Cardiovascular disease is the leading cause of morbidity and mortality in Western countries. Previous studies have highlighted the beneficial effects of PPARγ activators on cardiovascular disease; however, the role of other PPAR family members in atherosclerosis is less clear. A report in this issue of the JCI expands our understanding of PPARs in vascular biology and highlights the potential use of multiple PPAR agonists to limit lipid accumulation in macrophages.
Antonio Castrillo, Peter Tontonoz
Title and authors | Publication | Year |
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An insight to treat cardiovascular diseases through phytochemicals targeting PPAR-α.
Sharma S, Sharma D, Dhobi M, Wang D, Tewari D |
Molecular and Cellular Biochemistry | 2023 |
KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy
Tan Z, Ren H, Liu Y, Yang H, Luo Q, Deng X |
Experimental and therapeutic medicine | 2022 |
Mechanistic Insight into PPARγ and Tregs in Atherosclerotic Immune Inflammation
Gao Z, Xu X, Li Y, Sun K, Yang M, Zhang Q, Wang S, Lin Y, Lou L, Wu A, Liu W, Nie B |
Frontiers in pharmacology | 2021 |
Sparse reduced-rank regression for integrating omics data
H Hilafu, SE Safo, L Haine |
BMC bioinformatics | 2020 |
Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions
BG Durgin, OA Cherepanova, D Gomez, T Karaoli, GF Alencar, JT Butcher, YQ Zhou, MP Bendeck, BE Isakson, GK Owens, JJ Connelly |
American journal of physiology. Heart and circulatory physiology | 2017 |
PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part I: PPAR-α
L Han, WJ Shen, S Bittner, FB Kraemer, S Azhar |
Future Cardiology | 2017 |
Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease
Inzucchi SE, Viscoli CM, Young LH, Furie KL, Gorman M, Lovejoy AM, Dagogo-Jack S, Ismail-Beigi F, Korytkowski MT, Pratley RE, Schwartz GG, Kernan WN |
Diabetes care | 2016 |
Polydatin Inhibits Formation of Macrophage-Derived Foam Cells
M Wu, M Liu, G Guo, W Zhang, L Liu |
Evidence-Based Complementary and Alternative Medicine | 2015 |
A potential therapeutic effect of CYP2C8 overexpression on anti-TNF-α activity
W Liu, B Wang, H Ding, DW Wang, H Zeng |
International journal of molecular medicine | 2014 |
Nonhuman primates and other animal models in diabetes research.
Harwood HJ Jr, Listrani P, Wagner JD |
Journal of diabetes science and technology | 2012 |
25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages
Xu L, Shen S, Ma Y, Kim JK, Rodriguez-Agudo D, Heuman DM, Hylemon PB, Pandak WM, Ren S |
American journal of physiology. Endocrinology and metabolism | 2012 |
TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation
S Xie, YF Lee, E Kim, LM Chen, J Ni, LY Fang, S Liu, SJ Lin, JI Abe, B Berk, FM Ho, C Chang |
Proceedings of the National Academy of Sciences | 2009 |
Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate
FERREIRA AM, FERRARI MI, TROSTCHANSKY A, BATTHYANY C, SOUZA JM, ALVAREZ MN, LÓPEZ GV, BAKER PR, SCHOPFER FJ, O\u2019DONNELL V, FREEMAN BA, RUBBO H |
Biochemical Journal | 2009 |
Nuclear Receptors and Inflammatory Diseases
K Wang, YJ Wan |
Experimental biology and medicine (Maywood, N.J.) | 2008 |
Inhibition of Interleukin-1β-Induced Group IIA Secretory Phospholipase A2 Expression by Peroxisome Proliferator-Activated Receptors (PPARs) in Rat Vascular Smooth Muscle Cells: Cooperation between PPARβ and the Proto-Oncogene BCL-6
L Ravaux, C Denoyelle, C Monne, I Limon, M Raymondjean, KE Hadri |
Molecular and cellular biology | 2007 |