Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
Donata Vercelli
Title and authors | Publication | Year |
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Genetic polymorphisms in arginase I and II and childhood asthma and atopy
H Li, I Romieu, JJ Sienra-Monge, M Ramirez-Aguilar, BE Rio-Navarro, EO Kistner, HK Gjessing, ID Lara-Sanchez, GY Chiu, SJ London |
Journal of Allergy and Clinical Immunology | 2005 |