, Nian LM, Zakaria Z, Majumdar AS
Stem Cell Research & Therapy 2017
miR‑203 inhibits the expression of collagen‑related genes and the proliferation of hepatic stellate cells through a SMAD3‑dependent mechanism.
Hu D, Hu Y, Xu W, Yu H, Yang N, Ni S, Fu R
Molecular medicine reports 2017
Immunobiology of Newcastle Disease Virus and Its Use for Prophylactic Vaccination in Poultry and as Adjuvant for Therapeutic Vaccination in Cancer Patients.
Schirrmacher V
International journal of molecular sciences 2017
MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2.
Wang Y, Du J, Niu X, Fu N, Wang R, Zhang Y, Zhao S, Sun D, Nan Y
Cell Death and Disease 2017
Therapeutic Effect and Location of GFP-Labeled Placental Mesenchymal Stem Cells on Hepatic Fibrosis in Rats.
Yu J, Hao G, Wang D, Liu J, Dong X, Sun Y, Pan Q, Li Y, Shi X, Li L, Cao H
Stem Cells International 2017
Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study.
Li W, Amet T, Xing Y, Yang D, Liangpunsakul S, Puri P, Kamath PS, Sanyal AJ, Shah VH, Katz BP, Radaeva S, Crabb DW, Chalasani N, Yu Q
Hepatology 2017
Development of a Simple Noninvasive Model to Predict Significant Fibrosis in Patients with Chronic Hepatitis B: Combination of Ultrasound Elastography, Serum Biomarkers, and Individual Characteristics.
Chen X, Wen H, Zhang X, Dong C, Lin H, Guo Y, Shan L, Yao S, Yang M, Le X, Liu Y
Clinical and Translational Gastroenterology 2017
Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model.
Tokunaga Y, Osawa Y, Ohtsuki T, Hayashi Y, Yamaji K, Yamane D, Hara M, Munekata K, Tsukiyama-Kohara K, Hishima T, Kojima S, Kimura K, Kohara M
Scientific Reports 2017
Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells via SKP2/P27 signaling pathway.
Xu T, Chen J, Zhu D, Chen L, Wang J, Sun X, Hu B, Duan Y
Scientific Reports 2017
Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells.
Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York SR, Motola DL, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev EV, Fuchs BC, Hannun Y, Chung RT, Mullen AC
Scientific Reports 2017
Metabolomic mechanisms of gypenoside against liver fibrosis in rats: An integrative analysis of proteomics and metabolomics data.
Song YN, Dong S, Wei B, Liu P, Zhang YY, Su SB
PloS one 2017
AAV gene therapy corrects OTC deficiency and prevents liver fibrosis in aged OTC-knock out heterozygous mice.
Wang L, Bell P, Morizono H, He Z, Pumbo E, Yu H, White J, Batshaw ML, Wilson JM
Molecular Genetics and Metabolism 2017
Tumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy.
Tahmasebi Birgani M, Carloni V
International journal of molecular sciences 2017
Mesothelial cell autoantibodies upregulate transcription factors associated with fibrosis.
Gilmer J, Harding T, Woods L, Black B, Flores R, Pfau J
Inhalation Toxicology 2017
Relationship of Serum Betatrophin with Nonalcoholic Fatty Liver in a Chinese Population.
Hu W, Shao X, Guo D, Hao H, Zhang Y, Xia M, Gong Y, Zhou H, Fan Y, Yu W
PloS one 2017
Ultrasound shear wave elastography and liver fibrosis: A Prospective Multicenter Study.
Sande JA, Verjee S, Vinayak S, Amersi F, Ghesani M
World journal of hepatology 2017
miRNA-338-3p/CDK4 signaling pathway suppressed hepatic stellate cell activation and proliferation.
Duan B, Hu J, Zhang T, Luo X, Zhou Y, Liu S, Zhu L, Wu C, Liu W, Chen C, Gao H
BMC Gastroenterology 2017
A Nitric Oxide-Donating Statin Decreases Portal Pressure with a Better Toxicity Profile than Conventional Statins in Cirrhotic Rats.
Rodríguez S, Raurell I, Torres-Arauz M, García-Lezana T, Genescà J, Martell M
Scientific Reports 2017
Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells.
Liu J, Li M, Gong J, Han P, Wang Y, Li D, Tian D, Liao J
Biology Open 2017
Protective effect of dehydroandrographolide on obstructive cholestasis in bile duct-ligated mice.
Weng Z, Liu X, Hu J, Mu J, Xie J, Yao C, Li L
Oncotarget 2017
Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway.
Seo HY, Jung YA, Lee SH, Hwang JS, Park KG, Kim MK, Jang BK
Oncotarget 2017
Clinicopathological and prognostic significance of PKM2 protein expression in cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma.
Liu Y, Wu H, Mei Y, Ding X, Yang X, Li C, Deng M, Gong J
Scientific Reports 2017
High serum N-terminal propeptide of procollagen type III concentration is associated with liver diseases.
Gudowska M, Gruszewska E, Panasiuk A, Cylwik B, Swiderska M, Flisiak R, Szmitkowski M, Chrostek L
2017
Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells.
Zhou X, Gu Y, Xiao H, Kang N, Xie Y, Zhang G, Shi Y, Hu X, Oldfield E, Zhang X, Zhang Y
Frontiers in immunology 2017
Evaluation of the branched-chain amino acid-to-tyrosine ratio prior to treatment as a prognostic predictor in patients with liver cirrhosis.
Ishikawa T, Imai M, Ko M, Sato H, Nozawa Y, Sano T, Iwanaga A, Seki K, Honma T, Yoshida T
Oncotarget 2017
Ethanol extracts collected from the Styela clava tunic alleviate hepatic injury induced by carbon tetrachloride (CCl(4)) through inhibition of hepatic apoptosis, inflammation, and fibrosis.
Koh EK, Kim JE, Song SH, Sung JE, Lee HA, Kim KS, Hong JT, Hwang DY
Journal of Toxicologic Pathology 2017
Pulmonary function impairment predicted poor prognosis of patients with hepatocellular carcinoma after hepatectomy.
Zhao Y, Leng S, Li D, Feng S, Wang Z, Tao C
Oncotarget 2017
Intestinal flora imbalance promotes alcohol-induced liver fibrosis by the TGFβ/smad signaling pathway in mice.
Zhang D, Hao X, Xu L, Cui J, Xue L, Tian Z
Oncology Letters 2017
Acetaminophen-Induced Liver Injury Alters the Acyl Ethanolamine-Based Anti-Inflammatory Signaling System in Liver.
Rivera P, Pastor A, Arrabal S, Decara J, Vargas A, Sánchez-Marín L, Pavón FJ, Serrano A, Bautista D, Boronat A, de la Torre R, Baixeras E, Lucena MI, de Fonseca FR, Suárez J
Frontiers in pharmacology 2017
Ursolic acid suppresses TGF-β1-induced quiescent HSC activation and transformation by inhibiting NADPH oxidase expression and Hedgehog signaling.
Yu SS, Chen B, Huang CK, Zhou JJ, Huang X, Wang AJ, Li BM, He WH, Zhu X
Experimental and therapeutic medicine 2017
Nanoparticles for the treatment of liver fibrosis.
Poilil Surendran S, George Thomas R, Moon MJ, Jeong YY
International Journal of Nanomedicine 2017
Automated Liver Elasticity Calculation for 3D MRE.
Dzyubak B, Glaser KJ, Manduca A, Ehman RL
Proceedings of SPIE--the International Society for Optical Engineering 2017
Reproducibility of shear wave elastography (SWE) in patients with chronic liver disease.
Mancini M, Salomone Megna A, Ragucci M, De Luca M, Marino Marsilia G, Nardone G, Coccoli P, Prinster A, Mannelli L, Vergara E, Monti S, Liuzzi R, Incoronato M
PloS one 2017
Thymosin-β4 inhibits proliferation and induces apoptosis of hepatic stellate cells through PI3K/AKT pathway.
Zhu L, Cheng M, Liu Y, Yao Y, Zhu Z, Zhang B, Mou Q, Cheng Y
Oncotarget 2017
Silencing of α-complex protein-2 reverses alcohol- and cytokine-induced fibrogenesis in hepatic stellate cells.
Liu H, Chen Z, Jin W, Barve A, Wan YY, Cheng K
Liver Research 2017
The regulatory role of IL-6R in hepatitis B-associated fibrosis and cirrhosis.
Chen Y, Yang S, Peng Y, Yang Z
2017
Expression of hnRNPK & Claudin-4 in HCV-Induced Early HCC and Adjacent Liver Tissue.
Hammam O, Magdy M, Anas A, Rahim AA, Heedaya M, Helmy A
Open Access Macedonian Journal of Medical Sciences 2017
Hepatocellular carcinoma in a mouse model fed a choline-deficient, L-amino acid-defined, high-fat diet.
Ikawa-Yoshida A, Matsuo S, Kato A, Ohmori Y, Higashida A, Kaneko E, Matsumoto M
International Journal of Experimental Pathology 2017
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C
Scientific Reports 2017
The pattern of IL-24/mda-7 and its cognate receptors expression following activation of human hepatic stellate cells.
Jamhiri I, Hosseini SY, Mehrabani D, Khodabandeh Z, Yaghobi R, Dowran R, Zahri S
Biomedical Reports 2017
Interleukin-17F expression is elevated in hepatitis C patients with fibrosis and hepatocellular carcinoma.
Wu MS, Wang CH, Tseng FC, Yang HJ, Lo YC, Kuo YP, Tsai DJ, Tsai WT, Yu GY
Infectious agents and cancer 2017
The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways.
Zhang K, Han X, Zhang Z, Zheng L, Hu Z, Yao Q, Cui H, Shu G, Si M, Li C, Shi Z, Chen T, Han Y, Chang Y, Yao Z, Han T, Hong W
Nature Communications 2017
Suppression of hepatic dysfunction in tenascin‑X‑deficient mice fed a high‑fat diet.
Yamaguchi S, Kawakami K, Satoh K, Fukunaga N, Akama K, Matsumoto KI
Molecular medicine reports 2017
Magnetic resonance imaging and spectroscopy for differential assessment of liver abnormalities induced by Opisthorchis felineus in an animal model.
Pershina AG, Ivanov VV, Efimova LV, Shevelev OB, Vtorushin SV, Perevozchikova TV, Sazonov AE, Ogorodova LM
PLoS neglected tropical diseases 2017
Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease
Wruck W, Adjaye J
World journal of hepatology 2017
Epalrestat Stimulated Oxidative Stress, Inflammation, and Fibrogenesis in Mouse Liver
Le Y, Chen L, Zhang Y, Bu P, Dai G, Cheng X
Toxicological Sciences 2017
Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis
A Iwasaki, K Sakai, K Moriya, T Sasaki, DR Keene, R Akhtar, T Miyazono, S Yasumura, M Watanabe, S Morishita, T Sakai
The Journal of biological chemistry 2016
Pathogenesis of nonalcoholic steatohepatitis
W Liu, RD Baker, T Bhatia, L Zhu, SS Baker
Cellular and Molecular Life Sciences 2016
Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts
ZC Nwosu, H Alborzinia, S Wölfl, S Dooley, Y Liu
Frontiers in physiology 2016
Targeting Hepatic Fibrosis in Autoimmune Hepatitis
AJ Montano-Loza, RB Thandassery, AJ Czaja
Digestive Diseases and Sciences 2016
Age-dependent development of liver fibrosis in Glmp gt/gt mice
CK Nesset, XY Kong, M Damme, C Schjalm, N Roos, EM Løberg, W Eskild
Fibrogenesis & Tissue Repair 2016
Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease
F Ezquer
World journal of gastroenterology : WJG 2016
Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells
N Magee, A Zou, Y Zhang
BioMed Research International 2016
Role of redoximiRs in fibrogenesis
M Fierro-Fernández, V Miguel, S Lamas
Redox Biology 2016
Controversies over the Epithelial-to-Mesenchymal Transition in Liver Fibrosis
K Taura, K Iwaisako, E Hatano, S Uemoto
Journal of Clinical Medicine 2016
Myofibroblast repair mechanisms post-inflammatory response: a fibrotic perspective
C Gerarduzzi, JA di Battista
Inflammation Research 2016
Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy
MN Kristiansen, SS Veidal, KT Rigbolt, KS Tølbøl, JD Roth, J Jelsing, N Vrang, M Feigh
World journal of hepatology 2016
Novel treatment options for lysosomal acid lipase deficiency: critical appraisal of sebelipase alfa
K Su, E Donaldson, R Sharma
The Application of Clinical Genetics 2016
Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis
M Hirata, M Ishigami, Y Matsushita, T Ito, H Hattori, H Hibi, H Goto, M Ueda, A Yamamoto
Stem Cells Translational Medicine 2016
Fibronectin expression is critical for liver fibrogenesis in vivo and in�vitro
XY Liu, RX Liu, F Hou, LJ Cui, CY Li, C Chi, E Yi, Y Wen, CH Yin
Molecular medicine reports 2016
Thymoquinone alleviates nonalcoholic fatty liver disease in rats via suppression of oxidative stress, inflammation, apoptosis
AS Awad, EN Haleem, WM El-Bakly, MA Sherief
Naunyn-Schmiedeberg's Archives of Pharmacology 2016
The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts
S Liang, T Kisseleva, DA Brenner
Frontiers in physiology 2016
New therapeutic targets in alcoholic hepatitis
D Arsene, O Farooq, R Bataller
Hepatology International 2016
Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis
S Mueller
World journal of gastroenterology : WJG 2016
Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation
Y Yu, X Sun, J Gu, C Yu, Y Wen, Y Gao, Q Xia, X Kong
International journal of biological sciences 2016
Thyroid hormones inhibit TGF-β signaling and attenuate fibrotic responses
E Alonso-Merino, RM Orozco, L Ruíz-Llorente, OA Martínez-Iglesias, JP Velasco-Martín, A Montero-Pedrazuela, L Fanjul-Rodríguez, C Contreras-Jurado, J Regadera, A Aranda
Proceedings of the National Academy of Sciences 2016
Bone marrow-derived mesenchymal stem cells effectively regenerate fibrotic liver in bile duct ligation rat model
HE Mohamed, SE Elswefy, LA Rashed, NN Younis, MA Shaheen, AM Ghanim
Experimental biology and medicine (Maywood, N.J.) 2016
Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis
D Povero, AE Feldstein
Diabetes & Metabolism Journal 2016
Obesity: An Immunometabolic Perspective
I Ray, SK Mahata, RK De
Frontiers in Endocrinology 2016
TGF- /SMAD Pathway and Its Regulation in Hepatic Fibrosis
F Xu, C Liu, D Zhou, L Zhang
Journal of Histochemistry & Cytochemistry 2016
New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy
B Law, S Mok, A Wu, C Lam, M Yu, V Wong
Molecules (Basel, Switzerland) 2016
Reversibility of Stricturing Crohnʼs Disease—Fact or Fiction?:
D Bettenworth, F Rieder
Inflammatory Bowel Diseases 2016
Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells
SV Siegmund, M Schlosser, FA Schildberg, E Seki, SD Minicis, H Uchinami, C Kuntzen, PA Knolle, CP Strassburg, RF Schwabe, MA Avila
PloS one 2016
Pharmacokinetics, Safety, and CCR2/CCR5 Antagonist Activity of Cenicriviroc in Participants With Mild or Moderate Hepatic Impairment: Cenicriviroc in Hepatic-Impaired Participants
E Lefebvre, M Gottwald, K Lasseter, W Chang, M Willett, PF Smith, A Somasunderam, NS Utay
Clinical and Translational Science 2016
Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
CY Han, JH Koo, SH Kim, S Gardenghi, S Rivella, P Strnad, SJ Hwang, SG Kim
Nature Communications 2016
The role of integrins in TGFβ activation in the tumour stroma
Z Khan, JF Marshall
Cell and Tissue Research 2016
Ces3/TGH Deficiency Attenuates Steatohepatitis
J Lian, E Wei, J Groenendyk, SK Das, M Hermansson, L Li, R Watts, A Thiesen, GY Oudit, M Michalak, R Lehner
Scientific Reports 2016
The importance of serum biglycan levels as a fibrosis marker in patients with chronic hepatitis B
R Ciftciler, S Ozenirler, AA Yucel, M Cengiz, G Erkan, E Buyukdemirci, C Sönmez, GY Esendaglı
Journal of Clinical Laboratory Analysis 2016
Adverse outcome pathway development from protein alkylation to liver fibrosis
T Horvat, B Landesmann, A Lostia, M Vinken, S Munn, M Whelan
Archives of Toxicology 2016
Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma
X Mu, JP Pradere, S Affò, DH Dapito, R Friedman, JH Lefkovitch, RF Schwabe
Gastroenterology 2016
Biomarker-Based Approaches for Assessing Alcohol Use Disorders
O Niemelä
International journal of environmental research and public health 2016
The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis
D Karin, Y Koyama, D Brenner, T Kisseleva
Differentiation 2016
Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation
YC Twu, TS Lee, YL Lin, SM Hsu, YH Wang, CY Liao, CK Wang, YC Liang, YJ Liao
International journal of molecular sciences 2016
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis
M Rezvani, R Español-Suñer, Y Malato, L Dumont, AA Grimm, E Kienle, JG Bindman, E Wiedtke, BY Hsu, SJ Naqvi, RF Schwabe, CU Corvera, D Grimm, H Willenbring
Cell Stem Cell 2016
Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin αvβ3 for staging liver fibrosis in rat model
DB Wang, C Zhang, H Liu, Y Cui, X Li, Z Zhang, Y Zhang
International Journal of Nanomedicine 2016
HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis
N Chang, J Ge, L Xiu, Z Zhao, X Duan, L Tian, J Xie, L Yang, L Li
Journal of Molecular Medicine 2016
Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease
PK Leong, KM Ko
Oxidative medicine and cellular longevity 2016
Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions
K Yoshida, M Murata, T Yamaguchi, K Matsuzaki, K Okazaki
Journal of Clinical Medicine 2016
Clinical Advancements in the Targeted Therapies against Liver Fibrosis
R Bansal, B Nagórniewicz, J Prakash
Mediators of Inflammation 2016
Influence of cytokine and cytokine receptor gene polymorphisms on the degree of liver damage in patients with chronic hepatitis C
ST Moreira, GF Silva, CF de Moraes, RM Grotto, MI de Pardini, MG Bicalho, RA Moliterno
Meta Gene 2016
New Concepts on Pathogenesis and Diagnosis of Liver Fibrosis; A Review Article
H Ebrahimi, M Naderian, AA Sohrabpour
Middle East journal of digestive diseases 2016
TAM receptor tyrosine kinase function and the immunopathology of liver disease
SK Mukherjee, A Wilhelm, CG Antoniades
AJP Gastrointestinal and Liver Physiology 2016
Epigenetics in liver disease: from biology to therapeutics
T Hardy, DA Mann
Gut 2016
Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu
J Chen, W Gao, P Zhou, X Ma, B Tschudy-Seney, C Liu, MA Zern, P Liu, Y Duan
Scientific Reports 2016
MicroRNA Expression Profiling in CCl4-Induced Liver Fibrosis of Mus musculus
J Hyun, J Park, S Wang, J Kim, HH Lee, YS Seo, Y Jung
International journal of molecular sciences 2016
Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases
AA Momtazi, G Derosa, P Maffioli, M Banach, A Sahebkar
Molecular diagnosis & therapy 2016
p53 on the crossroad between regeneration and cancer
M Charni, R Aloni-Grinstein, A Molchadsky, V Rotter
Cell Death and Differentiation 2016
Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human
M Sato, H Ikeda, B Uranbileg, M Kurano, D Saigusa, J Aoki, H Maki, H Kudo, K Hasegawa, N Kokudo, Y Yatomi
Scientific Reports 2016
Tissue- and Serum-Associated Biomarkers of Hepatocellular Carcinoma
R Chauhan, N Lahiri
Biomarkers in Cancer 2016
Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control
ZK Tuong, R Fitzsimmons, SC Wang, TG Oh, P Lau, F Steyn, G Thomas, GE Muscat
EBioMedicine 2016
Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis
T Saneyasu, R Akhtar, T Sakai
BioMed Research International 2016
Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells
K YOSHIZATO, LT THUY, G SHIOTA, N KAWADA
Proceedings of the Japan Academy, Series B 2016
Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
M Kitano, P Bloomston
Journal of Clinical Medicine 2016
MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
J Hyun, S Wang, J Kim, KM Rao, SY Park, I Chung, CS Ha, SW Kim, YH Yun, Y Jung
Nature Communications 2016
Natural Killer Cells and Liver Fibrosis
F Fasbender, A Widera, JG Hengstler, C Watzl
Frontiers in immunology 2016
Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells: PEGylated TRAIL Ameliorates Cirrhosis
Y Oh, O Park, M Swierczewska, JP Hamilton, JS Park, TH Kim, SM Lim, H Eom, DG Jo, CE Lee, R Kechrid, P Mastorakos, C Zhang, SK Hahn, OC Jeon, Y Byun, K Kim, J Hanes, KC Lee, MG Pomper, B Gao, S Lee
Hepatology 2016
Effects of recombinant human adenovirus-p53 on the regression of hepatic fibrosis
Y Liu, P Yang, N Chen, S Lin, M Liu
International journal of molecular medicine 2016
MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling
J Hyun, Y Jung
World journal of gastroenterology : WJG 2016
Inhibition of SIRT2 suppresses hepatic fibrosis
M Arteaga, N Shang, X Ding, S Yong, SJ Cotler, MF Denning, T Shimamura, P Breslin, B Lüscher, W Qiu
AJP Gastrointestinal and Liver Physiology 2016
Human Menstrual Blood-Derived Stem Cells Ameliorate Liver Fibrosis in Mice by Targeting Hepatic Stellate Cells via Paracrine Mediators: Paracrine Effects of MenSCs in Liver Fibrosis
L Chen, C Zhang, L Chen, X Wang, B Xiang, X Wu, Y Guo, X Mou, L Yuan, B Chen, J Wang, C Xiang
Stem Cells Translational Medicine 2016
CUG-binding protein 1 regulates HSC activation and liver fibrogenesis
X Wu, X Wu, Y Ma, F Shao, Y Tan, T Tan, L Gu, Y Zhou, B Sun, Y Sun, X Wu, Q Xu
Nature Communications 2016
Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway
L Liang, X Yang, Y Yu, X Li, Y Wu, R Shi, J Jiang, L Gao, F Ye, Q Zhao, R Li, L Wei, Z Han
Oncotarget 2016
Cancer-associated fibroblasts in hepatocellular carcinoma
N Kubo, K Araki, H Kuwano, K Shirabe
World journal of gastroenterology : WJG 2016
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer
A Duran, ED Hernandez, M Reina-Campos, EA Castilla, S Subramaniam, S Raghunandan, LR Roberts, T Kisseleva, M Karin, MT Diaz-Meco, J Moscat
Cancer Cell 2016
Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease
H Shoji, S Yoshio, Y Mano, E Kumagai, M Sugiyama, M Korenaga, T Arai, N Itokawa, M Atsukawa, H Aikata, H Hyogo, K Chayama, T Ohashi, K Ito, M Yoneda, Y Nozaki, T Kawaguchi, T Torimura, M Abe, Y Hiasa, M Fukai, T Kamiyama, A Taketomi, M Mizokami, T Kanto
Scientific Reports 2016
Knockdown of miR-23, miR-27, and miR-24 Alters Fetal Liver Development and Blocks Fibrosis in Mice
Rogler CE, Matarlo JS, Kosmyna B, Fulop D, Rogler LE
Gene expression 2016
Fibrinogen α-Chain as a Serum Marker of Liver Disease
Marfà S, Jimenez W
Biomarkers in Liver Disease 2016
Fas Regulates Macrophage Polarization and Fibrogenic Phenotype in a Model of Chronic Ethanol-Induced Hepatocellular Injury
F Isayama, S Moore, IN Hines, MD Wheeler
The American Journal of Pathology 2016
Regulation of matrix metalloproteinase-1 and alpha-smooth muscle actin expression by interleukin-1 alpha and tumour necrosis factor alpha in hepatic stellate cells
A Inoue, K Obayashi, Y Sonoda, A Nakamura, T Ueno, S Kuhara, K Tashiro
Cytotechnology 2016
Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
H Wang, H Zhang, Z Zhang, B Huang, X Cheng, D Wang, Z Gahu, Z Xue, Y Da, D Li, Z Yao, F Gao, A Xu, R Zhang
Scientific Reports 2016
Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins
C Zhou, SR York, JY Chen, JV Pondick, DL Motola, RT Chung, AC Mullen
Genome Medicine 2016
Virologic Cure of Hepatitis C: Impact on Hepatic Fibrosis and Patient Outcomes
HC Gonzalez, A Duarte-Rojo
Current Gastroenterology Reports 2016
Response of Hepatic Stellate Cells to TGFB1 Differs from the Response of Myofibroblasts. Decorin Protects against the Action of Growth Factor
A Fullár, G Firneisz, E Regős, J Dudás, T Szarvas, K Baghy, G Ramadori, I Kovalszky
Pathology & Oncology Research 2016
Antifibrotic effect of meloxicam in rat liver: role of nuclear factor kappa B, proinflammatory cytokines, and oxidative stress
MH Hassan, MM Ghobara
Naunyn-Schmiedeberg's Archives of Pharmacology 2016
Rhus verniciflua Stokes attenuates cholestatic liver cirrhosis-induced interstitial fibrosis via Smad3 down-regulation and Smad7 up-regulation
MN Gil, DR Choi, KS Yu, JH Jeong, DH Bak, DK Kim, NS Lee, JH Lee, YG Jeong, CS Na, DS Na, KH Ryu, SY Han
Anatomy & cell biology 2016
Effect of reversine on cell cycle, apoptosis, and activation of hepatic stellate cells
Y Huang, D Huang, J Weng, S Zhang, Q Zhang, Z Mai, W Gu
Molecular and Cellular Biochemistry 2016
PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis
P Pingitore, P Dongiovanni, BM Motta, M Meroni, SM Lepore, RM Mancina, S Pelusi, C Russo, A Caddeo, G Rossi, T Montalcini, A Pujia, O Wiklund, L Valenti, S Romeo
Human Molecular Genetics 2016
Roles of hepatic stellate cells in liver inflammation: a new perspective
T Fujita, S Narumiya
Inflammation and Regeneration 2016
Cirrhosis and autoimmune liver disease: Current understanding
R Liberal, CR Grant
World journal of hepatology 2016
Serum Metabolomic Characterization of Liver Fibrosis in Rats and Anti-Fibrotic Effects of Yin-Chen-Hao-Tang
Zhang H, Wang X, Hu P, Zhou W, Zhang M, Liu J, Wang Y, Liu P, Luo G
Molecules (Basel, Switzerland) 2016
The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease.
Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T
Current Pathobiology Reports 2016
Qinggan Huoxue Recipe suppresses epithelial-to-mesenchymal transition in alcoholic liver fibrosis through TGF-β1/Smad signaling pathway.
Wu T, Chen JM, Xiao TG, Shu XB, Xu HC, Yang LL, Xing LJ, Zheng PY, Ji G
World Journal of Gastroenterology 2016
Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.
Algandaby MM
Saudi Journal of Biological Sciences 2016
Therapeutic effect of renin angiotensin system inhibitors on liver fibrosis
Zhu Q, Li N, Li F, Zhou Z, Han Q, Lv Y, Sang J, Liu Z
2016
CARTILAGE OLIGOMERIC MATRIX PROTEIN PARTICIPATES IN THE PATHOGENESIS OF LIVER FIBROSIS
Magdaleno F, Arriazu E, de Galarreta MR, Chen Y, Ge X, de la Rosa LC, Nieto N
Journal of Hepatology 2016
Dynamically Tunable Cell Culture Platforms for Tissue Engineering and Mechanobiology.
Uto K, Tsui JH, DeForest CA, Kim DH
Progress in Polymer Science 2016
Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and C.
Kalita K, Filipczak K, Bieńkiewicz M, Deroń W, Deroń Z, Piekarska A, Płachcińska A, Kuśmierek J
2016
Noninvasive Assessment of Liver Fibrosis By Transient Elastography and FIB4/APRI for Prediction of Treatment Response in Chronic Hepatitis C-An Experience from a Tertiary Care Hospital.
Taneja S, Tohra S, Duseja A, Dhiman RK, Chawla YK
Journal of Clinical and Experimental Hepatology 2016
Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice.
Dutta R, Kumar V, Peng Y, Evande RE, Grem JL, Mahato RI
Pharmaceutical Research 2016
Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis.
Arffa ML, Zapf MA, Kothari AN, Chang V, Gupta GN, Ding X, Al-Gayyar MM, Syn W, Elsherbiny NM, Kuo PC, Mi Z
PloS one 2016
A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts.
Pizzo F, Lombardo A, Manganaro A, Benfenati E
Frontiers in pharmacology 2016
Toll-like receptors in pathophysiology of liver diseases.
Kiziltas S
World journal of hepatology 2016
Concentrations of fetuin-A, osteoprotegerin and α-Klotho in patients with alcoholic liver cirrhosis.
Prystupa A, Dąbrowska A, Sak JJ, Tarach J, Toruń-Jurkowska A, Lachowska-Kotowska P, Dzida G
Experimental and therapeutic medicine 2016
Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells.
Fiore E, Malvicini M, Bayo J, Peixoto E, Atorrasagasti C, Sierra R, Rodríguez M, Gómez Bustillo S, García MG, Aquino JB, Mazzolini G
Stem Cell Research & Therapy 2016
Alcohol use disorder and its impact on chronic hepatitis C virus and human immunodeficiency virus infections.
Fuster D, Sanvisens A, Bolao F, Rivas I, Tor J, Muga R
World journal of hepatology 2016
Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.
Wang R, Ding Q, De Assuncao TM, Mounajjed T, Maiers JL, Dou C, Cao S, Yaqoob U, Huebert RC, Shah VH
The American Journal of Pathology 2016
mTOR Overactivation in Mesenchymal cells Aggravates CCl(4)- Induced liver Fibrosis.
Shan L, Ding Y, Fu Y, Zhou L, Dong X, Chen S, Wu H, Nai W, Zheng H, Xu W, Bai X, Jia C, Dai M
Scientific Reports 2016
Collagen-binding vascular endothelial growth factor attenuates CCl4-induced liver fibrosis in mice.
Wu K, Huang R, Wu H, Liu Y, Yang C, Cao S, Hou X, Chen B, DaI J, Wu C
Molecular medicine reports 2016
An ω-3-enriched diet alone does not attenuate CCl(4)-induced hepatic fibrosis.
Harris TR, Kodani S, Yang J, Imai DM, Hammock BD
The Journal of Nutritional Biochemistry 2016
Commercial Production of Autologous Stem Cells and Their Therapeutic Potential for Liver Cirrhosis.
Lin YC, Harn HJ, Lin PC, Chuang MH, Chen CH, Lin SZ, Chiou TW
Cell transplantation 2016
Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice.
Nakashima H, Nakashima M, Kinoshita M, Ikarashi M, Miyazaki H, Hanaka H, Imaki J, Seki S
Scientific Reports 2016
Tumor necrosis factor-α -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients.
Bader El Din NG, Farouk S, El-Shenawy R, Ibrahim MK, Dawood RM, Elhady MM, Salem AM, Zayed N, Khairy A, El Awady MK
World Journal of Gastroenterology 2016
Increased Expression of TGF-β1 in Correlation with Liver Fibrosis during Echinococcus granulosus Infection in Mice.
Liu Y, Abudounnasier G, Zhang T, Liu X, Wang Q, Yan Y, Ding J, Wen H, Yimiti D, Ma X
The Korean Journal of Parasitology 2016
Altered expression of A20 gene in peripheral blood mononuclear cells is associated with the progression of chronic hepatitis B virus infection.
Fan YC, Zhang YY, Sun YY, Wang N, Xiao XY, Wang K
Oncotarget 2016
Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo.
Tseng TH, Lin WL, Chen ZH, Lee YJ, Shie MS, Lee KF, Shen CH, Kuo HC
Journal of Translational Medicine 2016
Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues.
Norona LM, Nguyen DG, Gerber DA, Presnell SC, LeCluyse EL
Toxicological sciences : an official journal of the Society of Toxicology 2016
The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice.
Ogiso H, Ito H, Ando T, Arioka Y, Kanbe A, Ando K, Ishikawa T, Saito K, Hara A, Moriwaki H, Shimizu M, Seishima M
PloS one 2016
Ethyl Acetate Fraction of Amomum xanthioides Exerts Antihepatofibrotic Actions via the Regulation of Fibrogenic Cytokines in a Dimethylnitrosamine-Induced Rat Model.
Lee SB, Kim HG, Kim HS, Lee JS, Im HJ, Kim WY, Son CG
Evidence-based complementary and alternative medicine : eCAM 2016
Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice.
Kong L, Zhou Y, Bu H, Lv T, Shi Y, Yang J
Journal of experimental & clinical cancer research : CR 2016
Impact of Hepatitis C Virus/Schistosoma mansoni Coinfection on the Circulating Levels of HCV-NS4 Protein and Extracellular-Matrix Deposition in Patients with Different Hepatic Fibrosis Stages.
Attallah AM, Abdallah SO, Albannan MS, Omran MM, Attallah AA, Farid K
The American journal of tropical medicine and hygiene 2016
Personalized Clinical Trials in Hepatocellular Carcinoma Based on Biomarker Selection.
Zhang B, Finn RS
Liver Cancer 2016
Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway.
Chen J, Pan J, Wang J, Song K, Zhu D, Huang C, Duan Y
Scientific Reports 2016
Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.
Khamphaya T, Chansela P, Piyachaturawat P, Suksamrarn A, Nathanson MH, Weerachayaphorn J
European Journal of Pharmacology 2016
Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway.
Chen J, Xu T, Zhu D, Wang J, Huang C, Lyu L, Hu B, Sun W, Duan Y
Cell Death and Disease 2016
Task-based optimization of flip angle for fibrosis detection in T1-weighted MRI of liver.
Brand JF, Furenlid LR, Altbach MI, Galons JP, Bhattacharyya A, Sharma P, Bhattacharyya T, Bilgin A, Martin DR
2016
Spatially patterned matrix elasticity directs stem cell fate.
Yang C, DelRio FW, Ma H, Killaars AR, Basta LP, Kyburz KA, Anseth KS
Proceedings of the National Academy of Sciences 2016
ω-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation.
Zhang K, Chang Y, Shi Z, Han X, Han Y, Yao Q, Hu Z, Cui H, Zheng L, Han T, Hong W
Scientific Reports 2016
Changes in Hepatic Venous Pressure Gradient Induced by Physical Exercise in Cirrhosis: Results of a Pilot Randomized Open Clinical Trial.
Macías-Rodríguez RU, Ilarraza-Lomelí H, Ruiz-Margáin A, Ponce-de-León-Rosales S, Vargas-Vorácková F, García-Flores O, Torre A, Duarte-Rojo A
Clinical and Translational Gastroenterology 2016
Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs.
Tian XF, Ji FJ, Zang HL, Cao H
PloS one 2016
Anti-fibro-hepatocarcinogenic Chinese herbal medicines: A mechanistic overview.
Boye A, Yang Y, Asenso J, Wei W
Journal of Intercultural Ethnopharmacology 2016
Hepatitis C virus infection stimulates transforming growth factor-β1 expression through up-regulating miR-192.
Kim JH, Lee CH, Lee SW
The Journal of Microbiology 2016
Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis.
Wang X, Wu X, Zhang A, Wang S, Hu C, Chen W, Shen Y, Tan R, Sun Y, Xu Q
EBioMedicine 2016
Berberine Inhibition of Fibrogenesis in a Rat Model of Liver Fibrosis and in Hepatic Stellate Cells.
Wang N, Xu Q, Tan HY, Hong M, Li S, Yuen MF, Feng Y
Evidence-based complementary and alternative medicine : eCAM 2016
Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration.
Huang M, Xu J, Shin CH
Journal of visualized experiments : JoVE 2016
Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases.
Duval F, Cruz-Vega DE, González-Gamboa I, González-Garza MT, Ponz F, Sánchez F, Alarcón-Galván G, Moreno-Cuevas JE
Disease Markers 2016
Hydatid cyst fluid promotes peri-cystic fibrosis in cystic echinococcosis by suppressing miR-19 expression.
Zhang C, Wang L, Ali T, Li L, Bi X, Wang J, Lü G, Shao Y, Vuitton DA, Wen H, Lin R
Parasites & vectors 2016
Pathogenesis and Management of Alcoholic Liver Disease.
Farooq MO, Bataller R
Digestive diseases (Basel, Switzerland) 2016
Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease.
Ko BJ, Kim YS, Kim SG, Park JH, Lee SH, Jeong SW, Jang JY, Kim HS, Kim BS, Kim SM, Kim YD, Cheon GJ, Lee BR
Gut and Liver 2016
Modeling fibrosis using fibroblasts isolated from scarred rat vocal folds.
Kishimoto Y, Kishimoto AO, Ye S, Kendziorski C, Welham NV
Laboratory Investigation 2016
Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats.
Ishikawa M, Saito K, Yamada H, Nakatsu N, Maekawa K, Saito Y
Lipids in Health and Disease 2016
Hepatoprotective Effect of Wheat-Based Solid-State Fermented Antrodia cinnamomea in Carbon Tetrachloride-Induced Liver Injury in Rat.
Chiu HW, Hua KF
PloS one 2016
Inhibition of the translocation and extracellular release of high-mobility group box 1 alleviates liver damage in fibrotic mice in response to D-galactosamine/lipopolysaccharide challenge.
Bai L, Kong M, Zheng Q, Zhang X, Liu X, Zu K, Chen Y, Zheng S, Li J, Ren F, Lou J, Liu S, Duan Z
Molecular medicine reports 2016
Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution.
Baiocchini A, Montaldo C, Conigliaro A, Grimaldi A, Correani V, Mura F, Ciccosanti F, Rotiroti N, Brenna A, Montalbano M, D'Offizi G, Capobianchi MR, Alessandro R, Piacentini M, Schininà ME, Maras B, Del Nonno F, Tripodi M, Mancone C
PloS one 2016
New role and molecular mechanism of Gadd45a in hepatic fibrosis.
Hong L, Sun QF, Xu TY, Wu YH, Zhang H, Fu RQ, Cai FJ, Zhou QQ, Zhou K, Du QW, Zhang D, Xu S, Ding JG
World Journal of Gastroenterology 2016
Antioxidant, Liver Protective and Angiotensin I-converting Enzyme Inhibitory Activities of Old Laying Hen Hydrolysate in Crab Meat Analogue.
Jin SK, Choi JS, Choi YJ, Lee SJ, Lee SY, Hur SJ
Asian-Australasian Journal of Animal Sciences 2016
Microarray Study of Pathway Analysis Expression Profile Associated with MicroRNA-29a with Regard to Murine Cholestatic Liver Injuries.
Li SC, Wang FS, Yang YL, Tiao MM, Chuang JH, Huang YH
International journal of molecular sciences 2016
MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma.
Hayes CN, Chayama K
International journal of molecular sciences 2016
Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-β1.
Ge J, Chang N, Zhao Z, Tian L, Duan X, Yang L, Li L
Scientific Reports 2016
Visualizing Trimming Dependence of Biodistribution and Kinetics with Homo- and Heterogeneous N-Glycoclusters on Fluorescent Albumin.
Ogura A, Tahara T, Nozaki S, Morimoto K, Kizuka Y, Kitazume S, Hara M, Kojima S, Onoe H, Kurbangalieva A, Taniguchi N, Watanabe Y, Tanaka K
Scientific Reports 2016
Liver: DNA methylation controls liver fibrogenesis.
Liu X, Brenner DA
Nature reviews. Gastroenterology & hepatology 2016
High resolution Physio-chemical Tissue Analysis: Towards Non-invasive In Vivo Biopsy.
Xu G, Meng ZX, Lin JD, Deng CX, Carson PL, Fowlkes JB, Tao C, Liu X, Wang X
Scientific Reports 2016
Role of microRNAs in gastrointestinal smooth muscle fibrosis and dysfunction: novel molecular perspectives on the pathophysiology and therapeutic targeting.
Krishna CV, Singh J, Thangavel C, Rattan S
American journal of physiology. Gastrointestinal and liver physiology 2016
Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.
Stasi C, Milani S
World Journal of Gastroenterology 2016
Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators.
Algandaby MM, El-Halawany AM, Abdallah HM, Alahdal AM, Nagy AA, Ashour OM, Abdel-Naim AB
Naunyn-Schmiedeberg's Archives of Pharmacology 2016
Analytic Strategies to Evaluate the Association of Time-Varying Exposures to HIV-Related Outcomes: Alcohol Consumption as an Example
Cook RL, Kelso NE, Brumback BA, Chen X
Current HIV research 2016
Fibrosis assessment: impact on current management of chronic liver disease and application of quantitative invasive tools.
Wang Y, Hou JL
Hepatology International 2016
STK4 regulates TLR-mediated inflammatory responses and alleviates chronic inflammation-related HCC
Weiyun Li, Jun Xiao, Xin Zhou, Ming Xu, Chaobo Hu, Xiaoyan Xu, Yao Lu, Chang Liu, Shengjie Xue, Lei Nie, Haibin Zhang, Zhiqi Li, Yanbo Zhang, Fu Ji, Lijian hui, Wufan Tao, Bin Wei, Hongyan Wang
Journal of Clinical Investigation 2015
Secreted Protein Acidic and Rich in Cysteine in Ocular Tissue
K Scavelli, A Chatterjee, DJ Rhee
Journal of Ocular Pharmacology and Therapeutics 2015
Proteomic Analysis of Mice Fed Methionine and Choline Deficient Diet Reveals Marker Proteins Associated with Steatohepatitis
SJ Lee, JH Kang, W Iqbal, OS Kwon, R Aldabe
PloS one 2015
Reciprocal regulation of TGF-β and reactive oxygen species: a perverse cycle for fibrosis
RM Liu, LP Desai
Redox Biology 2015
Novel therapeutic targets in primary biliary cirrhosis
JK Dyson, GM Hirschfield, DH Adams, U Beuers, DA Mann, KD Lindor, DE Jones
Nature Reviews Gastroenterology & Hepatology 2015
The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases
PJ Wermuth, SA Jimenez
Clinical and Translational Medicine 2015
The Protective Effect of Bee Venom on Fibrosis Causing Inflammatory Diseases
WR Lee, S Pak, KK Park
Toxins 2015
A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty
D Dixon, J Coates, AC Pons, J Horabin, A Walker, N Abdul, NS Kalson, NT Brewster, DJ Weir, DJ Deehan, DA Mann, LA Borthwick
Scientific Reports 2015
SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis
A Uchinaka, Y Hamada, S Mori, S Miyagawa, A Saito, Y Sawa, N Matsuura, H Yamamoto, N Kawaguchi
Molecular and Cellular Biochemistry 2015
Mesenchymal stem cell therapy for liver fibrosis
YW Eom, KY Shim, SK Baik
The Korean Journal of Internal Medicine 2015
Use of mesenchymal stem cells to treat liver fibrosis: Current situation and future prospects
Silvia Berardis, Prenali Dwisthi Sattwika, Mustapha Najimi, Etienne Marc Sokal
World Journal of Gastroenterology 2015
Signal Transducer and Activator of Transcription 4 in Liver Diseases
Yan Wang, Aijuan Qu, Hua Wang
International journal of biological sciences 2015
Hepatic stellate cells: central modulators of hepatic carcinogenesis
AI Thompson, KP Conroy, NC Henderson
BMC Gastroenterology 2015
A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver
SF Zhou, W Li, F Shi, ZW Zhou, B Li, K Zhang, X Zhang, C Ouyang, X Zhu
Drug design, development and therapy 2015
Bone marrow-derived fibrocytes contribute to liver fibrosis
J Xu, T Kisseleva
Experimental biology and medicine (Maywood, N.J.) 2015
Bone marrow-derived fibrocytes contribute to liver fibrosis
J Xu, T Kisseleva
Experimental biology and medicine (Maywood, N.J.) 2015
GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance
N Nishio, K Isobe
Scientific Reports 2015
Recent advances in the pathogenesis and management of biliary atresia:
JA Zagory, MV Nguyen, KS Wang
Current Opinion in Pediatrics 2015
Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response
F Duval, JE Moreno-Cuevas, MT González-Garza, C Maldonado-Bernal, DE Cruz-Vega
International Journal of Inflammation 2015
How Inflammation Impinges on NAFLD: A Role for Kupffer Cells
N Duarte, IC Coelho, RS Patarrão, JI Almeida, C Penha-Gonçalves, MP Macedo
BioMed Research International 2015
Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
Y Osawa, K Oboki, J Imamura, E Kojika, Y Hayashi, T Hishima, T Saibara, F Shibasaki, M Kohara, K Kimura
EBioMedicine 2015
TNFα in Liver Fibrosis
YM Yang, E Seki
Current Pathobiology Reports 2015
Reversibility of liver fibrosis
M Sun, T Kisseleva
Clinics and Research in Hepatology and Gastroenterology 2015
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis
MA Karsdal, T Manon-Jensen, F Genovese, JH Kristensen, MJ Nielsen, JM Sand, NU Hansen, AC Bay-Jensen, CL Bager, A Krag, A Blanchard, H Krarup, DJ Leeming, D Schuppan
AJP Gastrointestinal and Liver Physiology 2015
Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?
K Song, Q Li, XY Yin, Y Lu, CF Liu, LF Hu
Oxidative medicine and cellular longevity 2015
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family
E Sziksz, D Pap, R Lippai, NJ Béres, A Fekete, AJ Szabó, Á Vannay
Mediators of Inflammation 2015
Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis
S Amara, K Lopez, B Banan, SK Brown, M Whalen, E Myles, MT Ivy, T Johnson, KL Schey, V Tiriveedhi
Molecular Immunology 2015
Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice
TR Harris, A Bettaieb, S Kodani, H Dong, R Myers, N Chiamvimonvat, FG Haj, BD Hammock
Toxicology and Applied Pharmacology 2015
Quantification of liver fibrosis via second harmonic imaging of the Glisson's capsule from liver surface
S Xu, CH Kang, X Gou, Q Peng, J Yan, S Zhuo, CL Cheng, Y He, Y Kang, W Xia, PT So, R Welsch, JC Rajapakse, H Yu
Journal of Biophotonics 2015
Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS
MJ Nielsen, J Lehmann, DJ Leeming, R Schierwagen, S Klein, C Jansen, CP Strassburg, F Bendtsen, S Møller, T Sauerbruch, MA Karsdal, A Krag, J Trebicka
Digestive Diseases and Sciences 2015
Study on the Antifibrotic Effects of Recombinant Shark Hepatical Stimulator Analogue (r-sHSA) in Vitro and in Vivo
Y Wang, X Zhang, Y Yang, X Yang, B Ye
Marine drugs 2015
The Effector Protein BPE005 from Brucella abortus Induces Collagen Deposition and Matrix Metalloproteinase 9 Downmodulation via Transforming Growth Factor β1 in Hepatic Stellate Cells
PC Benitez, DR Serantes, CK Herrmann, AI Viglietti, S Vanzulli, GH Giambartolomei, DJ Comerci, MV Delpino, VB Young
Infection and immunity 2015
Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration
MJ Radeke, CM Radeke, YH Shih, J Hu, D Bok, LV Johnson, PJ Coffey
Genome Medicine 2015
Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in Renal and Hepatic Fibrosis
A Tennakoon, T Izawa, M Kuwamura, J Yamate
Journal of Clinical Medicine 2015
Caring for children with NAFLD and navigating their care into adulthood
AA Mencin, R Loomba, JE Lavine
Nature Reviews Gastroenterology & Hepatology 2015
Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with acute liver injury
S Wang, JS Lee, J Hyun, J Kim, SU Kim, HJ Cha, Y Jung
Stem Cell Research & Therapy 2015
Correlation between Tgf-Β1 and Fsp-1 Expression in Chronic Viral Hepatitis - an Immunohistochemical Study
D E Tache, Ş G Firu, A M Andrei, A Predescu, Ş O Purcaru, A M Dobrescu, A Dricu, C G Pisoschi, E C Stănciulescu
Current Health Sciences Journal 2015
Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways
L Seifert, M Deutsch, S Alothman, D Alqunaibit, G Werba, M Pansari, M Pergamo, A Ochi, A Torres-Hernandez, E Levie, D Tippens, SH Greco, S Tiwari, NN Ly, A Eisenthal, E van Heerden, A Avanzi, R Barilla, CP Zambirinis, M Rendon, D Daley, HL Pachter, C Hajdu, G Miller
Cell Reports 2015
Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice
D Jia, F Duan, P Peng, L Sun, Y Ruan, J Gu, LA van Grunsven
PloS one 2015
Experimental models of liver fibrosis
SC Yanguas, B Cogliati, J Willebrords, M Maes, I Colle, B Bossche, CP de Oliveira, W Andraus, VA Alves, I Leclercq, M Vinken
Archives of Toxicology 2015
Hepatic myofibroblasts derived from Schistosoma mansoni-infected mice are a source of IL-5 and eotaxin: controls of eosinophil populations in vitro
LA Paiva, C Brand, C Bandeira-Melo, PT Bozza, MC El-Cheikh, PM Silva, R Borojevic, SA Perez
Parasites & vectors 2015
Contribution and Mobilization of Mesenchymal Stem Cells in a mouse model of carbon tetrachloride-induced liver fibrosis
Y Liu, X Yang, Y Jing, S Zhang, C Zong, J Jiang, K Sun, R Li, L Gao, X Zhao, D Wu, Y Shi, Z Han, L Wei
Scientific Reports 2015
The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease
P Almeda-Valdes, NE Olivos, B Barranco-Fragoso, M Uribe, N Méndez-Sánchez
BioMed Research International 2015
Potent natural products and herbal medicines for treating liver fibrosis
SR Chen, XP Chen, JJ Lu, Y Wang, YT Wang
Chinese medicine 2015
Exploring multiple quantitative trait loci models of hepatic fibrosis in a mouse intercross
RA Hall, S Hillebrandt, F Lammert
Mammalian Genome 2015
PDGFRα in Liver Pathophysiology: Emerging Roles in Development, Regeneration, Fibrosis, and Cancer
A Kikuchi, SP Monga
Gene expression 2015
EMT and tumor metastasis
S Heerboth, G Housman, M Leary, M Longacre, S Byler, K Lapinska, A Willbanks, S Sarkar
Clinical and Translational Medicine 2015
Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration
R Wang, Q Ding, U Yaqoob, TM de Assuncao, VK Verma, P Hirsova, S Cao, D Mukhopadhyay, RC Huebert, VH Shah
The Journal of biological chemistry 2015
EGFR Signaling in Liver Diseases
K Komposch, M Sibilia
International journal of molecular sciences 2015
Role of Noncoding RNAs as Biomarker and Therapeutic Targets for Liver Fibrosis
KY Teng, K Ghoshal
Gene expression 2015
An HNF1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells
H Qian, X Deng, ZW Huang, J Wei, CH Ding, RX Feng, X Zeng, YX Chen, J Ding, L Qiu, ZL Hu, X Zhang, HY Wang, JP Zhang, WF Xie
Cell Research 2015
MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells
M Nakamura, T Kanda, R Sasaki, Y Haga, X Jiang, S Wu, S Nakamoto, O Yokosuka, R Ray
PloS one 2015
Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation
T Lan, T Kisseleva, DA Brenner, MA Avila
PloS one 2015
Inhibition of IRF3 expression reduces TGF-β1-induced proliferation of hepatic stellate cells
M Ni, T Xu, Y Wang, Y He, Q Zhou, C Huang, X Meng, J Li
Journal of Physiology and Biochemistry 2015
Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation
C Bárcena, M Stefanovic, A Tutusaus, L Joannas, A Menéndez, C García-Ruiz, P Sancho-Bru, M Marí, J Caballeria, CV Rothlin, JC Fernández-Checa, PG de Frutos, A Morales
Journal of Hepatology 2015
Enhanced Effects of Novel Oridonin Analog CYD0682 for Hepatic Fibrosis
FJ Bohanon, X Wang, BM Graham, C Ding, Y Ding, C Rastellini, J Zhou, RS Radhakrishnan
Journal of Surgical Research 2015
Ethyl acetate fraction of Amomum xanthioides improves bile duct ligation-induced liver fibrosis of rat model via modulation of pro-fibrogenic cytokines
HG Kim, JM Han, JS Lee, JS Lee, CG Son
Scientific Reports 2015
Alleviation of Carbon-Tetrachloride-Induced Liver Injury and Fibrosis by Betaine Supplementation in Chickens
MT Tsai, CY Chen, YH Pan, SH Wang, HJ Mersmann, ST Ding
Evidence-Based Complementary and Alternative Medicine 2015
The role of miRNAs in the regulation of inflammatory processes during hepatofibrogenesis
Sanchari Roy, Fabian Benz, Tom Luedde, Christoph Roderburg
Hepatobiliary surgery and nutrition 2015
Hepatic Stellate Cells Express Thymosin Beta 4 in Chronically Damaged Liver
J Kim, S Wang, J Hyun, SS Choi, H Cha, M Ock, Y Jung, M Samson
PloS one 2015
MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells
J Hyun, S Wang, J Kim, GJ Kim, Y Jung
Scientific Reports 2015
Recent advancement of molecular mechanisms of liver fibrosis
E Seki, DA Brenner
Journal of Hepato-Biliary-Pancreatic Sciences 2015
Curcumin and hemopressin treatment attenuates cholestasis-induced liver fibrosis in rats: role of CB1 receptors
SE Swefy, RA Hasan, A Ibrahim, MF Mahmoud
Naunyn-Schmiedeberg's Archives of Pharmacology 2015
Identification of a novel TGF-β-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis.
