Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Liver fibrosis
Ramón Bataller, David A. Brenner
Ramón Bataller, David A. Brenner
Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):209-218. https://doi.org/10.1172/JCI24282.
View: Text | PDF | Corrigendum
Science in Medicine Article has an altmetric score of 213

Liver fibrosis

  • Text
  • PDF
Abstract

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Our knowledge of the cellular and molecular mechanisms of liver fibrosis has greatly advanced. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-β1, angiotensin II, and leptin. Reversibility of advanced liver fibrosis in patients has been recently documented, which has stimulated researchers to develop antifibrotic drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans is unknown. This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current antifibrotic strategies.

Authors

Ramón Bataller, David A. Brenner

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 65 147 153 179 178 149 133 138 131 150 152 119 102 102 88 73 53 44 27 22 2 2207
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2015 (152)

Title and authors Publication Year
STK4 regulates TLR-mediated inflammatory responses and alleviates chronic inflammation-related HCC
Weiyun Li, Jun Xiao, Xin Zhou, Ming Xu, Chaobo Hu, Xiaoyan Xu, Yao Lu, Chang Liu, Shengjie Xue, Lei Nie, Haibin Zhang, Zhiqi Li, Yanbo Zhang, Fu Ji, Lijian hui, Wufan Tao, Bin Wei, Hongyan Wang
Journal of Clinical Investigation 2015
Secreted Protein Acidic and Rich in Cysteine in Ocular Tissue
K Scavelli, A Chatterjee, DJ Rhee
Journal of Ocular Pharmacology and Therapeutics 2015
Proteomic Analysis of Mice Fed Methionine and Choline Deficient Diet Reveals Marker Proteins Associated with Steatohepatitis
SJ Lee, JH Kang, W Iqbal, OS Kwon, R Aldabe
PloS one 2015
Reciprocal regulation of TGF-β and reactive oxygen species: a perverse cycle for fibrosis
RM Liu, LP Desai
Redox Biology 2015
Novel therapeutic targets in primary biliary cirrhosis
JK Dyson, GM Hirschfield, DH Adams, U Beuers, DA Mann, KD Lindor, DE Jones
Nature Reviews Gastroenterology & Hepatology 2015
The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases
PJ Wermuth, SA Jimenez
Clinical and Translational Medicine 2015
The Protective Effect of Bee Venom on Fibrosis Causing Inflammatory Diseases
WR Lee, S Pak, KK Park
Toxins 2015
A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty
D Dixon, J Coates, AC Pons, J Horabin, A Walker, N Abdul, NS Kalson, NT Brewster, DJ Weir, DJ Deehan, DA Mann, LA Borthwick
Scientific Reports 2015
SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis
A Uchinaka, Y Hamada, S Mori, S Miyagawa, A Saito, Y Sawa, N Matsuura, H Yamamoto, N Kawaguchi
Molecular and Cellular Biochemistry 2015
Mesenchymal stem cell therapy for liver fibrosis
YW Eom, KY Shim, SK Baik
The Korean Journal of Internal Medicine 2015
Use of mesenchymal stem cells to treat liver fibrosis: Current situation and future prospects
Silvia Berardis, Prenali Dwisthi Sattwika, Mustapha Najimi, Etienne Marc Sokal
World Journal of Gastroenterology 2015
Signal Transducer and Activator of Transcription 4 in Liver Diseases
Yan Wang, Aijuan Qu, Hua Wang
International journal of biological sciences 2015
Hepatic stellate cells: central modulators of hepatic carcinogenesis
AI Thompson, KP Conroy, NC Henderson
BMC Gastroenterology 2015
A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver
SF Zhou, W Li, F Shi, ZW Zhou, B Li, K Zhang, X Zhang, C Ouyang, X Zhu
Drug design, development and therapy 2015
Bone marrow-derived fibrocytes contribute to liver fibrosis
J Xu, T Kisseleva
Experimental biology and medicine (Maywood, N.J.) 2015
Bone marrow-derived fibrocytes contribute to liver fibrosis
J Xu, T Kisseleva
Experimental biology and medicine (Maywood, N.J.) 2015
GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance
N Nishio, K Isobe
Scientific Reports 2015
Recent advances in the pathogenesis and management of biliary atresia:
JA Zagory, MV Nguyen, KS Wang
Current Opinion in Pediatrics 2015
Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response
F Duval, JE Moreno-Cuevas, MT González-Garza, C Maldonado-Bernal, DE Cruz-Vega
International Journal of Inflammation 2015
How Inflammation Impinges on NAFLD: A Role for Kupffer Cells
N Duarte, IC Coelho, RS Patarrão, JI Almeida, C Penha-Gonçalves, MP Macedo
BioMed Research International 2015
Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
Y Osawa, K Oboki, J Imamura, E Kojika, Y Hayashi, T Hishima, T Saibara, F Shibasaki, M Kohara, K Kimura
EBioMedicine 2015
TNFα in Liver Fibrosis
YM Yang, E Seki
Current Pathobiology Reports 2015
Reversibility of liver fibrosis
M Sun, T Kisseleva
Clinics and Research in Hepatology and Gastroenterology 2015
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis
MA Karsdal, T Manon-Jensen, F Genovese, JH Kristensen, MJ Nielsen, JM Sand, NU Hansen, AC Bay-Jensen, CL Bager, A Krag, A Blanchard, H Krarup, DJ Leeming, D Schuppan
AJP Gastrointestinal and Liver Physiology 2015
Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?
