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Citations to this article

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.
J Lawler, … , H Rayburn, R O Hynes
J Lawler, … , H Rayburn, R O Hynes
Published March 1, 1998
Citation Information: J Clin Invest. 1998;101(5):982-992. https://doi.org/10.1172/JCI1684.
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Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.

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Abstract

The thrombospondins are a family of extracellular calcium-binding proteins that modulate cellular phenotype. Thrombospondin-1 (TSP-1) reportedly regulates cellular attachment, proliferation, migration, and differentiation in vitro. To explore its function in vivo, we have disrupted the TSP-1 gene by homologous recombination in the mouse genome. Platelets from these mice are completely deficient in TSP-1 protein; however, thrombin-induced platelet aggregation is not diminished. TSP-1-deficient mice display a mild and variable lordotic curvature of the spine that is apparent from birth. These mice also display an increase in the number of circulating white blood cells, with monocytes and eosinophils having the largest percent increases. The brain, heart, kidney, spleen, stomach, intestines, aorta, and liver of TSP-1-deficient mice showed no major abnormalities. However, consistent with high levels of expression of TSP-1 in lung, we observe abnormalities in the lungs of mice that lack the protein. Although normal at birth, histopathological analysis of lungs from 4-wk-old TSP-1-deficient mice reveals extensive acute and organizing pneumonia, with neutrophils and macrophages. The macrophages stain for hemosiderin, indicating that diffuse alveolar hemorrhage is occurring. At later times, the number of neutrophils decreases and a striking increase in the number of hemosiderin-containing macrophages is observed associated with multiple-lineage epithelial hyperplasia and the deposition of collagen and elastin. A thickening and ruffling of the epithelium of the airways results from increasing cell proliferation in TSP-1-deficient mice. These results indicate that TSP-1 is involved in normal lung homeostasis.

Authors

J Lawler, M Sunday, V Thibert, M Duquette, E L George, H Rayburn, R O Hynes

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Cytokine & Growth Factor Reviews 2013
Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors
S Kaur, DR Soto-Pantoja, EV Stein, C Liu, AG Elkahloun, ML Pendrak, A Nicolae, SP Singh, Z Nie, D Levens, JS Isenberg, DD Roberts
Scientific Reports 2013
Central corneal thickness does not correlate with TonoLab-measured IOP in several mouse strains with single transgenic mutations of matricellular proteins
A Chatterjee, DJ Oh, MH Kang, DJ Rhee
Experimental Eye Research 2013
Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation
C Gonzalez-Quesada, M Cavalera, A Biernacka, P Kong, DW Lee, A Saxena, O Frunza, M Dobaczewski, A Shinde, NG Frangogiannis
Circulation research 2013
Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAF(V600E): New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment
M Duquette, PM Sadow, J Lawler, C Nucera
Frontiers in Endocrinology 2013
The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1
L Qin, D Zhao, J Xu, X Ren, EF Terwilliger, S Parangi, J Lawler, HF Dvorak, H Zeng
Blood 2013
Role of Thrombospondin-1 in Repair of Penetrating Corneal Wounds
JT Blanco-Mezquita, AE Hutcheon, JD Zieske
Investigative ophthalmology & visual science 2013
The NuRD Chromatin-Remodeling Enzyme CHD4 Promotes Embryonic Vascular Integrity by Transcriptionally Regulating Extracellular Matrix Proteolysis
KG Ingram, CD Curtis, R Silasi-Mansat, F Lupu, CT Griffin, B Bruneau
PLoS genetics 2013
Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation
P Kong, C Gonzalez-Quesada, N Li, M Cavalera, DW Lee, NG Frangogiannis
American journal of physiology. Endocrinology and metabolism 2013
TGF-β in Human Disease
A Moustakas, K Miyazawa
2013
Evolution of Extracellular Matrix
FW Keeley, RP Mecham
2013
Matricellular Proteins in Cardiac Adaptation and Disease
NG Frangogiannis
Physiological reviews 2012
Production of gastrointestinal tumors in mice by modulating latent TGF-β1 activation
K Shibahara, M Ota, M Horiguchi, K Yoshinaga, J Melamed, DB Rifkin
Cancer research 2012
Endogenous Thrombospondin-1 Regulates Leukocyte Recruitment and Activation and Accelerates Death from Systemic Candidiasis
G Martin-Manso, DH Navarathna, S Galli, DR Soto-Pantoja, SA Kuznetsova, M Tsokos, DD Roberts, J Xu
PloS one 2012
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1
PM Bauer, EM Bauer, NM Rogers, M Yao, M Feijoo-Cuaresma, JM Pilewski, HC Champion, BS Zuckerbraun, MJ Calzada, JS Isenberg
Cardiovascular Research 2012
Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation
KB DuBose, M Zayzafoon, JE Murphy-Ullrich
Biochemical and Biophysical Research Communications 2012
Bone Matrix and Mineralization
MD McKee, WG Cole
Pediatric Bone 2012
Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy
EW Brunskill, SS Potter
BMC Nephrology 2012
Environmental conditioning in the control of macrophage thrombospondin-1 production
JB Fordham, J Hua, SR Morwood, LP Schewitz-Bowers, DA Copland, AD Dick, LB Nicholson
Scientific Reports 2012
Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction
N Bige, N Shweke, S Benhassine, C Jouanneau, S Vandermeersch, JC Dussaule, C Chatziantoniou, P Ronco, JJ Boffa
Kidney International 2012
Pediatric Bone
M Bastepe, H Jüppner, RV Thakker
Pediatric Bone 2012
Transforming growth factor- 1 induces epithelial-mesenchymal transition and integrin  3 1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug
D Saito, S Kyakumoto, N Chosa, M Ibi, N Takahashi, N Okubo, S Sawada, A Ishisaki, M Kamo
Journal of Biochemistry 2012
Peroxisome proliferator-activated receptor gamma (PPARγ) regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation
DE Green, BY Kang, TC Murphy, CM Hart
Pulmonary circulation 2012
Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures
RI Haddadin, DJ Oh, MH Kang, G Villarreal, JH Kang, R Jin, H Gong, DJ Rhee
Investigative ophthalmology & visual science 2012
Lack of thrombospondin 1 and exacerbation of choroidal neovascularization
S Wang, CM Sorenson, N Sheibani
Archives of ophthalmology 2012
Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy via TGF-β1 activation in mice
H Hayashi, K Sakai, H Baba, T Sakai
Hepatology 2012
Thrombospondin-1 (TSP1)–Null and TSP2-Null Mice Exhibit Lower Intraocular Pressures
RI Haddadin, DJ Oh, MH Kang, G Villarreal, JH Kang, R Jin, H Gong, DJ Rhee
