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Citations to this article

Liver fibrosis
Ramón Bataller, David A. Brenner
Ramón Bataller, David A. Brenner
Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):209-218. https://doi.org/10.1172/JCI24282.
View: Text | PDF | Corrigendum
Science in Medicine Article has an altmetric score of 213

Liver fibrosis

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Abstract

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Our knowledge of the cellular and molecular mechanisms of liver fibrosis has greatly advanced. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-β1, angiotensin II, and leptin. Reversibility of advanced liver fibrosis in patients has been recently documented, which has stimulated researchers to develop antifibrotic drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans is unknown. This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current antifibrotic strategies.

Authors

Ramón Bataller, David A. Brenner

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 65 147 153 179 178 149 133 138 131 150 152 119 102 102 88 73 53 44 27 22 2 2207
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The American journal of tropical medicine and hygiene 2016
Personalized Clinical Trials in Hepatocellular Carcinoma Based on Biomarker Selection.
Zhang B, Finn RS
Liver Cancer 2016
Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway.
Chen J, Pan J, Wang J, Song K, Zhu D, Huang C, Duan Y
Scientific Reports 2016
Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.
Khamphaya T, Chansela P, Piyachaturawat P, Suksamrarn A, Nathanson MH, Weerachayaphorn J
European Journal of Pharmacology 2016
Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway.
Chen J, Xu T, Zhu D, Wang J, Huang C, Lyu L, Hu B, Sun W, Duan Y
Cell Death and Disease 2016
Task-based optimization of flip angle for fibrosis detection in T1-weighted MRI of liver.
Brand JF, Furenlid LR, Altbach MI, Galons JP, Bhattacharyya A, Sharma P, Bhattacharyya T, Bilgin A, Martin DR
2016
Spatially patterned matrix elasticity directs stem cell fate.
Yang C, DelRio FW, Ma H, Killaars AR, Basta LP, Kyburz KA, Anseth KS
Proceedings of the National Academy of Sciences 2016
ω-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation.
Zhang K, Chang Y, Shi Z, Han X, Han Y, Yao Q, Hu Z, Cui H, Zheng L, Han T, Hong W
Scientific Reports 2016
Changes in Hepatic Venous Pressure Gradient Induced by Physical Exercise in Cirrhosis: Results of a Pilot Randomized Open Clinical Trial.
Macías-Rodríguez RU, Ilarraza-Lomelí H, Ruiz-Margáin A, Ponce-de-León-Rosales S, Vargas-Vorácková F, García-Flores O, Torre A, Duarte-Rojo A
Clinical and Translational Gastroenterology 2016
Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs.
Tian XF, Ji FJ, Zang HL, Cao H
PloS one 2016
Anti-fibro-hepatocarcinogenic Chinese herbal medicines: A mechanistic overview.
Boye A, Yang Y, Asenso J, Wei W
Journal of Intercultural Ethnopharmacology 2016
Hepatitis C virus infection stimulates transforming growth factor-β1 expression through up-regulating miR-192.
Kim JH, Lee CH, Lee SW
The Journal of Microbiology 2016
Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis.
Wang X, Wu X, Zhang A, Wang S, Hu C, Chen W, Shen Y, Tan R, Sun Y, Xu Q
EBioMedicine 2016
Berberine Inhibition of Fibrogenesis in a Rat Model of Liver Fibrosis and in Hepatic Stellate Cells.
Wang N, Xu Q, Tan HY, Hong M, Li S, Yuen MF, Feng Y
Evidence-based complementary and alternative medicine : eCAM 2016
Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration.
Huang M, Xu J, Shin CH
Journal of visualized experiments : JoVE 2016
Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases.
Duval F, Cruz-Vega DE, González-Gamboa I, González-Garza MT, Ponz F, Sánchez F, Alarcón-Galván G, Moreno-Cuevas JE
Disease Markers 2016
Hydatid cyst fluid promotes peri-cystic fibrosis in cystic echinococcosis by suppressing miR-19 expression.
Zhang C, Wang L, Ali T, Li L, Bi X, Wang J, Lü G, Shao Y, Vuitton DA, Wen H, Lin R
