The thrombospondins are a family of extracellular calcium-binding proteins that modulate cellular phenotype. Thrombospondin-1 (TSP-1) reportedly regulates cellular attachment, proliferation, migration, and differentiation in vitro. To explore its function in vivo, we have disrupted the TSP-1 gene by homologous recombination in the mouse genome. Platelets from these mice are completely deficient in TSP-1 protein; however, thrombin-induced platelet aggregation is not diminished. TSP-1-deficient mice display a mild and variable lordotic curvature of the spine that is apparent from birth. These mice also display an increase in the number of circulating white blood cells, with monocytes and eosinophils having the largest percent increases. The brain, heart, kidney, spleen, stomach, intestines, aorta, and liver of TSP-1-deficient mice showed no major abnormalities. However, consistent with high levels of expression of TSP-1 in lung, we observe abnormalities in the lungs of mice that lack the protein. Although normal at birth, histopathological analysis of lungs from 4-wk-old TSP-1-deficient mice reveals extensive acute and organizing pneumonia, with neutrophils and macrophages. The macrophages stain for hemosiderin, indicating that diffuse alveolar hemorrhage is occurring. At later times, the number of neutrophils decreases and a striking increase in the number of hemosiderin-containing macrophages is observed associated with multiple-lineage epithelial hyperplasia and the deposition of collagen and elastin. A thickening and ruffling of the epithelium of the airways results from increasing cell proliferation in TSP-1-deficient mice. These results indicate that TSP-1 is involved in normal lung homeostasis.
J Lawler, M Sunday, V Thibert, M Duquette, E L George, H Rayburn, R O Hynes
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Journal of Bone and Mineral Research | 2014 |
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Neurochemistry International | 2014 |
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2014 | |
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Mucosal Immunology | 2013 |
The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis
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PLoS genetics | 2013 |
Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation
P Kong, C Gonzalez-Quesada, N Li, M Cavalera, DW Lee, NG Frangogiannis |
American journal of physiology. Endocrinology and metabolism | 2013 |
Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway
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Cellular and Molecular Immunology | 2013 |
Role of thrombospondin-1 in repair of penetrating corneal wounds
JT Blanco-Mezquita, AE Hutcheon, JD Zieske |
Investigative ophthalmology & visual science | 2013 |
Thrombospondin 1 Mediates High-Fat Diet-Induced Muscle Fibrosis and Insulin Resistance in Male Mice
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Endocrinology | 2013 |
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IB Robertson, DB Rifkin |
Cytokine & Growth Factor Reviews | 2013 |
Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors
S Kaur, DR Soto-Pantoja, EV Stein, C Liu, AG Elkahloun, ML Pendrak, A Nicolae, SP Singh, Z Nie, D Levens, JS Isenberg, DD Roberts |
Scientific Reports | 2013 |
Central corneal thickness does not correlate with TonoLab-measured IOP in several mouse strains with single transgenic mutations of matricellular proteins
A Chatterjee, DJ Oh, MH Kang, DJ Rhee |
Experimental Eye Research | 2013 |
Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation
C Gonzalez-Quesada, M Cavalera, A Biernacka, P Kong, DW Lee, A Saxena, O Frunza, M Dobaczewski, A Shinde, NG Frangogiannis |
Circulation research | 2013 |
Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAF(V600E): New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment
M Duquette, PM Sadow, J Lawler, C Nucera |
Frontiers in Endocrinology | 2013 |
The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1
L Qin, D Zhao, J Xu, X Ren, EF Terwilliger, S Parangi, J Lawler, HF Dvorak, H Zeng |
Blood | 2013 |
Role of Thrombospondin-1 in Repair of Penetrating Corneal Wounds
JT Blanco-Mezquita, AE Hutcheon, JD Zieske |
Investigative ophthalmology & visual science | 2013 |
The NuRD Chromatin-Remodeling Enzyme CHD4 Promotes Embryonic Vascular Integrity by Transcriptionally Regulating Extracellular Matrix Proteolysis
KG Ingram, CD Curtis, R Silasi-Mansat, F Lupu, CT Griffin, B Bruneau |
PLoS genetics | 2013 |
Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation
P Kong, C Gonzalez-Quesada, N Li, M Cavalera, DW Lee, NG Frangogiannis |
American journal of physiology. Endocrinology and metabolism | 2013 |
TGF-β in Human Disease
A Moustakas, K Miyazawa |
2013 | |
Evolution of Extracellular Matrix
FW Keeley, RP Mecham |
2013 | |
Matricellular Proteins in Cardiac Adaptation and Disease
NG Frangogiannis |
Physiological reviews | 2012 |
Production of gastrointestinal tumors in mice by modulating latent TGF-β1 activation
K Shibahara, M Ota, M Horiguchi, K Yoshinaga, J Melamed, DB Rifkin |
Cancer research | 2012 |
Endogenous Thrombospondin-1 Regulates Leukocyte Recruitment and Activation and Accelerates Death from Systemic Candidiasis
G Martin-Manso, DH Navarathna, S Galli, DR Soto-Pantoja, SA Kuznetsova, M Tsokos, DD Roberts, J Xu |
PloS one | 2012 |
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1
PM Bauer, EM Bauer, NM Rogers, M Yao, M Feijoo-Cuaresma, JM Pilewski, HC Champion, BS Zuckerbraun, MJ Calzada, JS Isenberg |
Cardiovascular Research | 2012 |
Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation
KB DuBose, M Zayzafoon, JE Murphy-Ullrich |
Biochemical and Biophysical Research Communications | 2012 |
Bone Matrix and Mineralization
MD McKee, WG Cole |
Pediatric Bone | 2012 |
Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy
EW Brunskill, SS Potter |
BMC Nephrology | 2012 |
Environmental conditioning in the control of macrophage thrombospondin-1 production
JB Fordham, J Hua, SR Morwood, LP Schewitz-Bowers, DA Copland, AD Dick, LB Nicholson |
Scientific Reports | 2012 |
Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction
N Bige, N Shweke, S Benhassine, C Jouanneau, S Vandermeersch, JC Dussaule, C Chatziantoniou, P Ronco, JJ Boffa |
Kidney International | 2012 |
Pediatric Bone
M Bastepe, H Jüppner, RV Thakker |
Pediatric Bone | 2012 |
Transforming growth factor- 1 induces epithelial-mesenchymal transition and integrin 3 1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug
D Saito, S Kyakumoto, N Chosa, M Ibi, N Takahashi, N Okubo, S Sawada, A Ishisaki, M Kamo |
Journal of Biochemistry | 2012 |
Peroxisome proliferator-activated receptor gamma (PPARγ) regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation
DE Green, BY Kang, TC Murphy, CM Hart |
Pulmonary circulation | 2012 |
Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures
RI Haddadin, DJ Oh, MH Kang, G Villarreal, JH Kang, R Jin, H Gong, DJ Rhee |