Zeng C, Wang YL, Xie C, Sang Y, Li TJ, Zhang M, Wang R, Zhang Q, Zheng L, Zhuang SM
Oncotarget 2015
The role of iNOS in cholesterol-induced liver fibrosis.
Anavi S, Eisenberg-Bord M, Hahn-Obercyger M, Genin O, Pines M, Tirosh O
Laboratory Investigation 2015
The Natural History of Cirrhosis From Parenteral Nutrition-Associated Liver Disease After Resolution of Cholestasis With Parenteral Fish Oil Therapy:
P Nandivada, MI Chang, AK Potemkin, SJ Carlson, E Cowan, AA Oʼloughlin, PD Mitchell, KM Gura, M Puder
Annals of Surgery 2015
High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers
I Mederacke, DH Dapito, S Affò, H Uchinami, RF Schwabe
Nature Protocols 2015
Developing an in vitro screening assay platform for evaluation of antifibrotic drugs using precision-cut liver slices
SK Sadasivan, N Siddaraju, KM Khan, B Vasamsetti, NR Kumar, V Haridas, MB Reddy, S Baggavalli, AM Oommen, RP Rao
Fibrogenesis & Tissue Repair 2015
Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis
P Stiedl, R McMahon, L Blaas, V Stanek, J Svinka, B Grabner, G Zollner, SM Kessler, T Claudel, M Müller, W Mikulits, M Bilban, H Esterbauer, R Eferl, J Haybaeck, M Trauner, E Casanova
Hepatology 2015
Sedum mexicanum Britt. Induces Apoptosis of Primary Rat Activated Hepatic Stellate Cells
SL Lee, TY Chin, CL Lai, WH Wang
Evidence-Based Complementary and Alternative Medicine 2015
Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells
M Coll, AE Taghdouini, L Perea, I Mannaerts, M Vila-Casadesús, D Blaya, D Rodrigo-Torres, S Affò, O Morales-Ibanez, I Graupera, JJ Lozano, M Najimi, E Sokal, J Lambrecht, P Ginès, LA van Grunsven, P Sancho-Bru
Scientific Reports 2015
In vitro reversion of activated primary human hepatic stellate cells
AE Taghdouini, M Najimi, P Sancho-Bru, E Sokal, LA van Grunsven
Fibrogenesis & Tissue Repair 2015
DPP4 in diabetes
D Röhrborn
Frontiers in immunology 2015
L59 TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice
M Hara, I Inoue, Y Yamazaki, A Kirita, T Matsuura, SL Friedman, DB Rifkin, S Kojima
Fibrogenesis & Tissue Repair 2015
Diabetes and Hepatitis C: A Two-Way Association
SS Hammerstad, SF Grock, HJ Lee, A Hasham, N Sundaram, Y Tomer
Frontiers in Endocrinology 2015
Kinetin inhibits proliferation of hepatic stellate cells by interrupting cell cycle and induces apoptosis by down-regulating ratio of Bcl-2/Bax
Z Zhang, J Zou, Y Huang, L Wu
Journal of Huazhong University of Science and Technology [Medical Sciences] 2015
Actions of Huangqi decoction against rat liver fibrosis: a gene expression profiling analysis
G Zhang, Y Song, Q Chen, S Dong, Y Lu, M Su, P Liu, S Su
Chinese medicine 2015
BRD4 is a novel therapeutic target for liver fibrosis
N Ding, N Hah, RT Yu, MH Sherman, C Benner, M Leblanc, M He, C Liddle, M Downes, RM Evans
Proceedings of the National Academy of Sciences 2015
Ethanol Enhances TGF-β Activity by Recruiting TGF-β Receptors From Intracellular Vesicles/Lipid Rafts/Caveolae to Non-Lipid Raft Microdomains
Huang SS, Chen CL, Huang FW, Johnson FE, Huang JS
Journal of Cellular Biochemistry 2015
Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy
DeSantis DA, Ko CW, Wang L, Lee P, Croniger CM
Mediators of Inflammation 2015
Use of magnetic resonance elastography for assessing liver functional reserve: A clinical study.
Li B, Min J, Liang WR, Zhang GQ, Wu JJ, Jin K, Huang W, Ying CY, Chao M
World Journal of Gastroenterology 2015
Hepatoprotective effect of juglone on dimethylnitrosamine-induced liver fibrosis and its effect on hepatic antioxidant defence and the expression levels of α-SMA and collagen III.
Zhou DJ, Mu D, Jiang MD, Zheng SM, Zhang Y, He S, Weng M, Zeng WZ
Molecular medicine reports 2015
Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats.
Zhen YZ, Li NR, He HW, Zhao SS, Zhang GL, Hao XF, Shao RG
World Journal of Gastroenterology 2015
Supplementation of Citrus maxima Peel Powder Prevented Oxidative Stress, Fibrosis, and Hepatic Damage in Carbon Tetrachloride (CCl4) Treated Rats.
Chowdhury MR, Sagor MA, Tabassum N, Potol MA, Hossain H, Alam MA
Evidence-based complementary and alternative medicine : eCAM 2015
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015
Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Gd-EOB-DTPA for the Evaluation of Liver Fibrosis Induced by Carbon Tetrachloride in Rats.
Zhang W, Kong X, Wang ZJ, Luo S, Huang W, Zhang LJ
PloS one 2015
Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Values Predict the Development of Hepatocellular Carcinoma among Patients with Chronic Hepatitis C after Sustained Virological Response.
Sasaki R, Yamasaki K, Abiru S, Komori A, Nagaoka S, Saeki A, Hashimoto S, Bekki S, Kugiyama Y, Kuno A, Korenaga M, Togayachi A, Ocho M, Mizokami M, Narimatsu H, Ichikawa T, Nakao K, Yatsuhashi H
PloS one 2015
Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease.
Russo FP, Rodríguez-Castro K, Scribano L, Gottardo G, Vanin V, Farinati F
World journal of hepatology 2015
Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.
Yi HS, Eun HS, Lee YS, Jung JY, Park SH, Park KG, Choi HS, Suh JM, Jeong WI
PloS one 2015
Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells.
Li J, Dong N, Cheng S, Li X, Wang W, Xiang Y
2015
Potential role of thymosin Beta 4 in liver fibrosis.
Kim J, Jung Y
International journal of molecular sciences 2015
Tregs: A Therapeutic Target for the Treatment of Portal Fibrosis?
Xue Y, Michalopoulos G
Digestive Diseases and Sciences 2015
BCL6B expression in hepatocellular carcinoma and its efficacy in the inhibition of liver damage and fibrogenesis.
Wang W, Huang P, Wu P, Kong R, Xu J, Zhang L, Yang Q, Xie Q, Zhang L, Zhou X, Chen L, Xie H, Zhou L, Zheng S
Oncotarget 2015
Hepatic ADC map as an adjunct to conventional abdominal MRI to evaluate hepatic fibrotic and clinical cirrhotic severity in biliary atresia patients.
Peng SS, Jeng YM, Hsu WM, Yang JC, Ho MC
European Radiology 2015
MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7.
Yu F, Guo Y, Chen B, Dong P, Zheng J
Laboratory Investigation 2015
Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma.
Massó-Vallés D, Jauset T, Serrano E, Sodir NM, Pedersen K, Affara NI, Whitfield JR, Beaulieu ME, Evan GI, Elias L, Arribas J, Soucek L
Cancer research 2015
Caffeic acid phenethyl ester inhibits liver fibrosis in rats.
Li M, Wang XF, Shi JJ, Li YP, Yang N, Zhai S, Dang SS
World Journal of Gastroenterology 2015
Prevalence and Predictors of Non-Alcoholic Fatty Liver Disease in Morbidly Obese South Indian Patients Undergoing Bariatric Surgery.
Praveenraj P, Gomes RM, Kumar S, Karthikeyan P, Shankar A, Parthasarathi R, Senthilnathan P, Rajapandian S, Palanivelu C
Obesity surgery 2015
Fibroblast growth factor receptor isotype expression and its association with overall survival in patients with hepatocellular carcinoma.
Lee HJ, Kang HJ, Kim KM, Yu ES, Kim KH, Kim SM, Kim TW, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS
Clinical and Molecular Hepatology 2015
Mesenchymal Stem/Stromal Cells in Liver Fibrosis: Recent Findings, Old/New Caveats and Future Perspectives.
Fiore EJ, Mazzolini G, Aquino JB
Stem Cell Reviews and Reports 2015
Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.
Scott C, Cha K, Rao R, Liddle C, George J, Gunton JE
PloS one 2015
Non-invasive detection of liver fibrosis: MR imaging features vs. MR elastography.
Venkatesh SK, Yin M, Takahashi N, Glockner JF, Talwalkar JA, Ehman RL
Abdominal Imaging 2015
Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging.
Wang H, Liang X, Mohammed YH, Thomas JA, Bridle KR, Thorling CA, Grice JE, Xu ZP, Liu X, Crawford DH, Roberts MS
Biomedical Optics Express 2015
miR-217 regulates ethanol-induced hepatic inflammation by disrupting sirtuin 1-lipin-1 signaling.
Yin H, Liang X, Jogasuria A, Davidson NO, You M
The American Journal of Pathology 2015
Evaluation of the prognostic value of liver stiffness in patients with hepatitis C virus treated with triple or dual antiviral therapy: A prospective pilot study.
Stasi C, Piluso A, Arena U, Salomoni E, Montalto P, Monti M, Boldrini B, Corti G, Marra F, Laffi G, Milani S, Zignego AL
World Journal of Gastroenterology 2015
Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus infection.
Matsue Y, Tsutsumi M, Hayashi N, Saito T, Tsuchishima M, Toshikuni N, Arisawa T, George J
PloS one 2015
Hepatosplanchnic circulation in cirrhosis and sepsis.
Prin M, Bakker J, Wagener G
World Journal of Gastroenterology 2015
Cluster of differentiation 147 is a key molecule during hepatocellular carcinoma cell-hepatic stellate cell cross-talk in the rat liver.
Ma T, Wang Z, Yang Z, Chen J
Molecular medicine reports 2015
Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model.
Shimozono R, Nishimura K, Akiyama H, Funamoto S, Izawa A, Sai T, Kunita K, Kainoh M, Suzuki T, Kawada N
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015
Noninvasive assessment of liver function.
Helmke S, Colmenero J, Everson GT
Current Opinion in Gastroenterology 2015
The expression dynamics of transforming growth factor-β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis.
Yan C, Wang L, Li B, Zhang BB, Zhang B, Wang YH, Li XY, Chen JX, Tang RX, Zheng KY
Parasites & vectors 2015
Current strategies for quantitating fibrosis in liver biopsy.
Wang Y, Hou JL
Chinese Medical Journal 2015
Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment.
Zhu D, Song K, Chen J, Wang J, Sun X, Qian H, Gu X, Zhang L, Qin Y, Duan Y
Parasites & vectors 2015
NS5ATP9 suppresses activation of human hepatic stellate cells, possibly via inhibition of Smad3/phosphorylated-Smad3 expression.
Zhang M, Zhang J, Liu S, Wang Q, Lin G, Qiu R, Quan M, Cheng J
Inflammation 2015
Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Liver Fibrosis in Rats.
Kubo K, Ohnishi S, Hosono H, Fukai M, Kameya A, Higashi R, Yamada T, Onishi R, Yamahara K, Takeda H, Sakamoto N
Transplantation Direct 2015
Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: A histopathologic correlation
Verloh N, Utpatel K, Haimerl M, Zeman F, Fellner C, Fichtner-Feigl S, Teufel A, Stroszczynski C, Evert M, Wiggermann P
Scientific Reports 2015
Automated Liver Elasticity Calculation for Magnetic Resonance Elastography
Dzyubak B, Venkatesh S, Manduca A, Glaser K, Ehman RL
Journal of magnetic resonance imaging : JMRI 2015
New Mechanism of Hepatic Fibrogenesis: Hepatitis C Virus Infection Induces Transforming Growth Factor β1 Production through Glucose-Regulated Protein 94.
Jee MH, Hong KY, Park JH, Lee JS, Kim HS, Lee SH, Jang SK
Journal of virology 2015
Propolis reduces Leishmania amazonensis-induced inflammation in the liver of BALB/c mice.
da Silva SS, Mizokami SS, Fanti JR, Miranda MM, Kawakami NY, Teixeira FH, Araújo EJ, Panis C, Watanabe MA, Sforcin JM, Pavanelli WR, Verri WA Jr, Felipe I, Conchon-Costa I
Parasitology Research 2015
Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.
Liu M, Xu Y, Han X, Yin L, Xu L, Qi Y, Zhao Y, Liu K, Peng J
Scientific Reports 2015
Utility of Translocator Protein (18 kDa) as a Molecular Imaging Biomarker to Monitor the Progression of Liver Fibrosis.
Hatori A, Yui J, Xie L, Kumata K, Yamasaki T, Fujinaga M, Wakizaka H, Ogawa M, Nengaki N, Kawamura K, Wang F, Zhang MR
Scientific Reports 2015
Kallistatin, a new and reliable biomarker for the diagnosis of liver cirrhosis.
Cheng Z, Lv Y, Pang S, Bai R, Wang M, Lin S, Xu T, Spalding D, Habib N, Xu R
Acta pharmaceutica Sinica. B 2015
Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review.
Palladini G, Ferrigno A, Richelmi P, Perlini S, Vairetti M
World Journal of Gastroenterology 2015
Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in rats.
Liu C, Yang Z, Wang L, Lu Y, Tang B, Miao H, Xu Q, Chen X
BMC Gastroenterology 2015
Non-invasive diagnosis of liver fibrosis and cirrhosis.
Lurie Y, Webb M, Cytter-Kuint R, Shteingart S, Lederkremer GZ
World Journal of Gastroenterology 2015
Inflammatory status in human hepatic cirrhosis.
Martínez-Esparza M, Tristán-Manzano M, Ruiz-Alcaraz AJ, García-Peñarrubia P
World Journal of Gastroenterology 2015
Fibrosis is a common outcome following total knee arthroplasty.
Abdul N, Dixon D, Walker A, Horabin J, Smith N, Weir DJ, Brewster NT, Deehan DJ, Mann DA, Borthwick LA
Scientific Reports 2015
Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells
El Taghdouini A, Sørensen AL, Reiner AH, Coll M, Verhulst S, Mannaerts I, Øie CI, Smedsrød B, Najimi M, Sokal E, Luttun A, Sancho-Bru P, Collas P, van Grunsven LA
Oncotarget 2015
Purinergic signaling in scarring
Ferrari D, Gambari R, Idzko M, Müller T, Albanesi C, Pastore S, La Manna G, Robson SC, Cronstein B
The FASEB Journal 2015
The role of P2X7 receptors in tissue fibrosis: a brief review
Gentile D, Natale M, Lazzerini PE, Capecchi PL, Laghi-Pasini F
Purinergic Signalling 2015
Clinical Features of Lysosomal Acid Lipase Deficiency
Burton BK, Deegan PB, Enns GM, Guardamagna O, Horslen S, Hovingh GK, Lobritto SJ, Malinova V, McLin VA, Raiman J, Di Rocco M, Santra S, Sharma R, Sykut-Cegielska J, Whitley CB, Eckert S, Valayannopoulos V, Quinn AG
Journal of Pediatric Gastroenterology and Nutrition 2015
Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis
Jiang DK, Ma XP, Wu X, Peng L, Yin J, Dan Y, Huang HX, Ding DL, Zhang LY, Shi Z, Zhang P, Yu H, Sun J, Lilly Zheng S, Deng G, Xu J, Liu Y, Guo J, Cao G, Yu L
Scientific Reports 2015
Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation
Liu J, Li J, Fu W, Tang J, Feng X, Chen J, Liang Y, Jin R, Xie A, Cai X
Drug design, development and therapy 2015
Periostin down-regulation attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-β1
Hong L, Shejiao D, Fenrong C, Gang Z, Lei D
Journal of Cellular and Molecular Medicine 2015
Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis
Klein S, Herath CB, Schierwagen R, Grace J, Haltenhof T, Uschner FE, Strassburg CP, Sauerbruch T, Walther T, Angus PW, Trebicka J
PloS one 2015
All-In-One: Advanced preparation of Human Parenchymal and Non-Parenchymal Liver Cells
Werner M, Driftmann S, Kleinehr K, Kaiser GM, Mathé Z, Treckmann JW, Paul A, Skibbe K, Timm J, Canbay A, Gerken G, Schlaak JF, Broering R
PloS one 2015
T1ρ MRI of healthy and fibrotic human livers at 1.5 T
Singh A, Reddy D, Haris M, Cai K, Rajender Reddy K, Hariharan H, Reddy R
Journal of Translational Medicine 2015
AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma
Kwon JH, Ahn KS, Moon YH, Park JY, Wang HJ, Choi KY, Kim G, Joh JW, Lee KG, Kang KJ
Journal of Korean Medical Science 2015
From the stomach to other organs: Helicobacter pylori and the liver
Waluga M, Kukla M, Żorniak M, Bacik A, Kotulski R
World journal of hepatology 2015
Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4
Huang YH, Tiao MM, Huang LT, Chuang JH, Kuo KC, Yang YL, Wang FS
PloS one 2015
Advances in the Diagnosis of Human Schistosomiasis
Weerakoon KG, Gobert GN, Cai P, McManus DP
Clinical microbiology reviews 2015
Efficacy of Hepatoprotective Agents With or Without Antiviral Drugs on Liver Function and Fibrosis in Patients With Hepatitis B: A Meta-Analysis
Long LH, Xue CQ, Shi JF, Dong JN, Wang L
Hepatitis Monthly 2015
Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy
Wang TH, Chen TC, Teng X, Liang KH, Yeh CT
Scientific Reports 2015
Antioxidants in liver health
Casas-Grajales S, Muriel P
World journal of gastrointestinal pharmacology and therapeutics 2015
Levels of 8-OxodG Predict Hepatobiliary Pathology in Opisthorchis viverrini Endemic Settings in Thailand
Saichua P, Yakovleva A, Kamamia C, Jariwala AR, Sithithaworn J, Sripa B, Brindley PJ, Laha T, Mairiang E, Pairojkul C, Khuntikeo N, Mulvenna J, Sithithaworn P, Bethony JM
PLoS neglected tropical diseases 2015
Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis
Hamazaki J, Hirayama S, Murata S
PLoS genetics 2015
Three-dimensional visualization of the microvasculature of bile duct ligation-induced liver fibrosis in rats by x-ray phase-contrast imaging computed tomography
Xuan R, Zhao X, Hu D, Jian J, Wang T, Hu C
Scientific Reports 2015
Efficacy and safety of sitagliptin for the treatment of diabetes mellitus complicated by chronic liver injury
Asakawa M, Mitsui H, Akihisa M, Sekine T, Niitsu Y, Kobayashi A, Miyake A, Hashimoto N, Kawamura M, Ogawa Y
SpringerPlus 2015
The Immune Interplay between Thyroid Papillary Carcinoma and Hepatic Fibrosis
Muhanna N, Amer J, Salhab A, Sichel JY, Safadi R
PloS one 2015
Inhibition of hepatic stellate cells by bone marrow-derived mesenchymal stem cells in hepatic fibrosis
Jang YO, Jun BG, Baik SK, Kim MY, Kwon SO
Clinical and Molecular Hepatology 2015
The multi-kinase inhibitor pazopanib targets hepatic stellate cell activation and apoptosis alleviating progression of liver fibrosis.
Elshal M, Abu-Elsaad N, El-Karef A, Ibrahim TM
Naunyn-Schmiedeberg's Archives of Pharmacology 2015
Green tea polyphenols and their potential role in health and disease.
Afzal M, Safer AM, Menon M
InflammoPharmacology 2015
Fibrosis: Ultimate and Proximate Causes
Victor J. Thannickal, Yong Zhou, Amit Gaggar, Steven Duncan
Journal of Clinical Investigation 2014
EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling
SA Park, MJ Kim, SY Park, JS Kim, SJ Lee, HA Woo, DK Kim, JS Nam, YY Sheen
Experientia 2014
Origin of myofibroblasts in the fibrotic liver in mice
K Iwaisako, C Jiang, M Zhang, M Cong, TJ Moore-Morris, TJ Park, X Liu, J Xu, P Wang, YH Paik, F Meng, M Asagiri, LA Murray, AF Hofmann, T Iida, CK Glass, DA Brenner, T Kisseleva
Proceedings of the National Academy of Sciences 2014
IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice: HEPATOLOGY, Vol. XX, No. X, 2014
A Mitra, A Satelli, J Yan, X Xueqing, M Gagea, CA Hunter, L Mishra, S Li
Hepatology 2014
Role of NADPH Oxidases in Liver Fibrosis
YH Paik, J Kim, T Aoyama, SD Minicis, R Bataller, DA Brenner
Antioxidants & Redox Signaling 2014
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells
XY Kong, CK Nesset, M Damme, EM Løberg, T Lübke, J Mæhlen, KB Andersson, PI Lorenzo, N Roos, GH Thoresen, AC Rustan, ET Kase, W Eskild
Disease models & mechanisms 2014
Small RNA- and DNA-based gene therapy for the treatment of liver cirrhosis, where we are?