Investigative ophthalmology & visual science 2012
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment
N Sheibani, ME Morrison, Z Gurel, SY Park, CM Sorenson
American journal of physiology. Renal physiology 2012
Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitisinfection
CH Woelk, JX Zhang, L Walls, S Viriyakosol, A Singhania, TN Kirkland, J Fierer
BMC Microbiology 2012
Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for  -Cell Function
J Olerud, D Mokhtari, M Johansson, G Christoffersson, J Lawler, N Welsh, PO Carlsson
Diabetes 2011
Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension
JP Maloney, RS Stearman, TM Bull, DW Calabrese, ML Tripp-Addison, MJ Wick, U Broeckel, IM Robbins, LA Wheeler, JD Cogan, JE Loyd
American journal of physiology. Lung cellular and molecular physiology 2011
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment
N Sheibani, ME Morrison, Z Gurel, SY Park, CM Sorenson
American journal of physiology. Renal physiology 2011
Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity
S McMaken, MC Exline, P Mehta, M Piper, Y Wang, SN Fischer, CA Newland, CA Schrader, SR Balser, A Sarkar, CP Baran, CB Marsh, CH Cook, GS Phillips, NA Ali, UG Munderloh
PloS one 2011
Endogenous Thrombospondin 1 Protects the Pressure-Overloaded Myocardium by Modulating Fibroblast Phenotype and Matrix Metabolism
Y Xia, M Dobaczewski, C Gonzalez-Quesada, W Chen, A Biernacka, N Li, DW Lee, NG Frangogiannis
Hypertension 2011
Thrombospondin-1: multiple paths to inflammation
Z Lopez-Dee, K Pidcock, LS Gutierrez
Mediators of Inflammation 2011
The thrombospondins
JC Adams, J Lawler
Cold Spring Harbor perspectives in biology 2011
A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling
K Moriya, E Bae, K Honda, K Sakai, T Sakaguchi, I Tsujimoto, H Kamisoyama, DR Keene, T Sasaki, T Sakai
Gastroenterology 2011
Choreographing Metastasis to the Tune of LTBP
A Chandramouli, J Simundza, A Pinderhughes, P Cowin
Journal of Mammary Gland Biology and Neoplasia 2011
Emerging functions of matricellular proteins
DD Roberts
Cellular and Molecular Life Sciences 2011
Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system
SJ Franco, U Müller
Developmental Neurobiology 2011
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices*
A Naba, KR Clauser, S Hoersch, H Liu, SA Carr, RO Hynes
Molecular & cellular proteomics : MCP 2011
Persistent Inflammation Subverts Thrombospondin-1-Induced Regulation of Retinal Angiogenesis and Is Driven by CCR2 Ligation
M Chen, DA Copland, J Zhao, J Liu, JV Forrester, AD Dick, H Xu
The American Journal of Pathology 2011
Current Topics in Developmental Biology
JE Qualls, PJ Murray
Cancer and Development 2011
Thrombospondin-1, endothelium and systemic vascular tone
CD Ochoa, BW Fouty, CA Hales
Future Cardiology 2011
The Thrombospondins
JC Adams, J Lawler
Cold Spring Harbor perspectives in biology 2011
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
A Naba, KR Clauser, S Hoersch, H Liu, SA Carr, RO Hynes
Molecular & cellular proteomics : MCP 2011
Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage
K Vanhees, S Coort, EJ Ruijters, RW Godschalk, FJ van Schooten, SB van Waalwijk van Doorn-Khosrovani
The FASEB Journal 2011
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis
A Zaslavsky, KH Baek, RC Lynch, S Short, J Grillo, J Folkman, JE Italiano, S Ryeom
Blood 2010
Thrombospondin-1 inhibits angiogenesis and promotes follicular atresia in a novel in vitro angiogenesis assay
SA Garside, CR Harlow, SG Hillier, HM Fraser, FH Thomas
Endocrinology 2010
A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome
O Garcia, M Torres, P Helguera, P Coskun, J Busciglio
PloS one 2010
Variable Inhibition of Thrombospondin 1 against Liver and Lung Metastases through Differential Activation of Metalloproteinase ADAMTS1
YJ Lee, M Koch, D Karl, AX Torres-Collado, NT Fernando, C Rothrock, D Kuruppu, S Ryeom, ML Iruela-Arispe, SS Yoon
Cancer research 2010
Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension
CD Ochoa, L Yu, E Al-Ansari, CA Hales, DA Quinn
Journal of Cardiothoracic Surgery 2010
A Thrombospondin-Mimetic Peptide, ABT-898, Suppresses Angiogenesis and Promotes Follicular Atresia in Pre- and Early-Antral Follicles in Vivo
SA Garside, J Henkin, KD Morris, SM Norvell, FH Thomas, HM Fraser
Endocrinology 2010
Thrombospondin-1 is not the major activator of TGF- 1 in thrombopoietin-induced myelofibrosis
S Evrard, O Bluteau, M Tulliez, P Rameau, P Gonin, E Zetterberg, J Palmblad, A Bonnefoy, JL Villeval, W Vainchenker, S Giraudier, O Wagner-Ballon
Blood 2010
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa
2010
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa
2010
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa
2010
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa
2010
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa
2010
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa
2010
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa
2010
O-Fucosylation of Thrombospondin Type 1 Repeats Restricts Epithelial to Mesenchymal Transition (EMT) and Maintains Epiblast Pluripotency During Mouse Gastrulation
J Du, H Takeuchi, C Leonhard-Melief, KR Shroyer, M Dlugosz, RS Haltiwanger, BC Holdener
Developmental Biology 2010
Angiogenesis
TH Adair, JP Montani
Colloquium Series on Integrated Systems Physiology: From Molecule to Function 2010
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation
PP Fitchev, SM Wcislak, C Lee, A Bergh, CB Brendler, VM Stellmach, SE Crawford, CD Mavroudis, ML Cornwell, JA Doll
Laboratory Investigation 2010
The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1
A Mallakin, T Sugiyama, F Kai, P Taneja, RD Kendig, DP Frazier, D Maglic, LA Matise, MC Willingham, K Inoue
International Journal of Cancer 2010
Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts
AI Alford, SP Terkhorn, AB Reddy, KD Hankenson
Bone 2010
Endothelial-derived thrombospondin-1 promotes macrophage recruitment and apoptotic cell clearance
T Kirsch, A Woywodt, J Klose, K Wyss, M Beese, U Erdbruegger, M Grossheim, H Haller, M Haubitz
Journal of Cellular and Molecular Medicine 2010
Thrombospondin 1
J Lawler
AfCS-Nature Molecule Pages 2010
Role of class A human thrombospondins in the clearance of dying cells and tolerance induction
A Tabib, A Krispin, D Mevorach
Annals of the New York Academy of Sciences 2010
Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme
R Airik, MO Trowe, A Foik, HF Farin, M Petry, K Schuster-Gossler, M Schweizer, G Scherer, R Kist, A Kispert
Human Molecular Genetics 2010
Matricellular proteins and inflammatory cells: A task force to promote or defeat cancer?