Investigative ophthalmology & visual science | 2012 |
Lack of thrombospondin 1 and exacerbation of choroidal neovascularization
S Wang, CM Sorenson, N Sheibani |
Archives of ophthalmology | 2012 |
Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy via TGF-β1 activation in mice
H Hayashi, K Sakai, H Baba, T Sakai |
Hepatology | 2012 |
Thrombospondin-1 (TSP1)–Null and TSP2-Null Mice Exhibit Lower Intraocular Pressures
RI Haddadin, DJ Oh, MH Kang, G Villarreal, JH Kang, R Jin, H Gong, DJ Rhee |
Investigative ophthalmology & visual science | 2012 |
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment
N Sheibani, ME Morrison, Z Gurel, SY Park, CM Sorenson |
American journal of physiology. Renal physiology | 2012 |
Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitisinfection
CH Woelk, JX Zhang, L Walls, S Viriyakosol, A Singhania, TN Kirkland, J Fierer |
BMC Microbiology | 2012 |
Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for -Cell Function
J Olerud, D Mokhtari, M Johansson, G Christoffersson, J Lawler, N Welsh, PO Carlsson |
Diabetes | 2011 |
Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension
JP Maloney, RS Stearman, TM Bull, DW Calabrese, ML Tripp-Addison, MJ Wick, U Broeckel, IM Robbins, LA Wheeler, JD Cogan, JE Loyd |
American journal of physiology. Lung cellular and molecular physiology | 2011 |
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment
N Sheibani, ME Morrison, Z Gurel, SY Park, CM Sorenson |
American journal of physiology. Renal physiology | 2011 |
Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity
S McMaken, MC Exline, P Mehta, M Piper, Y Wang, SN Fischer, CA Newland, CA Schrader, SR Balser, A Sarkar, CP Baran, CB Marsh, CH Cook, GS Phillips, NA Ali, UG Munderloh |
PloS one | 2011 |
Endogenous Thrombospondin 1 Protects the Pressure-Overloaded Myocardium by Modulating Fibroblast Phenotype and Matrix Metabolism
Y Xia, M Dobaczewski, C Gonzalez-Quesada, W Chen, A Biernacka, N Li, DW Lee, NG Frangogiannis |
Hypertension | 2011 |
Thrombospondin-1: multiple paths to inflammation
Z Lopez-Dee, K Pidcock, LS Gutierrez |
Mediators of Inflammation | 2011 |
The thrombospondins
JC Adams, J Lawler |
Cold Spring Harbor perspectives in biology | 2011 |
A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling
K Moriya, E Bae, K Honda, K Sakai, T Sakaguchi, I Tsujimoto, H Kamisoyama, DR Keene, T Sasaki, T Sakai |
Gastroenterology | 2011 |
Choreographing Metastasis to the Tune of LTBP
A Chandramouli, J Simundza, A Pinderhughes, P Cowin |
Journal of Mammary Gland Biology and Neoplasia | 2011 |
Emerging functions of matricellular proteins
DD Roberts |
Cellular and Molecular Life Sciences | 2011 |
Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system
SJ Franco, U Müller |
Developmental Neurobiology | 2011 |
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices*
A Naba, KR Clauser, S Hoersch, H Liu, SA Carr, RO Hynes |
Molecular & cellular proteomics : MCP | 2011 |
Persistent Inflammation Subverts Thrombospondin-1-Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation
M Chen, DA Copland, J Zhao, J Liu, JV Forrester, AD Dick, H Xu |
The American Journal of Pathology | 2011 |
Current Topics in Developmental Biology
JE Qualls, PJ Murray |
Cancer and Development | 2011 |
Thrombospondin-1, endothelium and systemic vascular tone
CD Ochoa, BW Fouty, CA Hales |
Future Cardiology | 2011 |
The Thrombospondins
JC Adams, J Lawler |
Cold Spring Harbor perspectives in biology | 2011 |
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
A Naba, KR Clauser, S Hoersch, H Liu, SA Carr, RO Hynes |
Molecular & cellular proteomics : MCP | 2011 |
Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage
K Vanhees, S Coort, EJ Ruijters, RW Godschalk, FJ van Schooten, SB van Waalwijk van Doorn-Khosrovani |
The FASEB Journal | 2011 |
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis
A Zaslavsky, KH Baek, RC Lynch, S Short, J Grillo, J Folkman, JE Italiano, S Ryeom |
Blood | 2010 |
Thrombospondin-1 inhibits angiogenesis and promotes follicular atresia in a novel in vitro angiogenesis assay
SA Garside, CR Harlow, SG Hillier, HM Fraser, FH Thomas |
Endocrinology | 2010 |
A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome
O Garcia, M Torres, P Helguera, P Coskun, J Busciglio |
PloS one | 2010 |
Variable Inhibition of Thrombospondin 1 against Liver and Lung Metastases through Differential Activation of Metalloproteinase ADAMTS1
YJ Lee, M Koch, D Karl, AX Torres-Collado, NT Fernando, C Rothrock, D Kuruppu, S Ryeom, ML Iruela-Arispe, SS Yoon |
Cancer research | 2010 |
Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension
CD Ochoa, L Yu, E Al-Ansari, CA Hales, DA Quinn |
Journal of Cardiothoracic Surgery | 2010 |
A Thrombospondin-Mimetic Peptide, ABT-898, Suppresses Angiogenesis and Promotes Follicular Atresia in Pre- and Early-Antral Follicles in Vivo
SA Garside, J Henkin, KD Morris, SM Norvell, FH Thomas, HM Fraser |
Endocrinology | 2010 |
Thrombospondin-1 is not the major activator of TGF- 1 in thrombopoietin-induced myelofibrosis
S Evrard, O Bluteau, M Tulliez, P Rameau, P Gonin, E Zetterberg, J Palmblad, A Bonnefoy, JL Villeval, W Vainchenker, S Giraudier, O Wagner-Ballon |
Blood | 2010 |
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
O-Fucosylation of Thrombospondin Type 1 Repeats Restricts Epithelial to Mesenchymal Transition (EMT) and Maintains Epiblast Pluripotency During Mouse Gastrulation
J Du, H Takeuchi, C Leonhard-Melief, KR Shroyer, M Dlugosz, RS Haltiwanger, BC Holdener |
Developmental Biology | 2010 |
Angiogenesis
TH Adair, JP Montani |
Colloquium Series on Integrated Systems Physiology: From Molecule to Function | 2010 |
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation
PP Fitchev, SM Wcislak, C Lee, A Bergh, CB Brendler, VM Stellmach, SE Crawford, CD Mavroudis, ML Cornwell, JA Doll |
Laboratory Investigation | 2010 |
The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1
A Mallakin, T Sugiyama, F Kai, P Taneja, RD Kendig, DP Frazier, D Maglic, LA Matise, MC Willingham, K Inoue |
International Journal of Cancer | 2010 |
Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts
AI Alford, SP Terkhorn, AB Reddy, KD Hankenson |
Bone | 2010 |
Endothelial-derived thrombospondin-1 promotes macrophage recruitment and apoptotic cell clearance
T Kirsch, A Woywodt, J Klose, K Wyss, M Beese, U Erdbruegger, M Grossheim, H Haller, M Haubitz |
Journal of Cellular and Molecular Medicine | 2010 |
Thrombospondin 1
J Lawler |
AfCS-Nature Molecule Pages | 2010 |
Role of class A human thrombospondins in the clearance of dying cells and tolerance induction
A Tabib, A Krispin, D Mevorach |
Annals of the New York Academy of Sciences | 2010 |
Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme
R Airik, MO Trowe, A Foik, HF Farin, M Petry, K Schuster-Gossler, M Schweizer, G Scherer, R Kist, A Kispert |
Human Molecular Genetics | 2010 |
Matricellular proteins and inflammatory cells: A task force to promote or defeat cancer?
