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ResearchIn-Press PreviewCardiology
Open Access | 
10.1172/JCI177077
Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide-bond catalytic activity
Qingnian Liu,1 Jiniu Huang,1 Hao Ding,1 Yue Tao,1 Jinliang Nan,1 Changchen Xiao,1 Yingchao Wang,1 Rongrong Wu,1 Cheng Ni,1 Zhiwei Zhong,1 Wei Zhu,2 Jinghai Chen,3 Chenyun Zhang,1 Xiao He,4 Danyang Xiong,4 Xinyang Hu,1 and Jian'an Wang1
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Liu, Q. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Huang, J. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Ding, H. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Tao, Y. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Nan, J. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Xiao, C. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Wang, Y. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Wu, R. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Ni, C. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Zhong, Z. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Zhu, W. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Chen, J. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Zhang, C. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by He, X. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Xiong, D. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Hu, X. in: JCI | PubMed | Google Scholar
1Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
2Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Provinc, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
3Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
4Shanghai Engineering Research Center of Molecular Therapeutics and New Drug, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineer, Shanghai, China
Find articles by Wang, J. in: JCI | PubMed | Google Scholar
Published October 31, 2024 - More info
Copyright © 2024, Liu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2024 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)