Schematic representation of the main clinical features of lymphatic anomalies characterized by lymphatic overgrowth (indicated in blue): cystic LMs, complex lymphatic anomalies (CLAs), and LMs associated with segmental overgrowth syndromes (PROS). The following definitions are based on the classification for vascular anomalies proposed by the International Society for the Study of Vascular Anomalies (ISSVA): LM, lymphatic malformation; GLA, generalized lymphatic anomaly; KLA, Kaposiform lymphangiomatosis; GSD, Gorham-Stout disease; CCLA, central conducting lymphatic anomaly; PROS, PIK3CA-related overgrowth spectrum; KTS, Klippel-Trenaunay syndrome; CLOVES, congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and scoliosis/skeletal/spinal anomalies. KLA and GSD are characterized by bone lesions (as indicated with asterisks), and CCLA is associated with dilation of and leakage from central lymphatic vessels.