AS Llera, MR Girotti, LG Benedetti, OL Podhajcer |
Cytokine & Growth Factor Reviews | 2010 |
Thrombospondin-1–Deficient Mice Are Not Protected from Bleomycin-Induced Pulmonary Fibrosis
ME Ezzie, MG Piper, C Montague, CA Newland, JM Opalek, C Baran, N Ali, D Brigstock, J Lawler, CB Marsh |
American journal of respiratory cell and molecular biology | 2010 |
The Evolution of Thrombospondins and Their Ligand-Binding Activities
AA Bentley, JC Adams |
Molecular Biology and Evolution | 2010 |
Regional Control of Tumor Growth
A Zaslavsky, C Chen, J Grillo, KH Baek, L Holmgren, SS Yoon, J Folkman, S Ryeom |
Molecular cancer research : MCR | 2010 |
CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo
M Koch, F Hussein, A Woeste, C Gründker, K Frontzek, G Emons, T Hawighorst |
Breast Cancer Research and Treatment | 2010 |
Do adipokines link obesity to its related metabolic and cardiovascular diseases?
M Blüher |
Clinical Lipidology | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Thrombospondins function as regulators of angiogenesis
P Bornstein |
Journal of Cell Communication and Signaling | 2009 |
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1
EA Scheef, CM Sorenson, N Sheibani |
American journal of physiology. Cell physiology | 2009 |
The role of thrombospondins in wound healing, ischemia, and the foreign body reaction
TR Kyriakides, S Maclauchlan |
Journal of Cell Communication and Signaling | 2009 |
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1
F Fouladkou, C Lu, C Jiang, L Zhou, Y She, JR Walls, H Kawabe, N Brose, RM Henkelman, A Huang, BG Bruneau, D Rotin |
The Journal of biological chemistry | 2009 |
Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1
SY Kang, OJ Halvorsen, K Gravdal, N Bhattacharya, JM Lee, NW Liu, BT Johnston, AB Johnston, SA Haukaas, K Aamodt, S Yoo, LA Akslen, RS Watnick |
Proceedings of the National Academy of Sciences | 2009 |
Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation
A Liu, P Garg, S Yang, P Gong, MA Pallero, DS Annis, Y Liu, A Passaniti, D Mann, DF Mosher, JE Murphy-Ullrich, SE Goldblum |
The Journal of biological chemistry | 2009 |
CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression
Y Tang, EA Scheef, S Wang, CM Sorenson, CB Marcus, CR Jefcoate, N Sheibani |
Blood | 2009 |
The Angiogenesis Inhibitor Thrombospondin-1 Inhibits Acute Cutaneous Hypersensitivity Reactions
P Velasco, R Huegel, J Brasch, JM Schröder, M Weichenthal, E Stockfleth, T Schwarz, J Lawler, M Detmar, B Lange-Asschenfeldt |
Journal of Investigative Dermatology | 2009 |
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9
L Gilles, D Bluteau, S Boukour, Y Chang, Y Zhang, T Robert, P Dessen, N Debili, OA Bernard, W Vainchenker, H Raslova |
Blood | 2009 |
Duplication and distinct expression patterns of two thrombospondin-1 isoforms in teleost fishes
FR Wu, LY Zhou, Y Nagahama, DS Wang |
Gene Expression Patterns | 2009 |
The Extracellular Matrix: Not Just Pretty Fibrils
RO Hynes |
Science | 2009 |
Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice: Muscle phenotype of TSP-1 null mice
MH Malek, IM Olfert |
Experimental Physiology | 2009 |
In Vitro and In Vivo Evidence that Thrombospondin-1 (TSP-1) Contributes to Stirring- and Shear-Dependent Activation of Platelet-Derived TGF-β1
J Ahamed, CA Janczak, KM Wittkowski, BS Coller, RE Morty |
PloS one | 2009 |
Epidermal Growth Factor-like Repeats of Thrombospondins Activate Phospholipase Cγ and Increase Epithelial Cell Migration through Indirect Epidermal Growth Factor Receptor Activation
A Liu, P Garg, S Yang, P Gong, MA Pallero, DS Annis, Y Liu, A Passaniti, D Mann, DF Mosher, JE Murphy-Ullrich, SE Goldblum |
The Journal of biological chemistry | 2009 |
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1
EA Scheef, CM Sorenson, N Sheibani |
American journal of physiology. Cell physiology | 2009 |
Phagocytosis of Dying Cells: From Molecular Mechanisms to Human Diseases
DV Krysko, P Vandenabeele |
2009 | |
Bone Pathology
JS Khurana |
2009 | |
The Biology of Gastric Cancers
TC Wang, JG Fox, AS Giraud |
2009 | |
Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1
NA Ali, AA Gaughan, CG Orosz, CP Baran, S McMaken, Y Wang, TD Eubank, M Hunter, FJ Lichtenberger, NA Flavahan, J Lawler, CB Marsh |
PloS one | 2008 |
Modulation of thrombospondin-1-induced macrophage activation state protects tissue from necrosis during critical hind limb ischemia
Nicolas Bréchot, Elisa Gomez, Marine Bignon, Jamila Khallou-Laschet, Aurélie Cazes, Cécile Alanio-Bréchot, Mélanie Durand, Josette Philippe, Jean-Sébastien Silvestre, Nico Van Rooijen, Pierre Corvol, Antonino Nicoletti, Bénédicte Chazaud, Stéphane Germain |
2008 | |
CD47: A New Target in Cardiovascular Therapy
JS Isenberg, DD Roberts, WA Frazier |
Arteriosclerosis, thrombosis, and vascular biology | 2008 |
Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