AS Llera, MR Girotti, LG Benedetti, OL Podhajcer
Cytokine & Growth Factor Reviews 2010
Thrombospondin-1–Deficient Mice Are Not Protected from Bleomycin-Induced Pulmonary Fibrosis
ME Ezzie, MG Piper, C Montague, CA Newland, JM Opalek, C Baran, N Ali, D Brigstock, J Lawler, CB Marsh
American journal of respiratory cell and molecular biology 2010
The Evolution of Thrombospondins and Their Ligand-Binding Activities
AA Bentley, JC Adams
Molecular Biology and Evolution 2010
Regional Control of Tumor Growth
A Zaslavsky, C Chen, J Grillo, KH Baek, L Holmgren, SS Yoon, J Folkman, S Ryeom
Molecular cancer research : MCR 2010
CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo
M Koch, F Hussein, A Woeste, C Gründker, K Frontzek, G Emons, T Hawighorst
Breast Cancer Research and Treatment 2010
Do adipokines link obesity to its related metabolic and cardiovascular diseases?
M Blüher
Clinical Lipidology 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Thrombospondins function as regulators of angiogenesis
P Bornstein
Journal of Cell Communication and Signaling 2009
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1
EA Scheef, CM Sorenson, N Sheibani
American journal of physiology. Cell physiology 2009
The role of thrombospondins in wound healing, ischemia, and the foreign body reaction
TR Kyriakides, S Maclauchlan
Journal of Cell Communication and Signaling 2009
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1
F Fouladkou, C Lu, C Jiang, L Zhou, Y She, JR Walls, H Kawabe, N Brose, RM Henkelman, A Huang, BG Bruneau, D Rotin
The Journal of biological chemistry 2009
Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1
SY Kang, OJ Halvorsen, K Gravdal, N Bhattacharya, JM Lee, NW Liu, BT Johnston, AB Johnston, SA Haukaas, K Aamodt, S Yoo, LA Akslen, RS Watnick
Proceedings of the National Academy of Sciences 2009
Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation
A Liu, P Garg, S Yang, P Gong, MA Pallero, DS Annis, Y Liu, A Passaniti, D Mann, DF Mosher, JE Murphy-Ullrich, SE Goldblum
The Journal of biological chemistry 2009
CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression
Y Tang, EA Scheef, S Wang, CM Sorenson, CB Marcus, CR Jefcoate, N Sheibani
Blood 2009
The Angiogenesis Inhibitor Thrombospondin-1 Inhibits Acute Cutaneous Hypersensitivity Reactions
P Velasco, R Huegel, J Brasch, JM Schröder, M Weichenthal, E Stockfleth, T Schwarz, J Lawler, M Detmar, B Lange-Asschenfeldt
Journal of Investigative Dermatology 2009
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9
L Gilles, D Bluteau, S Boukour, Y Chang, Y Zhang, T Robert, P Dessen, N Debili, OA Bernard, W Vainchenker, H Raslova
Blood 2009
Duplication and distinct expression patterns of two thrombospondin-1 isoforms in teleost fishes
FR Wu, LY Zhou, Y Nagahama, DS Wang
Gene Expression Patterns 2009
The Extracellular Matrix: Not Just Pretty Fibrils
RO Hynes
Science 2009
Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice: Muscle phenotype of TSP-1 null mice
MH Malek, IM Olfert
Experimental Physiology 2009
In Vitro and In Vivo Evidence that Thrombospondin-1 (TSP-1) Contributes to Stirring- and Shear-Dependent Activation of Platelet-Derived TGF-β1
J Ahamed, CA Janczak, KM Wittkowski, BS Coller, RE Morty
PloS one 2009
Epidermal Growth Factor-like Repeats of Thrombospondins Activate Phospholipase Cγ and Increase Epithelial Cell Migration through Indirect Epidermal Growth Factor Receptor Activation
A Liu, P Garg, S Yang, P Gong, MA Pallero, DS Annis, Y Liu, A Passaniti, D Mann, DF Mosher, JE Murphy-Ullrich, SE Goldblum
The Journal of biological chemistry 2009
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1
EA Scheef, CM Sorenson, N Sheibani
American journal of physiology. Cell physiology 2009
Phagocytosis of Dying Cells: From Molecular Mechanisms to Human Diseases
DV Krysko, P Vandenabeele
2009
Bone Pathology
JS Khurana
2009
The Biology of Gastric Cancers
TC Wang, JG Fox, AS Giraud
2009
Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1
NA Ali, AA Gaughan, CG Orosz, CP Baran, S McMaken, Y Wang, TD Eubank, M Hunter, FJ Lichtenberger, NA Flavahan, J Lawler, CB Marsh
PloS one 2008
Modulation of thrombospondin-1-induced macrophage activation state protects tissue from necrosis during critical hind limb ischemia
Nicolas Bréchot, Elisa Gomez, Marine Bignon, Jamila Khallou-Laschet, Aurélie Cazes, Cécile Alanio-Bréchot, Mélanie Durand, Josette Philippe, Jean-Sébastien Silvestre, Nico Van Rooijen, Pierre Corvol, Antonino Nicoletti, Bénédicte Chazaud, Stéphane Germain
2008
CD47: A New Target in Cardiovascular Therapy
JS Isenberg, DD Roberts, WA Frazier
Arteriosclerosis, thrombosis, and vascular biology 2008
Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
SM Blake, V Strasser, N Andrade, S Duit, R Hofbauer, WJ Schneider, J Nimpf
The EMBO Journal 2008
Thrombospondin-1: a physiological regulator of nitric oxide signaling
JS Isenberg, WA Frazier, DD Roberts
Cellular and molecular life sciences : CMLS 2008
Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen
KL Posey, K Hankenson, AC Veerisetty, P Bornstein, J Lawler, JT Hecht
The American Journal of Pathology 2008
Therapeutic potential of antiangiogenic agents for prevention and treatment of obesity
Y Cao, R Cao, Y Xue
Future Lipidology 2008
Tumor-vascular interactions and tumor dormancy 
GN Naumov, J Folkman, O Straume, LA Akslen
