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ResearchIn-Press PreviewAngiogenesisOncology
Open Access | 
10.1172/JCI190596
PAX5 modulates vascularization and contributes to neuroendocrine lineage transition during carcinoma progression
Ailing Wu,1 Yujie Hao,1 Xuemiao Yan,1 Junrong Liu,1 Lin Wang,1 Yan Jin,1 Wenxu Liu,1 Xiyue Chen,1 Yuan Jiang,2 Luc Girard,3 Zhiqun Shang,4 Jun Yan,5 Zhenfa Zhang,2 Wenchen Gong,6 Yuanjie Niu,4 Benjamin J. Drapkin,3 John D. Minna,3 Lance S. Terada,7 Zhenyi Ma,1 and Zhe Liu1
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Yan, X. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Liu, J. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Wang, L. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Chen, X. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Jiang, Y. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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Girard, L.
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1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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Shang, Z.
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1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Yan, J. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Zhang, Z. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Gong, W. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Niu, Y. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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Minna, J.
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1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Terada, L. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
Find articles by Ma, Z. in: PubMed | Google Scholar
1Zhejiang Key Laboratory of Medical Epigenetics, Jiande Hospital, Department, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China
2Department of Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, United States of America
4Tianjin Institute of Urology, The 2nd Hospital of Tianjin Medical University, Tianjin, China
5Department of Pathology, Tianjin First Center Hospital, Tianjin, China
6Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
7Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, United States of America
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Published July 23, 2026 - More info
Copyright © 2026, Wu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)