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Abstract
The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions between antigen-specific (Ag-specific) B cells, T cells, and dendritic cells. This process must be strictly regulated to ensure sufficient humoral immunity while avoiding production of pathogenic autoantibodies. BAFF, a member of the TNF family, is a key regulator of B cell homeostasis. BAFF exerts its effect by binding to three receptors — transmembrane activator of and CAML interactor (TACI), B cell maturation antigen (BCMA), and BAFF receptor (BAFF-R). To elucidate the contribution of BAFF to the differentiation of B cells into ISCs, we tracked the fate of human memory B cells stimulated with BAFF or CD40L. BAFF and CD40L significantly increased the overall number of surviving B cells. This was achieved via distinct mechanisms. CD40L induced proliferation of nondifferentiated blasts, while BAFF prevented apoptosis of ISCs without enhancing proliferation. The altered responsiveness of activated memory B cells to CD40L and BAFF correlated with changes in surface phenotype such that expression of CD40 and BAFF-R were reduced on ISCs while BCMA was induced. These results suggest BAFF may enhance humoral immunity in vivo by promoting survival of ISCs via a BCMA-dependent mechanism. These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases.
Authors
Danielle T. Avery, Susan L. Kalled, Julia I. Ellyard, Christine Ambrose, Sarah A. Bixler, Marilyn Thien, Robert Brink, Fabienne Mackay, Philip D. Hodgkin, Stuart G. Tangye
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Autophagy: controlling cell fate in rheumatic diseases
JS Rockel, M Kapoor |
Nature Reviews Rheumatology | 2016 |
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Dendritic Cells and Their Multiple Roles during Malaria Infection
KN Amorim, DC Chagas, FB Sulczewski, SB Boscardin |
Journal of Immunology Research | 2016 |
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Gene signatures related to HAI response following influenza A/H1N1 vaccine in older individuals
IG Ovsyannikova, AL Oberg, RB Kennedy, MT Zimmermann, IH Haralambieva, KM Goergen, DE Grill, GA Poland |
Heliyon | 2016 |
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Immunogenetic markers associated with a naturally acquired humoral immune response against an N-terminal antigen of Plasmodium vivax merozoite surface protein 1 (PvMSP-1)
GC Cassiano, AA Furini, MP Capobianco, LM Storti-Melo, ME Almeida, DR Barbosa, MM Póvoa, PA Nogueira, RL Machado |
Malaria Journal | 2016 |
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APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment
YT Tai, C Acharya, G An, M Moschetta, MY Zhong, X Feng, M Cea, A Cagnetta, K Wen, H Eenennaam, A Elsas, L Qiu, P Richardson, N Munshi, KC Anderson |
Blood | 2016 |
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Unraveling the Role of Allo-Antibodies and Transplant Injury
Y Matsuda, MM Sarwal |
Frontiers in immunology | 2016 |
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Post Hoc Analysis of the Phase II/III APRIL-SLE Study: Association Between Response to Atacicept and Serum Biomarkers Including BLyS and APRIL: POST HOC ANALYSIS OF THE APRIL-SLE STUDY
C Gordon, D Wofsy, S Wax, Y Li, CP Rossi, D Isenberg |
Arthritis & Rheumatology | 2016 |
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New monoclonal antibodies on the horizon in multiple myeloma
EK ODonnell, NS Raje |
Therapeutic Advances in Hematology | 2016 |
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Association of BAFF −871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients
MW Ayad, AA Elbanna, DA Elneily, AS Sakr |
Molecular diagnosis & therapy | 2015 |
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B-cell survival factors in autoimmune rheumatic disorders
SA Morais, A Vilas-Boas, DA Isenberg |
Therapeutic Advances in Musculoskeletal Diseases | 2015 |
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Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephritis based on clinical and histopathological outcome following induction therapy