APMIS 2008
Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling
JS Isenberg, MJ Romeo, C Yu, CK Yu, K Nghiem, J Monsale, ME Rick, DA Wink, WA Frazier, DD Roberts
Blood 2008
Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury
JS Isenberg, JB Maxhimer, F Hyodo, ML Pendrak, LA Ridnour, WG DeGraff, M Tsokos, DA Wink, DD Roberts
The American Journal of Pathology 2008
Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability
CB Carlson, Y Liu, JL Keck, DF Mosher
The Journal of biological chemistry 2008
A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation
Y Hirose, K Chiba, T Karasugi, M Nakajima, Y Kawaguchi, Y Mikami, T Furuichi, F Mio, A Miyake, T Miyamoto, K Ozaki, A Takahashi, H Mizuta, T Kubo, T Kimura, T Tanaka, Y Toyama, S Ikegawa
The American Journal of Human Genetics 2008
The effect of thrombospondin-1 on breast cancer metastasis
KO Yee, CM Connolly, M Duquette, S Kazerounian, R Washington, J Lawler
Breast Cancer Research and Treatment 2008
Thrombospondins: from structure to therapeutics
DD Roberts
Cellular and molecular life sciences : CMLS 2008
The Role of Thrombospondin 1 on Intestinal Inflammation and Carcinogenesis
LS Gutierrez
Biomarker insights 2008
Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling
JS Isenberg, WA Frazier, MC Krishna, DA Wink, DD Roberts
Current drug targets 2008
Regulation of thrombospondin1 by extracellular proteases
ML Iruela-Arispe
Current drug targets 2008
Therapeutic potential of novel modulators of neovascularization
S Rahman, YM Patel, ES Wijelath, MS Sobel
Future Cardiology 2008
Therapy of Marfan Syndrome
DP Judge, HC Dietz
Annual Review of Medicine 2008
Review of the activation of TGF-β in immunity
AW Taylor
Journal of leukocyte biology 2008
Thrombospondins: from structure to therapeutics: Thrombospondins in cancer
S Kazerounian, KO Yee, J Lawler
Cellular and Molecular Life Sciences 2008
Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
J Olerud, M Johansson, J Lawler, N Welsh, PO Carlsson
Diabetes 2008
Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells
LC Redmond, CI Dumur, KJ Archer, JL Haar, JA Lloyd
Developmental Dynamics 2008
Secreted thrombospondin-1 controls platelet sensitivity to NO
DF Mosher, LM Maurer, CB Carlson
Blood 2008
Influences of the N700S Thrombospondin-1 Polymorphism on Protein Structure and Stability
CB Carlson, Y Liu, JL Keck, DF Mosher
The Journal of biological chemistry 2008
Thrombospondin 1 and Its Mimetic Peptide ABT-510 Decrease Angiogenesis and Inflammation in a Murine Model of Inflammatory Bowel Disease
S Punekar, S Zak, VG Kalter, L Dobransky, I Punekar, JW Lawler, LS Gutierrez
Pathobiology 2008
Angiogenesis modulates adipogenesis and obesity
Yihai Cao
Journal of Clinical Investigation 2007
The extracellular matrix and blood vessel formation: not just a scaffold
JM Rhodes, M Simons
Journal of Cellular and Molecular Medicine 2007
Extracellular control of TGFbeta signalling in vascular development and disease
P Dijke, HM Arthur
Nature Reviews Molecular Cell Biology 2007
Vascular response to intra-arterial injury in the thrombospondin-1 null mouse
F Budhani, KA Leonard, A Bergdahl, J Gao, J Lawler, EC Davis
Journal of Molecular and Cellular Cardiology 2007
Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells
Y Lu, JM Thomson, HY Wong, SM Hammond, BL Hogan
Developmental Biology 2007
Cell-matrix adhesion in vascular development
RO Hynes
Journal of Thrombosis and Haemostasis 2007
A guide to murine platelet structure, function, assays, and genetic alterations
M Jirouskova, AS Shet, GJ Johnson
Journal of Thrombosis and Haemostasis 2007
Thrombospondin-1 Inhibits VEGF Levels in the Ovary Directly by Binding and Internalization Via the Low Density Lipoprotein Receptor-Related Protein-1 (LRP-1)
J Greenaway, J Lawler, R Moorehead, P Bornstein, J Lamarre, J Petrik
Journal of Cellular Physiology 2007
Thrombospondin-1 Is an Endogenous Activator of TGF-  in Experimental Diabetic Nephropathy In Vivo
C Daniel, K Schaub, K Amann, J Lawler, C Hugo
Diabetes 2007
When the lung is stretched, could it be thrombospondin via TGFβ1 peptide activation?
D Warburton, V Kaartinen
The Journal of Physiology 2007
Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle
M Yamauchi, S Imajoh-Ohmi, M Shibuya
Cancer Science 2007
Atorvastatin Neutralizes the Up-Regulation of Thrombospondin-1 Induced by Thrombin in Human Umbilical Vein Endothelial Cells
V Martínez-Sales, V Vila, M Ferrando, E Reganon
Endothelium : journal of endothelial cell research 2007
Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1
SV Bradley, TS Hyun, KI Oravecz-Wilson, L Li, EI Waldorff, AN Ermilov, SA Goldstein, CX Zhang, DG Drubin, K Varela, A Parlow, AA Dlugosz, TS Ross
Human Molecular Genetics 2007
Role of Thrombospondin-1 in T Cell Response to Ocular Pigment Epithelial Cells
Y Futagami, S Sugita, J Vega, K Ishida, H Takase, K Maruyama, H Aburatani, M Mochizuki
Journal of immunology (Baltimore, Md. : 1950) 2007
Novel antiangiogenic pathway of thrombospondin‐1 mediated by suppression of the cell cycle
Yamauchi M, Imajoh\u2010Ohmi S, Shibuya M
Cancer Science 2007
Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization
Hans-Georg Kopp, Andrea T. Hooper, M. Johan Broekman, Scott T. Avecilla, Isabelle Petit, Min Luo, Till Milde, Carlos A. Ramos, Fan Zhang, Tabitha Kopp, Paul Bornstein, Jack Lawler, David K Jin, Aaron J. Marcus, and Shahin Rafii