SM Blake, V Strasser, N Andrade, S Duit, R Hofbauer, WJ Schneider, J Nimpf |
The EMBO Journal | 2008 |
Thrombospondin-1: a physiological regulator of nitric oxide signaling
JS Isenberg, WA Frazier, DD Roberts |
Cellular and molecular life sciences : CMLS | 2008 |
Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen
KL Posey, K Hankenson, AC Veerisetty, P Bornstein, J Lawler, JT Hecht |
The American Journal of Pathology | 2008 |
Therapeutic potential of antiangiogenic agents for prevention and treatment of obesity
Y Cao, R Cao, Y Xue |
Future Lipidology | 2008 |
Tumor-vascular interactions and tumor dormancy
GN Naumov, J Folkman, O Straume, LA Akslen |
APMIS | 2008 |
Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling
JS Isenberg, MJ Romeo, C Yu, CK Yu, K Nghiem, J Monsale, ME Rick, DA Wink, WA Frazier, DD Roberts |
Blood | 2008 |
Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury
JS Isenberg, JB Maxhimer, F Hyodo, ML Pendrak, LA Ridnour, WG DeGraff, M Tsokos, DA Wink, DD Roberts |
The American Journal of Pathology | 2008 |
Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability
CB Carlson, Y Liu, JL Keck, DF Mosher |
The Journal of biological chemistry | 2008 |
A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation
Y Hirose, K Chiba, T Karasugi, M Nakajima, Y Kawaguchi, Y Mikami, T Furuichi, F Mio, A Miyake, T Miyamoto, K Ozaki, A Takahashi, H Mizuta, T Kubo, T Kimura, T Tanaka, Y Toyama, S Ikegawa |
The American Journal of Human Genetics | 2008 |
The effect of thrombospondin-1 on breast cancer metastasis
KO Yee, CM Connolly, M Duquette, S Kazerounian, R Washington, J Lawler |
Breast Cancer Research and Treatment | 2008 |
Thrombospondins: from structure to therapeutics
DD Roberts |
Cellular and molecular life sciences : CMLS | 2008 |
The Role of Thrombospondin 1 on Intestinal Inflammation and Carcinogenesis
LS Gutierrez |
Biomarker insights | 2008 |
Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling
JS Isenberg, WA Frazier, MC Krishna, DA Wink, DD Roberts |
Current drug targets | 2008 |
Regulation of thrombospondin1 by extracellular proteases
ML Iruela-Arispe |
Current drug targets | 2008 |
Therapeutic potential of novel modulators of neovascularization
S Rahman, YM Patel, ES Wijelath, MS Sobel |
Future Cardiology | 2008 |
Therapy of Marfan Syndrome
DP Judge, HC Dietz |
Annual Review of Medicine | 2008 |
Review of the activation of TGF-β in immunity
AW Taylor |
Journal of leukocyte biology | 2008 |
Thrombospondins: from structure to therapeutics: Thrombospondins in cancer
S Kazerounian, KO Yee, J Lawler |
Cellular and Molecular Life Sciences | 2008 |
Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
J Olerud, M Johansson, J Lawler, N Welsh, PO Carlsson |
Diabetes | 2008 |
Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells
LC Redmond, CI Dumur, KJ Archer, JL Haar, JA Lloyd |
Developmental Dynamics | 2008 |
Secreted thrombospondin-1 controls platelet sensitivity to NO
DF Mosher, LM Maurer, CB Carlson |
Blood | 2008 |
Influences of the N700S Thrombospondin-1 Polymorphism on Protein Structure and Stability
CB Carlson, Y Liu, JL Keck, DF Mosher |
The Journal of biological chemistry | 2008 |
Thrombospondin 1 and Its Mimetic Peptide ABT-510 Decrease Angiogenesis and Inflammation in a Murine Model of Inflammatory Bowel Disease
S Punekar, S Zak, VG Kalter, L Dobransky, I Punekar, JW Lawler, LS Gutierrez |
Pathobiology | 2008 |
Angiogenesis modulates adipogenesis and obesity
Yihai Cao |
Journal of Clinical Investigation | 2007 |
The extracellular matrix and blood vessel formation: not just a scaffold
JM Rhodes, M Simons |
Journal of Cellular and Molecular Medicine | 2007 |
Extracellular control of TGFbeta signalling in vascular development and disease
P Dijke, HM Arthur |
Nature Reviews Molecular Cell Biology | 2007 |
Vascular response to intra-arterial injury in the thrombospondin-1 null mouse
F Budhani, KA Leonard, A Bergdahl, J Gao, J Lawler, EC Davis |
Journal of Molecular and Cellular Cardiology | 2007 |
Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells
Y Lu, JM Thomson, HY Wong, SM Hammond, BL Hogan |
Developmental Biology | 2007 |
Cell-matrix adhesion in vascular development
RO Hynes |
Journal of Thrombosis and Haemostasis | 2007 |
A guide to murine platelet structure, function, assays, and genetic alterations
M Jirouskova, AS Shet, GJ Johnson |
Journal of Thrombosis and Haemostasis | 2007 |
Thrombospondin-1 Inhibits VEGF Levels in the Ovary Directly by Binding and Internalization Via the Low Density Lipoprotein Receptor-Related Protein-1 (LRP-1)
J Greenaway, J Lawler, R Moorehead, P Bornstein, J Lamarre, J Petrik |
Journal of Cellular Physiology | 2007 |
Thrombospondin-1 Is an Endogenous Activator of TGF- in Experimental Diabetic Nephropathy In Vivo
C Daniel, K Schaub, K Amann, J Lawler, C Hugo |
Diabetes | 2007 |
When the lung is stretched, could it be thrombospondin via TGFβ1 peptide activation?