K Song, Q Li, XY Yin, Y Lu, CF Liu, LF Hu
Oxidative medicine and cellular longevity 2015
Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family
E Sziksz, D Pap, R Lippai, NJ Béres, A Fekete, AJ Szabó, Á Vannay
Mediators of Inflammation 2015
Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis
S Amara, K Lopez, B Banan, SK Brown, M Whalen, E Myles, MT Ivy, T Johnson, KL Schey, V Tiriveedhi
Molecular Immunology 2015
Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice
TR Harris, A Bettaieb, S Kodani, H Dong, R Myers, N Chiamvimonvat, FG Haj, BD Hammock
Toxicology and Applied Pharmacology 2015
Quantification of liver fibrosis via second harmonic imaging of the Glisson's capsule from liver surface
S Xu, CH Kang, X Gou, Q Peng, J Yan, S Zhuo, CL Cheng, Y He, Y Kang, W Xia, PT So, R Welsch, JC Rajapakse, H Yu
Journal of Biophotonics 2015
Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS
MJ Nielsen, J Lehmann, DJ Leeming, R Schierwagen, S Klein, C Jansen, CP Strassburg, F Bendtsen, S Møller, T Sauerbruch, MA Karsdal, A Krag, J Trebicka
Digestive Diseases and Sciences 2015
Study on the Antifibrotic Effects of Recombinant Shark Hepatical Stimulator Analogue (r-sHSA) in Vitro and in Vivo
Y Wang, X Zhang, Y Yang, X Yang, B Ye
Marine drugs 2015
The Effector Protein BPE005 from Brucella abortus Induces Collagen Deposition and Matrix Metalloproteinase 9 Downmodulation via Transforming Growth Factor β1 in Hepatic Stellate Cells
PC Benitez, DR Serantes, CK Herrmann, AI Viglietti, S Vanzulli, GH Giambartolomei, DJ Comerci, MV Delpino, VB Young
Infection and immunity 2015
Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration
MJ Radeke, CM Radeke, YH Shih, J Hu, D Bok, LV Johnson, PJ Coffey
Genome Medicine 2015
Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in Renal and Hepatic Fibrosis
A Tennakoon, T Izawa, M Kuwamura, J Yamate
Journal of Clinical Medicine 2015
Caring for children with NAFLD and navigating their care into adulthood
AA Mencin, R Loomba, JE Lavine
Nature Reviews Gastroenterology & Hepatology 2015
Tumor necrosis factor-inducible gene 6 promotes liver regeneration in mice with acute liver injury
S Wang, JS Lee, J Hyun, J Kim, SU Kim, HJ Cha, Y Jung
Stem Cell Research & Therapy 2015
Correlation between Tgf-Β1 and Fsp-1 Expression in Chronic Viral Hepatitis - an Immunohistochemical Study
D E Tache, Ş G Firu, A M Andrei, A Predescu, Ş O Purcaru, A M Dobrescu, A Dricu, C G Pisoschi, E C Stănciulescu
Current Health Sciences Journal 2015
Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways
L Seifert, M Deutsch, S Alothman, D Alqunaibit, G Werba, M Pansari, M Pergamo, A Ochi, A Torres-Hernandez, E Levie, D Tippens, SH Greco, S Tiwari, NN Ly, A Eisenthal, E van Heerden, A Avanzi, R Barilla, CP Zambirinis, M Rendon, D Daley, HL Pachter, C Hajdu, G Miller
Cell Reports 2015
Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice
D Jia, F Duan, P Peng, L Sun, Y Ruan, J Gu, LA van Grunsven
PloS one 2015
Experimental models of liver fibrosis
SC Yanguas, B Cogliati, J Willebrords, M Maes, I Colle, B Bossche, CP de Oliveira, W Andraus, VA Alves, I Leclercq, M Vinken
Archives of Toxicology 2015
Hepatic myofibroblasts derived from Schistosoma mansoni-infected mice are a source of IL-5 and eotaxin: controls of eosinophil populations in vitro
LA Paiva, C Brand, C Bandeira-Melo, PT Bozza, MC El-Cheikh, PM Silva, R Borojevic, SA Perez
Parasites & vectors 2015
Contribution and Mobilization of Mesenchymal Stem Cells in a mouse model of carbon tetrachloride-induced liver fibrosis
Y Liu, X Yang, Y Jing, S Zhang, C Zong, J Jiang, K Sun, R Li, L Gao, X Zhao, D Wu, Y Shi, Z Han, L Wei