KH Kim
World journal of gastroenterology : WJG 2014
Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis
M Correa-Costa, V Andrade-Oliveira, TT Braga, A Castoldi, CF Aguiar, CS Origassa, AC Rodas, MI Hiyane, DM Malheiros, FJ Rios, S Jancar, NO Câmara
Laboratory Investigation 2014
Targeting the insulin-like growth factor pathway in hepatocellular carcinoma
M Enguita-Germán
World journal of hepatology 2014
New Approaches for Studying Alcoholic Liver Disease
J Xu, X Liu, B Gao, M Karin, H Tsukamoto, D Brenner, T Kisseleva
Current Pathobiology Reports 2014
Endoglin in liver fibrogenesis: Bridging basic science and clinical practice
SK Meurer, M Alsamman, D Scholten, R Weiskirchen
World journal of biological chemistry 2014
Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis
M Granzow, R Schierwagen, S Klein, B Kowallick, S Huss, M Linhart, IG Mazar, J Görtzen, A Vogt, FA Schildberg, MA Gonzalez-Carmona, A Wojtalla, B Krämer, J Nattermann, SV Siegmund, N Werner, DO Fürst, W Laleman, P Knolle, VH Shah, T Sauerbruch, J Trebicka
Hepatology 2014
Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression
SH Lee, SI Do, HS Kim
World journal of gastroenterology : WJG 2014
The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies
J Xu, X Liu, Y Koyama, P Wang, T Lan, IG Kim, IH Kim, HY Ma, T Kisseleva
Frontiers in pharmacology 2014
HIV-1 Infected Peripheral Blood Mononuclear Cells Modulate the Fibrogenic Activity of Hepatic Stellate Cells through Secreted TGF-β and JNK Signaling
D Gupta, M Rani, N Khan, S Jameel, N Kaushik-Basu
PloS one 2014
Bone Marrow Stromal Cells Inhibit the Activation of Liver Cirrhotic Fat-Storing Cells via Adrenomedullin Secretion
X Wang, W Zhao, J Wang, K Shi, X Qin, Q Kong, G Wang, L Mu, H Li, B Sun, L Shi
Digestive Diseases and Sciences 2014
Protective Effects of Calycosin Against CCl4-Induced Liver Injury with Activation of FXR and STAT3 in Mice
X Chen, Q Meng, C Wang, Q Liu, H Sun, X Huo, P Sun, X Yang, J Peng, K Liu
Pharmaceutical Research 2014
Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics
Y Bi, D Mukhopadhyay, M Drinane, B Ji, X Li, S Cao, VH Shah
American journal of physiology. Cell physiology 2014
Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice
L Yang, J Kwon, Y Popov, GB Gajdos, T Ordog, RA Brekken, D Mukhopadhyay, D Schuppan, Y Bi, D Simonetto, VH Shah
Gastroenterology 2014
Hypoxia and the extracellular matrix: drivers of tumour metastasis
DM Gilkes, GL Semenza, D Wirtz
Nature Reviews Cancer 2014
Anti-Inflammatory and Anti-Fibrotic Profile of Fish Oil Emulsions Used in Parenteral Nutrition-Associated Liver Disease
A Pastor-Clerigues, E Marti-Bonmati, J Milara, P Almudever, J Cortijo, P Mukhopadhyay
PloS one 2014
Liver fibrosis and repair: immune regulation of wound healing in a solid organ
A Pellicoro, P Ramachandran, JP Iredale, JA Fallowfield
Nature Reviews Immunology 2014
Role of Toll-Like Receptors in Immune Activation and Tolerance in the Liver
N Nakamoto, T Kanai
Frontiers in immunology 2014
Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis
JS Fernandes, MI Araujo, DM Lopes, RP de Souza, EM Carvalho, LS Cardoso
Mediators of Inflammation 2014
Liver myofibroblasts up-regulate monocyte CD163 expression via PGE2 during hepatitis B induced liver failure
M Zhang, Y Ye, F Wang, J Zhu, Q Zhao, Y Zheng, Y Gu, C Xie, Z Huang, Q Tai, Y Chong, Z Gao
Journal of Translational Medicine 2014
NF-κB inhibition alleviates carbon tetrachloride-induced liver fibrosis via suppression of activated hepatic stellate cells
F Wang, S Liu, T DU, H Chen, Z Li, J Yan
Experimental and therapeutic medicine 2014
Deficiency of Formyl Peptide Receptor 1 and 2 Is Associated with Increased Inflammation and Enhanced Liver Injury after LPS-Stimulation
A Giebeler, KL Streetz, O Soehnlein, U Neumann, JM Wang, LO Brandenburg
PloS one 2014
NHE1 deficiency in liver: implications for non-alcoholic fatty liver disease
V Prasad, S Chirra, R Kohli, GE Shull
Biochemical and Biophysical Research Communications 2014
Myofibroblasts: Trust your heart and let fate decide
J Davis, JD Molkentin
Journal of Molecular and Cellular Cardiology 2014
Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection
X Chen, X Yang, Y Li, J Zhu, S Zhou, Z Xu, L He, X Xue, W Zhang, X Dong, H Wu, CJ Li, HT Hsu, W Kong, F Liu, PB Tripathi, MS Yu, J Chang, L Zhou, C Su
PLoS pathogens 2014
A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression
J Dutta-Moscato, A Solovyev, Q Mi, T Nishikawa, A Soto-Gutierrez, IJ Fox, Y Vodovotz
Frontiers in Bioengineering and Biotechnology 2014
FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells
Y Kong, H Wang, S Wang, N Tang
Inflammation 2014
Extracellular Matrix and Liver Disease
E Arriazu, MR de Galarreta, FJ Cubero, M Varela-Rey, MP de Obanos, TM Leung, A Lopategi, A Benedicto, I Abraham-Enachescu, N Nieto
Antioxidants & Redox Signaling 2014
Transforming Growth Factor-β–Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis
K Sakai, S Jawaid, T Sasaki, G Bou-Gharios, T Sakai
The American Journal of Pathology 2014
Emerging role of HMGB1 in fibrotic diseases
LC Li, J Gao, J Li
Journal of Cellular and Molecular Medicine 2014
Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis: ROH ET AL
YS Roh, S Park, JW Kim, CW Lim, E Seki, B Kim
Hepatology 2014
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency
S Fernández-Álvarez, VG Juan, I Zubiete-Franco, L Barbier-Torres, A Lahoz, A Parés, Z Luka, C Wagner, SC Lu, JM Mato, ML Martínez-Chantar, N Beraza
Laboratory Investigation 2014
Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis
MA Barnes, MR McMullen, S Roychowdhury, NZ Madhun, K Niese, MA Olman, AB Stavitsky, R Bucala, LE Nagy
Journal of leukocyte biology 2014
Molecular Mechanisms of Liver Fibrosis in HIV/HCV Coinfection
C Mastroianni, M Lichtner, C Mascia, P Zuccalà, V Vullo
International journal of molecular sciences 2014
Pathogenesis of liver cirrhosis
WC Zhou, QB Zhang, L Qiao
World journal of gastroenterology : WJG 2014
Curcumin Targets Multiple Pathways to Halt Hepatic Stellate Cell Activation: Updated Mechanisms In Vitro and In Vivo
Y Tang
Digestive Diseases and Sciences 2014
Immune Components of Liver Damage Associated with Connective Tissue Diseases
AA Chentoufi, YA Serov, M Alazmi, K Baba
Journal of Clinical and Translational Hepatology 2014
Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment
J Zhao, Z Zhang, Y Luan, Z Zou, Y Sun, Y Li, L Jin, C Zhou, J Fu, B Gao, Y Fu, FS Wang
Hepatology 2014
Autophagy in Hepatic Fibrosis
Y Song, Y Zhao, F Wang, L Tao, J Xiao, C Yang
BioMed Research International 2014
Neurotropin Suppresses Inflammatory Cytokine Expression and Cell Death through Suppression of NF-κB and JNK in Hepatocytes
B Zhang, YS Roh, S Liang, C Liu, M Naiki, K Masuda, E Seki, S Papa
PloS one 2014
Bone marrow derived stem cells for the treatment of end-stage liver disease
C Margini, R Vukotic, L Brodosi, M Bernardi, P Andreone
World journal of gastroenterology : WJG 2014
A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells: Suppression of hepatic fibrosis
KC Park, JH Park, JY Jeon, SY Kim, JM Kim, CY Lim, TH Lee, HK Kim, HG Lee, SM Kim, HJ Kwon, JS Suh, SW Kim, SH Choi
British Journal of Pharmacology 2014
Gadoxetic Acid-Enhanced MRI and Sonoelastography: Non-Invasive Assessments of Chemoprevention of Liver Fibrosis in Thioacetamide-Induced Rats with Sho-Saiko-To
YW Chen, MY Tsai, HB Pan, HH Tseng, YT Hung, CP Chou, E Villa
PloS one 2014
Systems Level Analysis and Identification of Pathways and Networks Associated with Liver Fibrosis
MD AbdulHameed, GJ Tawa, K Kumar, DL Ippolito, JA Lewis, JD Stallings, A Wallqvist, C Chan
PloS one 2014
Adiponectin Agonist ADP355 Attenuates CCl4-Induced Liver Fibrosis in Mice
P Kumar, T Smith, K Rahman, NE Thorn, FA Anania, Y Wang
PloS one 2014
Insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) contributes to liver inflammation and fibrosis via activation of the ERK1/2 pathway.
Guo Y, Zhang Y, Zhang Q, Guo X, Zhang H, Zheng G, Liu L
Hepatology International 2014
Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis
BJ Hayes, KJ Riehle, M Shimizu-Albergine, RL Bauer, KL Hudkins, F Johansson, MM Yeh, WM Mahoney, RS Yeung, JS Campbell
PloS one 2014
Targeted recombinant fusion proteins of IFNγ and mimetic IFNγ with PDGFβR bicyclic peptide inhibits liver fibrogenesis in vivo
R Bansal, J Prakash, MD Ruiter, K Poelstra
PloS one 2014
Role of gamma-delta T cells in liver inflammation and fibrosis
L Hammerich, F Tacke
World journal of gastrointestinal pathophysiology 2014
IGFBPrP1 induces liver fibrosis by inducing hepatic stellate cell activation and hepatocyte apoptosis via Smad2/3 signaling
Y Zhang, QQ Zhang, XH Guo, HY Zhang, LX Liu
World journal of gastroenterology : WJG 2014
Vitamin D and S-Farnesylthiosalicylic Acid Have a Synergistic Effect on Hepatic Stellate Cells Proliferation
R Neeman, S Abramovitch, E Sharvit, G Elad-Sfadia, R Haklai, Y Kloog, S Reif
Digestive Diseases and Sciences 2014
Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis
J Li, Y Gao, S Chu, Z Zhang, C Xia, Z Mou, X Song, W He, X Guo, N Chen
Acta Pharmacologica Sinica 2014
Chronic hepatitis C and liver fibrosis
G Sebastiani, K Gkouvatsos, K Pantopoulos
World journal of gastroenterology : WJG 2014
The Interplay between inflammation and fibrosis in kidney transplantation
IB Torres, F Moreso, E Sarró, A Meseguer, D Serón
BioMed Research International 2014
Mouse Models of Liver Fibrosis Mimic Human Liver Fibrosis of Different Etiologies
AK Martínez, L Maroni, M Marzioni, ST Ahmed, M Milad, D Ray, G Alpini, SS Glaser
2014
The influence of astragalus polysaccharide and β-elemene on LX-2 cell growth, apoptosis and activation
J Zheng, L Ma, Q Ren, L Li, Y Zhang, H Shi, Y Liu, C Li, Y Dou, S Li, H Zhang, M Yang
2014
Regulator of G-Protein Signaling-5 Is a Marker of Hepatic Stellate Cells and Expression Mediates Response to Liver Injury
AJ Bahrami, JJ Gunaje, BJ Hayes, KJ Riehle, HL Kenerson, RS Yeung, AS Stempien-Otero, JS Campbell, WM Mahoney, M Samson
PloS one 2014
Alcohol Abuse: Critical Pathophysiological Processes and Contribution to Disease Burden
PE Molina, JD Gardner, FM Souza-Smith, AM Whitaker
Physiology (Bethesda, Md.) 2014
Cardiac and Renal Effects of Atrasentan in Combination with Enalapril and Paricalcitol in Uremic Rats
C Ritter, S Zhang, JL Finch, H Liapis, E Suarez, L Ferder, J Delmez, E Slatopolsky
Kidney and Blood Pressure Research 2014
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis
Y Han, P Onori, F Meng, S DeMorrow, J Venter, H Francis, A Franchitto, D Ray, L Kennedy, J Greene, A Renzi, R Mancinelli, E Gaudio, S Glaser, G Alpini
AJP Gastrointestinal and Liver Physiology 2014
Toxic Damage Increases Angiogenesis and Metastasis in Fibrotic Livers via PECAM-1
Raskopf E, Gonzalez Carmona MA, Van Cayzeele CJ, Strassburg C, Sauerbruch T, Schmitz V
BioMed Research International 2014
Transcriptional Repression of the Transforming Growth Factor β (TGF-β) Pseudoreceptor BMP and Activin Membrane-bound Inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 Enhances TGF-β Signaling in Hepatic Stellate Cells
Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E
The Journal of biological chemistry 2014
Systems Genetics of Liver Fibrosis: Identification of Fibrogenic and Expression Quantitative Trait Loci in the BXD Murine Reference Population
Hall RA, Liebe R, Hochrath K, Kazakov A, Alberts R, Laufs U, Böhm M, Fischer HP, Williams RW, Schughart K, Weber SN, Lammert F
PloS one 2014
Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats
Qian H, Shi J, Fan TT, Lv J, Chen SW, Song CY, Zheng ZW, Xie WF, Chen YX
World journal of gastroenterology : WJG 2014
Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment
Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B
Development (Cambridge, England) 2014
Value of MR diffusion imaging in hepatic fibrosis and its correlations with serum indices.
Hu XR, Cui XN, Hu QT, Chen J
World Journal of Gastroenterology 2014
Nanotechnology applications for the therapy of liver fibrosis.
Giannitrapani L, Soresi M, Bondì ML, Montalto G, Cervello M
World Journal of Gastroenterology 2014
A boswellic acid-containing extract ameliorates schistosomiasis liver granuloma and fibrosis through regulating NF-κB signaling in mice.
Liu M, Wu Q, Chen P, Büchele B, Bian M, Dong S, Huang D, Ren C, Zhang Y, Hou X, Simmet T, Shen J
PloS one 2014
TGF-β2-mediated ocular hypertension is attenuated in SPARC-null mice.
Swaminathan SS, Oh DJ, Kang MH, Shepard AR, Pang IH, Rhee DJ
Investigative ophthalmology & visual science 2014
LAP degradation product reflects plasma kallikrein-dependent TGF-β activation in patients with hepatic fibrosis.
Hara M, Kirita A, Kondo W, Matsuura T, Nagatsuma K, Dohmae N, Ogawa S, Imajoh-Ohmi S, Friedman SL, Rifkin DB, Kojima S
SpringerPlus 2014
Degradation of AIMP1/p43 induced by hepatitis C virus E2 leads to upregulation of TGF-β signaling and increase in surface expression of gp96.
Kim MS, Kim S, Myung H
PloS one 2014
Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice.
Quillin RC 3rd, Wilson GC, Nojima H, Freeman CM, Wang J, Schuster RM, Blanchard JA, Edwards MJ, Gandhi CR, Gulbins E, Lentsch AB
Hepatology research : the official journal of the Japan Society of Hepatology 2014
Experimenting liver fibrosis diagnostic by two photon excitation microscopy and Bag-of-Features image classification.
Stanciu SG, Xu S, Peng Q, Yan J, Stanciu GA, Welsch RE, So PT, Csucs G, Yu H
Scientific Reports 2014
Expression of microRNA-454 in TGF-β1-stimulated hepatic stellate cells and in mouse livers infected with Schistosoma japonicum.
Zhu D, He X, Duan Y, Chen J, Wang J, Sun X, Qian H, Feng J, Sun W, Xu F, Zhang L
Parasites & vectors 2014
Rapid acquisition technique for MR elastography of the liver.
Chamarthi SK, Raterman B, Mazumder R, Michaels A, Oza VM, Hanje J, Bolster B, Jin N, White RD, Kolipaka A
Magnetic Resonance Imaging 2014
Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.
Elshazly SM, Mahmoud AA
Naunyn-Schmiedeberg's Archives of Pharmacology 2014
qFibrosis: a fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients.
Xu S, Wang Y, Tai DCS, Wang S, Cheng CL, Peng Q, Yan J, Chen Y, Sun J, Liang X, Zhu Y, Rajapakse JC, Welsch RE, So PTC, Wee A, Hou J, Yu H
Journal of Hepatology 2014
Local control of hepatic phenotype with growth factor-encoded surfaces.
Patel D, Haque A, Jones CN, Tuleouva N, Foster E, Vu T, Reddi AH, Revzin A
Integrative biology : quantitative biosciences from nano to macro 2014
Ursodeoxycholyl lysophosphatidylethanolamide attenuates hepatofibrogenesis by impairment of TGF-β1/Smad2/3 signalling.
Pathil A, Mueller J, Ludwig JM, Wang J, Warth A, Chamulitrat W, Stremmel W
British Journal of Pharmacology 2014
Roles of Oxidized Diacylglycerol for Carbon Tetrachloride-induced Liver Injury and Fibrosis in Mouse.
Takekoshi S, Kitatani K, Yamamoto Y
ACTA HISTOCHEMICA ET CYTOCHEMICA 2014
Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study.
Safer AM, Afzal M, Hanafy N, Mousa S
Experimental and therapeutic medicine 2014
Role of transforming growth factor-β1 in serum and - 509 C>T promoter gene polymorphism in development of liver cirrhosis in Egyptian patients.
Mohy A, Fouad A
Meta Gene 2014
Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis.
Duval F, Moreno-Cuevas JE, González-Garza MT, Rodríguez-Montalvo C, Cruz-Vega DE
Chinese medicine 2014
Performance of real-time elastography for the staging of hepatic fibrosis: a meta-analysis.
Hong H, Li J, Jin Y, Li Q, Li W, Wu J, Huang Z
PloS one 2014
Immuno-pathomechanism of liver fibrosis: targeting chemokine CCL2-mediated HIV:HCV nexus.
Ansari AW, Schmidt RE, Shankar EM, Kamarulzaman A
Journal of Translational Medicine 2014
p53 in liver pathologies-taking the good with the bad.
Charni M, Rivlin N, Molchadsky A, Aloni-Grinstein R, Rotter V
Journal of Molecular Medicine 2014
Strategies to Detect Hepatic Myofibroblasts in Liver Cirrhosis of Different Etiologies.
Iwaisako K, Taura K, Koyama Y, Takemoto K, Asagiri M
Current Pathobiology Reports 2014
Ergosterol Is the Active Compound of Cultured Mycelium Cordyceps sinensis on Antiliver Fibrosis.
Peng Y, Tao Y, Wang Q, Shen L, Yang T, Liu Z, Liu C
Evidence-based complementary and alternative medicine : eCAM 2014
Transplantation of ATP7B-transduced bone marrow mesenchymal stem cells decreases copper overload in rats.
Chen S, Shao C, Dong T, Chai H, Xiong X, Sun D, Zhang L, Yu Y, Wang P, Cheng F
PloS one 2014
Astragalus and Paeoniae radix rubra extract inhibits liver fibrosis by modulating the transforming growth factor‑β/Smad pathway in rats.
Huang W, Li L, Tian X, Yan J, Yang X, Wang X, Liao G, Qiu G
Molecular medicine reports 2014
Diethylnitrosamine-induced cirrhosis in Wistar rats: an experimental feasibility study.
Bona S, Moreira AJ, Rodrigues GR, Cerski CT, da Silveira TR, Marroni CA, Marroni NP
Protoplasma 2014
Attenuation of early liver fibrosis by herbal compound "Diwu Yanggan" through modulating the balance between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition.
Shen X, Cheng S, Peng Y, Song H, Li H
BMC complementary and alternative medicine 2014
Bone marrow-derived mesenchymal stem cell therapy for decompensated liver cirrhosis: a meta-analysis.
Pan XN, Zheng LQ, Lai XH
World Journal of Gastroenterology 2014
Mesenchymal stromal cells engineered to produce IGF-I by recombinant adenovirus ameliorate liver fibrosis in mice.
Fiore EJ, Bayo JM, Garcia MG, Malvicini M, Lloyd R, Piccioni F, Rizzo M, Peixoto E, Sola MB, Atorrasagasti C, Alaniz L, Camilletti MA, Enguita M, Prieto J, Aquino JB, Mazzolini G
Stem Cells and Development 2014
Multimodal cancer therapy involving oncolytic newcastle disease virus, autologous immune cells, and bi-specific antibodies.
Schirrmacher V, Fournier P
Frontiers in Oncology 2014
Inhibition of tyrosine kinase receptor Tie2 reverts HCV-induced hepatic stellate cell activation.
Martín-Vílchez S, Rodríguez-Muñoz Y, López-Rodríguez R, Hernández-Bartolomé, Borque-Iñurrita MJ, Molina-Jiménez F, García-Buey L, Moreno-Otero R, Sanz-Cameno P
PloS one 2014
Hepatoprotective effects of Limonium tetragonum, edible medicinal halophyte growing near seashores.
Yang MH, Kim NH, Heo JD, Sung SH, Jeong EJ
Pharmacognosy magazine 2014
Heparin modulation on hepatic nitric oxide synthase in experimental steatohepatitis.
Hassanin A, Malek HA, Saleh D
Experimental and therapeutic medicine 2014
Lack of a 5.9 kDa peptide C-terminal fragment of fibrinogen α chain precedes fibrosis progression in patients with liver disease.
Marfà S, Crespo G, Reichenbach V, Forns X, Casals G, Morales-Ruiz M, Navasa M, Jiménez W
PloS one 2014
Novel management of acute or secondary biliary liver conditions using hepatically differentiated human dental pulp cells.
Ishkitiev N, Yaegaki K, Imai T, Tanaka T, Fushimi N, Mitev V, Okada M, Tominaga N, Ono S, Ishikawa H
Tissue Engineering Part A 2014
Characterization of chemically induced liver injuries using gene co-expression modules.
Tawa GJ, AbdulHameed MD, Yu X, Kumar K, Ippolito DL, Lewis JA, Stallings JD, Wallqvist A
PloS one 2014
Vitamin D modulates biliary fibrosis in ABCB4-deficient mice.
Hochrath K, Stokes CS, Geisel J, Pollheimer MJ, Fickert P, Dooley S, Lammert F
Hepatology International 2014
Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis.
Kim MD, Kim SS, Cha HY, Jang SH, Chang DY, Kim W, Suh-Kim H, Lee JH
Experimental & molecular medicine 2014
Lower urinary tract symptoms in men.
Hollingsworth JM, Wilt TJ
BMJ 2014
Detecting transforming growth factor-β release from liver cells using an aptasensor integrated with microfluidics.
Matharu Z, Patel D, Gao Y, Haque A, Zhou Q, Revzin A
Analytical Chemistry 2014
Moderate, chronic ethanol feeding exacerbates carbon-tetrachloride-induced hepatic fibrosis via hepatocyte-specific hypoxia inducible factor 1α.
Roychowdhury S, Chiang DJ, McMullen MR, Nagy LE
Pharmacology Research & Perspectives 2014
Computational models of liver fibrosis progression for hepatitis C virus chronic infection.
Lara J, López-Labrador F, González-Candelas F, Berenguer M, Khudyakov YE
BMC bioinformatics 2014
Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis.
Calabro SR, Maczurek AE, Morgan AJ, Tu T, Wen VW, Yee C, Mridha A, Lee M, d'Avigdor W, Locarnini SA, McCaughan GW, Warner FJ, McLennan SV, Shackel NA
PloS one 2014
Quantifying tissue mechanical properties using photoplethysmography.
Akl TJ, Wilson MA, Ericson MN, Coté GL
Biomedical Optics Express 2014
Toxicogenomic analysis reveals profibrogenic effects of trichloroethylene in autoimmune-mediated cholangitis in mice.
Kopec AK, Sullivan BP, Kassel KM, Joshi N, Luyendyk JP
Toxicological sciences : an official journal of the Society of Toxicology 2014
Everolimus immunosuppression reduces the serum expression of fibrosis markers in liver transplant recipients.
Fernández-Yunquera A, Ripoll C, Bañares R, Puerto M, Rincón D, Yepes I, Catalina V, Salcedo M
World Journal of Transplantation 2014
Fluorine-Containing Diazines in Medicinal Chemistry and Agrochemistry
Volochnyuk DM, Grygorenko OO, Gorlova AO
2014
Could Stem Cell Therapy be the Cure in Liver Cirrhosis?