D Warburton, V Kaartinen |
The Journal of Physiology | 2007 |
Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle
M Yamauchi, S Imajoh-Ohmi, M Shibuya |
Cancer Science | 2007 |
Atorvastatin Neutralizes the Up-Regulation of Thrombospondin-1 Induced by Thrombin in Human Umbilical Vein Endothelial Cells
V Martínez-Sales, V Vila, M Ferrando, E Reganon |
Endothelium : journal of endothelial cell research | 2007 |
Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1
SV Bradley, TS Hyun, KI Oravecz-Wilson, L Li, EI Waldorff, AN Ermilov, SA Goldstein, CX Zhang, DG Drubin, K Varela, A Parlow, AA Dlugosz, TS Ross |
Human Molecular Genetics | 2007 |
Role of Thrombospondin-1 in T Cell Response to Ocular Pigment Epithelial Cells
Y Futagami, S Sugita, J Vega, K Ishida, H Takase, K Maruyama, H Aburatani, M Mochizuki |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
Novel antiangiogenic pathway of thrombospondin‐1 mediated by suppression of the cell cycle
Yamauchi M, Imajoh\u2010Ohmi S, Shibuya M |
Cancer Science | 2007 |
Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization
Hans-Georg Kopp, Andrea T. Hooper, M. Johan Broekman, Scott T. Avecilla, Isabelle Petit, Min Luo, Till Milde, Carlos A. Ramos, Fan Zhang, Tabitha Kopp, Paul Bornstein, Jack Lawler, David K Jin, Aaron J. Marcus, and Shahin Rafii |
Journal of Clinical Investigation | 2006 |
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2
NV Lee, M Sato, DS Annis, JA Loo, L Wu, DF Mosher, ML Iruela-Arispe |
The EMBO Journal | 2006 |
Requirements for Apoptotic Cell Contact in Regulation of Macrophage Responses
M Lucas, LM Stuart, A Zhang, K Hodivala-Dilke, M Febbraio, R Silverstein, J Savill, A Lacy-Hulbert |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
The Mechanistic Basis of Infarct Healing
NG Frangogiannis |
Antioxidants & Redox Signaling | 2006 |
Thrombospondin 1, thrombospondin 2 and the eye
P Hiscott, L Paraoan, A Choudhary, JL Ordonez, A Al-Khaier, DJ Armstrong |
Progress in Retinal and Eye Research | 2006 |
Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13
A Bonnefoy, K Daenens, HB Feys, RD Vos, P Vandervoort, J Vermylen, J Lawler, MF Hoylaerts |
Blood | 2006 |
Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation
P McKenzie, SC Chadalavada, J Bohrer, JC Adams |
BMC Evolutionary Biology | 2006 |
The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin
K Tan, M Duquette, JH Liu, R Zhang, A Joachimiak, J Wang, J Lawler |
Structure (London, England : 1993) | 2006 |
Attenuation of retinal vascular development and neovascularization in transgenic mice over-expressing thrombospondin-1 in the lens
Z Wu, S Wang, CM Sorenson, N Sheibani |
Developmental Dynamics | 2006 |
Parathyroid Hormone Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin
AG Diamond, RM Gonterman, AL Anderson, K Menon, CD Offutt, CH Weaver, WM Philbrick, J Foley |
Journal of Investigative Dermatology | 2006 |
Induced thrombospondin expression in the mouse pancreas during pancreatic injury
BA Neuschwander-Tetri, V Talkad, FO Stephen |
The International Journal of Biochemistry & Cell Biology | 2006 |
Deficiency of thrombospondin-1 in mice does not affect adipose tissue development
G Voros, HR Lijnen |
Journal of Thrombosis and Haemostasis | 2006 |
CD47 Is Necessary for Inhibition of Nitric Oxide-stimulated Vascular Cell Responses by Thrombospondin-1
JS Isenberg, LA Ridnour, J Dimitry, WA Frazier, DA Wink, DD Roberts |
The Journal of biological chemistry | 2006 |
Shear Stress Modulates the Expression of Thrombospondin-1 and CD36 in Endothelial Cells in vitro and during Shear Stress-Induced Angiogenesis in vivo
M Bongrazio, LD Silva-Azevedo, EC Bergmann, O Baum, B Hinz, AR Pries, A Zakrzewicz |
International journal of immunopathology and pharmacology | 2006 |
Ocular Angiogenesis
J Tombrain-Tink, CJ Barnstable |
2006 | |
Identification of Thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia
Charuhas V. Thakar, Kamyar Zahedi, Monica P Revelo, Zhaohui Wang, Charles E. Burnham, Sharon Barone, Shannon Bevans, Alex B. Lentsch, Jack Lawler, Hamid Rabb, and Manoocher Soleimani |
Journal of Clinical Investigation | 2005 |
Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis
Y Shaked, F Bertolini, S Man, MS Rogers, D Cervi, T Foutz, K Rawn, D Voskas, DJ Dumont, Y Ben-David, J Lawler, J Henkin, J Huber, DJ Hicklin, RJ D'Amato, RS Kerbel |
Cancer Cell | 2005 |
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner
JS Isenberg, LA Ridnour, EM Perruccio, MG Espey, DA Wink, DD Roberts |
Proceedings of the National Academy of Sciences | 2005 |
Thrombospondin‐1 up‐regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium
NV Narizhneva, OV Razorenova, EA Podrez, J Chen, UM Chandrasekharan, PE Dicorleto, EF Plow, EJ Topol, TV Byzova |
The FASEB Journal | 2005 |
Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells
K Breitkopf, I Sawitza, JH Westhoff, L Wickert, S Dooley, AM Gressner |
Gut | 2005 |
Regulation of tumor angiogenesis by thrombospondin-1
B Ren, KO Yee, J Lawler, R Khosravi-Far |
Biochimica et Biophysica Acta | 2005 |
Characterization of integrin β6 and thrombospondin‐1 double‐null mice
Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J |
Journal of Cellular and Molecular Medicine | 2005 |
The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein
R Simantov, M Febbraio, RL Silverstein |
Matrix Biology | 2005 |
The N-terminal module of thrombospondin-1 interacts with the link domain of TSG-6 and enhances its covalent association with the heavy chains of inter-alpha-trypsin inhibitor
SA Kuznetsova, AJ Day, DJ Mahoney, MS Rugg, DF Mosher, DD Roberts |
The Journal of biological chemistry | 2005 |
Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases
SM Wahl, W Chen |
Arthritis Research & Therapy | 2005 |
Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors
M Sund, Y Hamano, H Sugimoto, A Sudhakar, M Soubasakos, U Yerramalla, LE Benjamin, J Lawler, M Kieran, A Shah, R Kalluri |
Proceedings of the National Academy of Sciences | 2005 |
Activation of Latent TGF-β1 by Thrombospondin-1 is a Major Component of Wound Repair
JE Nör, L Dipietro, JE Murphy-Ullrich, RO Hynes, J Lawler, PJ Polverini |