Journal of Clinical Investigation 2006
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2
NV Lee, M Sato, DS Annis, JA Loo, L Wu, DF Mosher, ML Iruela-Arispe
The EMBO Journal 2006
Requirements for Apoptotic Cell Contact in Regulation of Macrophage Responses
M Lucas, LM Stuart, A Zhang, K Hodivala-Dilke, M Febbraio, R Silverstein, J Savill, A Lacy-Hulbert
Journal of immunology (Baltimore, Md. : 1950) 2006
The Mechanistic Basis of Infarct Healing
NG Frangogiannis
Antioxidants & Redox Signaling 2006
Thrombospondin 1, thrombospondin 2 and the eye
P Hiscott, L Paraoan, A Choudhary, JL Ordonez, A Al-Khaier, DJ Armstrong
Progress in Retinal and Eye Research 2006
Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13
A Bonnefoy, K Daenens, HB Feys, RD Vos, P Vandervoort, J Vermylen, J Lawler, MF Hoylaerts
Blood 2006
Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation
P McKenzie, SC Chadalavada, J Bohrer, JC Adams
BMC Evolutionary Biology 2006
The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin
K Tan, M Duquette, JH Liu, R Zhang, A Joachimiak, J Wang, J Lawler
Structure (London, England : 1993) 2006
Attenuation of retinal vascular development and neovascularization in transgenic mice over-expressing thrombospondin-1 in the lens
Z Wu, S Wang, CM Sorenson, N Sheibani
Developmental Dynamics 2006
Parathyroid Hormone Hormone-Related Protein and the PTH Receptor Regulate Angiogenesis of the Skin
AG Diamond, RM Gonterman, AL Anderson, K Menon, CD Offutt, CH Weaver, WM Philbrick, J Foley
Journal of Investigative Dermatology 2006
Induced thrombospondin expression in the mouse pancreas during pancreatic injury
BA Neuschwander-Tetri, V Talkad, FO Stephen
The International Journal of Biochemistry & Cell Biology 2006
Deficiency of thrombospondin-1 in mice does not affect adipose tissue development
G Voros, HR Lijnen
Journal of Thrombosis and Haemostasis 2006
CD47 Is Necessary for Inhibition of Nitric Oxide-stimulated Vascular Cell Responses by Thrombospondin-1
JS Isenberg, LA Ridnour, J Dimitry, WA Frazier, DA Wink, DD Roberts
The Journal of biological chemistry 2006
Shear Stress Modulates the Expression of Thrombospondin-1 and CD36 in Endothelial Cells in vitro and during Shear Stress-Induced Angiogenesis in vivo
M Bongrazio, LD Silva-Azevedo, EC Bergmann, O Baum, B Hinz, AR Pries, A Zakrzewicz
International journal of immunopathology and pharmacology 2006
Ocular Angiogenesis
J Tombrain-Tink, CJ Barnstable
2006
Identification of Thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia
Charuhas V. Thakar, Kamyar Zahedi, Monica P Revelo, Zhaohui Wang, Charles E. Burnham, Sharon Barone, Shannon Bevans, Alex B. Lentsch, Jack Lawler, Hamid Rabb, and Manoocher Soleimani
Journal of Clinical Investigation 2005
Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis
Y Shaked, F Bertolini, S Man, MS Rogers, D Cervi, T Foutz, K Rawn, D Voskas, DJ Dumont, Y Ben-David, J Lawler, J Henkin, J Huber, DJ Hicklin, RJ D'Amato, RS Kerbel
Cancer Cell 2005
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner
JS Isenberg, LA Ridnour, EM Perruccio, MG Espey, DA Wink, DD Roberts
Proceedings of the National Academy of Sciences 2005
Thrombospondin‐1 up‐regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium
NV Narizhneva, OV Razorenova, EA Podrez, J Chen, UM Chandrasekharan, PE Dicorleto, EF Plow, EJ Topol, TV Byzova
The FASEB Journal 2005
Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells
K Breitkopf, I Sawitza, JH Westhoff, L Wickert, S Dooley, AM Gressner
Gut 2005
Regulation of tumor angiogenesis by thrombospondin-1
B Ren, KO Yee, J Lawler, R Khosravi-Far
Biochimica et Biophysica Acta 2005
Characterization of integrin β6 and thrombospondin‐1 double‐null mice
Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J
Journal of Cellular and Molecular Medicine 2005
The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein
R Simantov, M Febbraio, RL Silverstein
Matrix Biology 2005
The N-terminal module of thrombospondin-1 interacts with the link domain of TSG-6 and enhances its covalent association with the heavy chains of inter-alpha-trypsin inhibitor
SA Kuznetsova, AJ Day, DJ Mahoney, MS Rugg, DF Mosher, DD Roberts
The Journal of biological chemistry 2005
Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases
SM Wahl, W Chen
Arthritis Research & Therapy 2005
Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors
M Sund, Y Hamano, H Sugimoto, A Sudhakar, M Soubasakos, U Yerramalla, LE Benjamin, J Lawler, M Kieran, A Shah, R Kalluri
Proceedings of the National Academy of Sciences 2005
Activation of Latent TGF-β1 by Thrombospondin-1 is a Major Component of Wound Repair
JE Nör, L Dipietro, JE Murphy-Ullrich, RO Hynes, J Lawler, PJ Polverini
Oral biosciences & medicine : OBM 2005
Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation
A Reheman, P Gross, H Yang, P Chen, D Allen, V Leytin, J Freedman, H Ni
Journal of Thrombosis and Haemostasis 2005
Characterization of integrin ?6 and thrombospondin-1 double-null mice
A Ludlow, KO Yee, R Lipman, R Bronson, P Weinreb, X Huang, D Sheppard, J Lawler
Journal of Cellular and Molecular Medicine 2005
CD36:A Multiligand Molecule
Y Ge, MT Elghetany
Laboratory Hematology 2005
Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor
JS Isenberg, MJ Calzada, L Zhou, N Guo, J Lawler, XQ Wang, WA Frazier, DD Roberts
