Citations to this article

Unbuckling lipodystrophy from insulin resistance and hypertension
Robert A. Hegele, Todd Leff
Robert A. Hegele, Todd Leff
Published July 15, 2004
Citation Information: J Clin Invest. 2004;114(2):163-165. https://doi.org/10.1172/JCI22382.
View: Text | PDF
Commentary Article has an altmetric score of 3

Unbuckling lipodystrophy from insulin resistance and hypertension

Abstract

Lipodystrophy and insulin resistance are the core features of human PPARγ deficiency states. Metabolic complications in PPARγ deficiency, such as hypertension, have been considered to be secondary to insulin resistance. However, a new mouse model that expresses the analog of a human PPARG mutation displays minimal lipodystrophy and insulin resistance but rather severe hypertension. Furthermore, the mutant protein appears to directly modulate the renin-angiotensin system in adipose tissue, providing evidence of the pleiotropic effects of PPARγ.

Authors

Robert A. Hegele, Todd Leff

×

Total citations by year

Year: 2023 2022 2021 2019 2013 2008 2007 2006 Total
Citations: 1 1 1 1 1 1 1 1 8
Citation information

Citations to this article (8)

Title and authors Publication Year
Progranulin Maintains Blood Pressure and Vascular Tone Dependent on EphrinA2 and Sortilin1 Receptors and Endothelial Nitric Oxide Synthase Activation
Bruder\u2010Nascimento A, Awata WM, Alves JV, Singh S, Costa RM, Bruder\u2010Nascimento T 		Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2023
Molecular and Cellular Bases of Lipodystrophy Syndromes
J Zammouri, C Vatier, E Capel, M Auclair, C Storey-London, E Bismuth, H Mosbah, B Donadille, S Janmaat, B Fève, I Jéru, C Vigouroux 		Frontiers in Endocrinology 2022
Reduced Endothelial Leptin Signaling Increases Vascular Adrenergic Reactivity in a Mouse Model of Congenital Generalized Lipodystrophy
Bruder-Nascimento T, Kress TC, Pearson M, Chen W, Kennard S, Belin de Chantemèle EJ 		International journal of molecular sciences 2021
Recent advances in understanding lipodystrophy: a focus on lipodystrophy-associated cardiovascular disease and potential effects of leptin therapy on cardiovascular function
T Bruder-Nascimento, TC Kress, EJ de Chantemele 		F1000Research 2019
A Clinical Link Between Peroxisome Proliferator-Activated Receptor γ and the Renin–Angiotensin System
CD Sigmund 		Arteriosclerosis, thrombosis, and vascular biology 2013
Is adiposopathy (sick fat) an endocrine disease?
Bays HE, González-Campoy JM, Henry RR, Bergman DA, Kitabchi AE, Schorr AB, Rodbard HW 		International Journal of Clinical Practice 2008
PPARgamma in human and mouse physiology
S Heikkinen, J Auwerx, CA Argmann 		Biochimica et Biophysica Acta 2007
Peroxisomal proliferator activated receptor-γ deficiency in a Canadian kindred with familial partial lipodystrophy type 3 (FPLD3)
GA Francis, G Li, R Casey, J Wang, H Cao, T Leff, RA Hegele 		BMC Medical Genetics 2006

Advertisement