Irfan A, Ahmed I
Journal of Clinical and Experimental Hepatology 2014
A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis
Otte CM, Rothuizen J, Favier RP, Penning LC, Vreman S
Journal of Feline Medicine & Surgery 2014
Cancer stem cells in the development of liver cancer
Taro Yamashita, Xin Wei Wang
Journal of Clinical Investigation 2013
Cationized ferritin as a magnetic resonance imaging probe to detect microstructural changes in a rat model of non-alcoholic steatohepatitis
SC Beeman, LJ Mandarino, JF Georges, KM Bennett
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2013
Maraviroc, a CCR5 antagonist, prevents development of hepatocellular carcinoma in a mouse model
L Ochoa-Callejero, L Pérez-Martínez, S Rubio-Mediavilla, JA Oteo, A Martínez, JR Blanco
PloS one 2013
miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1
CL Cardenas, IS Henaoui, E Courcot, C Roderburg, C Cauffiez, S Aubert, MC Copin, B Wallaert, F Glowacki, E Dewaeles, J Milosevic, J Maurizio, J Tedrow, B Marcet, JM Lo-Guidice, N Kaminski, P Barbry, T Luedde, M Perrais, B Mari, N Pottier
PLoS genetics 2013
Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts
KH Kim, CC Chen, RI Monzon, LF Lau
Molecular and cellular biology 2013
Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial–mesenchymal transition in liver injury
Yuchang Li, Jiaohong Wang, Kinji Asahina
Proceedings of the National Academy of Sciences 2013
Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis: Hepatology, Vol. 00, No. 0, 2013 Hammerich et al
L Hammerich, JM Bangen, O Govaere, HW Zimmermann, N Gassler, S Huss, C Liedtke, I Prinz, SA Lira, T Luedde, T Roskams, C Trautwein, F Heymann, F Tacke
Hepatology 2013
Current concepts on the role of nitric oxide in portal hypertension
LS Hu, J George, JH Wang
World journal of gastroenterology : WJG 2013
Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair
M Li, S Ikehara
Stem Cells International 2013
Differentiation and Migration of Bone Marrow Mesenchymal Stem Cells Transplanted through the Spleen in Rats with Portal Hypertension
S Sun, G Chen, M Xu, Y Qiao, S Zheng, G Almeida-Porada
PloS one 2013
From fatty liver to fibrosis: a tale of "second hit"
M Basaranoglu, G Basaranoglu, H Sentürk
World journal of gastroenterology : WJG 2013
Hepatic regeneration and the epithelial to mesenchymal transition
ZF Xue, XM Wu, M Liu
World journal of gastroenterology : WJG 2013
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, JG Bode, J Bolleyn, C Borner, J Böttger, A Braeuning, RA Budinsky, B Burkhardt, NR Cameron, G Camussi, CS Cho, YJ Choi, JC Rowlands, U Dahmen, G Damm, O Dirsch, MT Donato, J Dong, S Dooley, D Drasdo, R Eakins, KS Ferreira, V Fonsato, J Fraczek, R Gebhardt, A Gibson, M Glanemann, CE Goldring, MJ Gómez-Lechón, GM Groothuis, L Gustavsson, C Guyot, D Hallifax, S Hammad, A Hayward, D Häussinger, C Hellerbrand, P Hewitt, S Hoehme, HG Holzhütter, JB Houston, J Hrach, K Ito, H Jaeschke, V Keitel, JM Kelm, BK Park, C Kordes, GA Kullak-Ublick, EL LeCluyse, P Lu, J Luebke-Wheeler, A Lutz, DJ Maltman, M Matz-Soja, P McMullen, I Merfort, S Messner, C Meyer, J Mwinyi, DJ Naisbitt, AK Nussler, P Olinga, F Pampaloni, J Pi, L Pluta, SA Przyborski, A Ramachandran, V Rogiers, C Rowe, C Schelcher, K Schmich, M Schwarz, B Singh, EH Stelzer, B Stieger, R Stöber, Y Sugiyama, C Tetta, WE Thasler, T Vanhaecke, M Vinken, TS Weiss, A Widera, CG Woods, JJ Xu, KM Yarborough, JG Hengstler
Archives of Toxicology 2013
Semaphorin 7A Contributes to TGF-β–Mediated Liver Fibrogenesis
SD Minicis, C Rychlicki, L Agostinelli, S Saccomanno, L Trozzi, C Candelaresi, R Bataller, C Millán, DA Brenner, M Vivarelli, F Mocchegiani, M Marzioni, A Benedetti, G Svegliati-Baroni
The American Journal of Pathology 2013
Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line
SK Meurer, M Alsamman, H Sahin, HE Wasmuth, T Kisseleva, DA Brenner, C Trautwein, R Weiskirchen, D Scholten
PloS one 2013
Promising Molecular Targets and Biomarkers for Male BPH and LUTS
M Gharaee-Kermani, JA Macoska
Current Urology Reports 2013
Resistin mediates the hepatic stellate cell phenotype
ZX Dong, L Su, J Brymora, C Bird, Q Xie, J George, JH Wang
World journal of gastroenterology : WJG 2013
Hepatoprotective Effects of Swimming Exercise against D-Galactose-Induced Senescence Rat Model
CC Huang, WD Chiang, WC Huang, CY Huang, MC Hsu, WT Lin
Evidence-Based Complementary and Alternative Medicine 2013
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice: Hepatology, Vol. 57, No. X, 2013
JP Pradere, J Kluwe, SD Minicis, JJ Jiao, GY Gwak, DH Dapito, MK Jang, ND Guenther, I Mederacke, R Friedman, AC Dragomir, C Aloman, RF Schwabe
Hepatology 2013
Matrine Inhibits Infiltration of the Inflammatory Gr1(hi) Monocyte Subset in Injured Mouse Liver through Inhibition of Monocyte Chemoattractant Protein-1
D Shi, J Zhang, L Qiu, J Li, Z Hu, J Zhang
Evidence-Based Complementary and Alternative Medicine 2013
Non-Cell-Autonomous Tumor Suppression by p53
A Lujambio, L Akkari, J Simon, D Grace, DF Tschaharganeh, JE Bolden, Z Zhao, V Thapar, JA Joyce, V Krizhanovsky, SW Lowe
Cell 2013
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
BS Ding, Z Cao, R Lis, DJ Nolan, P Guo, M Simons, ME Penfold, K Shido, SY Rabbany, S Rafii
Nature 2013
Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice
H Cynis, A Kehlen, M Haegele, T Hoffmann, U Heiser, M Fujii, Y Shibazaki, H Yoneyama, S Schilling, HU Demuth
International Journal of Experimental Pathology 2013
Contribution of Myofibroblasts of Different Origins to Liver Fibrosis
M Fausther, EG Lavoie, JA Dranoff
Current Pathobiology Reports 2013
Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts
X Liu, J Xu, DA Brenner, T Kisseleva
Current Pathobiology Reports 2013
Fibrosis: a key feature of Fabry disease with potential therapeutic implications
F Weidemann, MD Sanchez-Niño, J Politei, JP Oliveira, C Wanner, DG Warnock, A Ortiz
Orphanet Journal of Rare Diseases 2013
PF2401-SF, Standardized Fraction of Salvia miltiorrhiza, Induces Apoptosis of Activated Hepatic Stellate Cells in Vitro and in Vivo
D Parajuli, EJ Park, XH Che, WY Jiang, YC Kim, D Sohn, S Lee
Molecules (Basel, Switzerland) 2013
Bevacizumab attenuates hepatic fibrosis in rats by inhibiting activation of hepatic stellate cells
Y Huang, H Feng, T Kan, B Huang, M Zhang, Y Li, C Shi, M Wu, Y Luo, J Yang, F Xu
PloS one 2013
Eosinophil-derived cytokines in health and disease: unraveling novel mechanisms of selective secretion
RC Melo, L Liu, JJ Xenakis, LA Spencer
Allergy 2013
Effects of taurine supplementation on hepatic markers of inflammation and lipid metabolism in mothers and offspring in the setting of maternal obesity
M Li, CM Reynolds, DM Sloboda, C Gray, MH Vickers
PloS one 2013
Using Immunoproteomics to Identify Alpha-enolase as an Autoantigen in Liver Fibrosis
B Peng, X Huang, ES Nakayasu, JR Petersen, S Qiu, IC Almeida, JY Zhang
Journal of Proteome Research 2013
Experimental liver fibrosis research: update on animal models, legal issues and translational aspects
C Liedtke, T Luedde, T Sauerbruch, D Scholten, K Streetz, F Tacke, R Tolba, C Trautwein, J Trebicka, R Weiskirchen
Fibrogenesis & Tissue Repair 2013
The chemokine CCL3 promotes experimental liver fibrosis in mice
D Heinrichs, ML Berres, A Nellen, P Fischer, D Scholten, C Trautwein, HE Wasmuth, H Sahin
PloS one 2013
Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis
T Mchedlidze, M Waldner, S Zopf, J Walker, AL Rankin, M Schuchmann, D Voehringer, AN McKenzie, MF Neurath, S Pflanz, S Wirtz
Immunity 2013
Serious Non-AIDS events: Immunopathogenesis and interventional strategies
DC Hsu, I Sereti, J Ananworanich
AIDS Research and Therapy 2013
Inhibition of connective tissue growth factor suppresses hepatic stellate cell activation in vitro and prevents liver fibrosis in vivo
C Hao, Y Xie, M Peng, L Ma, Y Zhou, Y Zhang, W Kang, J Wang, X Bai, P Wang, Z Jia
Clinical and Experimental Medicine 2013
Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice: Yang et al
L Yang, YS Roh, J Song, B Zhang, C Liu, R Loomba, E Seki
Hepatology 2013
Up-regulation of RACK1 by TGF-β1 promotes hepatic fibrosis in mice
D Jia, F Duan, P Peng, L Sun, X Liu, L Wang, W Wu, Y Ruan, J Gu
PloS one 2013
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
I Mederacke, CC Hsu, JS Troeger, P Huebener, X Mu, DH Dapito, JP Pradere, RF Schwabe
Nature Communications 2013
Assessment of clinical signs of liver cirrhosis using T1 mapping on Gd-EOB-DTPA-enhanced 3T MRI
M Haimerl, N Verloh, F Zeman, C Fellner, R Müller-Wille, AG Schreyer, C Stroszczynski, P Wiggermann
PloS one 2013
Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells
Y Osawa, M Hoshi, I Yasuda, T Saibara, H Moriwaki, O Kozawa
PloS one 2013
BML-11, a lipoxin receptor agonist, protected carbon tetrachloride-induced hepatic fibrosis in rats.
Zhou XY, Yu ZJ, Yan D, Wang HM, Huang YH, Sha J, Xu FY, Cai ZY, Min WP
Inflammation 2013
Absence of Nogo-B (Reticulon 4B) Facilitates Hepatic Stellate Cell Apoptosis and Diminishes Hepatic Fibrosis in Mice
K Tashiro, A Satoh, T Utsumi, C Chung, Y Iwakiri
The American Journal of Pathology 2013
Triggering the landslide: The tumor-promotional effects of myofibroblasts
C Mehner, DC Radisky
Experimental Cell Research 2013
Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis
JA Dranoff, N Bhatia, M Fausther, EG Lavoie, S Granell, G Baldini, DA Hickman, N Sheung
Physiological Reports 2013
Inactivation of myofibroblasts during regression of liver fibrosis
T Kisseleva, DA Brenner
Cell cycle (Georgetown, Tex.) 2013
Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection
YM Attia, EF Elalkamy, OA Hammam, SS Mahmoud, AS El-Khatib
Parasites & vectors 2013
Adenosine 2A receptor antagonist prevented and reversed liver fibrosis in a mouse model of ethanol-exacerbated liver fibrosis
DJ Chiang, S Roychowdhury, K Bush, MR McMullen, S Pisano, K Niese, MA Olman, MT Pritchard, LE Nagy
PloS one 2013
Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma
ML Bacigalupo, M Manzi, GA Rabinovich, MF Troncoso
World journal of gastroenterology : WJG 2013
Calcium signaling in the liver
MJ Amaya, MH Nathanson
Comprehensive Physiology 2013
Activated effects of parathyroid hormone-related protein on human hepatic stellate cells
FF Liang, CP Liu, LX Li, MM Xue, F Xie, Y Guo, L Bai
PloS one 2013
Therapeutic potential of targeting the renin angiotensin system in portal hypertension
CB Herath, JA Grace, PW Angus
World journal of gastrointestinal pathophysiology 2013
Identification of combined genetic determinants of liver stiffness within the SREBP1c-PNPLA3 pathway
M Krawczyk, F Grünhage, F Lammert
International journal of molecular sciences 2013
Angiopoietin-2 Serum Levels Improve Noninvasive Fibrosis Staging in Chronic Hepatitis C: A Fibrogenic-Angiogenic Link
A Hernández-Bartolomé, R López-Rodríguez, Y Rodríguez-Muñoz, S Martín-Vílchez, MJ Borque, L García-Buey, L González-Moreno, Y Real, R Moreno-Otero, P Sanz-Cameno
PloS one 2013
Interleukin-6 is associated with noninvasive markers of liver fibrosis in HIV-infected patients with alcohol problems
D Fuster, JI Tsui, DM Cheng, EK Quinn, KA Armah, D Nunes, MS Freiberg, JH Samet
AIDS Research and Human Retroviruses 2013
Angiotensin II induces endothelin-1 expression in human hepatic stellate cells.
He C, Miao X, Li J, Qi H
Digestive Diseases and Sciences 2013
KASL clinical practice guidelines: management of alcoholic liver disease.
Clinical and Molecular Hepatology 2013
Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension
Leeming DJ, Karsdal MA, Byrjalsen I, Bendtsen F, Trebicka J, Nielsen MJ, Christiansen C, Møller S, Krag A
Alimentary Pharmacology & Therapeutics 2013
Prediction of fibrosis in hepatitis C patients: assessment using hydroxyproline and oxidative stress biomarkers
Gabr SA, Alghadir AH
VirusDisease 2013
Spleen Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a New Method for Staging Liver Fibrosis in a Piglet Model
Zhou L, Chen TW, Zhang XM, Li CJ, Yang ZF, Zeng NL, Wang LY, Li T, Wang D, Li J, Li CP, Li L, Xie XY
PloS one 2013
The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis
DeZwaan-McCabe D, Riordan JD, Arensdorf AM, Icardi MS, Dupuy AJ, Rutkowski DT
PLoS genetics 2013
Expression and Function of Methylthioadenosine Phosphorylase in Chronic Liver Disease
Czech B, Dettmer K, Valletta D, Saugspier M, Koch A, Stevens AP, Thasler WE, Müller M, Oefner PJ, Bosserhoff AK, Hellerbrand C
PloS one 2013
Role of viral and host factors in interferon based therapy of hepatitis C virus infection
Imran M, Manzoor S, Ashraf J, Khalid M, Tariq M, Khaliq HM, Azam S
Virology Journal 2013
The role of mouse strain differences in the susceptibility to fibrosis: a systematic review
Walkin L, Herrick SE, Summers A, Brenchley PE, Hoff CM, Korstanje R, Margetts PJ
Fibrogenesis & Tissue Repair 2013
Modeling and Simulating Dynamics of Complete- and Poor-Response Chronic Hepatitis B Chinese Patients for Adefovir and Traditional Chinese Medicine Plus Adefovir Therapy
Min L, Chen X, Ye Y, Zhang Q, Ru S, Li X
Evidence-based complementary and alternative medicine : eCAM 2013
Combined Taurine, Epigallocatechin Gallate and Genistein Therapy Reduces HSC-T6 Cell Proliferation and Modulates the Expression of Fibrogenic Factors
Li Y, Luo Y, Zhang X, Lin X, He M, Liao M
International journal of molecular sciences 2013
High-Frequency Ultrasound Imaging to Evaluate Liver Fibrosis Progression in Rats and Yi Guan Jian Herbal Therapeutic Effects
Chen W, Chen JY, Tung YT, Chen HL, Kuo CW, Chuang CH, Chong KY, Mao FC, Chen CM
Evidence-based complementary and alternative medicine : eCAM 2013
Liver Lobe Volumes and the Ratios of Liver Lobe Volumes to Spleen Volume on Magnetic Resonance Imaging for Staging Liver Fibrosis in a Minipig Model
Li H, Chen TW, Zhang XM, Li ZL, Zhang JL, Wang D, Li T, Wu JL, Guo X, Chen XL, Li L, Xie XY, Zhang ZS
PloS one 2013
Corn Peptides Protect Against Thioacetamide-Induced Hepatic Fibrosis in Rats
Lv J, Nie ZK, Zhang JL, Liu FY, Wang ZZ, Ma ZL, He H
Journal of Medicinal Food 2013
Microcomputed Tomography with Diffraction-Enhanced Imaging for Morphologic Characterization and Quantitative Evaluation of Microvessel of Hepatic Fibrosis in Rats
Duan J, Hu C, Luo S, Zhao X, Wang T
PloS one 2013
Inactivated Orf Virus Shows Antifibrotic Activity and Inhibits Human Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Replication in Preclinical Models
Paulsen D, Urban A, Knorr A, Hirth-Dietrich C, Siegling A, Volk HD, Mercer AA, Limmer A, Schumak B, Knolle P, Ruebsamen-Schaeff H, Weber O
PloS one 2013
Meta-Analysis of the Clinical Value of Danshen Injection and Huangqi Injection in Liver Cirrhosis
Zhu C, Cao H, Zhou X, Dong C, Luo J, Zhang C, Liu J, Ling Y
Evidence-based complementary and alternative medicine : eCAM 2013
Hypoxia-Inducible Factor-1alpha and MAPK Co-Regulate Activation of Hepatic Stellate Cells upon Hypoxia Stimulation
Wang Y, Huang Y, Guan F, Xiao Y, Deng J, Chen H, Chen X, Li J, Huang H, Shi C
PloS one 2013
A health technology assessment of transient elastography in adult liver disease
Steadman R, Myers RP, Leggett L, Lorenzetti D, Noseworthy T, Rose S, Sutherland L, Clement F
Canadian Journal of Gastroenterology 2013
Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats
Schierwagen R, Leeming DJ, Klein S, Granzow M, Nielsen MJ, Sauerbruch T, Krag A, Karsdal MA, Trebicka J
Frontiers in physiology 2013
Development of Adenoviral Delivery Systems to Target Hepatic Stellate Cells In Vivo
Reetz J, Genz B, Meier C, Kowtharapu BS, Timm F, Vollmar B, Herchenröder O, Abshagen K, Pützer BM
PloS one 2013
A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response
Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, Leblanc M, Coulter S, He M, Scott C, Lau SL, Atkins AR, Barish GD, Gunton JE, Liddle C, Downes M, Evans RM
Cell 2013
MAPK Signal Transduction Pathway Regulation: A Novel Mechanism of Rat HSC-T6 Cell Apoptosis Induced by FUZHENGHUAYU Tablet
Wang Q, Du H, Li M, Li Y, Liu S, Gao P, Zhang X, Cheng J
Evidence-based complementary and alternative medicine : eCAM 2013
Red ginseng extract protects against carbon tetrachloride-induced liver fibrosis
Ki SH, Yang JH, Ku SK, Kim SC, Kim YW, Cho IJ
Journal of Ginseng Research 2013
Hepatic Stellate Cell–Targeted Delivery of Hepatocyte Growth Factor Transgene via Bile Duct Infusion Enhances Its Expression at Fibrotic Foci to Regress Dimethylnitrosamine-Induced Liver Fibrosis
Narmada BC, Kang Y, Venkatraman L, Peng Q, Sakban RB, Nugraha B, Jiang X, Bunte RM, So PT, Tucker-Kellogg L, Mao HQ, Yu H
Human Gene Therapy 2013
Herbal compound “Songyou Yin” attenuates hepatoma cell invasiveness and metastasis through downregulation of cytokines secreted by activated hepatic stellate cells
Jia QA, Wang ZM, Ren ZG, Bu Y, Xie XY, Wang YH, Zhang L, Zhang QB, Xue TC, Deng LF, Tang ZY
BMC complementary and alternative medicine 2013
Is Assessing the Presence of NASH by Liver Histology or Surrogate Markers Always Advisable?
Tarantino G
Hepatitis Monthly 2013
Regulation of SPARC by Transforming Growth Factor β2 in Human Trabecular Meshwork
Kang MH, Oh DJ, Kang JH, Rhee DJ
Investigative ophthalmology & visual science 2013
The role of hepatic myofibroblasts in liver cirrhosis in fallow deer (Dama dama) naturally infected with giant liver fluke (Fascioloides magna)
Marinković D, Kukolj V, Aleksić-Kovačević S, Jovanović M, Knežević M
BMC veterinary research 2013
Expression of Interleukin-17 associated with disease progression and liver fibrosis with hepatitis B virus infection: IL-17 in HBV infection
Du WJ, Zhen JH, Zeng ZQ, Zheng ZM, Xu Y, Qin LY, Chen SJ
Diagnostic Pathology 2013
Activation of TGF-β1 Promoter by Hepatitis C Virus-Induced AP-1 and Sp1: Role of TGF-β1 in Hepatic Stellate Cell Activation and Invasion
Presser LD, McRae S, Waris G
PloS one 2013
Efficacy of liver parenchymal enhancement and liver volume to standard liver volume ratio on Gd-EOB-DTPA-enhanced MRI for estimation of liver function.
Yoneyama T, Fukukura Y, Kamimura K, Takumi K, Umanodan A, Ueno S, Nakajo M
European Radiology 2013
Hepatic actions of vitamin D receptor ligands: a sunshine option for chronic liver disease?
Ding N, Liddle C, Evans RM, Downes M
Expert Review of Clinical Pharmacology 2013
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.
Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL
Journal of Hepatology 2013
Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse.
Hyun J, Choi SS, Diehl AM, Jung Y
Journal Of Molecular Histology 2013
Proteomic Analysis of the Effect of Fuzheng Huayu Recipe on Fibrotic Liver in Rats
Xie H, Tao Y, Lv J, Liu P, Liu C
Evidence-based complementary and alternative medicine : eCAM 2013
Transforming Growth Factor β Neutralization Ameliorates Pre-Existing Hepatic Fibrosis and Reduces Cholangiocarcinoma in Thioacetamide-Treated Rats
Ling H, Roux E, Hempel D, Tao J, Smith M, Lonning S, Zuk A, Arbeeny C, Ledbetter S
PloS one 2013
CD4+CD25+Foxp3+ regulatory T cells contribute in liver fibrosis improvement with interferon alpha.
Feng L, Kang H, Liu LN, Cao YM
Inflammation 2013
Protein O glycosylation regulates activation of hepatic stellate cells.
Fan X, Chuan S, Hongshan W
Inflammation 2013
Ascorbic acid is superior to silymarin in the recovery of ethanol-induced inflammatory reactions in hepatocytes of guinea pigs.
Abhilash PA, Harikrishnan R, Indira M
Journal of Physiology and Biochemistry 2013
Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells.
Shi H, Dong L, Dang X, Liu Y, Jiang J, Wang Y, Lu X, Guo X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013
Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats.
Kaji K, Yoshiji H, Ikenaka Y, Noguchi R, Aihara Y, Douhara A, Moriya K, Kawaratani H, Shirai Y, Yoshii J, Yanase K, Kitade M, Namisaki T, Fukui H
Journal of Gastroenterology 2013
Hepatic stellate cells--the pericytes in the liver.
Hellerbrand C
2013
Molecular MRI of liver fibrosis by a peptide-targeted contrast agent in an experimental mouse model.
Chow AM, Tan M, Gao DS, Fan SJ, Cheung JS, Man K, Lu ZR, Wu EX
Investigative Radiology 2013
Stable Automated Segmentation of Liver MR Elastography Images for Clinical Stiffness Measurement
Dzyubak B, Venkatesh SK, Glaser K, Yin M, Talwalkar J, Chen J, Manduca A, Ehman RL
Proceedings of SPIE--the International Society for Optical Engineering 2013
Hepatocyte-mediated cytotoxicity and host defense mechanisms in the alcohol-injured liver.
McVicker BL, Thiele GM, Tuma DJ, Casey CA
Hepatology International 2013
Development of a non-invasive fibrosis test for chronic hepatitis B patients and comparison with other unpatented scores
Hsu CW, Liang KH, Huang SF, Tsao KC, Yeh CT
BMC Research Notes 2013
Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
X Kong, D Feng, H Wang, F Hong, A Bertola, FS Wang, B Gao
Hepatology 2012
PAI-1 in Tissue Fibrosis
AK Ghosh, DE Vaughan
Journal of Cellular Physiology 2012
Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism
JI Beier, GE Arteel
Experimental biology and medicine (Maywood, N.J.) 2012
Protective role of estrogen-induced miRNA-29 expression in carbon tetrachloride-induced mouse liver injury
Y Zhang, L Wu, Y Wang, M Zhang, L Li, D Zhu, X Li, H Gu, CY Zhang, K Zen
The Journal of biological chemistry 2012
Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver
ST Rashid, JD Humphries, A Byron, A Dhar, JA Askari, JN Selley, D Knight, RD Goldin, M Thursz, MJ Humphries
Journal of Proteome Research 2012
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
TA Wynn, TR Ramalingam
Nature Medicine 2012
Osteopontin Contributes to TGF-β1 Mediated Hepatic Stellate Cell Activation
X Xiao, Y Gang, Y Gu, L Zhao, J Chu, J Zhou, X Cai, H Zhang, L Xu, Y Nie, K Wu, Z Liu, D Fan
Digestive Diseases and Sciences 2012
Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling
N Subramaniam, MH Sherman, R Rao, C Wilson, S Coulter, AR Atkins, RM Evans, C Liddle, M Downes
Cancer prevention research (Philadelphia, Pa.) 2012
IL-13 Signaling in Liver Fibrogenesis
Y Liu, S Munker, R Müllenbach, HL Weng
Frontiers in immunology 2012
New Insights into the Role of Oxidative Stress in Scleroderma Fibrosis
A Gabrielli, S Svegliati, G Moroncini, D Amico
The open rheumatology journal 2012
Farnesoid X Receptor Protects Hepatocytes From Injury by Repressing miR-199a-3p, Which Increases Levels of LKB1
CG Lee, YW Kim, EH Kim, Z Meng, W Huang, SJ Hwang, SG Kim
Gastroenterology 2012
Cell signals influencing hepatic fibrosis
M Cong, K Iwaisako, C Jiang, T Kisseleva
International Journal of Hepatology 2012
Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent
T Aoyama, YH Paik, S Watanabe, B Laleu, F Gaggini, L Fioraso-Cartier, S Molango, F Heitz, C Merlot, C Szyndralewiez, P Page, DA Brenner
Hepatology 2012
Regulation of wound healing and organ fibrosis by toll-like receptors
P Huebener, RF Schwabe
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2012
What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis: The origin of myofibroblasts
K Iwaisako, DA Brenner, T Kisseleva
Journal of Gastroenterology and Hepatology 2012
Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice
F Heymann, L Hammerich, D Storch, M Bartneck, S Huss, V Rüsseler, N Gassler, SA Lira, T Luedde, C Trautwein, F Tacke
Hepatology 2012
Immunological Orchestration of Liver Fibrosis
H Tanaka, PS Leung, TP Kenny, ME Gershwin, CL Bowlus
Clinical Reviews in Allergy & Immunology 2012
Natural killer and natural killer T cells in liver fibrosis
B Gao, S Radaeva
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2012
Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics
E Liaskou, HW Zimmermann, KK Li, YH Oo, S Suresh, Z Stamataki, O Qureshi, PF Lalor, J Shaw, W Syn, SM Curbishley, DH Adams
Hepatology 2012
Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis
C Liu, G Wang, G Chen, Y Mu, L Zhang, X Hu, M Sun, C Liu, P Liu
BMC complementary and alternative medicine 2012
Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo
F Tacke
Fibrogenesis & Tissue Repair 2012
Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis
M Zhang, FL Wang, JY Zhu, YB Zheng, QY Zhao, YR Gu, Q Zhang, YT Chong, ZL Gao
Experimental and therapeutic medicine 2012
Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats
X Chen, C Liu, Y Lu, Z Yang, Z Lv, Q Xu, Q Pan, L Lu
BMC complementary and alternative medicine 2012
Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways
JU Marquardt, D Seo, LE Gómez-Quiroz, K Uchida, MC Gillen, M Kitade, P Kaposi-Novak, EA Conner, VM Factor, SS Thorgeirsson
Biochimica et Biophysica Acta 2012
IL-17 signaling in inflammatory cells, Kupffer cells and Hepatic Stellate cells exacerbates liver fibrosis
F Meng, K Wang, T Aoyama, SI Grivennikov, YH Paik, D Scholten, M Cong, K Iwaisako, X Liu, M Zhang, CH Österreicher, F Stickel, K Ley, DA Brenner, T Kisseleva
Gastroenterology 2012
Retinyl ester hydrolases and their roles in vitamin A homeostasis☆
R Schreiber, U Taschler, K Preiss-Landl, N Wongsiriroj, R Zimmermann, A Lass
Biochimica et Biophysica Acta 2012
The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease
P Hartmann, WC Chen, B Schnabl
Frontiers in physiology 2012
Global analysis of DNA methylation in early-stage liver fibrosis
Y Komatsu, T Waku, N Iwasaki, W Ono, C Yamaguchi, J Yanagisawa
BMC Medical Genomics 2012
Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography
K Wahl, W Rosenberg, B Vaske, MP Manns, K Schulze-Osthoff, MJ Bahr, H Bantel
PloS one 2012
Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats
Q Yao, B Xu, J Wang, H Liu, S Zhang, C Tu
BMC complementary and alternative medicine 2012
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models
M Polasek, BC Fuchs, R Uppal, DT Schühle, JK Alford, GS Loving, S Yamada, L Wei, GY Lauwers, AR Guimaraes, KK Tanabe, P Caravan
Journal of Hepatology 2012
Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats
Y Chen, S Zheng, D Qi, S Zheng, J Guo, S Zhang, Z Weng
PloS one 2012
Molecular Serum Markers of Liver Fibrosis
T Liu, X Wang, MA Karsdal, DJ Leeming, F Genovese
Biomarker insights 2012
General mechanisms of nicotine-induced fibrogenesis
K Jensen, D Nizamutdinov, M Guerrier, S Afroze, D Dostal, S Glaser
The FASEB Journal 2012
Col1A1 production and apoptotic resistance in TGF-β1-induced epithelial-to-mesenchymal transition-like phenotype of 603B cells
J Liu, AN Eischeid, XM Chen
PloS one 2012
Interference with Oligomerization and Glycosaminoglycan Binding of the Chemokine CCL5 Improves Experimental Liver Injury
A Nellen, D Heinrichs, ML Berres, H Sahin, P Schmitz, AE Proudfoot, C Trautwein, HE Wasmuth
PloS one 2012
Toll-Like Receptors in Liver Fibrosis: Cellular Crosstalk and Mechanisms
L Yang, E Seki
Frontiers in physiology 2012
Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice
JS Troeger, I Mederacke, GY Gwak, DH Dapito, X Mu, CC Hsu, JP Pradere, RA Friedman, RF Schwabe
Gastroenterology 2012
Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut: Toll-like receptors, microbiota and liver fibrosis
E Seki, B Schnabl
The Journal of Physiology 2012
Dendritic Cell Populations With Different Concentrations of Lipid Regulate Tolerance and Immunity in Mouse and Human Liver
J Ibrahim, AH Nguyen, A Rehman, A Ochi, M Jamal, CS Graffeo, JR Henning, CP Zambirinis, NC Fallon, R Barilla, S Badar, A Mitchell, RS Rao, D Acehan, AB Frey, G Miller
Gastroenterology 2012
Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression
N Liu, Z Meng, G Lou, W Zhou, X Wang, Y Zhang, L Zhang, X Liu, Y Yen, L Lai, BM Forman, Z Xu, R Xu, W Huang
Molecular Endocrinology 2012
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist
K Iwaisako, M Haimerl, YH Paik, K Taura, Y Kodama, C Sirlin, E Yu, RT Yu, M Downes, RM Evans, DA Brenner, B Schnabl
Proceedings of the National Academy of Sciences 2012
Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness
ML Taddei, E Giannoni, G Raugei, S Scacco, AM Sardanelli, S Papa, P Chiarugi
Journal of Signal Transduction 2012
Inhibition of hepatic stellate cell activation and liver fibrosis by fat-specific protein 27.