Matrix Biology 2005
Chondromodulin-I and tenomodulin: A new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues
C Shukunami, Y Oshima, Y Hiraki
Biochemical and Biophysical Research Communications 2005
Reduced Expression of Thrombospondins and Craniofacial Dysmorphism in Mice Overexpressing Fra1
T Nishiwaki, T Yamaguchi, C Zhao, H Amano, KD Hankenson, P Bornstein, Y Toyama, K Matsuo
Journal of Bone and Mineral Research 2005
Downregulation of Decorin and Transforming Growth Factor-β1 by Decorin Gene Suppression in Tendinocytes
Y Hosaka, R Kirisawa, N Mafune, K Takehana
Connective Tissue Research 2005
Characterization of integrin beta6 and thrombospondin-1 double-null mice
Anna Ludlow, Karen O Yee, Ruth Lipman, R Bronson, P Weinreb, Xiaozhu Huang, D Sheppard, J Lawler
Journal of Cellular and Molecular Medicine 2005
The N-terminal Module of Thrombospondin-1 Interacts with the Link Domain of TSG-6 and Enhances Its Covalent Association with the Heavy Chains of Inter-α-trypsin Inhibitor
SA Kuznetsova, AJ Day, DJ Mahoney, MS Rugg, DF Mosher, DD Roberts
The Journal of biological chemistry 2005
Thrombin Modulates the Expression of a Set of Genes Including Thrombospondin-1 in Human Microvascular Endothelial Cells
JN McLaughlin, MR Mazzoni, JH Cleator, L Earls, AL Perdigoto, JD Brooks, JA Muldowney, DE Vaughan, HE Hamm
The Journal of biological chemistry 2005
Thrombospondin-1 is Induced in Rat Myocardial Infarction and Its Induction is Accelerated by Ischemia/Reperfusion
S Sezaki, S Hirohata, A Iwabu, K Nakamura, K Toeda, T Miyoshi, H Yamawaki, K Demircan, S Kusachi, Y Shiratori, Y Ninomiya
Experimental biology and medicine (Maywood, N.J.) 2005
The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells
M Soula-Rothhut, C Coissard, H Sartelet, C Boudot, G Bellon, L Martiny, B Rothhut
Experimental Cell Research 2005
Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo
C Daniel, J Wiede, HC Krutzsch, SM Ribeiro, DD Roberts, JE Murphy-Ullrich, C Hugo
Kidney International 2004
Dysfunctional platelet membrane receptors: from humans to mice
J Ware
Thrombosis and haemostasis 2004
Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction
NV Narizhneva, VJ Byers-Ward, MJ Quinn, FJ Zidar, EF Plow, EJ Topol, TV Byzova
The Journal of biological chemistry 2004
The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury
P Bornstein, A Agah, TR Kyriakides
The International Journal of Biochemistry & Cell Biology 2004
Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans
S Wang, ME Herndon, S Ranganathan, S Godyna, J Lawler, WS Argraves, G Liau
Journal of Cellular Biochemistry 2004
The thrombospondins
JC Adams, J Lawler
The International Journal of Biochemistry & Cell Biology 2004
Functions of the conserved thrombospondin carboxy-terminal cassette in cell–extracellular matrix interactions and signaling
JC Adams
The International Journal of Biochemistry & Cell Biology 2004
Thrombospondin modules and angiogenesis
ML Iruela-Arispe, A Luque, N Lee
The International Journal of Biochemistry & Cell Biology 2004
Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation
S Saika, T Miyamoto, I Ishida, WK Barbour, Y Ohnishi, A Ooshima
Experimental Eye Research 2004
Matrix metalloproteinases and matrikines in angiogenesis
G Bellon, L Martiny, A Robinet
Critical Reviews in Oncology/Hematology 2004
Functional regulation of T lymphocytes by modulatory extracellular matrix proteins
SA Kuznetsova, DD Roberts
The International Journal of Biochemistry & Cell Biology 2004
Coronary artery disease and the thrombospondin single nucleotide polymorphisms
OI Stenina, TV Byzova, JC Adams, JJ McCarthy, EJ Topol, EF Plow
The International Journal of Biochemistry & Cell Biology 2004
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-β1 and dexamethasone in vitro
C Flügel-Koch, A Ohlmann, R Fuchshofer, U Welge-Lüssen, ER Tamm
Experimental Eye Research 2004
Ultraviolet B-Induced Skin Angiogenesis Is Associated with a Switch in the Balance of Vascular Endothelial Growth Factor and Thrombospondin-1 Expression
K Yano, K Kajiya, M Ishiwata, YK Hong, T Miyakawa, M Detmar
Journal of Investigative Dermatology 2004
Bone Tissue Engineering
H Donahue, E Vogler, C Siedlecki
Bone Tissue Engineering 2004
The role of ECM molecules in activity-dependent synaptic development and plasticity
I Pavlov, S Lauri, T Taira, H Rauvala
Birth Defects Research Part C: Embryo Today: Reviews 2004
Latent TGF-?1 activation by platelets
R Blakytny, A Ludlow, GE Martin, G Ireland, LR Lund, MW Ferguson, G Brunner
Journal of Cellular Physiology 2004
Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts
KI Oravecz-Wilson, MJ Kiel, L Li, DS Rao, D Saint-Dic, PD Kumar, MM Provot, KD Hankenson, VN Reddy, AP Lieberman, SJ Morrison, TS Ross
Human Molecular Genetics 2004
Role of Thrombospondin-1 in Control of von Willebrand Factor Multimer Size in Mice
JE Pimanda, T Ganderton, A Maekawa, CL Yap, J Lawler, G Kershaw, CN Chesterman, PJ Hogg
The Journal of biological chemistry 2004
Thrombospondin-1 Associated with Tumor Microenvironment Contributes to Low-Dose Cyclophosphamide-Mediated Endothelial Cell Apoptosis and Tumor Growth Suppression
Y Hamano, H Sugimoto, MA Soubasakos, M Kieran, BR Olsen, J Lawler, A Sudhakar, R Kalluri
Cancer research 2004
Dysfunctional platelet membrane receptors: from humans to mice.
