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Citations to this article

Liver fibrosis
Ramón Bataller, David A. Brenner
Ramón Bataller, David A. Brenner
Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):209-218. https://doi.org/10.1172/JCI24282.
View: Text | PDF | Corrigendum
Science in Medicine Article has an altmetric score of 213

Liver fibrosis

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Abstract

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Our knowledge of the cellular and molecular mechanisms of liver fibrosis has greatly advanced. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-β1, angiotensin II, and leptin. Reversibility of advanced liver fibrosis in patients has been recently documented, which has stimulated researchers to develop antifibrotic drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans is unknown. This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current antifibrotic strategies.

Authors

Ramón Bataller, David A. Brenner

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 65 147 153 179 178 149 133 138 131 150 152 119 102 102 88 73 53 44 27 22 2 2207
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2009 (53)

Title and authors Publication Year
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In liver fibrosis, dendritic cells govern hepatic inflammation by acquiring enhanced capacity to engage innate and adaptive immunity via TNF-alpha
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WK Syn, Y Jung, A Omenetti, M Abdelmalek, CD Guy, L Yang, J Wang, RP Witek, CM Fearing, TA Pereira, V Teaberry, SS Choi, J Conde-Vancells, GF Karaca, AM Diehl
Gastroenterology 2009
Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney
Z Péterfi, A Donkó, A Orient, A Sum, A Prókai, B Molnár, Z Veréb, E Rajnavölgyi, KJ Kovács, V Müller, AJ Szabó, M Geiszt
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Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential
A Moles, N Tarrats, JC Fernández-Checa, M Marí
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HE Wasmuth, F Lammert, MM Zaldivar, R Weiskirchen, C Hellerbrand, D Scholten, ML Berres, H Zimmermann, KL Streetz, F Tacke, S Hillebrandt, P Schmitz, H Keppeler, T Berg, E Dahl, N Gassler, SL Friedman, C Trautwein
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Role of the receptor for advanced glycation end products in hepatic fibrosis
C Lohwasser, D Neureiter, Y Popov, M Bauer, D Schuppan
World journal of gastroenterology : WJG 2009
Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
S Inokuchi, T Aoyama, K Miura, CH Osterreicher, Y Kodama, K Miyai, S Akira, DA Brenner, E Seki
Proceedings of the National Academy of Sciences 2009
Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
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CCR2 promotes hepatic fibrosis in mice
E Seki, S Minicis, S Inokuchi, K Taura, K Miyai, N Rooijen, RF Schwabe, DA Brenner
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Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice
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Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis
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Hepatology 2009
Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice
C Mitchell, D Couton, JP Couty, M Anson, AM Crain, V Bizet, L Rénia, S Pol, V Mallet, H Gilgenkrantz
The American Journal of Pathology 2009
Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1
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O Park, WI Jeong, L Wang, H Wang, ZX Lian, ME Gershwin, B Gao
Hepatology 2009
Hepatic wound repair
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Hepatic Stellate Cell-Specific Gene Silencing Induced by an Artificial MicroRNA for Antifibrosis In Vitro
Y Chang, H Jiang, X Sun, X Cai, X He, P Li, W Tang, Y Song, J Lin
Digestive Diseases and Sciences 2009
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F Joanna, V Mathieu, S Sarah, D Sarah, V Karin, V Tamara, R Vera
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Role of host genetics in fibrosis
GL Hold, P Untiveros, KA Saunders, EM El-Omar
Fibrogenesis & Tissue Repair 2009
Insulin-like growth factor binding protein-7 induces activation and transdifferentiation of hepatic stellate cells in vitro
LX Liu, S Huang, QQ Zhang, Y Liu, DM Zhang, XH Guo, DW Han
World journal of gastroenterology : WJG 2009
Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells
A Gentilini, B Lottini, M Brogi, A Caligiuri, L Cosmi, F Marra, M Pinzani
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Alterations of Bone Marrow Sinusoidal Endothelium in Rat and Patients with Liver Cirrhosis
S Zhao, YM Fu, XF Li, ZF Jin, RB Zhao, Q Huang, FM Zhang, WH Zhang
Digestive Diseases and Sciences 2009