I Parodis, A Zickert, B Sundelin, M Axelsson, J Gerhardsson, E Svenungsson, V Malmstrom, I Gunnarsson |
Lupus Science & Medicine | 2015 |
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B Cells, Antibodies, and More
W Hoffman, FG Lakkis, G Chalasani |
Clinical journal of the American Society of Nephrology : CJASN | 2015 |
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The Evolving Roles of Memory Immune Cells in Transplantation:
W Chen, RM Ghobrial, XC Li |
Transplantation | 2015 |
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Characterization of B cells in muscle-specific kinase antibody myasthenia gravis
JT Guptill, JS Yi, DB Sanders, AC Guidon, VC Juel, JM Massey, JF Howard, F Scuderi, E Bartoccioni, A Evoli, KJ Weinhold |
Neurology: Neuroimmunology & Neuroinflammation | 2015 |
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Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease
RD Niro, O Snir, K Kaukinen, G Yaari, KE Lundin, NT Gupta, SH Kleinstein, M Cols, A Cerutti, M Mäki, MJ Shlomchik, LM Sollid |
Mucosal Immunology | 2015 |
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γ-secretase directly sheds the survival receptor BCMA from plasma cells
SA Laurent, FS Hoffmann, PH Kuhn, Q Cheng, Y Chu, M Schmidt-Supprian, SM Hauck, E Schuh, M Krumbholz, H Rübsamen, J Wanngren, M Khademi, T Olsson, T Alexander, F Hiepe, HW Pfister, F Weber, D Jenne, H Wekerle, R Hohlfeld, SF Lichtenthaler, E Meinl |
Nature Communications | 2015 |
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Targeting B-cell maturation antigen in multiple myeloma
YT Tai, KC Anderson |
Immunotherapy | 2015 |
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B cell non-Hodgkin’s lymphoma in chronic hepatitis C virus patients: An interesting relationship
HS Hamdy, NA Abdelkader, A Mansour, EH Allam, HM El-Wakiel, D Elshenawy |
Indian Journal of Gastroenterology | 2015 |
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Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children
DM Muema, GN Macharia, AS Hassan, SM Mwaringa, GW Fegan, JA Berkley, EW Nduati, BC Urban |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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IL-4-Secreting Secondary T Follicular Helper (Tfh) Cells Arise from Memory T Cells, Not Persisting Tfh Cells, through a B Cell-Dependent Mechanism
KC Fairfax, B Everts, E Amiel, AM Smith, G Schramm, H Haas, GJ Randolph, JJ Taylor, EJ Pearce |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Dual B Cell Immunotherapy Is Superior to Individual Anti-CD20 Depletion or BAFF Blockade in Murine Models of Spontaneous or Accelerated Lupus: Dual B Cell Immunotherapy in Murine Lupus
WY Lin, D Seshasayee, WP Lee, P Caplazi, S McVay, E Suto, A Nguyen, Z Lin, Y Sun, L DeForge, M Balazs, F Martin, AA Zarrin |
Arthritis & Rheumatology | 2014 |
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Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma
YT Tai, PA Mayes, C Acharya, MY Zhong, M Cea, A Cagnetta, J Craigen, J Yates, L Gliddon, W Fieles, B Hoang, J Tunstead, AL Christie, AL Kung, P Richardson, NC Munshi, KC Anderson |
Blood | 2014 |
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Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells
G Magri, M Miyajima, S Bascones, A Mortha, I Puga, L Cassis, CM Barra, L Comerma, A Chudnovskiy, M Gentile, D Llige, M Cols, S Serrano, JI Aróstegui, M Juan, J Yagüe, M Merad, S Fagarasan, A Cerutti |
Nature Immunology | 2014 |
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Abatacept (cytotoxic T lymphocyte antigen 4-immunoglobulin) improves B cell function and regulatory T cell inhibitory capacity in rheumatoid arthritis patients non-responding to anti-tumour necrosis factor-α agents: B and T reg functional rescue by abatacept in RA
AP Diamanti, MM Rosado, M Scarsella, V Germano, E Giorda, S Cascioli, B Laganà, R D'Amelio, R Carsetti |
Clinical & Experimental Immunology | 2014 |
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Clinical trials in systemic lupus erythematosus: a status report on ongoing trials.
