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Disrupted TGF-β signaling: a link between bronchopulmonary dysplasia and alveolar type 1 cells
Rongbo Li
Rongbo Li
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Disrupted TGF-β signaling: a link between bronchopulmonary dysplasia and alveolar type 1 cells

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Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease common in extreme preterm infants and is characterized by alveolar simplification. Current BPD research mainly focuses on alveolar type 2 (AT2) cells, myofibroblasts, and the endothelium. However, a notable gap exists in the involvement of AT1 cells, which constitute a majority of the alveolar surface area. In this issue of the JCI, Callaway and colleagues explored the role of TGF-β signaling in AT1 cells for managing the AT1-to-AT2 transition and its involvement in the integration of mechanical forces with the pulmonary matrisome during development. The findings implicate AT1 cells in the pathogenesis of BPD.

Authors

Rongbo Li

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
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PDF 202 27
Citation downloads 227 0
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Total Views 1,265

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ISSN: 0021-9738 (print), 1558-8238 (online)

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