Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
Donata Vercelli
Title and authors | Publication | Year |
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Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-4
Ishida K, Nagatake T, Saika A, Kawai S, Node E, Hosomi K, Kunisawa J |
Frontiers in immunology | 2023 |