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Serum cAMP levels are increased in patients with asthma
Steven S. An, … , Sally Wenzel, Reynold A. Panettieri Jr.
Steven S. An, … , Sally Wenzel, Reynold A. Panettieri Jr.
Published January 7, 2025
Citation Information: J Clin Invest. 2025;135(5):e186937. https://doi.org/10.1172/JCI186937.
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Research Letter Cell biology Pulmonology Article has an altmetric score of 21

Serum cAMP levels are increased in patients with asthma

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Abstract

Authors

Steven S. An, Gaoyuan Cao, Kwangmi Ahn, Jordan Lee, Dae Young Jung, Loren Denlinger, John Fahy, Elliot Israel, Wendy Moore, Brenda Phillips, David Mauger, Sally Wenzel, Reynold A. Panettieri Jr.

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Figure 1

Serum cAMP levels are increased in patients with asthma.

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Serum cAMP levels are increased in patients with asthma.
(A) Histogram o...
(A) Histogram of cAMP levels detected in the blood of RCC study participants without a known history of asthma or other lung diseases (n = 273) and patients with asthma in the SARP-3 (n = 87). For each sample, cAMP levels (pmol per 60 μl serum) were measured in duplicate by using the cAMP-Screen System ELISA kit (Applied Biosystems) and presented as mean ± SD. (B) Serum cAMP levels by asthma severity. Asthma severity was defined as “nonsevere” (n = 48) and “severe” (n = 39) according to European Respiratory Society/American Thoracic Society criteria. Linear regression models were used with age and sex as covariates across clinical groups. To satisfy the normalization assumption necessary for linear regression testing, cAMP levels underwent log transformation and the analysis was conducted using R version 4.4.1.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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