Yu F, Su L, Ji S, Zhang S, Yu P, Zheng Y, Zhang Q
Molecular and Cellular Biochemistry 2012
Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model
J Xiao, YP Ching, EC Liong, AA Nanji, ML Fung, GL Tipoe
European Journal of Nutrition 2012
Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease
DE Fouts, M Torralba, KE Nelson, DA Brenner, B Schnabl
Journal of Hepatology 2012
Protective Effect of Sodium Ferulate on Acetaldehyde-Treated Precision-Cut Rat Liver Slices
Y Guo, XQ Wu, C Zhang, ZX Liao, Y Wu, H Wang
Journal of Medicinal Food 2012
Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C
MG Neuman, H Schmilovitz-Weiss, N Hilzenrat, M Bourliere, P Marcellin, C Trepo, T Mazulli, G Moussa, A Patel, AA Baig, L Cohen
International Journal of Hepatology 2012
The Role of Humoral Innate Immunity in Hepatitis C Virus Infection
AW Tarr, RA Urbanowicz, JK Ball
Viruses 2012
Cytokines and STATs in Liver Fibrosis
X Kong, N Horiguchi, M Mori, B Gao
Frontiers in physiology 2012
Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis
W Zhao, JJ Li, DY Cao, X Li, LY Zhang, Y He, SQ Yue, DS Wang, KF Dou
World journal of gastroenterology : WJG 2012
Hepatic encephalopathy: An approach to its multiple pathophysiological features
JC Perazzo, S Tallis, A Delfante, PA Souto, A Lemberg, FX Eizayaga, S Romay
World journal of hepatology 2012
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
T Kisseleva, M Cong, Y Paik, D Scholten, C Jiang, C Benner, K Iwaisako, T Moore-Morris, B Scott, H Tsukamoto, SM Evans, W Dillmann, CK Glass, DA Brenner
Proceedings of the National Academy of Sciences 2012
Fibronectin is essential for survival but is dispensable for proliferation of hepatocytes in acute liver injury in mice
K Moriya, K Sakai, MH Yan, T Sakai
Hepatology 2012
Accumulation of platelets in the liver may be an important contributory factor to thrombocytopenia and liver fibrosis in chronic hepatitis C
R Kondo, H Yano, O Nakashima, K Tanikawa, Y Nomura, M Kage
Journal of Gastroenterology 2012
Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress
A Szuster-Ciesielska, M Mizerska-Dudka, J Daniluk, M Kandefer-Szerszeń
Journal of Gastroenterology 2012
Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury
CC Duwaerts, S Gehring, CW Cheng, N Rooijen, SH Gregory
Liver International 2012
HuR contributes to Hepatic Stellate Cell activation and liver fibrosis
A Woodhoo, M Iruarrizaga-Lejarreta, N Beraza, JL García-Rodríguez, N Embade, D Fernández-Ramos, N Matinez-Lopez, V Gutiérrez, B Arteta, J Caballeria, SC Lu, JM Mato, M Varela-Rey, ML Martinez-Chantar
Hepatology 2012
Effects of Angiotensin Converting Enzyme Inhibitors on Liver Fibrosis in HIV and Hepatitis C Coinfection
LJ Reese, DS Tider, AC Stivala, DA Fishbein
AIDS Research and Treatment 2012
Lipopolysaccharide enhances transforming growth factor β1-induced platelet-derived growth factor-B expression in bile duct epithelial cells
KM Kassel, BP Sullivan, JP Luyendyk
Journal of Gastroenterology and Hepatology 2012
Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis
P Farci, K Wollenberg, G Diaz, RE Engle, ME Lai, P Klenerman, RH Purcell, OG Pybus, HJ Alter
Proceedings of the National Academy of Sciences 2012
Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism
Lee MY, Choi R, Kim HM, Cho EJ, Kim BH, Choi YS, Naowaboot J, Lee EY, Yang YC, Shin JY, Shin YG, Chung CH
Experimental & molecular medicine 2012
Association of MICA gene polymorphisms with liver fibrosis in schistosomiasis patients in the Dongting Lake region
Gong Z, Luo QZ, Lin L, Su YP, Peng HB, Du K, Yu P, Wang SP
Brazilian Journal of Medical and Biological Research 2012
Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis
Krishnan A, Li X, Kao WW, Viker K, Butters K, Masuoka H, Knudsen B, Gores G, Charlton M
Laboratory Investigation 2012
Granule exocytosis mediates immune surveillance of senescent cells
Sagiv A, Biran A, Yon M, Simon J, Lowe SW, Krizhanovsky V
Oncogene 2012
Automated Liver Stiffness Measurements with Magnetic Resonance Elastography
Dzyubak B, Glaser K, Yin M, Talwalkar J, Chen J, Manduca A, Ehman RL
Journal of magnetic resonance imaging : JMRI 2012
p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species
Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M
Cancer research 2012
Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence.
Ohyama T, Sato K, Kishimoto K, Yamazaki Y, Horiguchi N, Ichikawa T, Kakizaki S, Takagi H, Izumi T, Mori M
British Journal of Pharmacology 2012
Prolidase and Oxidative Stress in Chronic Hepatitis C
Duygu F, Koruk ST, Karsen H, Aksoy N, Taskin A, Hamidanoglu M
Journal of Clinical Laboratory Analysis 2012
Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile duct-ligated rats and human hepatic stellate cells
Chen YH, Lan T, Li J, Qiu CH, Wu T, Gou HJ, Lu MQ
World journal of gastroenterology : WJG 2012
Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis
Wang H, Wu G, Park HJ, Jiang PP, Sit WH, van Griensven LJ, Wan JM
Chinese medicine 2012
CD271+ Subpopulation of Pancreatic Stellate Cells Correlates with Prognosis of Pancreatic Cancer and Is Regulated by Interaction with Cancer Cells
Fujiwara K, Ohuchida K, Mizumoto K, Shindo K, Eguchi D, Kozono S, Ikenaga N, Ohtsuka T, Takahata S, Aishima S, Tanaka M
PloS one 2012
Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling
Li S, Wang L, Yan X, Wang Q, Tao Y, Li J, Peng Y, Liu P, Liu C
Evidence-based complementary and alternative medicine : eCAM 2012
Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines
Rangwala F, Williams KP, Smith GR, Thomas Z, Allensworth JL, Lyerly HK, Diehl AM, Morse MA, Devi GR
BMC Cancer 2012
Acyclic retinoid in chemoprevention of hepatocellular carcinoma: Targeting phosphorylated retinoid X receptor-α for prevention of liver carcinogenesis
Shimizu M, Shirakami Y, Imai K, Takai K, Moriwaki H
Journal of carcinogenesis 2012
Oral Administration of Recombinant Adeno-associated Virus-mediated Bone Morphogenetic Protein-7 Suppresses CCl4-induced Hepatic Fibrosis in Mice
Hao ZM, Cai M, Lv YF, Huang YH, Li HH
Molecular Therapy 2012
The Effects of Transforming Growth Factor-β2 on the Expression of Follistatin and Activin A in Normal and Glaucomatous Human Trabecular Meshwork Cells and Tissues
Fitzgerald AM, Benz C, Clark AF, Wordinger RJ
Investigative ophthalmology & visual science 2012
Attenuating Effect of Ginkgo biloba Leaves Extract on Liver Fibrosis Induced by Thioacetamide in Mice
Al-Attar AM
Journal of Biomedicine and Biotechnology 2012
Review of MR Elastography Applications and Recent Developments
Glaser KJ, Manduca A, Ehman RL
Journal of magnetic resonance imaging : JMRI 2012
Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress
Lin J, Tang Y, Kang Q, Feng Y, Chen A
British Journal of Pharmacology 2012
Curative propensity of green tea extract towards hepatic fibrosis induced by CCl4: A histopathological study
SAFER AM, AFZAL M, NOMANI A, SOSAMMA O, MOUSA SA
Experimental and therapeutic medicine 2012
Yes-Associated Protein Regulates the Hepatic Response After Bile Duct Ligation
Bai H, Zhang N, Xu Y, Chen Q, Khan M, Potter JJ, Nayar SK, Cornish T, Alpini G, Bronk S, Pan D, Anders RA
Hepatology 2012
Beta-Adrenergic Receptor 1 Selective Antagonism Inhibits Norepinephrine-Mediated TNF-Alpha Downregulation in Experimental Liver Cirrhosis
Zapater P, Gómez-Hurtado I, Peiró G, González-Navajas JM, García I, Giménez P, Moratalla A, Such J, Francés R
PloS one 2012
Nitric oxide augments mesenchymal stem cell ability to repair liver fibrosis
Ali G, Mohsin S, Khan M, Nasir GA, Shams S, Khan SN, Riazuddin S
Journal of Translational Medicine 2012
Hepatitis D Virus Isolates with Low Replication and Epithelial-Mesenchymal Transition-Inducing Activity Are Associated with Disease Remission
Shih HH, Sheen IJ, Su CW, Peng WL, Lin LH, Wu JC
Journal of virology 2012
Discovery of Novel Biomarker Candidates for Liver Fibrosis in Hepatitis C Patients: A Preliminary Study
Gangadharan B, Bapat M, Rossa J, Antrobus R, Chittenden D, Kampa B, Barnes E, Klenerman P, Dwek RA, Zitzmann N
PloS one 2012
Noninvasive Evaluation of Portal Hypertension: Emerging Tools and Techniques
Snowdon VK, Guha N, Fallowfield JA
International Journal of Hepatology 2012
Elevated Plasma IL-6 Associates with Increased Risk of Advanced Fibrosis and Cholangiocarcinoma in Individuals Infected by Opisthorchis viverrini
Sripa B, Thinkhamrop B, Mairiang E, Laha T, Kaewkes S, Sithithaworn P, Periago MV, Bhudhisawasdi V, Yonglitthipagon P, Mulvenna J, Brindley PJ, Loukas A, Bethony JM
PLoS neglected tropical diseases 2012
Evaluation of protective effect of Butea monosperma (lam.) Taub in experimental hepatotoxicity in rats
Gupta A, Sheth NR, Pandey S, Yadav JS, Shah DR, Vyas B, Joshi S
Journal of pharmacology & pharmacotherapeutics 2012
Gene expression profiling of HCV genotype 3a initial liver fibrosis and cirrhosis patients using microarray
Ahmad W, Ijaz B, Hassan S
Journal of Translational Medicine 2012
Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease
Yan AW, Schnabl B
World journal of hepatology 2012
Revision and update on clinical practice guideline for liver cirrhosis
Suk KT, Baik SK, Yoon JH, Cheong JY, Paik YH, Lee CH, Kim YS, Lee JW, Kim DJ, Cho SW, Hwang SG, Sohn JH, Kim MY, Kim YB, Kim JG, Cho YK, Choi MS, Kim HJ, Lee HW, Kim SU, Kim JK, Choi JY, Jun DW, Tak WY, Lee BS, Jang BK, Chung WJ, Kim HS, Jang JY, Jeong SW, Kim SG, Kwon OS, Jung YK, Choe WH, Lee JS, Kim IH, Shim JJ, Cheon GJ, Bae SH, Seo YS, Choi DH, Jang SJ
The Korean Journal of Hepatology 2012
Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials
Cheung F, Feng Y, Wang N, Yuen MF, Tong Y, Wong VT
Chinese medicine 2012
Micro-RNA Profiling in Human Serum Reveals Compartment-Specific Roles of miR-571 and miR-652 in Liver Cirrhosis
Roderburg C, Mollnow T, Bongaerts B, Elfimova N, Vargas Cardenas D, Berger K, Zimmermann H, Koch A, Vucur M, Luedde M, Hellerbrand C, Odenthal M, Trautwein C, Tacke F, Luedde T
PloS one 2012
Hepatic stellate cell progenitor cells
Asahina K
Journal of Gastroenterology and Hepatology 2012
Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro
Tang LX, He RH, Yang G, Tan JJ, Zhou L, Meng XM, Huang XR, Lan HY
PloS one 2012
Separation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA.
Norén B, Forsgren MF, Dahlqvist Leinhard O, Dahlström N, Kihlberg J, Romu T, Kechagias S, Almer S, Smedby Ö, Lundberg P
European Radiology 2012
Genomics and proteomics in liver fibrosis and cirrhosis
Hannivoort RA, Hernandez-Gea V, Friedman SL
Fibrogenesis & Tissue Repair 2012
Liver
Canine and Feline Gastroenterology 2012
Noninvasive screening for liver fibrosis and portal hypertension by transient elastography--a large single center experience.
Reiberger T, Ferlitsch A, Payer BA, Pinter M, Schwabl P, Stift J, Trauner M, Peck-Radosavljevic M
Wiener klinische Wochenschrift 2012
Hepatic stimulator substance alleviates toxin-induced and immune-mediated liver injury and fibrosis in rats.
Yi X, Song M, Yuan Y, Zhang X, Chen W, Li J, Tong M, Liu G, You S, Kong X
Digestive Diseases and Sciences 2012
Therapeutic effect of alpha lipoic acid combined with praziquantel on liver fibrosis induced by Schistosoma mansoni challenged mice.
Abdel-Hafeez EH, Ahmad AK, Abdulla AM, Aabdel-Wahab S, Mosalem FA
Parasitology Research 2012
A crucial role of hepatocyte p53 in liver fibrogenesis
Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Minoru Shigekawa, Hinako Tsunematsu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Satoshi Kubota, Masaharu Takigawa, Yoshito Tomimaru, Akira Tomokuni, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Norio Hayashi
Journal of Clinical Investigation 2011
Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis
Z Wang, F Liu, W Tu, Y Chang, J Yao, W Wu, X Jiang, X He, J Lin, Y Song
Journal of Cellular and Molecular Medicine 2011
Hepatocyte-Derived Snail1 Propagates Liver Fibrosis Progression ▿ †
RG Rowe, Y Lin, R Shimizu-Hirota, S Hanada, EG Neilson, JK Greenson, SJ Weiss
Molecular and cellular biology 2011
Endothelin and hepatic wound healing
A Khimji, DC Rockey
Pharmacological Research 2011
Hepatic stellate cells and innate immunity in alcoholic liver disease
YG Suh, WI Jeong
World journal of gastroenterology : WJG 2011
The effect of cocoa supplementation on hepatic steatosis, reactive oxygen species and LFABP in a rat model of NASH
M Janevski, KN Antonas, MJ Sullivan-Gunn, MA McGlynn, PA Lewandowski
Comparative hepatology 2011
NADPH oxidase mediated oxidative stress in hepatic fibrogenesis
YH Paik, DA Brenner
The Korean Journal of Hepatology 2011
Cross-presentation of antigen by diverse subsets of murine liver cells
MR Ebrahimkhani, I Mohar, IN Crispe
Hepatology 2011
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
N Alkhouri, C Carter-Kent, AE Feldstein
Expert Review of Gastroenterology & Hepatology 2011
Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis
E Patsenker, M Stoll, G Millonig, A Agaimy, T Wissniowski, V Schneider, S Mueller, R Brenneisen, HK Seitz, M Ocker, F Stickel
Molecular Medicine 2011
Loss of Discoidin Domain Receptor 2 Promotes Hepatic Fibrosis after Chronic Carbon Tetrachloride through Altered Paracrine Interactions between Hepatic Stellate Cells and Liver-Associated Macrophages
E Olaso, B Arteta, A Benedicto, O Crende, SL Friedman
The American Journal of Pathology 2011
Unraveling the biological functions of Smad7 with mouse models
L Zhu, S Chen, Y Chen
Cell & Bioscience 2011
Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis
E Seki, E Park, J Fujimoto
Hepatology Research 2011
Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells
K Matsuzaki
Cell and Tissue Research 2011
Anti-fibrogenic Strategies and the regression of fibrosis
T Kisseleva, DA Brenner
Best practice & research. Clinical gastroenterology 2011
Regulation of hepatocyte fate by interferon-γ
CJ Horras, CL Lamb, KA Mitchell
Cytokine & Growth Factor Reviews 2011
Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74
D Heinrichs, M Knauel, C Offermanns, ML Berres, A Nellen, L Leng, P Schmitz, R Bucala, C Trautwein, C Weber, J Bernhagen, HE Wasmuth
Proceedings of the National Academy of Sciences 2011
Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats
YH Paik, YJ Yoon, HC Lee, MK Jung, SH Kang, SI Chung, JK Kim, JY Cho, KS Lee, KH Han
Experimental & molecular medicine 2011
Plasminogen activator inhibitor-1 deficient mice are protected from angiotensin II-induced fibrosis
JI Beier, JP Kaiser, L Guo, M Martínez-Maldonado, GE Arteel
Archives of Biochemistry and Biophysics 2011
Animal models for the study of liver fibrosis: new insights from knockout mouse models
H Hayashi, T Sakai
AJP Gastrointestinal and Liver Physiology 2011
The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis
T Kisseleva, DA Brenner
Journal of Hepatology 2011
New Insights into the Role of Macrophages in Adipose Tissue Inflammation and Fatty Liver Disease: Modulation by Endogenous Omega-3 Fatty Acid-Derived Lipid Mediators
J Clària, A González-Périz, C López-Vicario, B Rius, E Titos
Frontiers in immunology 2011
Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models
KK Lai, S Shang, N Lohia, GC Booth, DJ Masse, N Fausto, JS Campbell, L Beretta
PLoS genetics 2011
NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma
T Luedde, RF Schwabe
Nature Reviews Gastroenterology & Hepatology 2011
Liver fibrosis: mechanisms of immune-mediated liver injury
R Xu, Z Zhang, FS Wang
Cellular and Molecular Immunology 2011
Regulation of Transforming Growth Factor-β1-Dependent Integrin β6 Expression by p38 Mitogen-Activated Protein Kinase in Bile Duct Epithelial Cells
BP Sullivan, KM Kassel, S Manley, AK Baker, JP Luyendyk
The Journal of pharmacology and experimental therapeutics 2011
Targeted TFO delivery to hepatic stellate cells
N Yang, S Singh, RI Mahato
Journal of Controlled Release 2011
TGF-β in progression of liver disease
S Dooley, P Dijke
Cell and Tissue Research 2011
Hepatocyte IKK2 Protects Mdr2−/− Mice from Chronic Liver Failure
H Ehlken, V Kondylis, J Heinrichsdorff, L Ochoa-Callejero, T Roskams, M Pasparakis
PloS one 2011
Accelerated and Progressive and Lethal Liver Fibrosis in Mice that Lack Interleukin (IL)-10, IL-12p40, and IL-13R α2
MM Mentink-Kane, AW Cheever, MS Wilson, SK Madala, LM Beers, TR Ramalingam, T A.Wynn
Gastroenterology 2011
Dendritic Cells: Novel Players in Fibrosis and Scleroderma
TT Lu
Current Rheumatology Reports 2011
Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders
S Piera-Velazquez, Z Li, SA Jimenez
The American Journal of Pathology 2011
Platelet-derived serotonin links vascular disease and tissue fibrosis
C Dees, A Akhmetshina, P Zerr, N Reich, K Palumbo, A Horn, A Jüngel, C Beyer, G Krönke, J Zwerina, R Reiter, N Alenina, L Maroteaux, S Gay, G Schett, O Distler, JH Distler
Journal of Experimental Medicine 2011
A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling
K Moriya, E Bae, K Honda, K Sakai, T Sakaguchi, I Tsujimoto, H Kamisoyama, DR Keene, T Sasaki, T Sakai
Gastroenterology 2011
Innate immunity in alcoholic liver disease
B Gao, E Seki, DA Brenner, S Friedman, JI Cohen, L Nagy, G Szabo, S Zakhari
American journal of physiology. Gastrointestinal and liver physiology 2011
Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches
E Mormone, J George, N Nieto
Chemico-Biological Interactions 2011
Fibrosis in Autoimmune and Cholestatic Liver Disease
M Penz-Österreicher, CH Österreicher, M Trauner
Best Practice & Research Clinical Gastroenterology 2011
Mechanisms of Hepatic Fibrogenesis
UE Lee, SL Friedman
Best practice & research. Clinical gastroenterology 2011
Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice
S Inokuchi, H Tsukamoto, EJ Park, ZX Liu, DA Brenner, E Seki
Alcoholism, clinical and experimental research 2011
Vitamin A Metabolism: An Update
DN D'Ambrosio, RD Clugston, WS Blaner
Nutrients 2011
Danoprevir monotherapy decreases inflammatory markers in patients with chronic hepatitis C virus infection
CJ Schaefer, K Kossen, SR Lim, JH Lin, L Pan, W Bradford, PF Smith, SD Seiwert
Antimicrobial agents and chemotherapy 2011
Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice
Q Zhu, L Zou, K Jagavelu, DA Simonetto, RC Huebert, ZD Jiang, HL DuPont, VH Shah
Journal of Hepatology 2011
Induced pluripotent stem cells and personalized medicine: current progress and future perspectives
YS Chun, K Byun, B Lee
Anatomy & cell biology 2011
Adiponectin inhibits leptin signaling via multiple mechanisms to exert protective effects against hepatic fibrosis
JA Handy, PP Fu, P Kumar, JE Mells, S Sharma, NK Saxena, FA Anania
Biochemical Journal 2011
Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
B Gao, R Bataller
Gastroenterology 2011
Coordinated Defects in Hepatic Long Chain Fatty Acid Metabolism and Triglyceride Accumulation Contribute to Insulin Resistance in Non-Human Primates
S Kamath, AO Chavez, A Gastaldelli, F Casiraghi, GA Halff, GA Abrahamian, AM Davalli, RA Bastarrachea, AG Comuzzie, R Guardado-Mendoza, LM Jimenez-Ceja, V Mattern, AM Paez, A Ricotti, ME Tejero, PB Higgins, IP Rodriguez-Sanchez, D Tripathy, RA DeFronzo, EJ Dick, GW Cline, F Folli
PloS one 2011
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
Wang H, Lafdil F, Kong X, Gao B
International journal of biological sciences 2011
Th2-associated alternative Kupffer cell activation promotes liver fibrosis without inducing local inflammation.
López-Navarrete G, Ramos-Martínez E, Suárez-Álvarez K, Aguirre-García J, Ledezma-Soto Y, León-Cabrera S, Gudiño-Zayas M, Guzmán C, Gutiérrez-Reyes G, Hernández-Ruíz J, Camacho-Arroyo I, Robles-Díaz G, Kershenobich D, Terrazas LI, Escobedo G
International journal of biological sciences 2011
Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells
Lu P, Liu H, Yin H, Yang L
Medical science monitor : international medical journal of experimental and clinical research 2011
Epigenetic cell fate regulation of hepatic stellate cells
H Tsukamoto, NL Zhu, K Asahina, DA Mann, J Mann
Hepatology Research 2011
miRNA studies in in vitro and in vivo activated hepatic stellate cells
G Maubach, MC Lim, J Chen, H Yang, L Zhuo
World journal of gastroenterology : WJG 2011
Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients
N Bouzgarrou, E Hassen, O Bahri, S Gabbouj, NB Mami, H Triki, L Chouchane
Hepatology International 2011
Hepatic metabolism of retinoids and disease associations
Y Shirakami, SA Lee, RD Clugston, WS Blaner
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2011
Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats
MA Morsy, AM Abdalla, AM Mahmoud, SA Abdelwahab, ME Mahmoud
Journal of Physiology and Biochemistry 2011
The function of integrin-linked kinase in normal and activated stellate cells: implications for fibrogenesis in wound healing
MS Shafiei, DC Rockey
Laboratory Investigation 2011
Serum cytokine levels in patients with chronic hepatitis B according to lamivudine therapy
Y Park, Y Park, KH Han, HS Kim
Journal of Clinical Laboratory Analysis 2011
Distinct Populations of Hepatic Stellate Cells in the Mouse Liver Have Different Capacities for Retinoid and Lipid Storage
DN D'Ambrosio, JL Walewski, RD Clugston, PD Berk, RA Rippe, WS Blaner
PloS one 2011
NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats
J Yang, J Zheng, L Wu, M Shi, H Zhang, X Wang, N Xia, D Wang, X Liu, L Yao, Y Li, K Dou
PloS one 2011
Nonmuscle myosin II regulates migration but not contraction in rat hepatic stellate cells
CC Moore, AM Lakner, CM Yengo, LW Schrum
World journal of hepatology 2011
SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-β1 and PDGF
C Atorrasagasti, JB Aquino, L Hofman, L Alaniz, M Malvicini, M Garcia, L Benedetti, SL Friedman, O Podhajcer, G Mazzolini
AJP Gastrointestinal and Liver Physiology 2011
Critical role of factor XIII in the initial stages of carbon tetrachloride-induced adult liver remodeling
I Tsujimoto, K Moriya, K Sakai, G Dickneite, T Sakai
The American Journal of Pathology 2011
A secreted form of the asialoglycoprotein receptor, sH2a, as a novel potential noninvasive marker for liver fibrosis.
