Mammals coexist in an overall symbiotic relationship with a complex array of commensal bacterial flora that colonizes the gastrointestinal tract. These intestinal bacteria interface with cells of the mucosal immune system, including DCs. Here we discuss mechanisms of interaction between intestinal bacteria and DCs and the role of localized gastrointestinal immune responses.
Holm H. Uhlig, Fiona Powrie
Title and authors | Publication | Year |
---|---|---|
Dextran Sulphate Sodium Acute Colitis Rat Model: A Suitable Tool for Advancing Our Understanding of Immune and Microbial Mechanisms in the Pathogenesis of Inflammatory Bowel Disease
Adamkova P, Hradicka P, Kupcova Skalnikova H, Cizkova V, Vodicka P, Farkasova Iannaccone S, Kassayova M, Gancarcikova S, Demeckova V |
Veterinary Sciences | 2022 |
Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease
M Stürzl, M Kunz, SM Krug, E Naschberger |
Frontiers in Medicine | 2021 |
The Role of Segmented Filamentous Bacteria in Immune Barrier Maturation of the Small Intestine at Weaning
Oemcke LA, Anderson RC, Altermann E, Roy NC, McNabb WC |
Frontiers in Nutrition | 2021 |
IFN-gamma drives inflammatory bowel disease pathogenesis through ve-cadherin-directed vascular barrier disruption
Victoria Langer, Eugenia Vivi, Daniela Regensburger, Thomas Winkler, Maximilian J. Waldner, Timo Rath, Benjamin Schmid, Lisa Skottke, Somin Lee, Noo Li Jeon, Thomas Wohlfahrt, Viktoria Kramer, Philipp Tripal, Michael Schumann, Stephan Kersting, Claudia Handtrack, Carol I. Geppert, Karina Suchowski, Ralf H. Adams, Christoph Becker, Andreas Ramming, Elisabeth Naschberger, Nathalie Britzen-Laurent, Michael Stürzl |
Journal of Clinical Investigation | 2019 |
β-Defensins: Farming the Microbiome for Homeostasis and Health
Meade KG, O'Farrelly C |
Frontiers in immunology | 2019 |
The matter of the reproductive microbiome
Schoenmakers S, Steegers-Theunissen R, Faas M |
Obstetric Medicine | 2018 |
Thymic Stromal Lymphopoietin: To Cut a Long Story Short
K Tsilingiri, G Fornasa, M Rescigno |
Cellular and Molecular Gastroenterology and Hepatology | 2017 |
EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
L Jiang, Y Shen, D Guo, D Yang, J Liu, X Fei, Y Yang, B Zhang, Z Lin, F Yang, X Wang, K Wang, J Wang, Z Cai |
Nature Communications | 2016 |
Role of secretory IgA in the mucosal sensing of commensal bacteria.
Mathias A, Pais B, Favre L, Benyacoub J, Corthésy B |
Gut microbes | 2014 |
Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain.
Yang Y, Millán JL, Mecsas J, Guillemin K |
Infection and immunity | 2014 |
Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis
V Galitovskiy, J Qian, AI Chernyavsky, S Marchenko, V Gindi, RA Edwards, SA Grando |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
The intraperitoneal inoculation of Lactobacillus casei in mice induces total protection against Trichinella spiralis infection at low challenge doses.
Martínez-Gómez F, Fuentes-Castro BE, Bautista-Garfias CR |
Parasitology Research | 2011 |
Innate signaling networks in mucosal IgA class switching
A Chorny, I Puga, A Cerutti |
Advances in immunology | 2010 |
The Role of the Lactadherin in Promoting Intestinal DCs Development In Vivo and Vitro
YJ Zhou, J Gao, HM Yang, XL Yuan, TX Chen, ZJ He |
Clinical and Developmental Immunology | 2010 |
Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease
DC Baumgart, S Thomas, I Przesdzing, D Metzke, C Bielecki, SM Lehmann, S Lehnardt, Y Dörffel, A Sturm, A Scheffold, J Schmitz, A Radbruch |
Clinical & Experimental Immunology | 2009 |
Probiotics for photoprotection.
Guéniche A, Philippe D, Bastien P, Blum S, Buyukpamukcu E, Castiel-Higounenc I |
Dermato-endocrinology | 2009 |
Morphology and ontogeny of dendritic cells in rats at different development periods.
Zhou YJ, Gao J, Yang HM, Zhu JX, Chen TX, He ZJ |
World Journal of Gastroenterology | 2009 |
Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection.
Cruickshank SM, Deschoolmeester ML, Svensson M, Howell G, Bazakou A, Logunova L, Little MC, English N, Mack M, Grencis RK, Else KJ, Carding SR |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade.
Reynoso ED, Elpek KG, Francisco L, Bronson R, Bellemare-Pelletier A, Sharpe AH, Freeman GJ, Turley SJ |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
The Role of Mannan-Binding Lectin (MBL) Gene Polymorphism in Ulcerative Colitis.
Wang FY, Arisawa T, Tahara T, Nagasaka M, Fujita H, Hirata I, Nakano H |
Journal of Clinical Biochemistry and Nutrition | 2008 |
Absence of Bacterially-Induced RELMbeta Reduces Injury in the DSS Model of Colitis
Laila D. McVay, Sue A. Keilbaugh, Tracie M.H. Wong, Marcus E. Shin, Sonja Kierstein, Michael Lehrke, Martina I. Lefterova, D. Edward Schifflett, Sean L. Barnes, Fabio Cominelli, Steven M. Cohn, Gail Hecht, Mitchell A. Lazar, Angela Haczku, and Gary D. Wu |
Journal of Clinical Investigation | 2006 |
Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant
WW Overwijk, KE de Visser, FH Tirion, LA de Jong, TW Pols, YU van der Velden, JG van Boorn, AM Keller, WA Buurman, MR Theoret, B Blom, NP Restifo, AM Kruisbeek, RA Kastelein, JB Haanen |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease
MP Conte, S Schippa, I Zamboni, M Penta, F Chiarini, L Seganti, J Osborn, P Falconieri, O Borrelli, S Cucchiara |
Gut | 2006 |
Treatment of Murine Th1- and Th2-mediated Inflammatory Bowel Disease with NF-kappaB Decoy Oligonucleotides
Stefan Fichtner-Feigl, Ivan J. Fuss, Jan C. Preiss, Warren Strober and Atsushi Kitani |
Journal of Clinical Investigation | 2005 |
L-selectin and β7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease
S Dutt, J Ermann, D Tseng, YP Liu, TI George, CG Fathman, S Strober |
Blood | 2005 |
Activation of RegIIIbeta/gamma and interferon gamma expression in the intestinal tract of SCID mice: an innate response to bacterial colonisation of the gut
SA Keilbaugh, ME Shin, RF Banchereau, LD McVay, N Boyko, D Artis, JJ Cebra, GD Wu |
Gut | 2005 |