Scientific Reports 2015
The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease
P Almeda-Valdes, NE Olivos, B Barranco-Fragoso, M Uribe, N Méndez-Sánchez
BioMed Research International 2015
Potent natural products and herbal medicines for treating liver fibrosis
SR Chen, XP Chen, JJ Lu, Y Wang, YT Wang
Chinese medicine 2015
Exploring multiple quantitative trait loci models of hepatic fibrosis in a mouse intercross
RA Hall, S Hillebrandt, F Lammert
Mammalian Genome 2015
PDGFRα in Liver Pathophysiology: Emerging Roles in Development, Regeneration, Fibrosis, and Cancer
A Kikuchi, SP Monga
Gene expression 2015
EMT and tumor metastasis
S Heerboth, G Housman, M Leary, M Longacre, S Byler, K Lapinska, A Willbanks, S Sarkar
Clinical and Translational Medicine 2015
Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration
R Wang, Q Ding, U Yaqoob, TM de Assuncao, VK Verma, P Hirsova, S Cao, D Mukhopadhyay, RC Huebert, VH Shah
The Journal of biological chemistry 2015
EGFR Signaling in Liver Diseases
K Komposch, M Sibilia
International journal of molecular sciences 2015
Role of Noncoding RNAs as Biomarker and Therapeutic Targets for Liver Fibrosis
KY Teng, K Ghoshal
Gene expression 2015
An HNF1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells
H Qian, X Deng, ZW Huang, J Wei, CH Ding, RX Feng, X Zeng, YX Chen, J Ding, L Qiu, ZL Hu, X Zhang, HY Wang, JP Zhang, WF Xie
Cell Research 2015
MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells
M Nakamura, T Kanda, R Sasaki, Y Haga, X Jiang, S Wu, S Nakamoto, O Yokosuka, R Ray
PloS one 2015
Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation
T Lan, T Kisseleva, DA Brenner, MA Avila
PloS one 2015
Inhibition of IRF3 expression reduces TGF-β1-induced proliferation of hepatic stellate cells
M Ni, T Xu, Y Wang, Y He, Q Zhou, C Huang, X Meng, J Li
Journal of Physiology and Biochemistry 2015
Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation
C Bárcena, M Stefanovic, A Tutusaus, L Joannas, A Menéndez, C García-Ruiz, P Sancho-Bru, M Marí, J Caballeria, CV Rothlin, JC Fernández-Checa, PG de Frutos, A Morales
Journal of Hepatology 2015
Enhanced Effects of Novel Oridonin Analog CYD0682 for Hepatic Fibrosis
FJ Bohanon, X Wang, BM Graham, C Ding, Y Ding, C Rastellini, J Zhou, RS Radhakrishnan
Journal of Surgical Research 2015
Ethyl acetate fraction of Amomum xanthioides improves bile duct ligation-induced liver fibrosis of rat model via modulation of pro-fibrogenic cytokines
HG Kim, JM Han, JS Lee, JS Lee, CG Son
Scientific Reports 2015
Alleviation of Carbon-Tetrachloride-Induced Liver Injury and Fibrosis by Betaine Supplementation in Chickens
MT Tsai, CY Chen, YH Pan, SH Wang, HJ Mersmann, ST Ding
Evidence-Based Complementary and Alternative Medicine 2015
The role of miRNAs in the regulation of inflammatory processes during hepatofibrogenesis
Sanchari Roy, Fabian Benz, Tom Luedde, Christoph Roderburg
Hepatobiliary surgery and nutrition 2015
Hepatic Stellate Cells Express Thymosin Beta 4 in Chronically Damaged Liver
J Kim, S Wang, J Hyun, SS Choi, H Cha, M Ock, Y Jung, M Samson
PloS one 2015
MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells
J Hyun, S Wang, J Kim, GJ Kim, Y Jung
Scientific Reports 2015
Recent advancement of molecular mechanisms of liver fibrosis
E Seki, DA Brenner
Journal of Hepato-Biliary-Pancreatic Sciences 2015
Curcumin and hemopressin treatment attenuates cholestasis-induced liver fibrosis in rats: role of CB1 receptors
SE Swefy, RA Hasan, A Ibrahim, MF Mahmoud
Naunyn-Schmiedeberg's Archives of Pharmacology 2015
Identification of a novel TGF-β-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis.