Ware J
Thrombosis and haemostasis 2004
Purification and analysis of thrombospondin-1
KO Yee, M Duquette, A Ludlow, J Lawler
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2003
Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice
S Weng, L Zemany, KN Standley, DV Novack, ML Regina, C Bernal-Mizrachi, T Coleman, CF Semenkovich
Proceedings of the National Academy of Sciences 2003
Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase
K Yano, LF Brown, J Lawler, T Miyakawa, M Detmar
Journal of Investigative Dermatology 2003
Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliteration
S Wang, Z Wu, CM Sorenson, J Lawler, N Sheibani
Developmental Dynamics 2003
Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation
V Doyen, M Rubio, D Braun, T Nakajima, J Abe, H Saito, G Delespesse, M Sarfati
Journal of Experimental Medicine 2003
Thrombospondin‐1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor
K Jurk, KJ Clemetson, PG Groot, MF Brodde, M Steiner, N Savion, D Varon, JJ Sixma, HV Aken, BE Kehrel
The FASEB Journal 2003
Antisense Oligonucleotides Against Thrombospondin-1 Inhibit Activation of TGF-β in Fibrotic Renal Disease in the Rat in Vivo
C Daniel, Y Takabatake, M Mizui, Y Isaka, H Kawashi, H Rupprecht, E Imai, C Hugo
The American Journal of Pathology 2003
Plasma fibronectin promotes thrombus growth and stability in injured arterioles
H Ni, PS Yuen, JM Papalia, JE Trevithick, T Sakai, R Fässler, RO Hynes, DD Wagner
Proceedings of the National Academy of Sciences 2003
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
G Bocci, G Francia, S Man, J Lawler, RS Kerbel
Proceedings of the National Academy of Sciences 2003
Antisense oligonucleotides against thrombospondin-1 inhibit activation of tgf-beta in fibrotic renal disease in the rat in vivo
C Daniel, Y Takabatake, M Mizui, Y Isaka, H Kawashi, H Rupprecht, E Imai, C Hugo
The American Journal of Pathology 2003
Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36
Y Moodley, P Rigby, C Bundell, S Bunt, H Hayashi, N Misso, R McAnulty, G Laurent, A Scaffidi, P Thompson, D Knight
The American Journal of Pathology 2003
Pulmonary gene expression profiling of inhaled ricin
L DaSilva, D Cote, C Roy, M Martinez, S Duniho, ML Pitt, T Downey, M Dertzbaugh
Toxicon 2003
The thrombospondin 1-TGF-  axis in fibrotic renal disease
C Hugo
Nephrology Dialysis Transplantation 2003
Lung Biology in Health and Disease
N Zamel
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential 2003
Differential Regulation of Thrombospondin-1 and Thrombospondin-2 After Focal Cerebral Ischemia/Reperfusion
T Lin, GM Kim, JJ Chen, WM Cheung, YY He, CY Hsu
Stroke; a journal of cerebral circulation 2003
Thrombospondin and fibrinogen bind serotonin-derivatized proteins on COAT-platelets
R Szasz, GL Dale
Blood 2002
Cellular response to hypoxia involves signaling via Smad proteins
H Zhang
Blood 2002
Wiley Encyclopedia of Molecular Medicine
WT Morgan
Wiley Encyclopedia of Molecular Medicine 2002
Matricellular proteins: extracellular modulators of cell function
P Bornstein, EH Sage
Current Opinion in Cell Biology 2002
The Diverse Roles of Integrins and Their Ligands in Angiogenesis
R Hynes, J Lively, J Mccarty, D Taverna, S Francis, K Hodivala-Dilke, Q Xiao
Cold Spring Harbor Symposia on Quantitative Biology 2002
The face of TSR revealed: an extracellular signaling domain is exposed
RL Silverstein
The Journal of Cell Biology 2002
The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice
A Agah, TR Kyriakides, J Lawler, P Bornstein
The American Journal of Pathology 2002
ENDOCRINE EXPRESSION OF THE ACTIVE FORM OF TGF-β1 IN THE TGF-β1 NULL MICE FAILS TO AMELIORATE LETHAL PHENOTYPE
G Longenecker, T Thyagarajan, CN Nagineni, KC Flanders, V Factor, G Miller, JM Ward, A Nalca, VM Rangnekar, S Thorgeirsson, AB Kulkarni
Cytokine 2002
Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth
J Lawler
Journal of Cellular and Molecular Medicine 2002
Interactions of thrombospondins with α4β1 integrin and CD47 differentially modulate T cell behavior
Z Li, MJ Calzada, JM Sipes, JA Cashel, HC Krutzsch, DS Annis, DF Mosher, DD Roberts
The Journal of Cell Biology 2002
Drug Discovery and Evaluation
HG Vogel, WH Vogel, BA Schölkens, J Sandow, G Müller, WF Vogel
2002
Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily
H Chang, CW Brown, MM Matzuk
Endocrine reviews 2002
Trimeric assembly of the C-terminal region of Thrombospondin-1 or Thrombospondin-2 is necessary for cell spreading and fascin spike organisation
N Anilkumar, DS Annis, DF Mosher, JC Adams
Journal of cell science 2002
Thrombospondins as matricellular modulators of cell function
Paul Bornstein
Journal of Clinical Investigation 2001
Japanese Journal of Thrombosis and Hemostasis
M OKUDAIRA, H ASAKURA, Y SANO, Y SUGA, M YAMAZAKI, K AOSHIMA, E MORISHITA, M SAITO, Y ONTACHI, T MIZUTANI, M KATO, T ITO, K MIYAMOTO, S NAKAO
Japanese Journal of Thrombosis and Hemostasis 2001
Thrombospondins and tumor angiogenesis
F Fraipont, AC Nicholson, JJ Feige, EG van Meir
Trends in Molecular Medicine 2001
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor
JC Rodriguez-Manzaneque, TF Lane, MA Ortega, RO Hynes, J Lawler, ML Iruela-Arispe
Proceedings of the National Academy of Sciences 2001
PTEN controls tumor-induced angiogenesis
S Wen, J Stolarov, MP Myers, JD Su, MH Wigler, NK Tonks, DL Durden
Proceedings of the National Academy of Sciences 2001
Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice
J Lawler, WM Miao, M Duquette, N Bouck, RT Bronson, RO Hynes
The American Journal of Pathology 2001
THROMBOSPONDINS: Multifunctional Regulators of Cell Interactions
JC Adams
Annual Review of Cell and Developmental Biology 2001
Smad7 Misexpression during Embryonic Angiogenesis Causes Vascular Dilation and Malformations Independently of Vascular Smooth Muscle Cell Function
N Vargesson, E Laufer
Developmental Biology 2001
Special Considerations in the Evaluation of the Hematology and Hemostasis of Mutant Mice
BD Car, VM Eng
Veterinary pathology 2001
TGF?2 activation status during cardiac morphogenesis
KM McCormick
Developmental Dynamics 2001
Vascular Morphogenesis in the Female Reproductive System
HG Augustin, PA Rogers, ML Iruela-Arispe, SK Smith
2001
Thrombospondin-1 Inhibits TCR-Mediated T Lymphocyte Early Activation
Z Li, L He, KE Wilson, DD Roberts
Journal of immunology (Baltimore, Md. : 1950) 2001
Insights into Extracellular Matrix Functions from Mutant Mouse Models
E Gustafsson, R Fässler
Experimental Cell Research 2000
Increased Marrow-Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2
KD Hankenson, SD Bain, TR Kyriakides, EA Smith, SA Goldstein, P Bornstein
Journal of Bone and Mineral Research 2000