Veselkin E, Kondratyev M, Lurie Y, Ron E, Santo M, Reif S, Elashvili I, Bar L, Lederkremer GZ
PloS one 2011
Current status of novel antifibrotic therapies in patients with chronic liver disease.
Cohen-Naftaly M, Friedman SL
Therapeutic advances in gastroenterology 2011
Inhibition of high-mobility group box 1 expression by siRNA in rat hepatic stellate cells.
Ge WS, Wu JX, Fan JG, Wang YJ, Chen YW
World Journal of Gastroenterology 2011
Identification of ionotrophic purinergic receptors in Huh-7 cells and their response towards structural proteins of HCV genotype 3a.
Manzoor S, Idrees M, Ashraf J, Mehmood A, Butt S, Fatima K, Akbar H, Rehaman IU, Qadri I
Virology Journal 2011
Noninvasive tools to assess hepatic fibrosis: ready for prime time?
Schmeltzer PA, Talwalkar JA
Gastroenterology Clinics of North America 2011
Non-invasive markers for hepatic fibrosis.
Baranova A, Lal P, Birerdinc A, Younossi ZM
BMC Gastroenterology 2011
Zinc finger protein 267 is up-regulated in hepatocellular carcinoma and promotes tumor cell proliferation and migration.
Schnabl B, Valletta D, Kirovski G, Hellerbrand C
Experimental and Molecular Pathology 2011
Gut microbiota dysbiosis is associated with inflammation and bacterial translocation in mice with CCl4-induced fibrosis.
Gómez-Hurtado I, Santacruz A, Peiró G, Zapater P, Gutiérrez A, Pérez-Mateo M, Sanz Y, Francés R
PloS one 2011
Schistosomiasis mansoni: ultrasound-evaluated hepatic fibrosis and serum concentrations of hyaluronic acid.
Silva CC, Domingues AL, Lopes EP, Morais CN, Santos RB, Luna CF, Nader HB, Martins JR
Annals of Tropical Medicine and Parasitology 2011
Reactive oxygen species released from hypoxic hepatocytes regulates MMP-2 expression in hepatic stellate cells.
Li J, Fan R, Zhao S, Liu L, Guo S, Wu N, Zhang W, Chen P
International journal of molecular sciences 2011
Diffusion-weighted magnetic resonance imaging for the staging of liver fibrosis.
Bonekamp S, Torbenson MS, Kamel IR
Journal of Clinical Gastroenterology 2011
Hepatoprotective activity of Leptadenia reticulata stems against carbon tetrachloride-induced hepatotoxicity in rats.
Nema AK, Agarwal A, Kashaw V
Indian journal of pharmacology 2011
PCBP2 siRNA reverses the alcohol-induced pro-fibrogenic effects in hepatic stellate cells.
Shukla RS, Qin B, Wan YJ, Cheng K
Pharmaceutical Research 2011
Identification of mesenchymal stem cells in perinodular fat and skin in Dupuytren's disease: a potential source of myofibroblasts with implications for pathogenesis and therapy.
Iqbal SA, Manning C, Syed F, Kolluru V, Hayton M, Watson S, Bayat A
Stem Cells and Development 2011
A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma.
Schröder PC, Segura V, Riezu JI, Sangro B, Mato JM, Prieto J, Santamaría E, Corrales FJ
Functional & Integrative Genomics 2011
Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis.
Tarrats N, Moles A, Morales A, García-Ruiz C, Fernández-Checa JC, Marí M
Hepatology 2011
Measurement of CO3-610, a potential liver biomarker derived from matrix metalloproteinase-9 degradation of collagen type iii, in a rat model of reversible carbon-tetrachloride-induced fibrosis.
Vassiliadis E, Larsen DV, Clausen RE, Veidal SS, Barascuk N, Larsen L, Simonsen H, Silvestre TS, Hansen C, Overgaard T, Leeming DJ, Karsdal MA
Biomarker insights 2011
Transient micro-elastography: A novel non-invasive approach to measure liver stiffness in mice.
Bastard C, Bosisio MR, Chabert M, Kalopissis AD, Mahrouf-Yorgov M, Gilgenkrantz H, Mueller S, Sandrin L
World Journal of Gastroenterology 2011
Serum markers of hepatocyte death and apoptosis are non invasive biomarkers of severe fibrosis in patients with alcoholic liver disease.
Lavallard VJ, Bonnafous S, Patouraux S, Saint-Paul MC, Rousseau D, Anty R, Le Marchand-Brustel Y, Tran A, Gual P
PloS one 2011
New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients.
Gangadharan B, Antrobus R, Chittenden D, Rossa J, Bapat M, Klenerman P, Barnes E, Dwek RA, Zitzmann N
Journal of Proteome Research 2011
Effect of preischemic treatment with fenofibrate, a peroxisome proliferator-activated receptor-α ligand, on hepatic ischemia-reperfusion injury in rats.
Boshra V, Moustafa AM
Journal Of Molecular Histology 2011
Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver.
Asahina K, Zhou B, Pu WT, Tsukamoto H
Hepatology 2011
Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation.
Pan RL, Wang P, Xiang LX, Shao JZ
The Journal of biological chemistry 2011
Gut Microbiota and Inflammation
Hakansson A, Molin G
Nutrients 2011
Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease
Wen J
Clinical and Translational Science 2011
Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis
Benyair R, Kondratyev M, Veselkin E, Tolchinsky S, Shenkman M, Lurie Y, Lederkremer GZ
World journal of gastroenterology : WJG 2011
Pivotal Role of Toll-Like Receptors 2 and 4, Its Adaptor Molecule MyD88, and Inflammasome Complex in Experimental Tubule-Interstitial Nephritis
Correa-Costa M, Braga TT, Semedo P, Hayashida CY, Bechara LR, Elias RM, Barreto CR, Silva-Cunha C, Hyane MI, Gonçalves GM, Brum PC, Fujihara C, Zatz R, Pacheco-Silva A, Zamboni DS, Camara NO
PloS one 2011
Neuropilin-1 Enhances PDGF and TGFβ Dependent Hepatic Stellate Cell Signaling Thereby Promoting Liver Cirrhosis
Sheng Cao, Usman Yaqoob, Amitava Das, Uday Shergill, Kumaravelu Jagavelu, Robert Huebert, Chittaranjan Routray, Soha Abdelmoneim, Meher Vasdev, Edward B. Leof, Michael R. Charlton, Ryan Watts, Debabrata Mukhopadhyay, Vijay Shah
Journal of Clinical Investigation 2010
Antagonism of the chemokine Ccl5 (Rantes) ameliorates experimental liver fibrosis in mice
Marie-Luise Berres, Rory Koenen, Anna Rueland, Mirko Moreno Zaldivar, Daniel Heinrichs, Hacer Sahin, Petra Schmitz, Konrad Streetz, Thomas Berg, Nikolaus Gaßler, Ralf Weiskirchen, Amanda Proudfoot, Christian Weber, Christian Trautwein, Hermann E. Wasmuth
Journal of Clinical Investigation 2010
Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis
A Moles, N Tarrats, A Morales, M Domínguez, R Bataller, J Caballería, C García-Ruiz, JC Fernández-Checa, M Marí
The American Journal of Pathology 2010
Liver X Receptor Signaling is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease
SW Beaven, K Wroblewski, J Wang, C Hong, S Bensinger, H Tsukamoto, P Tontonoz
Gastroenterology 2010
Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis
J Behari, TH Yeh, L Krauland, W Otruba, B Cieply, B Hauth, U Apte, T Wu, R Evans, SP Monga
The American Journal of Pathology 2010
Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc knockout mice providing a model for hepatic cirrhosis
Y Chen, E Johansson, Y Yang, ML Miller, D Shen, DJ Orlicky, HG Shertzer, V Vasiliou, DW Nebert, TP Dalton
Journal of Hepatology 2010
Toll-like receptor 4 and hepatic fibrogenesis
JP Pradere, JS Troeger, DH Dapito, AA Mencin, RF Schwabe
Seminars in liver disease 2010
Oxidative stress and glutathione in TGF-β-mediated fibrogenesis
RM Liu, KA Pravia
Free radical biology & medicine 2010
Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice
VE de Meijer, DY Sverdlov, Y Popov, HD Le, JA Meisel, V Nosé, D Schuppan, M Puder
PloS one 2010
Macrophages: master regulators of inflammation and fibrosis
TA Wynn, L Barron
Seminars in liver disease 2010
Potential treatment options and future research to increase hepatitis C virus treatment response rate
V Tencate, B Sainz, SJ Cotler, SL Uprichard
Hepatic medicine : evidence and research 2010
Genetic labeling does not detect epithelial-to-mesenchymal transition (EMT) of cholangiocytes in liver fibrosis in mice
D Scholten, CH Osterreicher, A Scholten, K Iwaisako, G Gu, DA Brenner, T Kisseleva
Gastroenterology 2010
Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
K Taura, K Miura, K Iwaisako, CH Österreicher, Y Kodama, M Penz-Österreicher, DA Brenner
Hepatology 2010
CX3CL1-CX3CR1 interaction prevents CCl4-induced liver inflammation and fibrosis
T Aoyama, S Inokuchi, DA Brenner, E Seki
Hepatology 2010
Hypoxia, angiogenesis and liver fibrogenesis in the progression of chronic liver diseases
C Paternostro, E David, E Novo, M Parola
World journal of gastroenterology : WJG 2010
The Tumor Microenvironment in Hepatocellular Carcinoma: Current Status and Therapeutic Targets
JD Yang, I Nakamura, LR Roberts
Seminars in Cancer Biology 2010
Genome-wide association studies and genetic risk assessment of liver diseases
M Krawczyk, R Müllenbach, SN Weber, V Zimmer, F Lammert
Nature Reviews Gastroenterology & Hepatology 2010
CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation
E Hintermann, M Bayer, JM Pfeilschifter, AD Luster, U Christen
Journal of Autoimmunity 2010
Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition
J Kluwe, JP Pradere, GY Gwak, A Mencin, SD Minicis, CH Osterreicher, J Colmenero, R Bataller, RF Schwabe
Gastroenterology 2010
Triplex Forming Oligonucleotides against Type α 1(I) Collagen attenuates Liver Fibrosis induced by Bile Duct ligation
R Panakanti, A Pratap, N Yang, JS Jackson, RI Mahato
Biochemical Pharmacology 2010
Renin-angiotensin System Activation in Congenital Hepatic Fibrosis in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease:
M Goto, N Hoxha, R Osman, J Wen, RG Wells, KM Dell
Journal of Pediatric Gastroenterology and Nutrition 2010
Toll-like receptor 3 in liver diseases
S Yin, B Gao
Gastroenterology Research and Practice 2010
The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases
JB Soares, P Pimentel-Nunes, R Roncon-Albuquerque, A Leite-Moreira
Hepatology International 2010
Combinatorial gene therapy renders increased survival in cirrhotic rats
FJ Gálvez-Gastélum, AA Segura-Flores, MD Senties-Gomez, JF Muñoz-Valle, JS Armendáriz-Borunda
Journal of Biomedical Science 2010
Mediators leading to fibrosis - how to measure and control them in tissue engineering
X Mu, I Bellayr, T Walters, Y Li
Operative techniques in orthopaedics 2010
Somatic Cell Plasticity and Niemann-Pick Type C2 Protein
C Csepeggi, M Jiang, F Kojima, LJ Crofford, A Frolov
The Journal of biological chemistry 2010
Oncogenic Potential of Hepatitis C Virus Proteins
A Banerjee, RB Ray, R Ray
Viruses 2010
The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice
P Fickert, A Thueringer, T Moustafa, D Silbert, J Gumhold, O Tsybrovskyy, M Lebofsky, H Jaeschke, H Denk, M Trauner
Laboratory Investigation 2010
Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice
K Miura, Y Kodama, S Inokuchi, B Schnabl, T Aoyama, H Ohnishi, JM Olefsky, DA Brenner, E Seki
Gastroenterology 2010
Mechanistic connection between inflammation and fibrosis
SB Lee, R Kalluri
Kidney International 2010
Toll-Like Receptor Signaling and Liver Fibrosis
T Aoyama, YH Paik, E Seki
Gastroenterology Research and Practice 2010
In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity
MK Connolly, AS Bedrosian, A Malhotra, JR Henning, J Ibrahim, V Vera, NE Cieza-Rubio, BU Hassan, HL Pachter, S Cohen, AB Frey, G Miller
Journal of immunology (Baltimore, Md. : 1950) 2010
Applications of Patient-Specific Induced Pluripotent Stem Cells; Focused on Disease Modeling, Drug Screening and Therapeutic Potentials for Liver Disease
Chun YS, Chaudhari P, Jang YY
International journal of biological sciences 2010
Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice
MU Latasa, C Gil-Puig, MG Fernández-Barrena, CM Rodríguez-Ortigosa, JM Banales, R Urtasun, S Goñi, M Méndez, S Arcelus, N Juanarena, JA Recio, S Lotersztajn, J Prieto, C Berasain, FJ Corrales, J Lecanda, MA Avila
PloS one 2010
Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth
T Amann, F Bataille, T Spruss, K Dettmer, P Wild, C Liedtke, M Mühlbauer, P Kiefer, PJ Oefner, C Trautwein, AK Bosserhoff, C Hellerbrand
The American Journal of Pathology 2010
Contribution of gut bacteria to liver pathobiology
G Son, M Kremer, IN Hines
Gastroenterology Research and Practice 2010
Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis
M Correa-Costa, P Semedo, AP Monteiro, RC Silva, RL Pereira, GM Gonçalves, GD Marques, MA Cenedeze, AC Faleiros, AC Keller, MH Shimizu, AC Seguro, MA Reis, A Pacheco-Silva, NO Câmara
PloS one 2010
Protective effect of quercetin on liver damage induced by biliary obstruction in rats
M Kanter
Journal Of Molecular Histology 2010
Epigenetic Repression of Matrix Metalloproteinases in Myofibroblastic Hepatic Stellate Cells through Histone Deacetylases 4
L Qin, YP Han
The American Journal of Pathology 2010
Liver stiffness: a novel parameter for the diagnosis of liver disease
Mueller S, Sandrin L
Hepatic medicine : evidence and research 2010
Hepatic progenitors for liver disease: current position
Conigliaro A, Brenner DA, Kisseleva T
Stem cells and cloning : advances and applications 2010
Curcumin improves sclerosing cholangitis in Mdr2−/− mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation
Baghdasaryan A, Claudel T, Kosters A, Gumhold J, Silbert D, Thüringer A, Leski K, Fickert P, Karpen SJ, Trauner M
Gut 2010
Aflatoxin B1 albumin adducts in plasma and aflatoxin M1 in urine are associated with plasma concentrations of vitamins A and E.
Obuseh FA, Jolly PE, Jiang Y, Shuaib FM, Waterbor J, Ellis WO, Piyathilake CJ, Desmond RA, Afriyie-Gyawu E, Phillips TD
2010
Immunohistochemical localization of transforming growth factor β-1 and its relationship with collagen expression in advanced liver fibrosis due to biliary atresia.
Farrington C, Novak D, Liu C, Haafiz AB
Clinical and experimental gastroenterology 2010
Enteric dysbiosis associated with a mouse model of alcoholic liver disease.
Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner DA, Schnabl B
Hepatology 2010
Role of serotonin in development of esophageal and gastric fundal varices.
Rudić JS, Culafić DM, Mirković DS, Ješić RS, Krstić MN
World Journal of Gastroenterology 2010
Activation of protein serine/threonine phosphatase PP2Cα efficiently prevents liver fibrosis.
Wang L, Wang X, Chen J, Yang Z, Yu L, Hu L, Shen X
PloS one 2010
Antifibrotic effect of MMP13-encoding plasmid DNA delivered using polyethylenimine shielded with hyaluronic acid.
Kim EJ, Cho HJ, Park D, Kim JY, Kim YB, Park TG, Shim CK, Oh YK
Molecular Therapy 2010
A polymorphism in the integrin αV subunit gene affects the progression of primary biliary cirrhosis in Japanese patients.
Inamine T, Nakamura M, Kawauchi A, Shirakawa Y, Hashiguchi H, Aiba Y, Taketomi A, Shirabe K, Nakamuta M, Hayashi S, Saoshiro T, Komori A, Yatsuhashi H, Kondo S, Omagari K, Maehara Y, Ishibashi H, Tsukamoto K
Journal of Gastroenterology 2010
Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways
Liu Q, Chen J, Wang X, Yu L, Hu LH, Shen X
Acta Pharmacologica Sinica 2010
Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production
Liu Q, Wang X, Zhang Y, Li CJ, Hu LH, Shen X
Acta Pharmacologica Sinica 2010
miR-194 Is a Marker of Hepatic Epithelial Cells and Suppresses Metastasis of Liver Cancer Cells in Mice
Meng Z, Fu X, Chen X, Zeng S, Tian Y, Jove R, Xu R, Huang W
Hepatology 2010
Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation
Zhu L, Mahato RI
Bioconjugate Chemistry 2010
Cellular senescence controls fibrosis in wound healing
Jun JI, Lau LF
Aging 2010
Effect of dietary supplementation of grape skin and seeds on liver fibrosis induced by dimethylnitrosamine in rats
Shin MO, Moon JO
Nutrition Research and Practice 2010
Smad7 dependent expression signature highlights BMP2 and HK2 signaling in HSC transdifferentiation
Denecke B, Wickert L, Liu Y, Ciuclan L, Dooley S, Meindl-Beinker NM
World journal of gastroenterology : WJG 2010
E3 Ubiquitin Ligase Synoviolin Is Involved in Liver Fibrogenesis
Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, Araya N, Koike J, Tadokoro M, Suzuki N, Nagata K, Senoo H, Friedman SL, Nishioka K, Yamano Y, Itoh F, Nakajima T
PloS one 2010
Prevention of Liver Fibrosis by Triple Helix-Forming Oligodeoxyribonucleotides Targeted to the Promoter Region of Type I Collagen Gene
Koilan S, Hamilton D, Baburyan N, Padala MK, Weber KT, Guntaka RV
Oligonucleotides 2010
A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway
Lin HJ, Tseng CP, Lin CF, Liao MH, Chen CM, Kao ST, Cheng JC
Evidence-based complementary and alternative medicine : eCAM 2010
Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses
Schoenherr C, Weiskirchen R, Haan S
Cell communication and signaling : CCS 2010
A Structure-Based Approach for Mapping Adverse Drug Reactions to the Perturbation of Underlying Biological Pathways
Wallach I, Jaitly N, Lilien R
PloS one 2010
Novel biomarkers predict liver fibrosis in hepatitis C patients: alpha 2 macroglobulin, vitamin D binding protein and apolipoprotein AI
Ho AS, Cheng CC, Lee SC, Liu ML, Lee JY, Wang WM, Wang CC
Journal of biomedical science 2010
Non-invasive index of liver fibrosis induced by alcohol, thioacetamide and schistosomal infection in mice
Hessien MH, El-Sharkawi IM, El-Barbary AA, El-Beltagy DM, Snyder N
BMC Gastroenterology 2010
HCV regulates TGF-β1 production through the generation of reactive oxygen species in an NFκB-dependent manner
Lin W, Tsai WL, Shao RX, Wu G, Peng LF, Barlow LL, Chung WJ, Zhang L, Zhao H, Jang JY, Chung RT
Gastroenterology 2010
Natural taurine promotes apoptosis of human hepatic stellate cells in proteomics analysis
Deng X, Liang J, Lin ZX, Wu FS, Zhang YP, Zhang ZW
World journal of gastroenterology : WJG 2010
Neutrophil Depletion Blocks Early Collagen Degradation in Repairing Cholestatic Rat Livers
Harty MW, Muratore CS, Papa EF, Gart MS, Ramm GA, Gregory SH, Tracy TF Jr
The American Journal of Pathology 2010
Analysis of intrahepatic vascular morphological changes of chronic liver disease for assessment of liver fibrosis stages by micro-flow imaging with contrast-enhanced ultrasound: preliminary experience.
Sugimoto K, Shiraishi J, Moriyasu F, Ichimura S, Metoki R, Doi K
European Radiology 2010
rAAV2-TGF-β(3) decreases collagen synthesis and deposition in the liver of experimental hepatic fibrosis rat.
Zhang Y, Liu P, Gao X, Qian W, Xu K
Digestive Diseases and Sciences 2010
Effects of Danggui Buxue Decoction () on lipid peroxidation and MMP-2/9 activities of fibrotic liver in rats.
Chen Y, Chen Q, Lu J, Li FH, Tao YY, Liu CH
Chinese Journal of Integrative Medicine 2010
S-nitroso-N-acetylcysteine attenuates liver fibrosis in cirrhotic rats.
Vercelino R, Crespo I, de Souza GF, Cuevas MJ, de Oliveira MG, Marroni NP, González-Gallego J, Tuñón MJ
Journal of Molecular Medicine 2010
Gene expression profiles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum.
Xia Y, Chen R, Song Z, Ye S, Sun R, Xue Q, Zhang Z
Journal of Cancer Research and Clinical Oncology 2010
Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells.
Shin E, Lee C, Sung SH, Kim YC, Hwang BY, Lee MK
Journal of Natural Medicines 2010
The role of the gut microbiota in nonalcoholic fatty liver disease.
Abu-Shanab A, Quigley EM
Nature reviews. Gastroenterology & hepatology 2010
CCR1 and CCR5 Promote Hepatic Fibrosis
Ekihiro Seki , Samuele De Minicis, Johannes Kluwe, Sayaka Inokuchi, Geum-Youn Gwak, Christina A. Bursill, Josep M. Llovet, David A. Brenner and Robert F. Schwabe
Journal of Clinical Investigation 2009
In liver fibrosis, dendritic cells govern hepatic inflammation by acquiring enhanced capacity to engage innate and adaptive immunity via TNF-alpha
Michael Connolly, Andrea Bedrosian, Jon Mallen-St. Clair, Aaron Mitchell, Junaid Ibrahim, Andrea Stroud, H. Leon Pachter, Dafna Bar-Sagi, Alan Frey, George Miller
Journal of Clinical Investigation 2009
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease
WK Syn, Y Jung, A Omenetti, M Abdelmalek, CD Guy, L Yang, J Wang, RP Witek, CM Fearing, TA Pereira, V Teaberry, SS Choi, J Conde-Vancells, GF Karaca, AM Diehl
Gastroenterology 2009
Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney
Z Péterfi, A Donkó, A Orient, A Sum, A Prókai, B Molnár, Z Veréb, E Rajnavölgyi, KJ Kovács, V Müller, AJ Szabó, M Geiszt
The American Journal of Pathology 2009
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential
A Moles, N Tarrats, JC Fernández-Checa, M Marí
Hepatology 2009
Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans
HE Wasmuth, F Lammert, MM Zaldivar, R Weiskirchen, C Hellerbrand, D Scholten, ML Berres, H Zimmermann, KL Streetz, F Tacke, S Hillebrandt, P Schmitz, H Keppeler, T Berg, E Dahl, N Gassler, SL Friedman, C Trautwein
Gastroenterology 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Toll-like receptors as targets in chronic liver diseases
A Mencin, J Kluwe, RF Schwabe
Gut 2009
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives
B Viollet, B Guigas, J Leclerc, S Hébrard, L Lantier, R Mounier, F Andreelli, M Foretz
Acta physiologica (Oxford, England) 2009
Role of the receptor for advanced glycation end products in hepatic fibrosis
C Lohwasser, D Neureiter, Y Popov, M Bauer, D Schuppan
World journal of gastroenterology : WJG 2009
Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
S Inokuchi, T Aoyama, K Miura, CH Osterreicher, Y Kodama, K Miyai, S Akira, DA Brenner, E Seki
Proceedings of the National Academy of Sciences 2009
Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
B Gao, S Radaeva, O Park
Journal of leukocyte biology 2009
CCR2 promotes hepatic fibrosis in mice
E Seki, S Minicis, S Inokuchi, K Taura, K Miyai, N Rooijen, RF Schwabe, DA Brenner
Hepatology 2009
Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice
C Mitchell, MA Robin, A Mayeuf, M Mahrouf-Yorgov, A Mansouri, M Hamard, D Couton, B Fromenty, H Gilgenkrantz
The American Journal of Pathology 2009
Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis
E Patsenker, Y Popov, F Stickel, V Schneider, M Ledermann, H Sägesser, G Niedobitek, SL Goodman, D Schuppan
Hepatology 2009
Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice
C Mitchell, D Couton, JP Couty, M Anson, AM Crain, V Bizet, L Rénia, S Pol, V Mallet, H Gilgenkrantz
The American Journal of Pathology 2009
Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1
Q Kang, A Chen
Laboratory Investigation 2009
Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride
O Park, WI Jeong, L Wang, H Wang, ZX Lian, ME Gershwin, B Gao
Hepatology 2009
Hepatic wound repair
M Parola, M Pinzani
Fibrogenesis & Tissue Repair 2009
Hepatic Stellate Cell-Specific Gene Silencing Induced by an Artificial MicroRNA for Antifibrosis In Vitro
Y Chang, H Jiang, X Sun, X Cai, X He, P Li, W Tang, Y Song, J Lin
Digestive Diseases and Sciences 2009
Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology
F Joanna, V Mathieu, S Sarah, D Sarah, V Karin, V Tamara, R Vera
Journal of Cellular and Molecular Medicine 2009
Role of host genetics in fibrosis
GL Hold, P Untiveros, KA Saunders, EM El-Omar
Fibrogenesis & Tissue Repair 2009
Insulin-like growth factor binding protein-7 induces activation and transdifferentiation of hepatic stellate cells in vitro
LX Liu, S Huang, QQ Zhang, Y Liu, DM Zhang, XH Guo, DW Han
World journal of gastroenterology : WJG 2009
Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells
A Gentilini, B Lottini, M Brogi, A Caligiuri, L Cosmi, F Marra, M Pinzani
Fibrogenesis & Tissue Repair 2009
Alterations of Bone Marrow Sinusoidal Endothelium in Rat and Patients with Liver Cirrhosis
S Zhao, YM Fu, XF Li, ZF Jin, RB Zhao, Q Huang, FM Zhang, WH Zhang
Digestive Diseases and Sciences 2009
Kupffer cells mediate leptin-induced liver fibrosis
J Wang, I Leclercq, JM Brymora, N Xu, M Ramezani-Moghadam, RM London, D Brigstock, J George
Gastroenterology 2009
Renin-angiotensin system in the pathogenesis of liver fibrosis
RM Pereira, RA Santos, FL da Dias, MM Teixeira, AC Silva
World journal of gastroenterology : WJG 2009
Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis
HK Kim, TH Yang, HY Cho
World journal of gastroenterology : WJG 2009
Retinoic Acid-mediated Nuclear Receptor Activation and Hepatocyte Proliferation
N Bushue, YJ Wan
Journal of Experimental & Clinical Medicine 2009
Molecular mechanisms underlying hepatocellular carcinoma.