Parasites & vectors 2016
Pathogenesis and Management of Alcoholic Liver Disease.
Farooq MO, Bataller R
Digestive diseases (Basel, Switzerland) 2016
Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease.
Ko BJ, Kim YS, Kim SG, Park JH, Lee SH, Jeong SW, Jang JY, Kim HS, Kim BS, Kim SM, Kim YD, Cheon GJ, Lee BR
Gut and Liver 2016
Modeling fibrosis using fibroblasts isolated from scarred rat vocal folds.
Kishimoto Y, Kishimoto AO, Ye S, Kendziorski C, Welham NV
Laboratory Investigation 2016
Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats.
Ishikawa M, Saito K, Yamada H, Nakatsu N, Maekawa K, Saito Y
Lipids in Health and Disease 2016
Hepatoprotective Effect of Wheat-Based Solid-State Fermented Antrodia cinnamomea in Carbon Tetrachloride-Induced Liver Injury in Rat.
Chiu HW, Hua KF
PloS one 2016
Inhibition of the translocation and extracellular release of high-mobility group box 1 alleviates liver damage in fibrotic mice in response to D-galactosamine/lipopolysaccharide challenge.
Bai L, Kong M, Zheng Q, Zhang X, Liu X, Zu K, Chen Y, Zheng S, Li J, Ren F, Lou J, Liu S, Duan Z
Molecular medicine reports 2016
Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution.
Baiocchini A, Montaldo C, Conigliaro A, Grimaldi A, Correani V, Mura F, Ciccosanti F, Rotiroti N, Brenna A, Montalbano M, D'Offizi G, Capobianchi MR, Alessandro R, Piacentini M, Schininà ME, Maras B, Del Nonno F, Tripodi M, Mancone C
PloS one 2016
New role and molecular mechanism of Gadd45a in hepatic fibrosis.
Hong L, Sun QF, Xu TY, Wu YH, Zhang H, Fu RQ, Cai FJ, Zhou QQ, Zhou K, Du QW, Zhang D, Xu S, Ding JG
World Journal of Gastroenterology 2016
Antioxidant, Liver Protective and Angiotensin I-converting Enzyme Inhibitory Activities of Old Laying Hen Hydrolysate in Crab Meat Analogue.
Jin SK, Choi JS, Choi YJ, Lee SJ, Lee SY, Hur SJ
Asian-Australasian Journal of Animal Sciences 2016
Microarray Study of Pathway Analysis Expression Profile Associated with MicroRNA-29a with Regard to Murine Cholestatic Liver Injuries.
Li SC, Wang FS, Yang YL, Tiao MM, Chuang JH, Huang YH
International journal of molecular sciences 2016
MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma.
Hayes CN, Chayama K
International journal of molecular sciences 2016
Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-β1.
Ge J, Chang N, Zhao Z, Tian L, Duan X, Yang L, Li L
Scientific Reports 2016
Visualizing Trimming Dependence of Biodistribution and Kinetics with Homo- and Heterogeneous N-Glycoclusters on Fluorescent Albumin.
Ogura A, Tahara T, Nozaki S, Morimoto K, Kizuka Y, Kitazume S, Hara M, Kojima S, Onoe H, Kurbangalieva A, Taniguchi N, Watanabe Y, Tanaka K
Scientific Reports 2016
Liver: DNA methylation controls liver fibrogenesis.
Liu X, Brenner DA
Nature reviews. Gastroenterology & hepatology 2016
High resolution Physio-chemical Tissue Analysis: Towards Non-invasive In Vivo Biopsy.
Xu G, Meng ZX, Lin JD, Deng CX, Carson PL, Fowlkes JB, Tao C, Liu X, Wang X
Scientific Reports 2016
Role of microRNAs in gastrointestinal smooth muscle fibrosis and dysfunction: novel molecular perspectives on the pathophysiology and therapeutic targeting.
Krishna CV, Singh J, Thangavel C, Rattan S
American journal of physiology. Gastrointestinal and liver physiology 2016
Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.
Stasi C, Milani S
World Journal of Gastroenterology 2016
Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators.
Algandaby MM, El-Halawany AM, Abdallah HM, Alahdal AM, Nagy AA, Ashour OM, Abdel-Naim AB
Naunyn-Schmiedeberg's Archives of Pharmacology 2016
Analytic Strategies to Evaluate the Association of Time-Varying Exposures to HIV-Related Outcomes: Alcohol Consumption as an Example
Cook RL, Kelso NE, Brumback BA, Chen X
Current HIV research 2016
Fibrosis assessment: impact on current management of chronic liver disease and application of quantitative invasive tools.
Wang Y, Hou JL
Hepatology International 2016

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