Citations to this article

Inducible costimulator is essential for collagen-induced arthritis
Roza I. Nurieva, … , Richard A. Flavell, Chen Dong
Roza I. Nurieva, … , Richard A. Flavell, Chen Dong
Published March 1, 2003
Citation Information: J Clin Invest. 2003;111(5):701-706. https://doi.org/10.1172/JCI17321.
View: Text | PDF | Retraction
Article Autoimmunity Article has an altmetric score of 7

Inducible costimulator is essential for collagen-induced arthritis

Abstract

CD4+ helper Th cells play a major role in the pathogenesis of rheumatoid arthritis. Th cell activation, differentiation, and immune function are regulated by costimulatory molecules. Inducible costimulator (ICOS) is a novel costimulatory receptor expressed on activated T cells. We, as well as others, recently demonstrated its importance in Th2 cytokine expression and Ab class switching by B cells. In this study, we examined the role of ICOS in rheumatoid arthritis using a collagen-induced arthritis model. We found that ICOS knockout mice on the DBA/1 background were completely resistant to collagen-induced arthritis and exhibited absence of joint tissue inflammation. These mice, when immunized with collagen, exhibited reduced anti-collagen IgM Ab’s in the initial stage and IgG2a Ab’s at the effector phase of collagen-induced arthritis. Furthermore, ICOS regulates the in vitro and in vivo expression of IL-17, a proinflammatory cytokine implicated in rheumatoid arthritis. These data indicate that ICOS is essential for collagen-induced arthritis and may suggest novel means for treating patients with rheumatoid arthritis.

Authors

Roza I. Nurieva, Piper Treuting, Julie Duong, Richard A. Flavell, Chen Dong

×

Total citations by year

Year: 2021 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Total
Citations: 1 1 1 2 1 3 1 2 4 5 3 3 1 5 2 1 3 39
Citation information

Citations to this article (39)