Merle P, Trepo C
Viruses 2009
Chinese medicinal herbs in treating model rats with hepatic fibrosis.
Zhou YX, Chen J, Li JP, Wang YL, Jin XD
African journal of traditional, complementary, and alternative medicines : AJTCAM 2009
Implications of Cellular Senescence in Tissue Damage Response, Tumor Suppression, and Stem Cell Biology
Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW
Cold Spring Harbor Symposia on Quantitative Biology 2009
Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection
Yonghong L, Chang M, Abar O, Garcia V, Rowland C, Catanese J, Ross D, Broder S, Shiffman M, Cheung R, Wright T, Friedman SL, Sninsky J
Journal of Hepatology 2009
CD38-mediated Ca2+ Signaling Contributes to Angiotensin II-induced Activation of Hepatic Stellate Cells: ATTENUATION OF HEPATIC FIBROSIS BY CD38 ABLATION
Kim SY, Cho BH, Kim UH
The Journal of biological chemistry 2009
Emerging role of microRNAs in liver diseases
Bala S, Marcos M, Szabo G
World journal of gastroenterology : WJG 2009
Involvement of Sphingosine 1-Phosphate (SIP)/S1P3 Signaling in Cholestasis-Induced Liver Fibrosis
Li C, Jiang X, Yang L, Liu X, Yue S, Li L
The American Journal of Pathology 2009
TGF-β1 Gene Silencing for Treating Liver Fibrosis
Cheng K, Yang N, Mahato RI
Molecular Pharmaceutics 2009
Effect of Fuzheng Huayu formula and its actions against liver fibrosis
Liu C, Hu Y, Xu L, Liu C, Liu P
Chinese medicine 2009
Liver and spleen volume variations in patients with hepatic fibrosis
Liu P, Li P, He W, Zhao LQ
World journal of gastroenterology : WJG 2009
Novel Serum Markers of Fibrosis Progression for the Follow-Up of Hepatitis C Virus-Infected Patients
Caillot F, Hiron M, Goria O, Gueudin M, Francois A, Scotte M, Daveau M, Salier JP
The American Journal of Pathology 2009
Insoluble, Speckled Cytosolic Distribution of Retinoic Acid Receptor Alpha Protein as a Marker of Hepatic Stellate Cell Activation In Vitro
Mezaki Y, Yamaguchi N, Yoshikawa K, Miura M, Imai K, Itoh H, Senoo H
Journal of Histochemistry & Cytochemistry 2009
Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different species
Mousavi SA, Fønhus MS, Berg T
BMC cell biology 2009
Relationship between angiotensin-(1-7) and angiotensin II correlates with hemodynamic changes in human liver cirrhosis
Vilas-Boas WW, Ribeiro-Oliveira Jr A, Pereira RM, da Cunha Ribeiro R, Almeida J, Nadu AP, Simões e Silva AC, dos Santos RA
World journal of gastroenterology : WJG 2009
Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis
Georgescu EF, Ionescu R, Niculescu M, Mogoanta L, Vancica L
World journal of gastroenterology : WJG 2009
HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice
Joyce MA, Walters KA, Lamb SE, Yeh MM, Zhu LF, Kneteman N, Doyle JS, Katze MG, Tyrrell DL
PLoS pathogens 2009
TNF-α plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease
Rimkunas VM, Graham MJ, Crooke RM, Liscum L
Journal of lipid research 2009
Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro.
Sun X, Zhang XD, Cheng G, Hu YH, Wang HY
Molecular and Cellular Biochemistry 2009
Natural killer cell receptors and their ligands in liver diseases.
Yamagiwa S, Kamimura H, Ichida T
Medical Molecular Morphology 2009
Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis.
Karantonis HC, Gribilas G, Stamoulis I, Giaginis C, Spiliopoulou C, Kouraklis G, Demopoulos C, Theocharis SE
Digestive Diseases and Sciences 2009
The GABAB receptor inhibits activation of hepatic stellate cells.
Xiao F, Yu K, Dong F, Liang Y, Jun C, Wei H
Digestive Diseases and Sciences 2009
Effect of anluohuaxian tablet combined with gamma-IFN on schistosomal liver fibrosis.
Huang J, Huang H, Jiao Y, Ai G, Huang T, Li L, Yu H, Ma K, Xiao F
2009
Reversal of liver fibrosis.
Ismail MH, Pinzani M
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 2009
Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma
Amann T, Bataille F, Spruss T, Mühlbauer M, Gäbele E, Schölmerich J, Kiefer P, Bosserhoff A, Hellerbrand C
Cancer Science 2009
Hedgehog signaling regulates epithelial mesenchymal transition during biliary fibrosis in rodents and humans
Alessia Omenetti, Alessandro Porrello, Youngmi Jung, Liu Yang, Yury Popov, Steve S. Choi, Rafal P. Witek, Gianfranco Alpini, Juliet Venter, Hendrika M. Vandongen, Wing-Kin Syn, Gianluca Svegliati Baroni, Antonio Benedetti,Detlef Schuppan and Anna Mae Diehl
Journal of Clinical Investigation 2008
Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats
Y Wei, SE Clark, EM Morris, JP Thyfault, GM Uptergrove, AT Whaley-Connell, CM Ferrario, JR Sowers, JA Ibdah
Journal of Hepatology 2008
Redox mechanisms in hepatic chronic wound healing and fibrogenesis
E Novo, M Parola
Fibrogenesis & Tissue Repair 2008
Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis
JA Jones, FG Spinale, JS Ikonomidis
Journal of Vascular Research 2008
Toll-like receptors, wound healing, and carcinogenesis
J Kluwe, A Mencin, RF Schwabe
Journal of Molecular Medicine 2008
New role of plasminogen activator inhibitor-1 in alcohol-induced liver injury
GE Arteel
Journal of Gastroenterology and Hepatology 2008
Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice
J Hamzavi, S Ehnert, P Godoy, L Ciuclan, H Weng, PR Mertens, R Heuchel, S Dooley
Journal of Cellular and Molecular Medicine 2008
Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies
JT Li, ZX Liao, J Ping, D Xu, H Wang
Journal of Gastroenterology 2008
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
SL Friedman
Physiological reviews 2008
Cellular Sources of Extracellular Matrix in Hepatic Fibrosis
RG Wells
Clinics in Liver Disease 2008
Fibrogenesis of parenchymal organs
T Kisseleva, DA Brenner
Proceedings of the American Thoracic Society 2008
Accumulation of Hedgehog-Responsive Progenitors Parallels Alcoholic Liver Disease Severity in Mice and Humans
Y Jung, KD Brown, RP Witek, A Omenetti, L Yang, M Vandongen, RJ Milton, IN Hines, RA Rippe, L Spahr, L Rubbia–Brandt, AM Diehl
Gastroenterology 2008
Recent advances in the pathogenesis and diagnosis of liver fibrosis
NJ Török
Journal of Gastroenterology 2008
Homocysteine enhances cell proliferation in hepatic myofibroblastic stellate cells
CG Zou, SY Gao, YS Zhao, SD Li, XZ Cao, Y Zhang, KQ Zhang
Journal of Molecular Medicine 2008
Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
K Takeda, Y Kojima, K Ikejima, K Harada, S Yamashina, K Okumura, T Aoyama, S Frese, H Ikeda, NM Haynes, E Cretney, H Yagita, N Sueyoshi, N Sato, Y Nakanuma, MJ Smyth, K Okumura
Proceedings of the National Academy of Sciences 2008
Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
C Henegar, J Tordjman, V Achard, D Lacasa, I Cremer, M Guerre-Millo, C Poitou, A Basdevant, V Stich, N Viguerie, D Langin, P Bedossa, JD Zucker, K Clement
Genome biology 2008
Immune Interactions in Hepatic Fibrosis
AP Holt, M Salmon, CD Buckley, DH Adams
Clinics in Liver Disease 2008
Experimental obstructive cholestasis: the wound-like inflammatory liver response
MA Aller, JL Arias, J García-Domínguez, JI Arias, M Durán, J Arias
Fibrogenesis & Tissue Repair 2008
Innate immunity and alcoholic liver fibrosis
WI Jeong, B Gao
Journal of Gastroenterology and Hepatology 2008
Liver cirrhosis
D Schuppan, NH Afdhal
Lancet 2008
Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis
WI Jeong, O Park, B Gao
Gastroenterology 2008
Nuclear Cathepsin F Regulates Activation Markers in Rat Hepatic Stellate Cells
G Maubach, MC Lim, L Zhuo, WP Tansey
Molecular biology of the cell 2008
Specific siRNA Targeting the Receptor for Advanced Glycation End Products Inhibits Experimental Hepatic Fibrosis in Rats
Xia JR, Liu NF, Zhu NX
International journal of molecular sciences 2008
Activation of peroxisome proliferator-activated receptor-γ by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells
J Lin, A Chen
Laboratory Investigation 2008
New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis
S Sagmeister, M Eisenbauer, C Pirker, T Mohr, K Holzmann, H Zwickl, C Bichler, D Kandioler, F Wrba, W Mikulits, C Gerner, M Shehata, O Majdic, B Streubel, W Berger, M Micksche, K Zatloukal, R Schulte-Hermann, B Grasl-Kraupp
British Journal of Cancer 2008
PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling
Y Liu, EL Lui, SL Friedman, L Li, T Ye, Y Chen, RT Poon, J Wo, TW Kok, ST Fan
Laboratory Investigation 2008
A red wine polyphenolic extract reduces the activation phenotype of cultured human liver myofibroblasts
V Neaud, J Rosenbaum
World journal of gastroenterology : WJG 2008
Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species
DA Langer, A Das, D Semela, N Kang-Decker, H Hendrickson, SF Bronk, ZS Katusic, GJ Gores, VH Shah
Hepatology 2008
Oxidized low-density-lipoprotein accumulation is associated with liver fibrosis in experimental cholestasis
G Karadeniz, S Acikgoz, IO Tekin, O Tascýlar, BD Gun, M Cömert
Clinics (São Paulo, Brazil) 2008
Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
JR Larrubia, S Benito-Martínez, M Calvino, E Sanz-de-Villalobos, T Parra-Cid
World journal of gastroenterology : WJG 2008
Recognition of Genetic Factors Influencing the Progression of Hepatitis C: Potential for Personalized Therapy
JR Jonsson, DM Purdie, AD Clouston, EE Powell
Molecular diagnosis & therapy 2008
TGF-beta and mesenchymal hepatic involvement after visceral leishmaniasis
MI Duarte, , CF Takamura, A Sesso, FF Tuon
Parasitology Research 2008
Effects of silymarin and pentoxifylline on matrix metalloproteinase-1 and -2 expression and apoptosis in experimental hepatic fibrosis.
Kara E, Coşkun T, Kaya Y, Yumuş O, Vatansever S, Var A
Current Therapeutic Research 2008
Inhibition of Integrin Alphavbeta6 on Cholangiocytes Blocks Tgfbeta Activation and Retards Biliary Fibrosis Progression
Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D
Gastroenterology 2008
Nonalcoholic fatty liver disease: diagnosis and relation to metabolic syndrome and approach to treatment.
Lidofsky SD
Current Diabetes Reports 2008
Senescence of activated stellate cells limits liver fibrosis
Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW
Cell 2008
Chronic Intermittent Hypoxia and Acetaminophen Induce Synergistic Liver Injury
Savransky V, Reinke C, Jun J, Bevans-Fonti S, Nanayakkara A, Li J, Myers AC, Torbenson MS, Polotsky VY
Experimental Physiology 2008
Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients
Vilas-Boas WW, Jr AR, da Cunha Ribeiro R, Vieira RL, Almeida J, Nadu AP, Silva AC, Santos RA
World journal of gastroenterology : WJG 2008
Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni
Oliveira SA, Souza BS, Guimarães-Ferreira CA, Barreto ES, Souza SC, Freitas LA, Ribeiro-dos-Santos R, Soares MB
World journal of gastroenterology : WJG 2008
Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis
Leung TM, Tipoe GL, Liong EC, Lau TY, Fung ML, Nanji AA
International Journal of Experimental Pathology 2008
TNFα is required for cholestasis-induced liver fibrosis in the mouse
Gäbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schölmerich J, Brenner DA, Thurman RG, Rippe RA
Biochemical and Biophysical Research Communications 2008
Involvement of hepatic stimulator substance in experimentally induced fibrosis and cirrhosis in the rat.
Gribilas G, Zarros A, Zira A, Giaginis C, Tsourouflis G, Liapi C, Spiliopoulou C, Theocharis SE
Digestive Diseases and Sciences 2008
Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats.
Lee HS, Jung KH, Park IS, Kwon SW, Lee DH, Hong SS
Digestive Diseases and Sciences 2008
Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor.
Bruck R, Weiss S, Aeed H, Pines M, Halpern Z, Zvibel I
Digestive Diseases and Sciences 2008
Models of Liver Fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
J. P. Iredale
Journal of Clinical Investigation 2007
Common and Unique Mechanisms Regulate Fibrosis in Various Fibroproliferative Diseases
Thomas A. Wynn
Journal of Clinical Investigation 2007
NOX in liver fibrosis
SD Minicis, DA Brenner
Archives of Biochemistry and Biophysics 2007
Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?
DC Radisky, PA Kenny, MJ Bissell
Journal of Cellular Biochemistry 2007
Bioconjugation of Oligonucleotides for Treating Liver Fibrosis
Z Ye, HS Houssein, RI Mahato
Oligonucleotides 2007
The Effect of Ras Inhibition on the Proliferation, Apoptosis and Matrix Metalloproteases Activity in Rat Hepatic Stellate Cells
I Zvibel, D Bar-Zohar, Y Kloog, R Oren, S Reif
Digestive Diseases and Sciences 2007
The Myofibroblast
B Hinz, SH Phan, VJ Thannickal, A Galli, ML Bochaton-Piallat, G Gabbiani
The American Journal of Pathology 2007
Inflammation and Repair in Viral Hepatitis C
MG Neuman, K Sha, R Esguerra, S Zakhari, RE Winkler, N Hilzenrat, J Wyse, CL Cooper, D Seth, MD Gorrell, PS Haber, GW McCaughan, MA Leo, CS Lieber, M Voiculescu, E Buzatu, C Ionescu, J Dudas, B Saile, G Ramadori
Digestive Diseases and Sciences 2007
Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options
OA Gressner, R Weiskirchen, AM Gressner
Comparative hepatology 2007
Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality
OA Gressner, R Weiskirchen, AM Gressner
Journal of Cellular and Molecular Medicine 2007
A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis
P Fickert, U Stöger, A Fuchsbichler, T Moustafa, HU Marschall, AH Weiglein, O Tsybrovskyy, H Jaeschke, K Zatloukal, H Denk, M Trauner
The American Journal of Pathology 2007
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets
Gressner AM, Weiskirchen R
Journal of Cellular and Molecular Medicine 2007
Treatment of fibrosis in nonalcoholic fatty liver disease.
Hoteit MA, Anania FA
Current Gastroenterology Reports 2007
Different profiles of Ca2+responses to endothelin-1 and PDGF in liver myofibroblasts during the process of cell differentiation
N Kojima, M Hori, T Murata, Y Morizane, H Ozaki
British Journal of Pharmacology 2007
A ribosomal S-6 kinase-mediated signal to C/EBP-beta is critical for the development of liver fibrosis
M Buck, M Chojkier
PloS one 2007
Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells
E Novo, S Cannito, E Zamara, LV di Bonzo, A Caligiuri, C Cravanzola, A Compagnone, S Colombatto, F Marra, M Pinzani, M Parola
The American Journal of Pathology 2007
Bone Morphogenetic Protein 7 is Elevated in Patients with Chronic Liver Disease and Exerts Fibrogenic Effects on Human Hepatic Stellate Cells
F Tacke, E Gäbele, F Bataille, RF Schwabe, C Hellerbrand, F Klebl, RH Straub, T Luedde, MP Manns, C Trautwein, DA Brenner, J Schölmerich, B Schnabl
Digestive Diseases and Sciences 2007
Simple Tests to Predict Hepatic Fibrosis in Nonalcoholic Chronic Liver Diseases
Shin WG, Park SH, Jun SY, Jung JO, Moon JH, Kim JP, Kim KO, Park CH, Hahn TH, Yoo KS, Kim JH, Park CK
Gut and Liver 2007
Gene Modulation for Treating Liver Fibrosis
Cheng K, Mahato RI
Critical reviews in therapeutic drug carrier systems 2007
Adeno-associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice
Suzumura K, Hirano T, Son G, Iimuro Y, Mizukami H, Ozawa K, Fujimoto J
Hepatology International 2007
Sonic Hedgehog Is An Autocrine Viability Factor for Myofibroblastic Hepatic Stellate Cells
Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick JK, Li YX, Diehl AM
Journal of Hepatology 2007
Cholangiocytes with Mesenchymal Features Contribute to Progressive Hepatic Fibrosis of the Polycystic Kidney Rat
Sato Y, Harada K, Ozaki S, Furubo S, Kizawa K, Sanzen T, Yasoshima M, Ikeda H, Sasaki M, Nakanuma Y
The American Journal of Pathology 2007
Tumor Necrosis Factor-α 308.2 Polymorphism Is Associated with Advanced Hepatic Fibrosis and Higher Risk for Hepatocellular Carcinoma
Jen-Eing J, Jung-Fa T, Lee-Yea C, Mei-Shang H, Zu-Yau L, Min-Yuh H, Shin-Chern C, Wan-Lung C, Liang-Yen W, Ming-Lung Y, Chia-Yen D, Jan-Gowth C
Neoplasia (New York, N.Y.) 2007
Pathophysiological characteristics of dimethylnitrosamine-induced liver fibrosis in acute and chronic injury models: a possible contribution of KLF5 to fibrogenic responses.
Ohara F, Nii A, Sakiyama Y, Tsuchiya M, Ogawa S
Digestive Diseases and Sciences 2007
Immunological response in alcoholic liver disease.
Duryee MJ, Klassen LW, Thiele GM
World Journal of Gastroenterology 2007
Role of iron in hepatic fibrosis: one piece in the puzzle.
Philippe MA, Ruddell RG, Ramm GA
World Journal of Gastroenterology 2007
Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule.
March S, Graupera M, Rosa Sarrias M, Lozano F, Pizcueta P, Bosch J, Engel P
The American Journal of Pathology 2007
Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia
R Khan, R Sheppard
Immunology 2006
Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice
A Lugea, L Nan, SW French, JA Bezerra, AS Gukovskaya, SJ Pandol
Gastroenterology 2006
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells
LM McAllister-Lucas, J Ruland, K Siu, X Jin, S Gu, DS Kim, P Kuffa, D Kohrt, TW Mak, G Nuñez, PC Lucas
Proceedings of the National Academy of Sciences 2006
Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein
P Sanz-Cameno, S Martín-Vílchez, E Lara-Pezzi, MJ Borque, J Salmerón, PM de Rueda, JA Solís, M López-Cabrera, R Moreno-Otero
The American Journal of Pathology 2006
Involvement of PPAR nuclear receptors in tissue injury and wound repair
L Michalik, W Wahli
Journal of Clinical Investigation 2006
Resistin as an Intrahepatic Cytokine
C Bertolani, P Sancho-Bru, P Failli, R Bataller, S Aleffi, R DeFranco, B Mazzinghi, P Romagnani, S Milani, P Ginés, J Colmenero, M Parola, S Gelmini, R Tarquini, G Laffi, M Pinzani, F Marra
The American Journal of Pathology 2006
Galectin-3 regulates myofibroblast activation and hepatic fibrosis
NC Henderson, AC Mackinnon, SL Farnworth, F Poirier, FP Russo, JP Iredale, C Haslett, KJ Simpson, T Sethi
Proceedings of the National Academy of Sciences 2006
Molecular therapy for hepatic injury and fibrosis: Where are we?
Prosser CC, Yen RD, Wu J
World journal of gastroenterology : WJG 2006
A Role for Serotonin (5-HT) in Hepatic Stellate Cell Function and Liver Fibrosis
RG Ruddell, F Oakley, Z Hussain, I Yeung, LJ Bryan-Lluka, GA Ramm, DA Mann
The American Journal of Pathology 2006
Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans
E Novo, F Marra, E Zamara, LV di Bonzo, L Monitillo, S Cannito, I Petrai, A Mazzocca, A Bonacchi, RS de Franco, S Colombatto, R Autelli, M Pinzani, M Parola
Gut 2006
Human hepatic stellate cells are resistant to apoptosis: implications for human fibrogenic liver disease
N Kawada
Gut 2006
Effect of Chinese medicine Qinggan Huoxuefang on inducing HSC apoptosis in alcoholic liver fibrosis rats
G Ji, L Wang, SH Zhang, JW Liu, PY Zheng, T Liu
World journal of gastroenterology : WJG 2006
Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats
Lin WC, Kuo SC, Lin WL, Fang HL, Wang BC
World journal of gastroenterology : WJG 2006
Assessment of liver fibrosis by a noninvasive method of transient elastography and biochemical markers
Kawamoto M, Mizuguchi T, Katsuramaki T, Nagayama M, Oshima H, Kawasaki H, Nobuoka T, Kimura Y, Hirata K
World journal of gastroenterology : WJG 2006
Gene expression profiling defined pathways correlated with fibroblast cell proliferation induced by Opisthorchis viverrini excretory/secretory product
Thuwajit C, Thuwajit P, Uchida K, Daorueang D, Kaewkes S, Wongkham S, Miwa M
World journal of gastroenterology : WJG 2006
Effect of interferon alpha and ribavirin treatment on serum levels of transforming growth factor-β1, vascular endothelial growth factor, and basic fibroblast growth factor in patients with chronic hepatitis C
Janczewska-Kazek E, Marek B, Kajdaniuk D, Borgiel-Marek H
World journal of gastroenterology : WJG 2006
GFAP promoter directs lacZ expression specifically in a rat hepatic stellate cell line
Maubach G, Lim MC, Zhang CY, Zhuo L
World journal of gastroenterology : WJG 2006
Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale).
Mei N, Guo L, Zhang L, Shi L, Sun YA, Fung C, Moland CL, Dial SL, Fuscoe JC, Chen T
BMC bioinformatics 2006
Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver.
Ijzer J, Roskams T, Molenbeek RF, Ultee T, Penning LC, Rothuizen J, van den Ingh TS
Comparative hepatology 2006
PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
Zhao C, Chen W, Yang L, Chen L, Stimpson SA, Diehl AM
Biochemical and Biophysical Research Communications 2006
Thiazolidinediones and hepatic fibrosis: don't wait too long.
Marra F
Gut 2006
The vignette for V13N3 issue
Lai MM
Journal of biomedical science 2006
Somatostatin at nanomolar concentration reduces collagen I and III synthesis by, but not proliferation of activated rat hepatic stellate cells
H Reynaert, K Rombouts, Y Jia, D Urbain, N Chatterjee, N Uyama, A Geerts
British Journal of Pharmacology 2005
Transforming Growth Factor-β1 Upregulates Transcription of α3 Integrin Gene in Hepatocellular Carcinoma Cells Via Ets-transcription Factor-binding Motif in the Promoter Region
K Katabami, H Mizuno, R Sano, Y Saito, M Ogura, S Itoh, T Tsuji
Clinical & Experimental Metastasis 2005

← Previous 1 2 … 78 79 80 … 88 89 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 20 news outlets
Blogged by 5
Referenced in 1 policy sources
Posted by 7 X users
Referenced in 31 patents
On 2 Facebook pages
Referenced in 1 Wikipedia pages
Referenced in 2 clinical guideline sources
1396 readers on Mendeley
6 readers on CiteULike
See more details