Gumber D, Paul J, Ranganathan P |
Rheumatology International | 2014 |
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Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells
VJ Sindhava, JL Scholz, MP Cancro |
Frontiers in immunology | 2013 |
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Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells
EK Deenick, DT Avery, A Chan, LJ Berglund, ML Ives, L Moens, JL Stoddard, J Bustamante, S Boisson-Dupuis, M Tsumura, M Kobayashi, PD Arkwright, D Averbuch, D Engelhard, J Roesler, J Peake, M Wong, S Adelstein, S Choo, JM Smart, MA French, DA Fulcher, MC Cook, C Picard, A Durandy, C Klein, SM Holland, G Uzel, JL Casanova, CS Ma, SG Tangye |
Journal of Experimental Medicine | 2013 |
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Development of Systemic Lupus Erythematosus in NZM 2328 Mice in the Absence of any Single BAFF Receptor
CO Jacob, N Yu, S Guo, N Jacob, WJ Quinn, V Sindhava, MP Cancro, B Goilav, C Putterman, TS Migone, W Stohl |
Arthritis & Rheumatism | 2013 |
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B-cell targeted therapeutics in clinical development
S Blüml, K McKeever, R Ettinger, J Smolen, R Herbst |
Arthritis Research & Therapy | 2013 |
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Long-Lived Plasma Cells in Autoimmunity: Lessons from B-Cell Depleting Therapy
M Mahévas, M Michel, JC Weill, CA Reynaud |
Frontiers in immunology | 2013 |
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Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10
C Doyle-Cooper, KE Hudson, AB Cooper, T Ota, P Skog, PE Dawson, MB Zwick, WR Schief, DR Burton, D Nemazee |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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The B cell helper side of neutrophils
A Cerutti, I Puga, G Magri |
2013 | |
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Elevated Pretransplantation Soluble BAFF Is Associated With an Increased Risk of Acute Antibody-Mediated Rejection:
G Banham, D Prezzi, S Harford, CJ Taylor, R Hamer, R Higgins, JA Bradley, MR Clatworthy |
2013 | |
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Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes
A Cerutti, M Cols, I Puga |
Nature Reviews Immunology | 2013 |
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Interstitial Lung Disease in Inflammatory Myopathies: Clinical Phenotypes and Prognosis
PD Kiely, F Chua |
Current Rheumatology Reports | 2013 |
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The Interplay of IL-21 and BAFF in the Formation and Maintenance of Human B Cell Memory
JL Karnell, R Ettinger |
Frontiers in immunology | 2012 |
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Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L
M Cols, CM Barra, B He, I Puga, W Xu, A Chiu, W Tam, DM Knowles, SR Dillon, JP Leonard, RR Furman, K Chen, A Cerutti |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
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B-cell activating factor targeted therapy and lupus
A Boneparth, A Davidson |
Arthritis Research & Therapy | 2012 |
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B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways
JL Allen, MS Fore, J Wooten, PA Roehrs, NS Bhuiya, T Hoffert, A Sharf, AM Deal, P Armistead, J Coghill, DA Gabriel, R Irons, A Essenmacher, TC Shea, K Richards, C Cutler, J Ritz, J Serody, AS Baldwin, S Sarantopoulos |
Blood | 2012 |
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New concepts in the generation and functions of IgA
O Pabst |
Nature Reviews Immunology | 2012 |
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Association between genetic variations in tumor necrosis factor receptor genes and survival of patients with T-cell lymphoma
K Zhai, J Chang, C Wu, N Lu, LM Huang, TW Zhang, DK Yu, W Tan, DX Lin |
Chinese journal of cancer | 2012 |
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Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival: Immunity to Infection
XQ Liu, KJ Stacey, JM Horne-Debets, JA Cridland, K Fischer, D Narum, F Mackay, SK Pierce, MN Wykes |
European Journal of Immunology | 2012 |
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Regulatory Roles of the Tumor Necrosis Factor Receptor BCMA
Coquery CM, Erickson LD |
Critical reviews in immunology | 2012 |
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The Plasma Concentration of the B Cell Activating Factor Is Increased in Children With Acute Malaria
E Nduati, A Gwela, H Karanja, C Mugyenyi, J Langhorne, K Marsh, BC Urban |
The Journal of Infectious Diseases | 2011 |
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Innate control of B cell responses
A Cerutti, I Puga, M Cols |
