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Lymphocytes in the neighborhood: good or bad for the kidney?
Hao Li, … , Maria G. Tsokos, George C. Tsokos
Hao Li, … , Maria G. Tsokos, George C. Tsokos
Published July 1, 2022
Citation Information: J Clin Invest. 2022;132(13):e160657. https://doi.org/10.1172/JCI160657.
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Lymphocytes in the neighborhood: good or bad for the kidney?

Abstract

Lupus nephritis (LN) is common in people with systemic lupus erythematosus (SLE) and advances, almost invariably, to end-stage renal disease (ESRD). In this issue of the JCI, Abraham, Durkee, et al. presented a large-scale immune cell landscape of kidney biopsies from patients with LN by combining multiplexed confocal microscopy imaging with customized computer vision and quantification. The presence of diverse CD4– T cells in small neighborhoods, but not of B cells or CD4+ T cells in large neighborhoods, is linked to the development of ESRD. Unexpectedly, B cells in the kidney heralded a good prognosis. The precise location of different types of immune cells allows inference on possible interactions between different immune cells and also between immune and kidney-resident cells. The data have important implications on the development of prognostic tools and effective targeted therapies in patients with LN.

Authors

Hao Li, Maria G. Tsokos, George C. Tsokos

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