Zeng C, Wang YL, Xie C, Sang Y, Li TJ, Zhang M, Wang R, Zhang Q, Zheng L, Zhuang SM
Oncotarget 2015
The role of iNOS in cholesterol-induced liver fibrosis.
Anavi S, Eisenberg-Bord M, Hahn-Obercyger M, Genin O, Pines M, Tirosh O
Laboratory Investigation 2015
The Natural History of Cirrhosis From Parenteral Nutrition-Associated Liver Disease After Resolution of Cholestasis With Parenteral Fish Oil Therapy:
P Nandivada, MI Chang, AK Potemkin, SJ Carlson, E Cowan, AA Oʼloughlin, PD Mitchell, KM Gura, M Puder
Annals of Surgery 2015
High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers
I Mederacke, DH Dapito, S Affò, H Uchinami, RF Schwabe
Nature Protocols 2015
Developing an in vitro screening assay platform for evaluation of antifibrotic drugs using precision-cut liver slices
SK Sadasivan, N Siddaraju, KM Khan, B Vasamsetti, NR Kumar, V Haridas, MB Reddy, S Baggavalli, AM Oommen, RP Rao
Fibrogenesis & Tissue Repair 2015
Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis
P Stiedl, R McMahon, L Blaas, V Stanek, J Svinka, B Grabner, G Zollner, SM Kessler, T Claudel, M Müller, W Mikulits, M Bilban, H Esterbauer, R Eferl, J Haybaeck, M Trauner, E Casanova
Hepatology 2015
Sedum mexicanum Britt. Induces Apoptosis of Primary Rat Activated Hepatic Stellate Cells
SL Lee, TY Chin, CL Lai, WH Wang
Evidence-Based Complementary and Alternative Medicine 2015
Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells
M Coll, AE Taghdouini, L Perea, I Mannaerts, M Vila-Casadesús, D Blaya, D Rodrigo-Torres, S Affò, O Morales-Ibanez, I Graupera, JJ Lozano, M Najimi, E Sokal, J Lambrecht, P Ginès, LA van Grunsven, P Sancho-Bru
Scientific Reports 2015
In vitro reversion of activated primary human hepatic stellate cells
AE Taghdouini, M Najimi, P Sancho-Bru, E Sokal, LA van Grunsven
Fibrogenesis & Tissue Repair 2015
DPP4 in diabetes
D Röhrborn
Frontiers in immunology 2015
L59 TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice
M Hara, I Inoue, Y Yamazaki, A Kirita, T Matsuura, SL Friedman, DB Rifkin, S Kojima
Fibrogenesis & Tissue Repair 2015
Diabetes and Hepatitis C: A Two-Way Association
SS Hammerstad, SF Grock, HJ Lee, A Hasham, N Sundaram, Y Tomer
Frontiers in Endocrinology 2015
Kinetin inhibits proliferation of hepatic stellate cells by interrupting cell cycle and induces apoptosis by down-regulating ratio of Bcl-2/Bax
Z Zhang, J Zou, Y Huang, L Wu
Journal of Huazhong University of Science and Technology [Medical Sciences] 2015
Actions of Huangqi decoction against rat liver fibrosis: a gene expression profiling analysis
G Zhang, Y Song, Q Chen, S Dong, Y Lu, M Su, P Liu, S Su
Chinese medicine 2015
BRD4 is a novel therapeutic target for liver fibrosis
N Ding, N Hah, RT Yu, MH Sherman, C Benner, M Leblanc, M He, C Liddle, M Downes, RM Evans
Proceedings of the National Academy of Sciences 2015
Ethanol Enhances TGF-β Activity by Recruiting TGF-β Receptors From Intracellular Vesicles/Lipid Rafts/Caveolae to Non-Lipid Raft Microdomains
Huang SS, Chen CL, Huang FW, Johnson FE, Huang JS
Journal of Cellular Biochemistry 2015
Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy
DeSantis DA, Ko CW, Wang L, Lee P, Croniger CM
Mediators of Inflammation 2015
Use of magnetic resonance elastography for assessing liver functional reserve: A clinical study.
