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Citations to this article

CD4+ Tregs and immune control
Zoltán Fehérvari, Shimon Sakaguchi
Zoltán Fehérvari, Shimon Sakaguchi
Published November 1, 2004
Citation Information: J Clin Invest. 2004;114(9):1209-1217. https://doi.org/10.1172/JCI23395.
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CD4+ Tregs and immune control

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Abstract

Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance of immunological tolerance and to impinge on a host of clinically important areas from cancer to infectious diseases. The identification of specific molecular markers in both human and murine immune systems has enabled the unprecedented investigation of these cells and should prove key to ultimately unlocking their clinical potential.

Authors

Zoltán Fehérvari, Shimon Sakaguchi

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
Citations: 3 5 1 7 4 5 2 3 7 11 6 6 12 6 10 8 11 6 15 10 5 1 144
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World journal of gastroenterology : WJG 2007
Transplantation of the spleen: effect of splenic allograft in human multivisceral transplantation
T Kato, AG Tzakis, G Selvaggi, JJ Gaynor, H Takahashi, J Mathew, R Garcia-Morales, E Hernandez, A David, S Nishida, D Levi, J Moon, E Island, G Kleiner, P Ruiz
Annals of Surgery 2007
Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + (Foxp3) regulatory T cells in human visceral leishmaniasis
S Nylén, R Maurya, L Eidsmo, KD Manandhar, S Sundar, D Sacks
Journal of Experimental Medicine 2007
Prevention of red cell alloimmunization by CD25 regulatory T cells in mouse models
Yu J, Heck S, Yazdanbakhsh K
American Journal of Hematology 2007
Resistance to apoptosis and expansion of regulatory T cells in relation to the detection of circulating tumor cells in patients with metastatic epithelial cancer.
Stanzer S, Dandachi N, Balic M, Resel M, Samonigg H, Bauernhofer T
Journal of Clinical Immunology 2007
DC immunotherapy is highly effective for the inhibition of tumor metastasis or recurrence, although it is not efficient for the eradication of established solid tumors
Lim DS, Kim JH, Lee DS, Yoon CH, Bae YS
Cancer Immunology, Immunotherapy 2007
Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis
M Sasaki, H Ikeda, S Sawada, Y Sato, Y Nakanuma
Journal of clinical pathology 2006
Defective antigen-presenting cell function in human neonates
PA Velilla, MT Rugeles, CA Chougnet
Clinical Immunology 2006
Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection?
N Faal, RL Bailey, D Jeffries, H Joof, I Sarr, M Laye, DC Mabey, MJ Holland
PLoS Medicine 2006
Regulatory T Cells, a Potent Immunoregulatory Target for CAM Researchers: Modulating Allergic and Infectious Disease Pathology (II)
A Vojdani, J Erde
Evidence-based complementary and alternative medicine : eCAM 2006
B cell–deficient NOD.H-2h4 mice have CD4 + CD25 + T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis
S Yu, PK Maiti, M Dyson, R Jain, H Braley-Mullen
Journal of Experimental Medicine 2006
The role of virus-induced regulatory T cells in immunopathology
SJ Robertson, KJ Hasenkrug
Springer Seminars in Immunopathology 2006
Increase of CD4+CD25+ T cells in Smad3-/- mice
Wang ZB, Cui YF, Liu YQ, Jin W, Xu H, Jiang ZJ, Lu YX, Zhang Y, Liu XL, Dong B
World journal of gastroenterology : WJG 2006
Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus
Lee JH, Wang LC, Lin YT, Yang YH, Lin DT, Chiang BL
Immunology 2006
Foxp3-Expressing CD103+ Regulatory T Cells Accumulate in Dendritic Cell Aggregates of the Colonic Mucosa in Murine Transfer Colitis
Leithäuser F, Meinhardt-Krajina T, Fink K, Wotschke B, Möller P, Reimann J
The American Journal of Pathology 2006
Interleukin‐12‐responding asialoGM1+CD8+ central memory‐type T cells as precursor cells for interferon‐γ‐producing killer T cells
Kosaka A, Lee U, Wakita D, Matsubara N, Togashi Y, Nishimura S, Kitamura H, Nishimura T
Cancer Science 2006
A tax on luxury: HTLV-I infection of CD4+CD25+ Tregs
RS Fujinami
Journal of Clinical Investigation 2005
Pathological role of IL-6 in the experimental allergic bronchial asthma in mice.
Doganci A, Sauer K, Karwot R, Finotto S
Clinical Reviews in Allergy & Immunology 2005
Depletion of CD25+CD4+T cells (Tregs) enhances the HBV-specific CD8+ T cell response primed by DNA immunization
Furuichi Y, Tokuyama H, Ueha S, Kurachi M, Moriyasu F, Kakimi K
World journal of gastroenterology : WJG 2005
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function
Schneider H, Valk E, da Rocha Dias S, Wei B, Rudd CE
Proceedings of the National Academy of Sciences 2005
Role of regulatory T cells in experimental arthritis and implications for clinical use
Londei M
Arthritis Research & Therapy 2005
An integrated view of suppressor T cell subsets in immunoregulation.
Jiang H, Chess L
Journal of Clinical Investigation 2004

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