Cardiovascular disease is the leading cause of morbidity and mortality in Western countries. Previous studies have highlighted the beneficial effects of PPARγ activators on cardiovascular disease; however, the role of other PPAR family members in atherosclerosis is less clear. A report in this issue of the JCI expands our understanding of PPARs in vascular biology and highlights the potential use of multiple PPAR agonists to limit lipid accumulation in macrophages.
Antonio Castrillo, Peter Tontonoz
Title and authors | Publication | Year |
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Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions
BG Durgin, OA Cherepanova, D Gomez, T Karaoli, GF Alencar, JT Butcher, YQ Zhou, MP Bendeck, BE Isakson, GK Owens, JJ Connelly |
American journal of physiology. Heart and circulatory physiology | 2017 |
PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part I: PPAR-α
L Han, WJ Shen, S Bittner, FB Kraemer, S Azhar |
Future Cardiology | 2017 |