Oral biosciences & medicine : OBM | 2005 |
Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation
A Reheman, P Gross, H Yang, P Chen, D Allen, V Leytin, J Freedman, H Ni |
Journal of Thrombosis and Haemostasis | 2005 |
Characterization of integrin ?6 and thrombospondin-1 double-null mice
A Ludlow, KO Yee, R Lipman, R Bronson, P Weinreb, X Huang, D Sheppard, J Lawler |
Journal of Cellular and Molecular Medicine | 2005 |
CD36:A Multiligand Molecule
Y Ge, MT Elghetany |
Laboratory Hematology | 2005 |
Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor
JS Isenberg, MJ Calzada, L Zhou, N Guo, J Lawler, XQ Wang, WA Frazier, DD Roberts |
Matrix Biology | 2005 |
Chondromodulin-I and tenomodulin: A new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues
C Shukunami, Y Oshima, Y Hiraki |
Biochemical and Biophysical Research Communications | 2005 |
Reduced Expression of Thrombospondins and Craniofacial Dysmorphism in Mice Overexpressing Fra1
T Nishiwaki, T Yamaguchi, C Zhao, H Amano, KD Hankenson, P Bornstein, Y Toyama, K Matsuo |
Journal of Bone and Mineral Research | 2005 |
Downregulation of Decorin and Transforming Growth Factor-β1 by Decorin Gene Suppression in Tendinocytes
Y Hosaka, R Kirisawa, N Mafune, K Takehana |
Connective Tissue Research | 2005 |
Characterization of integrin beta6 and thrombospondin-1 double-null mice
Anna Ludlow, Karen O Yee, Ruth Lipman, R Bronson, P Weinreb, Xiaozhu Huang, D Sheppard, J Lawler |
Journal of Cellular and Molecular Medicine | 2005 |
The N-terminal Module of Thrombospondin-1 Interacts with the Link Domain of TSG-6 and Enhances Its Covalent Association with the Heavy Chains of Inter-α-trypsin Inhibitor
SA Kuznetsova, AJ Day, DJ Mahoney, MS Rugg, DF Mosher, DD Roberts |
The Journal of biological chemistry | 2005 |
Thrombin Modulates the Expression of a Set of Genes Including Thrombospondin-1 in Human Microvascular Endothelial Cells
JN McLaughlin, MR Mazzoni, JH Cleator, L Earls, AL Perdigoto, JD Brooks, JA Muldowney, DE Vaughan, HE Hamm |
The Journal of biological chemistry | 2005 |
Thrombospondin-1 is Induced in Rat Myocardial Infarction and Its Induction is Accelerated by Ischemia/Reperfusion
S Sezaki, S Hirohata, A Iwabu, K Nakamura, K Toeda, T Miyoshi, H Yamawaki, K Demircan, S Kusachi, Y Shiratori, Y Ninomiya |
Experimental biology and medicine (Maywood, N.J.) | 2005 |
The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells
M Soula-Rothhut, C Coissard, H Sartelet, C Boudot, G Bellon, L Martiny, B Rothhut |
Experimental Cell Research | 2005 |
Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo
C Daniel, J Wiede, HC Krutzsch, SM Ribeiro, DD Roberts, JE Murphy-Ullrich, C Hugo |
Kidney International | 2004 |
Dysfunctional platelet membrane receptors: from humans to mice
J Ware |
Thrombosis and haemostasis | 2004 |
Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction
NV Narizhneva, VJ Byers-Ward, MJ Quinn, FJ Zidar, EF Plow, EJ Topol, TV Byzova |
The Journal of biological chemistry | 2004 |
The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury
P Bornstein, A Agah, TR Kyriakides |
The International Journal of Biochemistry & Cell Biology | 2004 |
Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans
S Wang, ME Herndon, S Ranganathan, S Godyna, J Lawler, WS Argraves, G Liau |
Journal of Cellular Biochemistry | 2004 |
The thrombospondins
JC Adams, J Lawler |
The International Journal of Biochemistry & Cell Biology | 2004 |
Functions of the conserved thrombospondin carboxy-terminal cassette in cell–extracellular matrix interactions and signaling
JC Adams |
The International Journal of Biochemistry & Cell Biology | 2004 |
Thrombospondin modules and angiogenesis
ML Iruela-Arispe, A Luque, N Lee |
The International Journal of Biochemistry & Cell Biology | 2004 |
Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation
S Saika, T Miyamoto, I Ishida, WK Barbour, Y Ohnishi, A Ooshima |
Experimental Eye Research | 2004 |
Matrix metalloproteinases and matrikines in angiogenesis
G Bellon, L Martiny, A Robinet |
Critical Reviews in Oncology/Hematology | 2004 |
Functional regulation of T lymphocytes by modulatory extracellular matrix proteins
SA Kuznetsova, DD Roberts |
The International Journal of Biochemistry & Cell Biology | 2004 |
Coronary artery disease and the thrombospondin single nucleotide polymorphisms
OI Stenina, TV Byzova, JC Adams, JJ McCarthy, EJ Topol, EF Plow |
The International Journal of Biochemistry & Cell Biology | 2004 |
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-β1 and dexamethasone in vitro
C Flügel-Koch, A Ohlmann, R Fuchshofer, U Welge-Lüssen, ER Tamm |
Experimental Eye Research | 2004 |
Ultraviolet B-Induced Skin Angiogenesis Is Associated with a Switch in the Balance of Vascular Endothelial Growth Factor and Thrombospondin-1 Expression
K Yano, K Kajiya, M Ishiwata, YK Hong, T Miyakawa, M Detmar |
Journal of Investigative Dermatology | 2004 |
Bone Tissue Engineering
H Donahue, E Vogler, C Siedlecki |
Bone Tissue Engineering | 2004 |
The role of ECM molecules in activity-dependent synaptic development and plasticity
I Pavlov, S Lauri, T Taira, H Rauvala |
Birth Defects Research Part C: Embryo Today: Reviews | 2004 |
Latent TGF-?1 activation by platelets
R Blakytny, A Ludlow, GE Martin, G Ireland, LR Lund, MW Ferguson, G Brunner |
Journal of Cellular Physiology | 2004 |
Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts
KI Oravecz-Wilson, MJ Kiel, L Li, DS Rao, D Saint-Dic, PD Kumar, MM Provot, KD Hankenson, VN Reddy, AP Lieberman, SJ Morrison, TS Ross |
Human Molecular Genetics | 2004 |
Role of Thrombospondin-1 in Control of von Willebrand Factor Multimer Size in Mice
JE Pimanda, T Ganderton, A Maekawa, CL Yap, J Lawler, G Kershaw, CN Chesterman, PJ Hogg |
The Journal of biological chemistry | 2004 |
Thrombospondin-1 Associated with Tumor Microenvironment Contributes to Low-Dose Cyclophosphamide-Mediated Endothelial Cell Apoptosis and Tumor Growth Suppression
Y Hamano, H Sugimoto, MA Soubasakos, M Kieran, BR Olsen, J Lawler, A Sudhakar, R Kalluri |
Cancer research | 2004 |
Dysfunctional platelet membrane receptors: from humans to mice.