Li B, Min J, Liang WR, Zhang GQ, Wu JJ, Jin K, Huang W, Ying CY, Chao M
World Journal of Gastroenterology 2015
Hepatoprotective effect of juglone on dimethylnitrosamine-induced liver fibrosis and its effect on hepatic antioxidant defence and the expression levels of α-SMA and collagen III.
Zhou DJ, Mu D, Jiang MD, Zheng SM, Zhang Y, He S, Weng M, Zeng WZ
Molecular medicine reports 2015
Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats.
Zhen YZ, Li NR, He HW, Zhao SS, Zhang GL, Hao XF, Shao RG
World Journal of Gastroenterology 2015
Supplementation of Citrus maxima Peel Powder Prevented Oxidative Stress, Fibrosis, and Hepatic Damage in Carbon Tetrachloride (CCl4) Treated Rats.
Chowdhury MR, Sagor MA, Tabassum N, Potol MA, Hossain H, Alam MA
Evidence-based complementary and alternative medicine : eCAM 2015
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015
Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Gd-EOB-DTPA for the Evaluation of Liver Fibrosis Induced by Carbon Tetrachloride in Rats.
Zhang W, Kong X, Wang ZJ, Luo S, Huang W, Zhang LJ
PloS one 2015
Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Values Predict the Development of Hepatocellular Carcinoma among Patients with Chronic Hepatitis C after Sustained Virological Response.
Sasaki R, Yamasaki K, Abiru S, Komori A, Nagaoka S, Saeki A, Hashimoto S, Bekki S, Kugiyama Y, Kuno A, Korenaga M, Togayachi A, Ocho M, Mizokami M, Narimatsu H, Ichikawa T, Nakao K, Yatsuhashi H
PloS one 2015
Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease.
Russo FP, Rodríguez-Castro K, Scribano L, Gottardo G, Vanin V, Farinati F
World journal of hepatology 2015
Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.
Yi HS, Eun HS, Lee YS, Jung JY, Park SH, Park KG, Choi HS, Suh JM, Jeong WI
PloS one 2015
Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells.
Li J, Dong N, Cheng S, Li X, Wang W, Xiang Y
2015
Potential role of thymosin Beta 4 in liver fibrosis.
Kim J, Jung Y
International journal of molecular sciences 2015
Tregs: A Therapeutic Target for the Treatment of Portal Fibrosis?
Xue Y, Michalopoulos G
Digestive Diseases and Sciences 2015
BCL6B expression in hepatocellular carcinoma and its efficacy in the inhibition of liver damage and fibrogenesis.
Wang W, Huang P, Wu P, Kong R, Xu J, Zhang L, Yang Q, Xie Q, Zhang L, Zhou X, Chen L, Xie H, Zhou L, Zheng S
Oncotarget 2015
Hepatic ADC map as an adjunct to conventional abdominal MRI to evaluate hepatic fibrotic and clinical cirrhotic severity in biliary atresia patients.
Peng SS, Jeng YM, Hsu WM, Yang JC, Ho MC
European Radiology 2015
MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7.
Yu F, Guo Y, Chen B, Dong P, Zheng J
Laboratory Investigation 2015
Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma.
Massó-Vallés D, Jauset T, Serrano E, Sodir NM, Pedersen K, Affara NI, Whitfield JR, Beaulieu ME, Evan GI, Elias L, Arribas J, Soucek L
Cancer research 2015
Caffeic acid phenethyl ester inhibits liver fibrosis in rats.