Kupffer cells mediate leptin-induced liver fibrosis
J Wang, I Leclercq, JM Brymora, N Xu, M Ramezani-Moghadam, RM London, D Brigstock, J George
Gastroenterology 2009
Renin-angiotensin system in the pathogenesis of liver fibrosis
RM Pereira, RA Santos, FL da Dias, MM Teixeira, AC Silva
World journal of gastroenterology : WJG 2009
Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis
HK Kim, TH Yang, HY Cho
World journal of gastroenterology : WJG 2009
Retinoic Acid-mediated Nuclear Receptor Activation and Hepatocyte Proliferation
N Bushue, YJ Wan
Journal of Experimental & Clinical Medicine 2009
Molecular mechanisms underlying hepatocellular carcinoma.
Merle P, Trepo C
Viruses 2009
Chinese medicinal herbs in treating model rats with hepatic fibrosis.
Zhou YX, Chen J, Li JP, Wang YL, Jin XD
African journal of traditional, complementary, and alternative medicines : AJTCAM 2009
Implications of Cellular Senescence in Tissue Damage Response, Tumor Suppression, and Stem Cell Biology
Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW
Cold Spring Harbor Symposia on Quantitative Biology 2009
Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection
Yonghong L, Chang M, Abar O, Garcia V, Rowland C, Catanese J, Ross D, Broder S, Shiffman M, Cheung R, Wright T, Friedman SL, Sninsky J
Journal of Hepatology 2009
CD38-mediated Ca2+ Signaling Contributes to Angiotensin II-induced Activation of Hepatic Stellate Cells: ATTENUATION OF HEPATIC FIBROSIS BY CD38 ABLATION
Kim SY, Cho BH, Kim UH
The Journal of biological chemistry 2009
Emerging role of microRNAs in liver diseases
Bala S, Marcos M, Szabo G
World journal of gastroenterology : WJG 2009
Involvement of Sphingosine 1-Phosphate (SIP)/S1P3 Signaling in Cholestasis-Induced Liver Fibrosis
Li C, Jiang X, Yang L, Liu X, Yue S, Li L
The American Journal of Pathology 2009
TGF-β1 Gene Silencing for Treating Liver Fibrosis
Cheng K, Yang N, Mahato RI
Molecular Pharmaceutics 2009
Effect of Fuzheng Huayu formula and its actions against liver fibrosis
Liu C, Hu Y, Xu L, Liu C, Liu P
Chinese medicine 2009
Liver and spleen volume variations in patients with hepatic fibrosis
Liu P, Li P, He W, Zhao LQ
World journal of gastroenterology : WJG 2009
Novel Serum Markers of Fibrosis Progression for the Follow-Up of Hepatitis C Virus-Infected Patients
Caillot F, Hiron M, Goria O, Gueudin M, Francois A, Scotte M, Daveau M, Salier JP
The American Journal of Pathology 2009
Insoluble, Speckled Cytosolic Distribution of Retinoic Acid Receptor Alpha Protein as a Marker of Hepatic Stellate Cell Activation In Vitro
Mezaki Y, Yamaguchi N, Yoshikawa K, Miura M, Imai K, Itoh H, Senoo H
Journal of Histochemistry & Cytochemistry 2009
Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different species
Mousavi SA, Fønhus MS, Berg T
BMC cell biology 2009
Relationship between angiotensin-(1-7) and angiotensin II correlates with hemodynamic changes in human liver cirrhosis
Vilas-Boas WW, Ribeiro-Oliveira Jr A, Pereira RM, da Cunha Ribeiro R, Almeida J, Nadu AP, Simões e Silva AC, dos Santos RA
World journal of gastroenterology : WJG 2009
Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis
Georgescu EF, Ionescu R, Niculescu M, Mogoanta L, Vancica L
World journal of gastroenterology : WJG 2009
HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice
Joyce MA, Walters KA, Lamb SE, Yeh MM, Zhu LF, Kneteman N, Doyle JS, Katze MG, Tyrrell DL
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TNF-α plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease
Rimkunas VM, Graham MJ, Crooke RM, Liscum L
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Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro.
Sun X, Zhang XD, Cheng G, Hu YH, Wang HY
Molecular and Cellular Biochemistry 2009
Natural killer cell receptors and their ligands in liver diseases.
Yamagiwa S, Kamimura H, Ichida T
Medical Molecular Morphology 2009
Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis.
Karantonis HC, Gribilas G, Stamoulis I, Giaginis C, Spiliopoulou C, Kouraklis G, Demopoulos C, Theocharis SE
Digestive Diseases and Sciences 2009
The GABAB receptor inhibits activation of hepatic stellate cells.
Xiao F, Yu K, Dong F, Liang Y, Jun C, Wei H
Digestive Diseases and Sciences 2009
Effect of anluohuaxian tablet combined with gamma-IFN on schistosomal liver fibrosis.
Huang J, Huang H, Jiao Y, Ai G, Huang T, Li L, Yu H, Ma K, Xiao F
2009
Reversal of liver fibrosis.
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Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 2009
Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma
Amann T, Bataille F, Spruss T, Mühlbauer M, Gäbele E, Schölmerich J, Kiefer P, Bosserhoff A, Hellerbrand C
Cancer Science 2009

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