The CRAC channel inhibitor Auxora Reprograms Pathogenic Alveolar Macrophage–T Cell Circuits in Viral Pneumonia

S. Marina Casalino-Matsuda; Vijeeth Guggilla; Catherine A. Gao; Kaitlyn E. DeMeulenaere; Luisa Cusick; Samuel W. Fenske; Zhan Yu; Ziyan Lu; Suchitra Swaminathan; Rogan A. Grant; Maxwell J. Schleck; Murali Prakriya; Sudarshan Hebbar; Kenneth Stauderman; Helen K. Donnelly; Chiagozie I. Pickens; Luisa Morales-Nebreda; The NU SCRIPT Study Investigators; Richard G. Wunderink; Alexander V. Misharin; Benjamin D. Singer; G.R. Scott Budinger

doi:10.1172/JCI209675

¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America

²Health Sciences Integrated Program, Health and Biomedical Informatics Track, Northwestern University Feinberg School of Medicine, Chicago, United States of America

³Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States of America

⁴CalciMedica, Inc, La Jolla, United States of America

⁵Northwestern University Feinberg School of Medicine, Chicago, United States of America

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J Clin Invest. https://doi.org/10.1172/JCI209675.
Copyright © 2026, Casalino-Matsuda et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Published July 28, 2026 - Version history

The CRAC channel inhibitor Auxora Reprograms Pathogenic Alveolar Macrophage–T Cell Circuits in Viral Pneumonia

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The CRAC channel inhibitor Auxora Reprograms Pathogenic Alveolar Macrophage–T Cell Circuits in Viral Pneumonia

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