Li M, Wang XF, Shi JJ, Li YP, Yang N, Zhai S, Dang SS
World Journal of Gastroenterology 2015
Prevalence and Predictors of Non-Alcoholic Fatty Liver Disease in Morbidly Obese South Indian Patients Undergoing Bariatric Surgery.
Praveenraj P, Gomes RM, Kumar S, Karthikeyan P, Shankar A, Parthasarathi R, Senthilnathan P, Rajapandian S, Palanivelu C
Obesity surgery 2015
Fibroblast growth factor receptor isotype expression and its association with overall survival in patients with hepatocellular carcinoma.
Lee HJ, Kang HJ, Kim KM, Yu ES, Kim KH, Kim SM, Kim TW, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS
Clinical and Molecular Hepatology 2015
Mesenchymal Stem/Stromal Cells in Liver Fibrosis: Recent Findings, Old/New Caveats and Future Perspectives.
Fiore EJ, Mazzolini G, Aquino JB
Stem Cell Reviews and Reports 2015
Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.
Scott C, Cha K, Rao R, Liddle C, George J, Gunton JE
PloS one 2015
Non-invasive detection of liver fibrosis: MR imaging features vs. MR elastography.
Venkatesh SK, Yin M, Takahashi N, Glockner JF, Talwalkar JA, Ehman RL
Abdominal Imaging 2015
Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging.
Wang H, Liang X, Mohammed YH, Thomas JA, Bridle KR, Thorling CA, Grice JE, Xu ZP, Liu X, Crawford DH, Roberts MS
Biomedical Optics Express 2015
miR-217 regulates ethanol-induced hepatic inflammation by disrupting sirtuin 1-lipin-1 signaling.
Yin H, Liang X, Jogasuria A, Davidson NO, You M
The American Journal of Pathology 2015
Evaluation of the prognostic value of liver stiffness in patients with hepatitis C virus treated with triple or dual antiviral therapy: A prospective pilot study.
Stasi C, Piluso A, Arena U, Salomoni E, Montalto P, Monti M, Boldrini B, Corti G, Marra F, Laffi G, Milani S, Zignego AL
World Journal of Gastroenterology 2015
Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus infection.
Matsue Y, Tsutsumi M, Hayashi N, Saito T, Tsuchishima M, Toshikuni N, Arisawa T, George J
PloS one 2015
Hepatosplanchnic circulation in cirrhosis and sepsis.
Prin M, Bakker J, Wagener G
World Journal of Gastroenterology 2015
Cluster of differentiation 147 is a key molecule during hepatocellular carcinoma cell-hepatic stellate cell cross-talk in the rat liver.
Ma T, Wang Z, Yang Z, Chen J
Molecular medicine reports 2015
Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model.
Shimozono R, Nishimura K, Akiyama H, Funamoto S, Izawa A, Sai T, Kunita K, Kainoh M, Suzuki T, Kawada N
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2015
Noninvasive assessment of liver function.
Helmke S, Colmenero J, Everson GT
Current Opinion in Gastroenterology 2015
The expression dynamics of transforming growth factor-β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis.
Yan C, Wang L, Li B, Zhang BB, Zhang B, Wang YH, Li XY, Chen JX, Tang RX, Zheng KY
Parasites & vectors 2015
Current strategies for quantitating fibrosis in liver biopsy.
Wang Y, Hou JL
Chinese Medical Journal 2015
Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment.
Zhu D, Song K, Chen J, Wang J, Sun X, Qian H, Gu X, Zhang L, Qin Y, Duan Y
Parasites & vectors 2015
NS5ATP9 suppresses activation of human hepatic stellate cells, possibly via inhibition of Smad3/phosphorylated-Smad3 expression.
Zhang M, Zhang J, Liu S, Wang Q, Lin G, Qiu R, Quan M, Cheng J
Inflammation 2015
Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Liver Fibrosis in Rats.
Kubo K, Ohnishi S, Hosono H, Fukai M, Kameya A, Higashi R, Yamada T, Onishi R, Yamahara K, Takeda H, Sakamoto N
Transplantation Direct 2015
Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: A histopathologic correlation
Verloh N, Utpatel K, Haimerl M, Zeman F, Fellner C, Fichtner-Feigl S, Teufel A, Stroszczynski C, Evert M, Wiggermann P
Scientific Reports 2015
Automated Liver Elasticity Calculation for Magnetic Resonance Elastography
Dzyubak B, Venkatesh S, Manduca A, Glaser K, Ehman RL
Journal of magnetic resonance imaging : JMRI 2015
New Mechanism of Hepatic Fibrogenesis: Hepatitis C Virus Infection Induces Transforming Growth Factor β1 Production through Glucose-Regulated Protein 94.