Trends in Immunology | 2011 |
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B-Cell-Activating Factor and Autoimmune Myasthenia Gravis
S Ragheb, RP Lisak |
Autoimmune Diseases | 2011 |
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Long-lived autoreactive plasma cells drive persistent autoimmune inflammation
F Hiepe, T Dörner, AE Hauser, BF Hoyer, H Mei, A Radbruch |
Nature Reviews Rheumatology | 2011 |
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BAFF inhibition: a new class of drugs for the treatment of autoimmunity
Z Liu, A Davidson |
Experimental Cell Research | 2011 |
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A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus
R Furie, M Petri, O Zamani, R Cervera, DJ Wallace, D Tegzová, J Sanchez-Guerrero, A Schwarting, JT Merrill, WW Chatham, W Stohl, EM Ginzler, DR Hough, ZJ Zhong, W Freimuth, RF van Vollenhoven |
Arthritis & Rheumatism | 2011 |
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Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease
S Sarantopoulos, KE Stevenson, HT Kim, WS Washel, NS Bhuiya, CS Cutler, EP Alyea, VT Ho, RJ Soiffer, JH Antin, J Ritz |
Blood | 2011 |
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The role of B cells in solid organ transplantation
J Kwun, P Bulut, E Kim, W Dar, B Oh, R Ruhil, N Iwakoshi, SJ Knechtle |
Seminars in Immunology | 2011 |
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Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica
N Chihara, T Aranami, W Sato, Y Miyazaki, S Miyake, T Okamoto, M Ogawa, T Toda, T Yamamura |
Proceedings of the National Academy of Sciences | 2011 |
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Enhanced immunogenicity of pneumococcal surface adhesin A (PsaA) in mice via fusion to recombinant human B lymphocyte stimulator (BLyS)
DO Gor, X Ding, Q Li, D Sultana, SS Mambula, RJ Bram, NS Greenspan |
Biology direct | 2011 |
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Upregulation of IL-21 Receptor on B Cells and IL-21 Secretion Distinguishes Novel 2009 H1N1 Vaccine Responders from Nonresponders among HIV-Infected Persons on Combination Antiretroviral Therapy
S Pallikkuth, SP Kanthikeel, SY Silva, M Fischl, R Pahwa, S Pahwa |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
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Systems Biology of Seasonal Influenza Vaccination in Humans
HI Nakaya, J Wrammert, EK Lee, L Racioppi, S Marie-Kunze, WN Haining, AR Means, SP Kasturi, N Khan, GM Li, M McCausland, V Kanchan, KE Kokko, S Li, R Elbein, AK Mehta, A Aderem, K Subbarao, R Ahmed, B Pulendran |
Nature Immunology | 2011 |
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Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients
S Pallikkuth, SP Kanthikeel, SY Silva, M Fischl, R Pahwa, S Pahwa |
Journal of Allergy and Clinical Immunology | 2011 |
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Cytokines as therapeutic targets in SLE
L Rönnblom, KB Elkon |
Nature Reviews Rheumatology | 2010 |
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Innate signaling networks in mucosal IgA class switching
A Chorny, I Puga, A Cerutti |
Advances in immunology | 2010 |
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Immunopathogenesis of thyroid eye disease: emerging paradigms
VM Naik, MN Naik, RA Goldberg, TJ Smith, RS Douglas |
Survey of Ophthalmology | 2010 |
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Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: Past, present, and future
N Jacob, W Stohl |
Autoimmunity | 2010 |
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Control systems and decision making for antibody production
CC Goodnow, CG Vinuesa, KL Randall, F Mackay, R Brink |
Nature Immunology | 2010 |
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Requirement for BAFF and APRIL during B Cell Development in GALT
VA Yeramilli, KL Knight |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
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B cells as therapeutic targets in SLE
I Sanz, FE Lee |
Nature Reviews Rheumatology | 2010 |
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Systems Vaccinology
B Pulendran, S Li, HI Nakaya |
Immunity | 2010 |
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B Cell Activating Factor (BAFF) and T Cells Cooperate to Breach B Cell Tolerance in Lupus-Prone New Zealand Black (NZB) Mice
NH Chang, YH Cheung, C Loh, E Pau, V Roy, YC Cai, J Wither, J Kanellopoulos |
PloS one | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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BAFF: a local and systemic target in autoimmune diseases
I Moisini, A Davidson |
Clinical & Experimental Immunology | 2009 |