The thrombospondin type 1 repeat (TSR) superfamily: Diverse proteins with related roles in neuronal development
JC Adams, RP Tucker
Developmental Dynamics 2000
An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype
CV Ngo, M Gee, N Akhtar, D Yu, O Volpert, R Auerbach, A Thomas-Tikhonenko
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000
Platelets
JN George
The Lancet 2000
A CD36-Binding Peptide from Thrombospondin-1 Can Stimulate Resorption by Osteoclasts in Vitro
JA Carron, SC Wagstaff, JA Gallagher, WB Bowler
Biochemical and Biophysical Research Communications 2000
Osteoclasts and giant cells: macrophage–macrophage fusion mechanism
A Vignery
International Journal of Experimental Pathology 2000
The heparin binding 25 kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinase and TIMP-2 production in endothelial cells
G Taraboletti, L Morbidelli, S Donnini, A Parenti, HJ Granger, R Giavazzi, M Ziche
The FASEB Journal 2000
Thrombospondin 2, a matricellular protein with diverse functions
P Bornstein, LC Armstrong, KD Hankenson, TR Kyriakides, Z Yang
Matrix Biology 2000
The functions of thrombospondin-1 and-2
J Lawler
Current Opinion in Cell Biology 2000
Nitric Oxide–Dependent Activation of P53 Suppresses Bleomycin-Induced Apoptosis in the Lung
DW Davis, DA Weidner, A Holian, DJ McConkey
Journal of Experimental Medicine 2000
Tissue Factor Pathway Inhibitor Binds to Platelet Thrombospondin-1
AE Mast, JE Stadanlick, JM Lockett, DJ Dietzen, KA Hasty, CL Hall
The Journal of biological chemistry 2000
Activation of Platelet-transforming Growth Factor β-1 in the Absence of Thrombospondin-1
M Abdelouahed, A Ludlow, G Brunner, J Lawler
The Journal of biological chemistry 2000
Thrombospondin-4 Binds Specifically to Both Collagenous and Non-collagenous Extracellular Matrix Proteins via Its C-terminal Domains
L Narouz-Ott, P Maurer, DP Nitsche, N Smyth, M Paulsson
The Journal of biological chemistry 2000
Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2: REGULATION OF METALLOPROTEINASE ACTIVITY
K Bein, M Simons
The Journal of biological chemistry 2000
Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2
Z Yang, TR Kyriakides, P Bornstein, R Hynes
Molecular biology of the cell 2000
Antiangiogenic Gene Therapy in Cancer
L Zhang, Q Chen, A Mixson
Current genomics 2000
Apoptosis and Its Modulation by Drugs
RG Cameron, G Feuer
2000
CD47 Ligation Selectively Inhibits the Development of Human Naive T Cells into Th1 Effectors
MN Avice, M Rubio, M Sergerie, G Delespesse, M Sarfati
Journal of immunology (Baltimore, Md. : 1950) 2000
Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo
CP Hugo, RP Pichler, E Schulze-Lohoff, F Prols, S Adler, HC Krutsch, JE Murphy-Ullrich, WG Couser, DD Roberts, RJ Johnson
Kidney International 1999
Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity
TR Kyriakides, KJ Leach, AS Hoffman, BD Ratner, P Bornstein
Proceedings of the National Academy of Sciences 1999
Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis
M Streit, L Riccardi, P Velasco, LF Brown, T Hawighorst, P Bornstein, M Detmar
Proceedings of the National Academy of Sciences 1999
CD47 ligation selectively downregulates human interleukin 12 production
M Armant, MN Avice, P Hermann, M Rubio, M Kiniwa, G Delespesse, M Sarfati
Journal of Experimental Medicine 1999
Expression of Members of the Thrombospondin Family by Human Skeletal Tissues and Cultured Cells
JA Carron, WB Bowler, SC Wagstaff, JA Gallagher
Biochemical and Biophysical Research Communications 1999
Cd47 Ligation Selectively Downregulates Human Interleukin 12 Production
M Armant, MN Avice, P Hermann, M Rubio, M Kiniwa, G Delespesse, M Sarfati
Journal of Experimental Medicine 1999
Overlapping and Independent Functions of Fibronectin Receptor Integrins in Early Mesodermal Development
JT Yang, BL Bader, JA Kreidberg, M Ullman-Culleré, JE Trevithick, RO Hynes
Developmental Biology 1999
Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis
M Streit, L Riccardi, P Velasco, LF Brown, T Hawighorst, P Bornstein, M Detmar
Proceedings of the National Academy of Sciences 1999
Detection of Exon Skipping and Retained Introns in Transcription of the Human Thrombospondin 2 Gene
KW Adolph
Biochemical and Biophysical Research Communications 1999
Relative Abundance of Thrombospondin 2 and Thrombospondin 3 mRNAs in Human Tissues
KW Adolph
Biochemical and Biophysical Research Communications 1999
Thrombospondin-1 and neural crest cell migration
RP Tucker, C Hagios, R Chiquet-Ehrismann, J Lawler, RJ Hall, CA Erickson
Developmental Dynamics 1999
F-Spondin, Expressed in Somite Regions Avoided by Neural Crest Cells, Mediates Inhibition of Distinct Somite Domains to Neural Crest Migration
A Debby-Brafman, T Burstyn-Cohen, A Klar, C Kalcheim
Neuron 1999
Integrins in vascular development
RO Hynes, BL Bader, K Hodivala-Dilke
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 1999
Pro-adhesive and Chemotactic Activities of Thrombospondin-1 for Breast Carcinoma Cells Are Mediated by α 3 β 1 Integrin and Regulated by Insulin-like Growth Factor-1 and CD98
S Chandrasekaran, N Guo, RG Rodrigues, J Kaiser, DD Roberts
The Journal of biological chemistry 1999
Restricted localization of thrombospondin-2 protein during mouse embryogenesis: A comparison to thrombospondin-1
PA Tooney, T Sakai, K Sakai, D Aeschlimann, DF Mosher
Matrix Biology 1998
Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays
H Zhu, JP Cong, G Mamtora, T Gingeras, T Shenk
Proceedings of the National Academy of Sciences 1998
Two-hybrid analysis reveals multiple direct interactions for thrombospondin 1
S Aho, J Uitto
Matrix Biology 1998
The Gene Knockout FactsBook
TW Mak, J Penninger, J Roder, J Rossant, M Saunders
The Gene Knockout FactsBook 1998
Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays
H Zhu, JP Cong, G Mamtora, T Gingeras, T Shenk
Proceedings of the National Academy of Sciences 1998
Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudochondroplasia musculoskeletal tissues
JT Hecht, M Deere, E Putnam, W Cole, B Vertel, H Chen, J Lawler
Matrix Biology 1998
Thrombospondin-1 is a major activator of TGF-beta1 in vivo
S E Crawford, V Stellmach, J E Murphy-Ullrich, S M Ribeiro, J Lawler, R O Hynes, G P Boivin, N Bouck
Cell 1998
Nitric Oxide
RA Schroeder, PC Kuo
Anesthesia & Analgesia 1995
Secretion and biological activities of heparin-binding growth-associated molecule. Neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein
E Raulo, I Julkunen, J Merenmies, R Pihlaskari, H Rauvala
The Journal of biological chemistry 1992
International Review of Cytology
RA Miller
International Review of Cytology 1991
Encyclopedic Reference of Vascular Biology & Pathology
A Bikfalvi
1990

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