Jee MH, Hong KY, Park JH, Lee JS, Kim HS, Lee SH, Jang SK
Journal of virology 2015
Propolis reduces Leishmania amazonensis-induced inflammation in the liver of BALB/c mice.
da Silva SS, Mizokami SS, Fanti JR, Miranda MM, Kawakami NY, Teixeira FH, Araújo EJ, Panis C, Watanabe MA, Sforcin JM, Pavanelli WR, Verri WA Jr, Felipe I, Conchon-Costa I
Parasitology Research 2015
Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.
Liu M, Xu Y, Han X, Yin L, Xu L, Qi Y, Zhao Y, Liu K, Peng J
Scientific Reports 2015
Utility of Translocator Protein (18 kDa) as a Molecular Imaging Biomarker to Monitor the Progression of Liver Fibrosis.
Hatori A, Yui J, Xie L, Kumata K, Yamasaki T, Fujinaga M, Wakizaka H, Ogawa M, Nengaki N, Kawamura K, Wang F, Zhang MR
Scientific Reports 2015
Kallistatin, a new and reliable biomarker for the diagnosis of liver cirrhosis.
Cheng Z, Lv Y, Pang S, Bai R, Wang M, Lin S, Xu T, Spalding D, Habib N, Xu R
Acta pharmaceutica Sinica. B 2015
Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review.
Palladini G, Ferrigno A, Richelmi P, Perlini S, Vairetti M
World Journal of Gastroenterology 2015
Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in rats.
Liu C, Yang Z, Wang L, Lu Y, Tang B, Miao H, Xu Q, Chen X
BMC Gastroenterology 2015
Non-invasive diagnosis of liver fibrosis and cirrhosis.
Lurie Y, Webb M, Cytter-Kuint R, Shteingart S, Lederkremer GZ
World Journal of Gastroenterology 2015
Inflammatory status in human hepatic cirrhosis.
Martínez-Esparza M, Tristán-Manzano M, Ruiz-Alcaraz AJ, García-Peñarrubia P
World Journal of Gastroenterology 2015
Fibrosis is a common outcome following total knee arthroplasty.
Abdul N, Dixon D, Walker A, Horabin J, Smith N, Weir DJ, Brewster NT, Deehan DJ, Mann DA, Borthwick LA
Scientific Reports 2015
Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells
El Taghdouini A, Sørensen AL, Reiner AH, Coll M, Verhulst S, Mannaerts I, Øie CI, Smedsrød B, Najimi M, Sokal E, Luttun A, Sancho-Bru P, Collas P, van Grunsven LA
Oncotarget 2015
Purinergic signaling in scarring
Ferrari D, Gambari R, Idzko M, Müller T, Albanesi C, Pastore S, La Manna G, Robson SC, Cronstein B
The FASEB Journal 2015
The role of P2X7 receptors in tissue fibrosis: a brief review
Gentile D, Natale M, Lazzerini PE, Capecchi PL, Laghi-Pasini F
Purinergic Signalling 2015
Clinical Features of Lysosomal Acid Lipase Deficiency
Burton BK, Deegan PB, Enns GM, Guardamagna O, Horslen S, Hovingh GK, Lobritto SJ, Malinova V, McLin VA, Raiman J, Di Rocco M, Santra S, Sharma R, Sykut-Cegielska J, Whitley CB, Eckert S, Valayannopoulos V, Quinn AG
Journal of Pediatric Gastroenterology and Nutrition 2015
Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis
Jiang DK, Ma XP, Wu X, Peng L, Yin J, Dan Y, Huang HX, Ding DL, Zhang LY, Shi Z, Zhang P, Yu H, Sun J, Lilly Zheng S, Deng G, Xu J, Liu Y, Guo J, Cao G, Yu L
Scientific Reports 2015
Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation
Liu J, Li J, Fu W, Tang J, Feng X, Chen J, Liang Y, Jin R, Xie A, Cai X
Drug design, development and therapy 2015
Periostin down-regulation attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-β1
Hong L, Shejiao D, Fenrong C, Gang Z, Lei D
Journal of Cellular and Molecular Medicine 2015
Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis
Klein S, Herath CB, Schierwagen R, Grace J, Haltenhof T, Uschner FE, Strassburg CP, Sauerbruch T, Walther T, Angus PW, Trebicka J