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A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus
DJ Wallace, W Stohl, RA Furie, JR Lisse, JD McKay, JT Merrill, MA Petri, EM Ginzler, WW Chatham, WJ McCune, V Fernandez, MR Chevrier, ZJ Zhong, WW Freimuth |
Arthritis & Rheumatism | 2009 |
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Expression of B-Cell Activating Factor Enhances Protective Immunity of a Vaccine against Pseudomonas aeruginosa
C Tertilt, J Joh, A Krause, P Chou, K Schneeweiss, RG Crystal, S Worgall |
Infection and immunity | 2009 |
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Blockade of B-cell-activating factor suppresses lupus-like syndrome in autoimmune BXSB mice
H Ding, L Wang, X Wu, J Yan, Y He, B Ni, W Gao, X Zhong |
Journal of Cellular and Molecular Medicine | 2009 |
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APRIL is overexpressed in cancer: link with tumor progression
J Moreaux, JL Veyrune, JD Vos, B Klein |
BMC Cancer | 2009 |
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Disease-Modifying Agents for Multiple Sclerosis: Recent Advances and Future Prospects
T Menge, MS Weber, B Hemmer, BC Kieseier, HC von Büdingen, C Warnke, SS Zamvil, A Boster, O Khan, HP Hartung, O Stüve |
Drugs | 2008 |
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Stimulation of the primary anti-HIV antibody response by IFN- in patients with acute HIV-1 infection
L Adalid-Peralta, V Godot, C Colin, R Krzysiek, T Tran, P Poignard, A Venet, A Hosmalin, P Lebon, C Rouzioux, G Chene, D Emilie |
Journal of leukocyte biology | 2008 |
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Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis
QL Lam, OK Ko, BJ Zheng, L Lu |
Proceedings of the National Academy of Sciences | 2008 |
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Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice
MR Schmidt, MC Appel, LJ Giassi, DL Greiner, LD Shultz, RT Woodland |
PloS one | 2008 |
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High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation
JA Burger, MP Quiroga, E Hartmann, A Burkle, WG Wierda, MJ Keating, A Rosenwald |
Blood | 2008 |
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Dendritic cell-dependent inhibition of B cell proliferation requires CD22.
Santos L, Draves KE, Boton M, Grewal PK, Marth JD, Clark EA |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
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Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, SLE-like autoimmunity
Stohl W, Jacob N, Quinn WJ III, Cancro MP, Gao H, Putterman C, Gao X, Pricop L, Koss MN |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
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High levels of B-cell activating factor in patients with active chronic graft-versus-host disease
S Sarantopoulos, KE Stevenson, HT Kim, NS Bhuiya, CS Cutler, RJ Soiffer, JH Antin, J Ritz |
Clinical cancer research | 2007 |
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Similarities and differences between selective and non-selective BAFF blockade in murine SLE
Meera Ramanujam, Xiaobo Wang, Weiqing Huang, Zheng Liu, Lena Schiffer, Haiou Tao, Daniel Frank, Jeffrey Rice, Betty Diamond, Karl O.A. Yu, Steven Porcelli, and Anne Davidson. |
Journal of Clinical Investigation | 2006 |
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Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis
T Vallerskog, M Heimbürger, I Gunnarsson, W Zhou, M Wahren-Herlenius, C Trollmo, V Malmström |
Arthritis Research & Therapy | 2006 |
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A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys
Y Vugmeyster, D Seshasayee, W Chang, A Storn, K Howell, S Sa, T Nelson, F Martin, I Grewal, E Gilkerson, B Wu, J Thompson, BN Ehrenfels, S Ren, A Song, TR Gelzleichter, DM Danilenko |
The American Journal of Pathology | 2006 |
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A checkpoint for autoreactivity in human IgM + memory B cell development
M Tsuiji, S Yurasov, K Velinzon, S Thomas, MC Nussenzweig, H Wardemann |
Journal of Experimental Medicine | 2006 |
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CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS
SI Tschen, SA Stohlman, C Ramakrishna, DR Hinton, RD Atkinson, CC Bergmann |
European Journal of Immunology | 2006 |
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B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia
SF Elsawa, AJ Novak, DM Grote, SC Ziesmer, TE Witzig, RA Kyle, SR Dillon, B Harder, JA Gross, SM Ansell |
Blood | 2006 |
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Early preplasma cells define a tolerance checkpoint for autoreactive B cells.