Ware J |
Thrombosis and haemostasis | 2004 |
Purification and analysis of thrombospondin-1
KO Yee, M Duquette, A Ludlow, J Lawler |
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] | 2003 |
Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice
S Weng, L Zemany, KN Standley, DV Novack, ML Regina, C Bernal-Mizrachi, T Coleman, CF Semenkovich |
Proceedings of the National Academy of Sciences | 2003 |
Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase
K Yano, LF Brown, J Lawler, T Miyakawa, M Detmar |
Journal of Investigative Dermatology | 2003 |
Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliteration
S Wang, Z Wu, CM Sorenson, J Lawler, N Sheibani |
Developmental Dynamics | 2003 |
Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation
V Doyen, M Rubio, D Braun, T Nakajima, J Abe, H Saito, G Delespesse, M Sarfati |
Journal of Experimental Medicine | 2003 |
Thrombospondin‐1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor
K Jurk, KJ Clemetson, PG Groot, MF Brodde, M Steiner, N Savion, D Varon, JJ Sixma, HV Aken, BE Kehrel |
The FASEB Journal | 2003 |
Antisense Oligonucleotides Against Thrombospondin-1 Inhibit Activation of TGF-β in Fibrotic Renal Disease in the Rat in Vivo
C Daniel, Y Takabatake, M Mizui, Y Isaka, H Kawashi, H Rupprecht, E Imai, C Hugo |
The American Journal of Pathology | 2003 |
Plasma fibronectin promotes thrombus growth and stability in injured arterioles
H Ni, PS Yuen, JM Papalia, JE Trevithick, T Sakai, R Fässler, RO Hynes, DD Wagner |
Proceedings of the National Academy of Sciences | 2003 |
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
G Bocci, G Francia, S Man, J Lawler, RS Kerbel |
Proceedings of the National Academy of Sciences | 2003 |
Antisense oligonucleotides against thrombospondin-1 inhibit activation of tgf-beta in fibrotic renal disease in the rat in vivo
C Daniel, Y Takabatake, M Mizui, Y Isaka, H Kawashi, H Rupprecht, E Imai, C Hugo |
The American Journal of Pathology | 2003 |
Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36
Y Moodley, P Rigby, C Bundell, S Bunt, H Hayashi, N Misso, R McAnulty, G Laurent, A Scaffidi, P Thompson, D Knight |
The American Journal of Pathology | 2003 |
Pulmonary gene expression profiling of inhaled ricin
L DaSilva, D Cote, C Roy, M Martinez, S Duniho, ML Pitt, T Downey, M Dertzbaugh |
Toxicon | 2003 |
The thrombospondin 1-TGF- axis in fibrotic renal disease
C Hugo |
Nephrology Dialysis Transplantation | 2003 |
Lung Biology in Health and Disease
N Zamel |
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential | 2003 |
Differential Regulation of Thrombospondin-1 and Thrombospondin-2 After Focal Cerebral Ischemia/Reperfusion
T Lin, GM Kim, JJ Chen, WM Cheung, YY He, CY Hsu |
Stroke; a journal of cerebral circulation | 2003 |
Thrombospondin and fibrinogen bind serotonin-derivatized proteins on COAT-platelets
R Szasz, GL Dale |
Blood | 2002 |
Cellular response to hypoxia involves signaling via Smad proteins
H Zhang |
Blood | 2002 |
Wiley Encyclopedia of Molecular Medicine
WT Morgan |
Wiley Encyclopedia of Molecular Medicine | 2002 |
Matricellular proteins: extracellular modulators of cell function
P Bornstein, EH Sage |
Current Opinion in Cell Biology | 2002 |
The Diverse Roles of Integrins and Their Ligands in Angiogenesis
R Hynes, J Lively, J Mccarty, D Taverna, S Francis, K Hodivala-Dilke, Q Xiao |
Cold Spring Harbor Symposia on Quantitative Biology | 2002 |
The face of TSR revealed: an extracellular signaling domain is exposed
RL Silverstein |
The Journal of Cell Biology | 2002 |
The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice
A Agah, TR Kyriakides, J Lawler, P Bornstein |
The American Journal of Pathology | 2002 |
ENDOCRINE EXPRESSION OF THE ACTIVE FORM OF TGF-β1 IN THE TGF-β1 NULL MICE FAILS TO AMELIORATE LETHAL PHENOTYPE
G Longenecker, T Thyagarajan, CN Nagineni, KC Flanders, V Factor, G Miller, JM Ward, A Nalca, VM Rangnekar, S Thorgeirsson, AB Kulkarni |
Cytokine | 2002 |
Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth
J Lawler |
Journal of Cellular and Molecular Medicine | 2002 |
Interactions of thrombospondins with α4β1 integrin and CD47 differentially modulate T cell behavior
Z Li, MJ Calzada, JM Sipes, JA Cashel, HC Krutzsch, DS Annis, DF Mosher, DD Roberts |
The Journal of Cell Biology | 2002 |
Drug Discovery and Evaluation
HG Vogel, WH Vogel, BA Schölkens, J Sandow, G Müller, WF Vogel |
2002 | |
Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily
H Chang, CW Brown, MM Matzuk |
Endocrine reviews | 2002 |
Trimeric assembly of the C-terminal region of Thrombospondin-1 or Thrombospondin-2 is necessary for cell spreading and fascin spike organisation
N Anilkumar, DS Annis, DF Mosher, JC Adams |
Journal of cell science | 2002 |
Thrombospondins as matricellular modulators of cell function
Paul Bornstein |
Journal of Clinical Investigation | 2001 |
Japanese Journal of Thrombosis and Hemostasis
M OKUDAIRA, H ASAKURA, Y SANO, Y SUGA, M YAMAZAKI, K AOSHIMA, E MORISHITA, M SAITO, Y ONTACHI, T MIZUTANI, M KATO, T ITO, K MIYAMOTO, S NAKAO |
Japanese Journal of Thrombosis and Hemostasis | 2001 |
Thrombospondins and tumor angiogenesis
F Fraipont, AC Nicholson, JJ Feige, EG van Meir |
Trends in Molecular Medicine | 2001 |
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor
JC Rodriguez-Manzaneque, TF Lane, MA Ortega, RO Hynes, J Lawler, ML Iruela-Arispe |
Proceedings of the National Academy of Sciences | 2001 |
PTEN controls tumor-induced angiogenesis
S Wen, J Stolarov, MP Myers, JD Su, MH Wigler, NK Tonks, DL Durden |
Proceedings of the National Academy of Sciences | 2001 |
Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice
J Lawler, WM Miao, M Duquette, N Bouck, RT Bronson, RO Hynes |
The American Journal of Pathology | 2001 |
THROMBOSPONDINS: Multifunctional Regulators of Cell Interactions
JC Adams |
Annual Review of Cell and Developmental Biology | 2001 |
Smad7 Misexpression during Embryonic Angiogenesis Causes Vascular Dilation and Malformations Independently of Vascular Smooth Muscle Cell Function
N Vargesson, E Laufer |
Developmental Biology | 2001 |
Special Considerations in the Evaluation of the Hematology and Hemostasis of Mutant Mice
BD Car, VM Eng |
Veterinary pathology | 2001 |
TGF?2 activation status during cardiac morphogenesis
KM McCormick |
Developmental Dynamics | 2001 |
Vascular Morphogenesis in the Female Reproductive System
HG Augustin, PA Rogers, ML Iruela-Arispe, SK Smith |
2001 | |
Thrombospondin-1 Inhibits TCR-Mediated T Lymphocyte Early Activation
Z Li, L He, KE Wilson, DD Roberts |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Insights into Extracellular Matrix Functions from Mutant Mouse Models
E Gustafsson, R Fässler |
Experimental Cell Research | 2000 |
Increased Marrow-Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2
KD Hankenson, SD Bain, TR Kyriakides, EA Smith, SA Goldstein, P Bornstein |
Journal of Bone and Mineral Research | 2000 |