PloS one 2015
All-In-One: Advanced preparation of Human Parenchymal and Non-Parenchymal Liver Cells
Werner M, Driftmann S, Kleinehr K, Kaiser GM, Mathé Z, Treckmann JW, Paul A, Skibbe K, Timm J, Canbay A, Gerken G, Schlaak JF, Broering R
PloS one 2015
T1ρ MRI of healthy and fibrotic human livers at 1.5 T
Singh A, Reddy D, Haris M, Cai K, Rajender Reddy K, Hariharan H, Reddy R
Journal of Translational Medicine 2015
AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma
Kwon JH, Ahn KS, Moon YH, Park JY, Wang HJ, Choi KY, Kim G, Joh JW, Lee KG, Kang KJ
Journal of Korean Medical Science 2015
From the stomach to other organs: Helicobacter pylori and the liver
Waluga M, Kukla M, Żorniak M, Bacik A, Kotulski R
World journal of hepatology 2015
Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4
Huang YH, Tiao MM, Huang LT, Chuang JH, Kuo KC, Yang YL, Wang FS
PloS one 2015
Advances in the Diagnosis of Human Schistosomiasis
Weerakoon KG, Gobert GN, Cai P, McManus DP
Clinical microbiology reviews 2015
Efficacy of Hepatoprotective Agents With or Without Antiviral Drugs on Liver Function and Fibrosis in Patients With Hepatitis B: A Meta-Analysis
Long LH, Xue CQ, Shi JF, Dong JN, Wang L
Hepatitis Monthly 2015
Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy
Wang TH, Chen TC, Teng X, Liang KH, Yeh CT
Scientific Reports 2015
Antioxidants in liver health
Casas-Grajales S, Muriel P
World journal of gastrointestinal pharmacology and therapeutics 2015
Levels of 8-OxodG Predict Hepatobiliary Pathology in Opisthorchis viverrini Endemic Settings in Thailand
Saichua P, Yakovleva A, Kamamia C, Jariwala AR, Sithithaworn J, Sripa B, Brindley PJ, Laha T, Mairiang E, Pairojkul C, Khuntikeo N, Mulvenna J, Sithithaworn P, Bethony JM
PLoS neglected tropical diseases 2015
Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis
Hamazaki J, Hirayama S, Murata S
PLoS genetics 2015
Three-dimensional visualization of the microvasculature of bile duct ligation-induced liver fibrosis in rats by x-ray phase-contrast imaging computed tomography
Xuan R, Zhao X, Hu D, Jian J, Wang T, Hu C
Scientific Reports 2015
Efficacy and safety of sitagliptin for the treatment of diabetes mellitus complicated by chronic liver injury
Asakawa M, Mitsui H, Akihisa M, Sekine T, Niitsu Y, Kobayashi A, Miyake A, Hashimoto N, Kawamura M, Ogawa Y
SpringerPlus 2015
The Immune Interplay between Thyroid Papillary Carcinoma and Hepatic Fibrosis
Muhanna N, Amer J, Salhab A, Sichel JY, Safadi R
PloS one 2015
Inhibition of hepatic stellate cells by bone marrow-derived mesenchymal stem cells in hepatic fibrosis
Jang YO, Jun BG, Baik SK, Kim MY, Kwon SO
Clinical and Molecular Hepatology 2015
The multi-kinase inhibitor pazopanib targets hepatic stellate cell activation and apoptosis alleviating progression of liver fibrosis.
Elshal M, Abu-Elsaad N, El-Karef A, Ibrahim TM
Naunyn-Schmiedeberg's Archives of Pharmacology 2015
Green tea polyphenols and their potential role in health and disease.
Afzal M, Safer AM, Menon M
InflammoPharmacology 2015

← Previous 1 2 3 … 6 7 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 20 news outlets
Blogged by 5
Referenced in 1 policy sources
Posted by 7 X users
Referenced in 31 patents
On 2 Facebook pages
Referenced in 1 Wikipedia pages
Referenced in 2 clinical guideline sources
1396 readers on Mendeley
6 readers on CiteULike
See more details