Culton DA, O'Conner BP, Conway KL, Diz R, Rutan J, Vilen BJ, Clarke SH |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
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Paucity of Clinical Disease despite Serological Autoimmunity and Kidney Pathology in Lupus-Prone New Zealand Mixed 2328 Mice Deficient in BAFF
Jacob CO, Pricop L, Putterman C, Koss MN, Liu Y, Kollaros M, Bixler SA, Ambrose CM, Scott ML, Stohl W |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
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Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
M Shapiro-Shelef, KI Lin, D Savitsky, J Liao, K Calame |
Journal of Experimental Medicine | 2005 |
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Identification and characterization of circulating human transitional B cells
GP Sims, R Ettinger, Y Shirota, CH Yarboro, GG Illei, PE Lipsky |
Blood | 2005 |
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Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor
R Bellucci, EP Alyea, S Chiaretti, CJ Wu, E Zorn, E Weller, B Wu, C Canning, R Schlossman, NC Munshi, KC Anderson, J Ritz |
Blood | 2005 |
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B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels
CE Collins, AL Gavin, TS Migone, DM Hilbert, D Nemazee, W Stohl |
Arthritis Research & Therapy | 2005 |
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Expression of BAFF-R (BR 3) in normal and neoplastic lymphoid tissues characterized with a newly developed monoclonal antibody.
Nakamura N, Hase H, Sakurai D, Yoshida S, Abe M, Tsukada N, Takizawa J, Aoki S, Kojima M, Nakamura S, Kobata T |
Virchows Archiv : an international journal of pathology | 2005 |
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BCMA is essential for the survival of long-lived bone marrow plasma cells
BP O'Connor, VS Raman, LD Erickson, WJ Cook, LK Weaver, C Ahonen, LL Lin, GT Mantchev, RJ Bram, RJ Noelle |
Journal of Experimental Medicine | 2004 |
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Raised levels of anti-glucose-6-phosphate isomerase IgG in serum and synovial fluid from patients with inflammatory arthritis
M Schaller, W Stohl, SM Tan, VM Benoit, DM Hilbert, HJ Ditzel |
Annals of the rheumatic diseases | 2004 |
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The current status of targeting BAFF/BLyS for autoimmune diseases
M Ramanujam, A Davidson |
Arthritis Research & Therapy | 2004 |
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Inverse association between circulating APRIL levels and serological and clinical disease activity in patients with systemic lupus erythematosus
W Stohl, S Metyas, SM Tan, GS Cheema, B Oamar, V Roschke, Y Wu, KP Baker, DM Hilbert |
Annals of the rheumatic diseases | 2004 |
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BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
J Moreaux, E Legouffe, E Jourdan, P Quittet, T Rème, C Lugagne, P Moine, JF Rossi, B Klein, K Tarte |
Blood | 2004 |
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Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily
S Moir, A Malaspina, OK Pickeral, ET Donoghue, J Vasquez, NJ Miller, SR Krishnan, MA Planta, JF Turney, JS Justement, S Kottilil, M Dybul, JA Mican, C Kovacs, TW Chun, CE Birse, AS Fauci |
Journal of Experimental Medicine | 2004 |
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Divide and conquer: the importance of cell division in regulating B-cell responses
SG Tangye, PD Hodgkin |
Immunology | 2004 |
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Targeting Plasma Cells in Autoimmune Diseases: Figure 1
DM Tarlinton, PD Hodgkin |
Journal of Experimental Medicine | 2004 |
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B cell abnormalities in systemic lupus erythematosus
AC Grammer, PE Lipsky |
Arthritis Research & Therapy | 2003 |
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