The thrombospondin type 1 repeat (TSR) superfamily: Diverse proteins with related roles in neuronal development
JC Adams, RP Tucker |
Developmental Dynamics | 2000 |
An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype
CV Ngo, M Gee, N Akhtar, D Yu, O Volpert, R Auerbach, A Thomas-Tikhonenko |
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research | 2000 |
Platelets
JN George |
The Lancet | 2000 |
A CD36-Binding Peptide from Thrombospondin-1 Can Stimulate Resorption by Osteoclasts in Vitro
JA Carron, SC Wagstaff, JA Gallagher, WB Bowler |
Biochemical and Biophysical Research Communications | 2000 |
Osteoclasts and giant cells: macrophage–macrophage fusion mechanism
A Vignery |
International Journal of Experimental Pathology | 2000 |
The heparin binding 25 kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinase and TIMP-2 production in endothelial cells
G Taraboletti, L Morbidelli, S Donnini, A Parenti, HJ Granger, R Giavazzi, M Ziche |
The FASEB Journal | 2000 |
Thrombospondin 2, a matricellular protein with diverse functions
P Bornstein, LC Armstrong, KD Hankenson, TR Kyriakides, Z Yang |
Matrix Biology | 2000 |
The functions of thrombospondin-1 and-2
J Lawler |
Current Opinion in Cell Biology | 2000 |
Nitric Oxide–Dependent Activation of P53 Suppresses Bleomycin-Induced Apoptosis in the Lung
DW Davis, DA Weidner, A Holian, DJ McConkey |
Journal of Experimental Medicine | 2000 |
Tissue Factor Pathway Inhibitor Binds to Platelet Thrombospondin-1
AE Mast, JE Stadanlick, JM Lockett, DJ Dietzen, KA Hasty, CL Hall |
The Journal of biological chemistry | 2000 |
Activation of Platelet-transforming Growth Factor β-1 in the Absence of Thrombospondin-1
M Abdelouahed, A Ludlow, G Brunner, J Lawler |
The Journal of biological chemistry | 2000 |
Thrombospondin-4 Binds Specifically to Both Collagenous and Non-collagenous Extracellular Matrix Proteins via Its C-terminal Domains
L Narouz-Ott, P Maurer, DP Nitsche, N Smyth, M Paulsson |
The Journal of biological chemistry | 2000 |
Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2: REGULATION OF METALLOPROTEINASE ACTIVITY
K Bein, M Simons |
The Journal of biological chemistry | 2000 |
Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2
Z Yang, TR Kyriakides, P Bornstein, R Hynes |
Molecular biology of the cell | 2000 |
Antiangiogenic Gene Therapy in Cancer
L Zhang, Q Chen, A Mixson |
Current genomics | 2000 |
Apoptosis and Its Modulation by Drugs
RG Cameron, G Feuer |
2000 | |
CD47 Ligation Selectively Inhibits the Development of Human Naive T Cells into Th1 Effectors
MN Avice, M Rubio, M Sergerie, G Delespesse, M Sarfati |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo
CP Hugo, RP Pichler, E Schulze-Lohoff, F Prols, S Adler, HC Krutsch, JE Murphy-Ullrich, WG Couser, DD Roberts, RJ Johnson |
Kidney International | 1999 |
Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity
TR Kyriakides, KJ Leach, AS Hoffman, BD Ratner, P Bornstein |
Proceedings of the National Academy of Sciences | 1999 |
Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis
M Streit, L Riccardi, P Velasco, LF Brown, T Hawighorst, P Bornstein, M Detmar |
Proceedings of the National Academy of Sciences | 1999 |
CD47 ligation selectively downregulates human interleukin 12 production
M Armant, MN Avice, P Hermann, M Rubio, M Kiniwa, G Delespesse, M Sarfati |
Journal of Experimental Medicine | 1999 |
Expression of Members of the Thrombospondin Family by Human Skeletal Tissues and Cultured Cells
JA Carron, WB Bowler, SC Wagstaff, JA Gallagher |
Biochemical and Biophysical Research Communications | 1999 |
Cd47 Ligation Selectively Downregulates Human Interleukin 12 Production
M Armant, MN Avice, P Hermann, M Rubio, M Kiniwa, G Delespesse, M Sarfati |
Journal of Experimental Medicine | 1999 |
Overlapping and Independent Functions of Fibronectin Receptor Integrins in Early Mesodermal Development
JT Yang, BL Bader, JA Kreidberg, M Ullman-Culleré, JE Trevithick, RO Hynes |
Developmental Biology | 1999 |
Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis
M Streit, L Riccardi, P Velasco, LF Brown, T Hawighorst, P Bornstein, M Detmar |
Proceedings of the National Academy of Sciences | 1999 |
Detection of Exon Skipping and Retained Introns in Transcription of the Human Thrombospondin 2 Gene
KW Adolph |
Biochemical and Biophysical Research Communications | 1999 |
Relative Abundance of Thrombospondin 2 and Thrombospondin 3 mRNAs in Human Tissues
KW Adolph |
Biochemical and Biophysical Research Communications | 1999 |
Thrombospondin-1 and neural crest cell migration
RP Tucker, C Hagios, R Chiquet-Ehrismann, J Lawler, RJ Hall, CA Erickson |
Developmental Dynamics | 1999 |
F-Spondin, Expressed in Somite Regions Avoided by Neural Crest Cells, Mediates Inhibition of Distinct Somite Domains to Neural Crest Migration
A Debby-Brafman, T Burstyn-Cohen, A Klar, C Kalcheim |
Neuron | 1999 |
Integrins in vascular development
RO Hynes, BL Bader, K Hodivala-Dilke |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 1999 |
Pro-adhesive and Chemotactic Activities of Thrombospondin-1 for Breast Carcinoma Cells Are Mediated by α 3 β 1 Integrin and Regulated by Insulin-like Growth Factor-1 and CD98
S Chandrasekaran, N Guo, RG Rodrigues, J Kaiser, DD Roberts |
The Journal of biological chemistry | 1999 |
Restricted localization of thrombospondin-2 protein during mouse embryogenesis: A comparison to thrombospondin-1
PA Tooney, T Sakai, K Sakai, D Aeschlimann, DF Mosher |
Matrix Biology | 1998 |
Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays
H Zhu, JP Cong, G Mamtora, T Gingeras, T Shenk |
Proceedings of the National Academy of Sciences | 1998 |
Two-hybrid analysis reveals multiple direct interactions for thrombospondin 1
S Aho, J Uitto |
Matrix Biology | 1998 |
The Gene Knockout FactsBook
TW Mak, J Penninger, J Roder, J Rossant, M Saunders |
The Gene Knockout FactsBook | 1998 |
Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays
H Zhu, JP Cong, G Mamtora, T Gingeras, T Shenk |
Proceedings of the National Academy of Sciences | 1998 |
Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudochondroplasia musculoskeletal tissues
JT Hecht, M Deere, E Putnam, W Cole, B Vertel, H Chen, J Lawler |
Matrix Biology | 1998 |
Thrombospondin-1 is a major activator of TGF-beta1 in vivo
S E Crawford, V Stellmach, J E Murphy-Ullrich, S M Ribeiro, J Lawler, R O Hynes, G P Boivin, N Bouck |
Cell | 1998 |
Nitric Oxide
RA Schroeder, PC Kuo |
Anesthesia & Analgesia | 1995 |
Secretion and biological activities of heparin-binding growth-associated molecule. Neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein
E Raulo, I Julkunen, J Merenmies, R Pihlaskari, H Rauvala |
The Journal of biological chemistry | 1992 |
International Review of Cytology
RA Miller |
International Review of Cytology | 1991 |
Encyclopedic Reference of Vascular Biology & Pathology
A Bikfalvi |
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