Title and authors Publication Year
The PI-3-Kinase P110α Catalytic Subunit of T Lymphocytes Modulates Collagen-Induced Arthritis
M Montes-Casado, G Ojeda, G Criado, JM Rojo, P Portolés 		International journal of molecular sciences 2021
Interleukin (IL)-21 in Inflammation and Immunity During Parasitic Diseases
S Solaymani-Mohammadi, L Eckmann, SM Singer 		Frontiers in Cellular and Infection Microbiology 2019
Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model
A Burlion, S Brunel, NY Petit, D Olive, G Marodon 		Frontiers in immunology 2017
Follicular helper T cell in immunity and autoimmunity
D Mesquita, WM Cruvinel, LS Resende, FV Mesquita, NP Silva, NO Câmara, LE Andrade 		Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2016
Synovial fluid proteome in rheumatoid arthritis
M Bhattacharjee, L Balakrishnan, S Renuse, J Advani, R Goel, G Sathe, TS Prasad, B Nair, R Jois, S Shankar, A Pandey 		Clinical Proteomics 2016
Th17 Down-regulation Is Involved in Reduced Progression of Schistosomiasis Fibrosis in ICOSL KO Mice
B Wang, S Liang, Y Wang, XQ Zhu, W Gong, HQ Zhang, Y Li, CM Xia, AS MacDonald 		PLoS neglected tropical diseases 2015
Regulatory T-cell vaccination independent of auto-antigen
DW Pascual, X Yang, K Holderness, SM Jun, M Maddaloni, I Kochetkova 		Experimental & molecular medicine 2014
Candida-Elicited Murine Th17 Cells Express High CTLA-4 Compared with Th1 Cells and Are Resistant to Costimulation Blockade
SM Krummey, TL Floyd, D Liu, ME Wagener, M Song, ML Ford 		Journal of immunology (Baltimore, Md. : 1950) 2014
Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells
P Sakthivel, M Gereke, A Breithaupt, D Fuchs, L Gigliotti, AD Gruber, U Dianzani, D Bruder 		PloS one 2014
Targeting co-stimulatory pathways: transplantation and autoimmunity
ML Ford, AB Adams, TC Pearson 		Nature Reviews Nephrology 2013
TLR9-Dependent IL-23/IL-17 Is Required for the Generation of Stachybotrys chartarum –Induced Hypersensitivity Pneumonitis
U Bhan, MJ Newstead, X Zeng, A Podsaid, M Goswami, MN Ballinger, SL Kunkel, TJ Standiford 		Journal of immunology (Baltimore, Md. : 1950) 2012
The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target
A Chakera, SC Bennett, O Morteau, P Bowness, RA Luqmani, RJ Cornall 		Clinical & developmental immunology 2012
Novel Treatments for Systemic Lupus Erythematosus
W Xiong, RG Lahita 		Therapeutic Advances in Musculoskeletal Diseases 2011
Expression of inducible co-stimulator on peripheral blood T lymphocytes in patients with lupus nephritis
WX Li, HF Pan, GP Chen, JH Tao, XP Li, DQ Ye 		Rheumatology International 2011
IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis
J Tao, M Kamanaka, J Hao, Z Hao, X Jiang, JE Craft, RA Flavell, Z Wu, Z Hong, L Zhao, Z Yin 		Arthritis Research & Therapy 2011
Selective upregulation of microRNA expression in peripheral blood leukocytes in IL-10-/- mice precedes expression in the colon
JS Schaefer, D Montufar-Solis, N Vigneswaran, JR Klein 		Journal of immunology (Baltimore, Md. : 1950) 2011
Activation of OX40 Augments Th17 Cytokine Expression and Antigen-Specific Uveitis
Z Zhang, W Zhong, D Hinrichs, X Wu, A Weinberg, M Hall, D Spencer, K Wegmann, JT Rosenbaum 		The American Journal of Pathology 2010
CD4+T-cell activation is differentially modulated by bacteria-primed dendritic cells, but is generally down-regulated by n-3 polyunsaturated fatty acids
S Brix, P Lund, TM Kjaer, EM Straarup, LI Hellgren, H Frøkiaer 		Immunology 2010
Plasma IL-17A Is Increased in New-Onset SLE Patients and Associated with Disease Activity
XQ Chen, YC Yu, HH Deng, JZ Sun, Z Dai, YW Wu, M Yang 		Journal of Clinical Immunology 2010
Pharmacotherapy: concepts of pathogenesis and emerging treatments. Co-stimulation and T cells as therapeutic targets
AM Gizinski, DA Fox, S Sarkar 		Best practice & research. Clinical rheumatology 2010
A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis
JR Abreu, W Dontje, S Krausz, D Launay, PB van Hennik, AM Stalborch, JP Klooster, ME Sanders, KA Reedquist, MJ Vervoordeldonk, PL Hordijk, PP Tak 		Arthritis Research & Therapy 2010
Down-regulation of inducible co-stimulator (ICOS) by intravitreal injection of small interfering RNA (siRNA) plasmid suppresses ongoing experimental autoimmune uveoretinitis in rats
Y Hou, L Xing, S Fu, X Zhang, J Liu, H Liu, B Lv, H Cui 		Graefe's Archive for Clinical and Experimental Ophthalmology 2009
ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10 −/− mice
JS Schaefer, D Montufar-Solis, N Vigneswaran, JR Klein 		Journal of leukocyte biology 2009
ICOS Deficiency Results in Exacerbated IL-17 Mediated Experimental Autoimmune Encephalomyelitis
G Galicia, A Kasran, C Uyttenhove, KD Swert, JV Snick, JL Ceuppens 		Journal of Clinical Immunology 2009
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ ROR t+ T cells
M Lochner, L Peduto, M Cherrier, S Sawa, F Langa, R Varona, D Riethmacher, M Si-Tahar, JP di Santo, G Eberl 		Journal of Experimental Medicine 2008
T-cell co-stimulatory pathways in autoimmunity
JJ Goronzy, CM Weyand 		Arthritis Research & Therapy 2008
An overview of IL-17 function and signaling
SL Gaffen 		Cytokine 2008
Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression
A Maitra, F Shen, W Hanel, K Mossman, J Tocker, D Swart, SL Gaffen 		Proceedings of the National Academy of Sciences 2007
Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis
T Honda, E Segi-Nishida, Y Miyachi, S Narumiya 		Journal of Experimental Medicine 2006
Inducible co-stimulator (ICOS) is upregulated in experimental autoimmune uveoretinitis
L Xing, P Yang, C Wu, HL Jin, X Chen, Y Gao, B Li, X Huang, H Zhou 		Graefe's Archive for Clinical and Experimental Ophthalmology 2006
Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-gamma and anti-double-stranded DNA antibody production
M Kawamoto, M Harigai, M Hara, Y Kawaguchi, K Tezuka, M Tanaka, T Sugiura, Y Katsumata, C Fukasawa, H Ichida, S Higami, N Kamatani 		Arthritis Research & Therapy 2006
B7RP-1-ICOS Interactions Are Required for Optimal Infection-Induced Expansion of CD4+ Th1 and Th2 Responses
Wilson EH, Zaph C, Mohrs M, Welcher A, Siu J, Artis D, Hunter CA 		Journal of immunology (Baltimore, Md. : 1950) 2006
Cutting Edge: Evidence for Ligand-Independent Multimerization of the IL-17 Receptor
Kramer JM, Yi L, Shen F, Maitra A, Jiao X, Jin T, Gaffen SL 		Journal of immunology (Baltimore, Md. : 1950) 2006
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
CL Langrish, Y Chen, WM Blumenschein, J Mattson, B Basham, JD Sedgwick, T McClanahan, RA Kastelein, DJ Cua 		Journal of Experimental Medicine 2005
The balance of immune responses: costimulation verse coinhibition
SK Subudhi, ML Alegre, YX Fu 		Journal of Molecular Medicine 2005
Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis
SL Gaffen 		Arthritis Research & Therapy 2004
The Role of the ICOS-B7h T Cell Costimulatory Pathway in transplantation immunity
Hiroshi Harada, Alan D. Salama, Masayuki Sho, Atsushi Izawa, Sigrid E. Sandner, Toshiro Ito, Hisaya Akiba, Hideo Yagita, Arlene H. Sharpe, Gordon J. Freeman, and Mohamed H. Sayegh 		Journal of Clinical Investigation 2003
Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing – a biochemical paradigm for the ageing immune system
T Fülöp, A Larbi, G Dupuis, G Pawelec 		Arthritis Research & Therapy 2003
B7h is required for T cell activation, differentiation, and effector function
RI Nurieva, XM Mai, K Forbush, MJ Bevan, C Dong 		Proceedings of the National Academy of Sciences 2003

Advertisement